-
2
-
-
58049196616
-
MicroRNA in cancer prognosis
-
Slack FJ, Weidhaas JB. MicroRNA in cancer prognosis. N Engl J Med 2008;359:2720-2.
-
(2008)
N Engl J Med
, vol.359
, pp. 2720-2722
-
-
Slack, F.J.1
Weidhaas, J.B.2
-
3
-
-
58849148000
-
MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes
-
Inomata M, Tagawa H, Guo YM, Kameoka Y, Takahashi N, Sawada K. MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes. Blood 2009;113:396-402.
-
(2009)
Blood
, vol.113
, pp. 396-402
-
-
Inomata, M.1
Tagawa, H.2
Guo, Y.M.3
Kameoka, Y.4
Takahashi, N.5
Sawada, K.6
-
4
-
-
69049120925
-
High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1
-
Qian B, Katsaros D, Lu L, et al. High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1. Breast Cancer Res Treat 2009;117:131-40.
-
(2009)
Breast Cancer Res Treat
, vol.117
, pp. 131-140
-
-
Qian, B.1
Katsaros, D.2
Lu, L.3
-
5
-
-
67649783639
-
Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma
-
Qi L, Bart J, Tan LP, et al. Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma. BMC Cancer 2009;9:163.
-
(2009)
BMC Cancer
, vol.9
, pp. 163
-
-
Qi, L.1
Bart, J.2
Tan, L.P.3
-
6
-
-
25444520537
-
MiR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005;102:13944-9.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
-
7
-
-
20044395613
-
RAS is regulated by the let-7 microRNA family
-
Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005;120:635-47.
-
(2005)
Cell
, vol.120
, pp. 635-647
-
-
Johnson, S.M.1
Grosshans, H.2
Shingara, J.3
-
8
-
-
34548746977
-
MicroRNA signatures in human ovarian cancer
-
Iorio MV, Visone R, Di Leva G, et al. MicroRNA signatures in human ovarian cancer. Cancer Res 2007;67:8699-707.
-
(2007)
Cancer Res
, vol.67
, pp. 8699-8707
-
-
Iorio, M.V.1
Visone, R.2
Di Leva, G.3
-
9
-
-
51049119231
-
Diagnostic and prognostic microRNAs in stage II colon cancer
-
Schepeler T, Reinert JT, Ostenfeld MS, et al. Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res 2008;68:6416-24.
-
(2008)
Cancer Res
, vol.68
, pp. 6416-6424
-
-
Schepeler, T.1
Reinert, J.T.2
Ostenfeld, M.S.3
-
10
-
-
0025078512
-
The cellular functions of small GTP-binding proteins
-
Hall A. The cellular functions of small GTP-binding proteins. Science 1990;249:635-40.
-
(1990)
Science
, vol.249
, pp. 635-640
-
-
Hall, A.1
-
11
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
Martin, J.4
Arnheim, N.5
Perucho, M.6
-
12
-
-
14444284330
-
Tumor-suppressive pathways in pancreatic carcinoma
-
Rozenblum E, Schutte M, Goggins M, et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 1997;57:1731-4.
-
(1997)
Cancer Res
, vol.57
, pp. 1731-1734
-
-
Rozenblum, E.1
Schutte, M.2
Goggins, M.3
-
13
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50.
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
-
14
-
-
33947199328
-
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling
-
Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ. K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res 2007;67:2098-106.
-
(2007)
Cancer Res
, vol.67
, pp. 2098-2106
-
-
Campbell, P.M.1
Groehler, A.L.2
Lee, K.M.3
Ouellette, M.M.4
Khazak, V.5
Der, C.J.6
-
15
-
-
67649637824
-
Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling
-
Kallifatidis G, Rausch V, Baumann B, et al. Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling. Gut 2009;58:949-63.
-
(2009)
Gut
, vol.58
, pp. 949-963
-
-
Kallifatidis, G.1
Rausch, V.2
Baumann, B.3
-
16
-
-
33746122005
-
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines
-
Li YY, Popivanova BK, Nagai Y, Ishikura H, Fujii C, Mukaida N. Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res 2006;66:6741-7.
-
(2006)
Cancer Res
, vol.66
, pp. 6741-6747
-
-
Li, Y.Y.1
Popivanova, B.K.2
Nagai, Y.3
Ishikura, H.4
Fujii, C.5
Mukaida, N.6
-
17
-
-
34547209343
-
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
-
McCubrey JA, Steelman LS, Chappell WH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007;1773:1263-84.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1263-1284
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
-
18
-
-
0347997608
-
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
-
Zhang W, Liu HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002;12:9-18.
-
(2002)
Cell Res
, vol.12
, pp. 9-18
-
-
Zhang, W.1
Liu, H.T.2
-
19
-
-
34248200155
-
MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
-
Szafranska AE, Davison TS, John J, et al. MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 2007;26:4442-52.
-
(2007)
Oncogene
, vol.26
, pp. 4442-4452
-
-
Szafranska, A.E.1
Davison, T.S.2
John, J.3
-
20
-
-
58049202164
-
MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia
-
Yu J, Ryan DG, Getsios S, Oliveira-Fernandes M, Fatima A, Lavker RM. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proc Natl Acad Sci U S A 2008;105:19300-5.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19300-19305
-
-
Yu, J.1
Ryan, D.G.2
Getsios, S.3
Oliveira-Fernandes, M.4
Fatima, A.5
Lavker, R.M.6
-
21
-
-
0030710098
-
Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation
-
Aoki K, Yoshida T, Matsumoto N, Ide H, Sugimura T, Terada M. Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation. Mol Carcinog 1997;20:251-8.
