Hexokinase II and VEGF expression in liver tumors: Correlation with hypoxia-inducible factor-1α and its significance

Journal of Hepatology

Volumn 40, Issue 1, 2004, Pages 117-123

  Yasuda, Seiichi ^a   Arii, Shigeki ^b   Mori, Akira ^a   Isobe, Naoki ^a   Yang, Weige ^a   Oe, Hideaki ^a   Fujimoto, Akihisa ^a   Yonenaga, Yoshikuni ^a   Sakashita, Hiromi ^a   Imamura, Masayuki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Hexokinase II; Hypoxia inducible factor 1; Liver tumors

Indexed keywords

HEXOKINASE; HEXOKINASE ISOENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; ARTICLE; ARTIFICIAL EMBOLISM; CANCER CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GLYCOLYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CANCER; LIVER CELL CARCINOMA; MALE; METASTASIS; MICROVASCULATURE; NECROSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TUMOR VASCULARIZATION;

EID: 0346689991     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00503-8     Document Type: Article

References (31)

1. Folkman J, Klagsbrun M. Angiogenic factors. Science 1987;235: 442-447.
2. Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M, Kojiro M. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998;28:68-77.
3. Wong MP, Cheung N, Yuen ST, Leung SY, Chung LP. Vascular endothelial growth factor is up-regulated in the early premalignant stage of colorectal tumour progression. Int J Cancer 1999;81: 845-850.
4. Mise M, Arii S, Higashituji H, Furutani M, Niwano M, Harada T, et al. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996;23:455-464.
5. Mori A, Arii S, Furutani M, Hanaki K, Takeda Y, Moriga T, et al. Vascular endothelial growth factor-induced tumor angiogenesis and tumorigenicity in relation to metastasis in a HT1080 human fibrosarcoma cell model. Int J Cancer 1999;80:738-743.
6. Sweeney MJ, Ashmore J, Morris HP, Weber G. Comparative biochemistry of hepatomas. IV. Isotope studies of glucose and fructose metabolism in liver tumors of different growth rates. Cancer Res 1963;23:995-1002.
7. Burk D, Woods M, Hunter J. On the significance of glucolysis for cancer growth, with special reference of Morris rat hepatomas. J Natl Cancer Inst 1967;38:839-863.
8. Shinohara Y, Ichihara J, Terada H. Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130. FEBS Lett 1991;291:55-57.
9. Adams V, Kempf W, Hassam S, Briner J. Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma. Biochem Mol Med 1995;54:53-58.
10. Rempel A, Bannasch P, Mayer D. Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages. Biochim Biophys Acta 1994;1219: 660-668.
11. Katabi MM, Chan HL, Karp SE, Batist G. Hexokinase type II: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells. Hum Gene Ther 1999;10:155-164.
12. 2 tension. Proc Natl Acad Sci USA 1995;92:5510-5514.
13. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998;12:149-162.
14. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394:485-490.
15. Salceda S, Caro J. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997;272:22642-22647.
16. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999;15:551-578.
17. Riddle SR, Ahmad A, Ahmad S, Deeb SS, Malkki M, Schneider BK, et al. Hypoxia induces hexokinase II gene expression in human lung cell line A549. Am J Physiol Lung Cell Mol Physiol 2000;278: L407-L416.
18. Mathupala SP, Rempel A, Pedersen PL. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem 2001;276:43407-43412.
19. Bossi P, Viale G, Lee AK, Alfano R, Coggi G, Bosari S. Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res 1995; 55:5049-5053.
20. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res 1999;59:5830-5835.
21. Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-890.
22. Karth J, Ferrer FA, Perlman E, Hanrahan C, Simons JW, Gearhart JP, et al. Coexpression of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in Wilms' tumor. J Pediatr Surg 2000;35: 1749-1753.
23. Terayama N, Terada T, Nakanuma Y. A morphometric and immunohistochemical study on angiogenesis of human metastatic carcinomas of the liver. Hepatology 1996;24:816-819.
24. Terayama N, Terada T, Nakanuma Y. An immunohistochemical study of tumour vessels in metastatic liver cancers and the surrounding liver tissue. Histopathology 1996;29:37-43.
25. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 1997;94:8104-8109.
26. Peoch M, Farion R, Hiou A, Le Bas JF, Pasquier B, Remy C. Immunohistochemical study of VEGF, angiopoietin 2 and their receptors in the neovascularization following microinjection of C6 glioma cells into rat brain. Anticancer Res 2002;22:2147-2151.
27. Song BC, Chung YH, Kim JA, Lee HC, Yoon HK, Sung KB, et al. Association between insulin-like growth factor-2 and metastases after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: a prospective study. Cancer 2001;91:2386-2393.
28. Mori A, Arii S, Furutani M, Mizumoto M, Uchida S, Furuyama H, et al. Soluble Flt-1 gene therapy for peritoneal metastases using HVJ-cationic liposomes. Gene Ther 2000;7:1027-1033.
29. Gorrin-Rivas MJ, Arii S, Mori A, Kaneda Y, Imamura M. Mouse macrophage metalloelastase gene delivery by HVJ-cationic liposomes in experimental antiangiogenic gene therapy for murine CT-26 colon cancer. Int J Cancer 2001;93:731-735.
30. Dachs GU, Patterson AV, Firth JD, Ratcliffe PJ, Townsend KM, Stratford IJ, et al. Targeting gene expression to hypoxic tumor cells. Nat Med 1997;3:515-520.
31. Shibata T, Giaccia AJ, Brown JM. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 2002;4:40-48.