Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy

PLoS Biology

Volumn 10, Issue 5, 2012, Pages

  Lu, Weiqin ^a   Hu, Yumin ^a,b   Chen, Gang ^a   Chen, Zhao ^a   Zhang, Hui ^a   Wang, Feng ^a,b   Feng, Li ^a   Pelicano, Helene ^a   Wang, Hua ^a   Keating, Michael J ^a   Liu, Jinsong ^a   McKeehan, Wallace ^c   Wang, Huamin ^a   Luo, Yongde ^c   Huang, Peng ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; K RAS PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN P22; PROTEIN P53; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; TETRACYCLINE; COPPER ZINC SUPEROXIDE DISMUTASE; CYBA PROTEIN, HUMAN; NOX1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

AEROBIC GLYCOLYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PANCREAS CANCER; UPREGULATION; ANIMAL; CELL STRAIN HEK293; CELL SURVIVAL; DRUG SCREENING; ENZYME ACTIVATION; ENZYMOLOGY; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; MITOCHONDRION; NUDE MOUSE; OXIDATIVE PHOSPHORYLATION; PANCREAS TUMOR; PATHOLOGY; PLASMID; TUMOR GENE;

ANIMALS; CELL SURVIVAL; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GENES, NEOPLASM; GLYCOLYSIS; HEK293 CELLS; HUMANS; MICE; MICE, NUDE; MITOCHONDRIA; NADPH OXIDASE; OXIDATIVE PHOSPHORYLATION; PANCREATIC NEOPLASMS; PLASMIDS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SUPEROXIDE DISMUTASE; TETRACYCLINE; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84861534727     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001326     Document Type: Article

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