Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

Biochemical Journal

Volumn 381, Issue 3, 2004, Pages 761-767

  Marxsen, Jan H ^a   Stengel, Petra ^a   Doege, Kathrin ^a   Heikkinen, Pekka ^b   Jokilehto, Terhi ^b   Wagner, Thomas ^a   Jelkmann, Wolfgang ^a   Jaakkola, Panu ^b   Metzen, Eric ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Hypoxia inducible factor; Oxygen sensing; Post translational modification; Prolyl hydroxylation; Protein degradation; Von Hippel Lindau protein

Indexed keywords

CELLS; DEGRADATION; OXYGEN; PROTEINS; RNA;

GENE EXPRESSION; REGULATORY MECHANISMS;

BIOCHEMISTRY;

CYTOPLASM PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR ALPHA PROPYL 4 HYDROLASE; NUCLEAR PROTEIN; OXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ALPHA CHAIN; ARTICLE; CELL LINE; ENZYME DEGRADATION; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; REOXYGENATION; UBIQUITINATION;

ADENOCARCINOMA, CLEAR CELL; ANOXIA; BONE NEOPLASMS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; DIOXYGENASES; DNA-BINDING PROTEINS; ENZYME INDUCTION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HALF-LIFE; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMEDIATE-EARLY PROTEINS; KIDNEY NEOPLASMS; KIDNEY TUBULES, PROXIMAL; LIVER NEOPLASMS; NUCLEAR PROTEINS; OSTEOSARCOMA; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 4344645563     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040620     Document Type: Article

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