-
(1997)
Mol Carcinog
, vol.20
, pp. 251-258
-
-
Aoki, K.1
Yoshida, T.2
Matsumoto, N.3
Ide, H.4
Sugimura, T.5
Terada, M.6
-
22
-
-
4143146567
-
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells
-
Agbunag C, Bar-Sagi D. Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res 2004;64:5659-63.
-
(2004)
Cancer Res
, vol.64
, pp. 5659-5663
-
-
Agbunag, C.1
Bar-Sagi, D.2
-
23
-
-
0021362206
-
Malignant activation of a K-RAS oncogene in lung carcinoma but not in normal tissue of the same patient
-
Santos E, Martin-Zanca D, Reddy E, Pierotti M, Della Porta G, Barbacid M. Malignant activation of a K-RAS oncogene in lung carcinoma but not in normal tissue of the same patient. Science 1984;223:661-4.
-
(1984)
Science
, vol.223
, pp. 661-664
-
-
Santos, E.1
Martin-Zanca, D.2
Reddy, E.3
Pierotti, M.4
Della Porta, G.5
Barbacid, M.6
-
24
-
-
0025074419
-
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung
-
Slebos RJ, Kibbelaar RE, Dalesio O, et al. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 1990;323:561-5.
-
(1990)
N Engl J Med
, vol.323
, pp. 561-565
-
-
Slebos, R.J.1
Kibbelaar, R.E.2
Dalesio, O.3
-
26
-
-
33749320834
-
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
-
Janssen KP, Alberici P, Fsihi H, et al. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 2006;131:1096-109.
-
(2006)
Gastroenterology
, vol.131
, pp. 1096-1109
-
-
Janssen, K.P.1
Alberici, P.2
Fsihi, H.3
-
27
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre AJ, Bardeesy N, Sinha M, et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 2003;17:3112-26.
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
-
28
-
-
28844505028
-
Mutant KRAS, chromosomal instability and prognosis in colorectal cancer
-
Castagnola P, Giaretti W. Mutant KRAS, chromosomal instability and prognosis in colorectal cancer. Biochim Biophys Acta 2005;1756:115-25.
-
(2005)
Biochim Biophys Acta
, vol.1756
, pp. 115-125
-
-
Castagnola, P.1
Giaretti, W.2
-
29
-
-
34247149803
-
Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
-
Lee J, Jang KT, Ki CS, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007;109:1561-9.
-
(2007)
Cancer
, vol.109
, pp. 1561-1569
-
-
Lee, J.1
Jang, K.T.2
Ki, C.S.3
-
30
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A 1996;93:3636-41.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
-
31
-
-
0041338049
-
Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
-
Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ. Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 2002;1:989-97.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 989-997
-
-
Bondar, V.M.1
Sweeney-Gotsch, B.2
Andreeff, M.3
Mills, G.B.4
McConkey, D.J.5
-
32
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005;7:469-83.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
-
33
-
-
0035863411
-
AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells
-
Tanno S, Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 2001;61:589-93.
-
(2001)
Cancer Res
, vol.61
, pp. 589-593
-
-
Tanno, S.1
Tanno, S.2
Mitsuuchi, Y.3
Altomare, D.A.4
Xiao, G.H.5
Testa, J.R.6
-
34
-
-
66249116702
-
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
-
Wee S, Jagani Z, Xiang KX, et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res 2009;69:4286-93.
-
(2009)
Cancer Res
, vol.69
, pp. 4286-4293
-
-
Wee, S.1
Jagani, Z.2
Xiang, K.X.3
-
35
-
-
0029011218
-
The MAPK signaling cascade
-
Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995;9:726-35.
-
(1995)
FASEB J
, vol.9
, pp. 726-735
-
-
Seger, R.1
Krebs, E.G.2
-
36
-
-
33646399160
-
Targeting the ERK signaling pathway in cancer therapy
-
Kohno M, Pouyssegur J. Targeting the ERK signaling pathway in cancer therapy. Ann Med 2006;38:200-11.
-
(2006)
Ann Med
, vol.38
, pp. 200-211
-
-
Kohno, M.1
Pouyssegur, J.2
-
37
-
-
0034816092
-
CAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition
-
Boucher MJ, Duchesne C, Lainé J, Morisset J, Rivard N. cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. Biochem Biophys Res Commun 2001;285:207-16.
-
(2001)
Biochem Biophys Res Commun
, vol.285
, pp. 207-216
-
-
Boucher, M.J.1
Duchesne, C.2
Lainé, J.3
Morisset, J.4
Rivard, N.5
-
38
-
-
33750370444
-
MicroRNA signatures in human cancers
-
Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 857-866
-
-
Calin, G.A.1
Croce, C.M.2
-
39
-
-
33645294070
-
Oncomirs - MicroRNAs with a role in cancer
-
Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006;6:259-69.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
40
-
-
69949119988
-
Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells
-
Guttilla IK, White BA. Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem 2009;284:23204-16.
-
(2009)
J Biol Chem
, vol.284
, pp. 23204-23216
-
-
Guttilla, I.K.1
White, B.A.2
|