-
1
-
-
33750370444
-
MicroRNA signatures in human cancers
-
Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 857-866
-
-
Calin, G.A.1
Croce, C.M.2
-
2
-
-
33749507943
-
A small piece in the cancer puzzle: MicroRNAs as tumor suppressors and oncogenes
-
Kent OA, Mendell JT. A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene 2006;25:6188-96.
-
(2006)
Oncogene
, vol.25
, pp. 6188-6196
-
-
Kent, O.A.1
Mendell, J.T.2
-
3
-
-
33645294070
-
Oncomirs - microRNAs with a role in cancer
-
Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006;6:259-69.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
4
-
-
20444467290
-
A microRNA polycistron as a potential human oncogene
-
He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature 2005;435:828-33.
-
(2005)
Nature
, vol.435
, pp. 828-833
-
-
He, L.1
Thomson, J.M.2
Hemann, M.T.3
-
5
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007;447:1130-4.
-
(2007)
Nature
, vol.447
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
-
6
-
-
22244467087
-
MicroRNA-21 Is an antiapoptotic factor in human glioblastoma cells
-
Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 Is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65:6029-33.
-
(2005)
Cancer Res
, vol.65
, pp. 6029-6033
-
-
Chan, J.A.1
Krichevsky, A.M.2
Kosik, K.S.3
-
7
-
-
20444460289
-
MicroRNA expression profiles classify human cancers
-
Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-8.
-
(2005)
Nature
, vol.435
, pp. 834-838
-
-
Lu, J.1
Getz, G.2
Miska, E.A.3
-
8
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
Volinia S, Calin GA, Liu C-G, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006;103:2257-61.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2257-2261
-
-
Volinia, S.1
Calin, G.A.2
Liu, C.-G.3
-
9
-
-
23844555119
-
MicroRNA gene expression deregulation in human breast cancer
-
Iorio MV, Ferracin M, Liu C-G, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65:7065-70.
-
(2005)
Cancer Res
, vol.65
, pp. 7065-7070
-
-
Iorio, M.V.1
Ferracin, M.2
Liu, C.-G.3
-
10
-
-
33744521896
-
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines
-
Meng F, Henson R, Lang M, et al. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 2006;130:2113-29.
-
(2006)
Gastroenterology
, vol.130
, pp. 2113-2129
-
-
Meng, F.1
Henson, R.2
Lang, M.3
-
11
-
-
34247495591
-
miR-21-mediated tumor growth
-
Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY. miR-21-mediated tumor growth. Oncogene 2006;26:2799-803.
-
(2006)
Oncogene
, vol.26
, pp. 2799-2803
-
-
Si, M.L.1
Zhu, S.2
Wu, H.3
Lu, Z.4
Wu, F.5
Mo, Y.Y.6
-
12
-
-
35148900227
-
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas
-
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res 2007;67:8994-9000.
-
(2007)
Cancer Res
, vol.67
, pp. 8994-9000
-
-
Corsten, M.F.1
Miranda, R.2
Kasmieh, R.3
Krichevsky, A.M.4
Weissleder, R.5
Shah, K.6
-
13
-
-
0035256772
-
Gliomagenesis: Genetic alterations and mouse models
-
Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2001;2:120-9.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 120-129
-
-
Holland, E.C.1
-
14
-
-
41749113108
-
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
-
Asangani IA, Rasheed SAK, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2007;27:2128-36.
-
(2007)
Oncogene
, vol.27
, pp. 2128-2136
-
-
Asangani, I.A.1
Rasheed, S.A.K.2
Nikolova, D.A.3
-
15
-
-
38149042783
-
Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
-
Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 2008;283:1026-33.
-
(2008)
J Biol Chem
, vol.283
, pp. 1026-1033
-
-
Frankel, L.B.1
Christoffersen, N.R.2
Jacobsen, A.3
Lindow, M.4
Krogh, A.5
Lund, A.H.6
-
16
-
-
34347266556
-
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
-
Zhu S, Si M-L, Wu H, Mo Y-Y. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 2007;282:14328-36.
-
(2007)
J Biol Chem
, vol.282
, pp. 14328-14336
-
-
Zhu, S.1
Si, M.-L.2
Wu, H.3
Mo, Y.-Y.4
-
17
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-7.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
18
-
-
0030799909
-
Somatic mutations of PTEN in glioblastoma multiforme
-
Wang SI, Puc J, Li J, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 1997;57:4183-6.
-
(1997)
Cancer Res
, vol.57
, pp. 4183-4186
-
-
Wang, S.I.1
Puc, J.2
Li, J.3
-
19
-
-
33847230852
-
The p53 family in differentiation and tumorigenesis
-
Stiewe T. The p53 family in differentiation and tumorigenesis. Nat Rev Cancer 2007;7:165-7.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 165-167
-
-
Stiewe, T.1
-
20
-
-
0035496607
-
Rescuing the function of mutant p53
-
Bullock AN, Fersht AR. Rescuing the function of mutant p53. Nat Rev Cancer 2001;1:68-76.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 68-76
-
-
Bullock, A.N.1
Fersht, A.R.2
-
21
-
-
18144371656
-
The p53 response: Emerging levels of co-factor complexity
-
Coutts AS, La Thangue NB. The p53 response: emerging levels of co-factor complexity. Biochem Biophys Res Commun 2005;331:778-85.
