Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways

Cancer Prevention Research

Volumn 5, Issue 3, 2012, Pages 374-384

  Silviera, Matthew L ^a   Smith, Brian P ^a   Powell, Jasmine ^a   Sapienza, Carmen ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CANCER PATIENT; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; COLON CANCER; COLON MUCOSA; CONTROLLED STUDY; DIET; DNA METHYLATION; EPIGENETICS; FEMALE; GENE FUNCTION; GENETIC ANALYSIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN TISSUE; LIPID METABOLISM; MALE; METABOLIC PARAMETERS; MORPHOLOGY; PRIORITY JOURNAL;

AGED; CASE-CONTROL STUDIES; COLON; COLONIC NEOPLASMS; CPG ISLANDS; DIET; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; METABOLIC NETWORKS AND PATHWAYS; MUCOUS MEMBRANE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84859463632     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-11-0336     Document Type: Article

References (39)

1. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881-5.
2. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38:320-3.
3. Denham S, Koppelman GH, Blakey J, Wjst M, Ferreira MA, Hall IP, et al. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respir Res 2008;9:38.
4. Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, Wong KC, et al. A genome-wide association study of global gene expression. Nat Genet 2007;39:1202-7. (Pubitemid 47482680)
5. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40: 955-62.
6. Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 2007;3:e58.
7. Zhang F, Sarginson J, Crombie C, Walker N, St Clair D, Shaw D. Genetic association between schizophrenia and the DISC1 gene in the Scottish population. Am J Med Genet B Neuropsychiatr Genet 2006;141B:155-9. (Pubitemid 43214791)
8. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-5. (Pubitemid 46871655)
9. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA 2008;299:2877-83. (Pubitemid 351930887)
10. Turan N, Katari S, Coutifaris C, Sapienza C. Explaining inter-individual variability in phenotype: is epigenetics up to the challenge? Epigenetics 2010;5:16-9.
11. American Cancer Society. Colorectal cancer facts & figures 2011-2013. Atlanta, GA: American Cancer Society; 2011.
12. Jasperson KW, Tuohy TM, Neklason DW, Burt RW. Hereditary and familial colon cancer. Gastroenterology 2010;138:2044-58.
13. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, et al. Environmental and heritable factors in the causation of canceranalyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85. (Pubitemid 30451850)
14. Willett WC. Diet and cancer. Oncologist 2000;5:393-404.
15. Khan N, Afaq F, Mukhtar H. Lifestyle as risk factor for cancer: evidence from human studies. Cancer Lett 2010;293:133-43.
16. Liang PS, Chen TY, Giovannucci E. Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis. Int J Cancer 2009;124:2406-15.
17. Limsui D, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, et al. Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst 2010;102: 1012-22.
18. Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 2003;299:1753-5. (Pubitemid 36337205)
19. Cui H, Horon IL, Ohlsson R, Hamilton SR, Feinberg AP. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nat Med 1998;4:1276-80. (Pubitemid 28512108)
20. Nakagawa H, Chadwick RB, Peltomaki P, Plass C, Nakamura Y, de La Chapelle A. Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A 2001;98:591-6. (Pubitemid 32105087)
21. Hiraoka S, Kato J, Horii J, Saito S, Harada K, Fujita H, et al. Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon. Hum Pathol 2010;41:38-47.
22. Kim MS, Louwagie J, Carvalho B, Terhaar Sive Droste JS, Park HL, Chae YK, et al. Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer. PLoS One 2009;4:e6555.
23. Widschwendter M, Fiegl H, Egle D, Mueller-Holzner E, Spizzo G, Marth C, et al. Epigenetic stem cell signature in cancer. Nat Genet 2007;39: 157-8. (Pubitemid 46184343)
24. Hinoue T, Weisenberger DJ, Pan F, Campan M, Kim M, Young J, et al. Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One 2009;4: e8357.
25. Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006;38:787-93. (Pubitemid 43980599)
26. Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009;41:178-86.
27. Zhang W, Press OA, Haiman CA, Yang DY, Gordon MA, Fazzone W, et al. Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer. J Clin Oncol 2007;25:3726-31. (Pubitemid 47372614)
28. Estécio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, Maegawa S, et al. Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Res 2010;20: 1369-82.
29. Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 2008;105:4283-8. (Pubitemid 351754372)
30. Andrieu N, Dondon MG, Goldstein AM. Increased power to detect gene-environment interaction using siblings controls. Ann Epidemiol 2005;15:705-11. (Pubitemid 41266975)
31. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc 1995;57:289-300.
32. Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet 2009;18:3769-78.
33. Turan N, Katari S, Gerson LF, Chalian R, Foster MW, Gaughan JP, et al. Inter- and intra-individual variation in allele-specific DNA methylation and gene expression in children conceived using assisted reproductive technology. PLoS Genet 2010;6:e1001033.
34. Sapienza C, Lee J, Powell J, Erinle O, Yafai F, Reichert J, et al. DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy. Epigenetics 2011;6:20-8.
35. Peterlik M, Grant WB, Cross HS. Calcium, vitamin D and cancer. Anticancer Res 2009;29:3687-98.
36. Rakyan VK, Down TA, Thorne NP, Flicek P, Kulesha E, Gräf S, et al. An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res 2008;18:1518-29.
37. Cheung VG, Spielman RS. Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet 2009;10:595-604.
38. Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, et al. MGMTpromoter methylation and field defect in sporadic colon cancer. J Natl Cancer Inst 2005;97:1330-8. (Pubitemid 41487800)
39. Moonesinghe R, Liu T, Khoury MJ. Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases. Eur J Hum Genet 2010;18:485-9.