Metabolic defects provide a spark for the epigenetic switch in cancer

Free Radical Biology and Medicine

Volumn 47, Issue 2, 2009, Pages 115-127

  Hitchler, Michael J ^a   Domann, Frederick E ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

5 hydroxymethylcytosine; Cancer metabolism; Carcinogenesis; DNA methylation; Epigenome; Free radicals; Histones; Warburg effect

Indexed keywords

DNA METHYLTRANSFERASE; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; SIRTUIN;

ACETYLATION; AEROBIC METABOLISM; CARBON METABOLISM; CARCINOGENESIS; CHROMOSOME ABERRATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; HUMAN; METABOLIC DISORDER; NEOPLASM; NONHUMAN; NUCLEOSOME; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

ACETYLATION; ANIMALS; DNA METHYLATION; EPIGENESIS, GENETIC; FREE RADICALS; GLUTATHIONE; HISTONES; HUMANS; NEOPLASMS; NUCLEOSOMES; OXIDATION-REDUCTION; S-ADENOSYLMETHIONINE;

EID: 67349240804     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.04.010     Document Type: Review

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