Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines

Anticancer Research

Volumn 27, Issue 1 A, 2007, Pages 251-258

  Rho, Minsuk ^a   Kim, Jin ^a   Chang, Do Jee ^a   You, Mie Lee ^a   Hee, Eun Lee ^a   Kim, Min A ^a   Hye, Seung Lee ^b   Woo, Ho Kim ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

Bcl 2; Hexokinase; Immunohistochemistry; Mitochondria; Stomach neoplasms; Tissue array

Indexed keywords

ACTIN; ANTIMYCIN A1; ETHIDIUM BROMIDE; GENE PRODUCT; HEXOKINASE; HEXOKINASE TYPE 2; PROTEIN BCL 2; PROTEIN P53; ROTENONE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HYPOXIA; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MITOCHONDRION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STOMACH CARCINOMA; TISSUE MICROARRAY; TRANSCRIPTION REGULATION;

CELL LINE, TUMOR; FEMALE; GENE EXPRESSION; HEXOKINASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRUVATE DEHYDROGENASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33847655286     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Lu H, Forbes RA and Verma A: Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277: 23111-23115, 2002.
2. Mathupala SP, Rempel A and Pedersen PL: Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase. J Bioenerg Biomembr 29: 339-343, 1997.
3. Pedersen PL, Mathupala S, Rempel A, Geschwind JF and Ko YH: Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim Biophys Acta 1555: 14-20, 2002.
4. Golshani-Hebroni SG and Bessman SP: Hexokinase binding to mitochondria: a basis for proliferative energy metabolism. J Bioenerg Biomembr 29: 331-338, 1997.
5. Marton A, Mihalik R, Bratincsak A, Adleff V, Petak I, Vegh M, Bauer PI and Krajcsi P: Apoptotic cell death -induced by inhibitors of energy conservation - Bcl-2 inhibits apoptosis downstream of a fall of ATP level. Eur J Biochem 250: 467-475, 1997.
6. Reitzer LJ, Wice BM and Kennell D: Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 254: 2669-2676, 1979.
7. Pastorino JG, Shulga N and Hoek JB: Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 277: 7610-7618, 2002.
8. Pastorino JG and Hoek JB: Hexokinase II: the integration of energy metabolism and control of apoptosis. Curr Med Chem 10: 1535-1551, 2003.
9. Majewski N, Nogueira V, Robey RB and Hay N: Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol 24: 730-740, 2004.
10. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D and Reed JC: Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95: 4997-5002, 1998.
11. Ebert BL, Firth JD and Ratcliffe PJ: Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 270: 29083-29089, 1995.
12. Dang CV, Lewis BC, Dolde C, Dang G and Shim H: Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Bioenerg Biomembr 29: 345-354, 1997.
13. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P and Moll UM: p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-590, 2003.
14. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI and Kim WH: MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer 92: 1427-1434, 2001.
15. Lee HS, Lee HK, Kim HS, Yang HK and Kim WH: Tumour suppressor gene expression correlates with gastric cancer prognosis. J Pathol 200: 39-46, 2003.
16. Rustin P: Mitochondria, from cell death to proliferation. Nat Genet 30: 352-353, 2002.
17. Helmlinger G, Sckell A, Dellian M, Forbes NS and Jain RK: Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res 8: 1284-1291, 2002.
18. Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A and Caro J: Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 276: 21995-21998, 2001.
19. Scheffler IE: Mitochondria make a come back. Adv Drug Deliv Rev 49: 3-26, 2001.
20. Bryson JM, Coy PE, Gottlob K, Hay N and Robey RB: Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death. J Biol Chem 277: 11392-11400, 2002.
21. Gottlieb E, Armour SM and Thompson CB: Mitochondrial respiratory control is lost during growth factor deprivation. Proc Natl Acad Sci USA 99: 12801-12806, 2002.
22. Plas DR and Thompson CB: Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab 13: 75-78, 2002.
23. Cheng EH, Sheiko TV, Fisher JK, Craigen WJ and Korsmeyer SJ: VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science 301: 513-517, 2003.
24. Chiarugi V and Ruggiero M: Role of three cancer "master genes" p53, bcl2 and c-myc on the apoptotic process. Tumori 82: 205-209, 1996.
25. Pastorino JG and Hoek JB: Hexokinase II: the integration of energy metabolism and control of apoptosis. Curr Med Chem 10: 1535-1551, 2003.
26. McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, Thompson CB, Hay N and Chandel NS: Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol 22: 94-104, 2002.
27. de Graaf AO, Meijerink JP, van den Heuvel LP, DeAbreu RA, de Witte T, Jansen JH and Smeitink JA: Bcl-2 protects against apoptosis induced by antimycin A and bongkrekic acid without restoring cellular ATP levels. Biochim Biophys Acta 1554: 57-65, 2002.
28. Hussain SA, Ganesan R, Hiller L, Cooke PW, Murray P, Young LS and James ND: BCL2 expression predicts survival in patients receiving synchronous chemoradiotherapy in advanced transitional cell carcinoma of the bladder. Oncol Rep 10: 571-576, 2003.
29. Brambilla E, Negoescu A, Gazzeri S, Lantuejoul S, Moro D, Brambilla C and Coll JL: Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol 149: 1941-1952, 1996.
30. Blagosklonny MV: Paradox of Bcl-2 (and p53): why may apoptosis-regulating proteins be irrelevant to cell death? Bioessays 23: 947-953, 2001.