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 778-785
-
-
Coutts, A.S.1
La Thangue, N.B.2
-
22
-
-
28944446040
-
hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
-
Moumen A, Masterson P, O'Connor MJ, Jackson SP. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell 2005;123:1065-78.
-
(2005)
Cell
, vol.123
, pp. 1065-1078
-
-
Moumen, A.1
Masterson, P.2
O'Connor, M.J.3
Jackson, S.P.4
-
23
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
Samuels-Lev Y, O'Connor DJ, Bergamaschi D, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001;8:781-94.
-
(2001)
Mol Cell
, vol.8
, pp. 781-794
-
-
Samuels-Lev, Y.1
O'Connor, D.J.2
Bergamaschi, D.3
-
24
-
-
33846421621
-
Daxx Cooperates with the Axin/HIPK2/p53 complex to induce cell death
-
Li Q, Wang X, Wu X, et al. Daxx Cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res 2007;67:66-74.
-
(2007)
Cancer Res
, vol.67
, pp. 66-74
-
-
Li, Q.1
Wang, X.2
Wu, X.3
-
25
-
-
0033197703
-
A Novel Cofactor for p300 that Regulates the p53 Response
-
Shikama N, Lee C-W, France S, et al. A Novel Cofactor for p300 that Regulates the p53 Response. Mol Cell 1999;4:365-76.
-
(1999)
Mol Cell
, vol.4
, pp. 365-376
-
-
Shikama, N.1
Lee, C.-W.2
France, S.3
-
26
-
-
19944412479
-
topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage
-
Lin L, Ozaki T, Takada Y, et al. topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. Oncogene 2005;24:3385-96.
-
(2005)
Oncogene
, vol.24
, pp. 3385-3396
-
-
Lin, L.1
Ozaki, T.2
Takada, Y.3
-
27
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-[β] in homeostasis and cancer
-
Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-[β] in homeostasis and cancer. Nat Rev Cancer 2003;3:807-20.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 807-820
-
-
Siegel, P.M.1
Massague, J.2
-
28
-
-
34250770436
-
-
Zavadila J, NarasimhanbM, Blumenbergc M, Schneiderb, RJ. Transforming growth factor-β and microRNA: mRNA regulatory networks in epithelial plasticity. Cells Tissues Organs 2007;185:157-61.
-
Zavadila J, NarasimhanbM, Blumenbergc M, Schneiderb, RJ. Transforming growth factor-β and microRNA: mRNA regulatory networks in epithelial plasticity. Cells Tissues Organs 2007;185:157-61.
-
-
-
-
29
-
-
0037459081
-
Mitochondria: Releasing power for life and unleashing the machineries of death
-
Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003;112:481-90.
-
(2003)
Cell
, vol.112
, pp. 481-490
-
-
Newmeyer, D.D.1
Ferguson-Miller, S.2
-
30
-
-
0043210428
-
Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
-
Wiznerowicz M, Trono D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol 2003;77:8957-1.
-
(2003)
J Virol
, vol.77
, pp. 8957-8961
-
-
Wiznerowicz, M.1
Trono, D.2
-
31
-
-
14844364472
-
Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
-
Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucl Acids Res 2005;33:1290-7.
-
(2005)
Nucl Acids Res
, vol.33
, pp. 1290-1297
-
-
Cheng, A.M.1
Byrom, M.W.2
Shelton, J.3
Ford, L.P.4
-
32
-
-
13944282215
-
Microarray analysis shows that some microRNAs down-regulate large numbers of target mRNAs
-
Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs down-regulate large numbers of target mRNAs. Nature 2005;433:769-73.
-
(2005)
Nature
, vol.433
, pp. 769-773
-
-
Lim, L.P.1
Lau, N.C.2
Garrett-Engele, P.3
-
33
-
-
33645075443
-
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
-
Esau C, Davis S, Murray SF, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabol 2006;3:87-98.
-
(2006)
Cell Metabol
, vol.3
, pp. 87-98
-
-
Esau, C.1
Davis, S.2
Murray, S.F.3
-
34
-
-
0028864667
-
Induction of the growth inhibitor IGF-binding protein 3 by p53
-
Buckbinder L, Talbott R, Velasco-Miguel S, et al. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 1995;377:646-9.
-
(1995)
Nature
, vol.377
, pp. 646-649
-
-
Buckbinder, L.1
Talbott, R.2
Velasco-Miguel, S.3
-
35
-
-
33749868662
-
Involvement of programmed cell death 4 in transforming growth factor-[β]1-induced apoptosis in human hepatocellular carcinoma
-
Zhang H, Ozaki I, Mizuta T, et al. Involvement of programmed cell death 4 in transforming growth factor-[β]1-induced apoptosis in human hepatocellular carcinoma. Oncogene 2006;25:6101-12.
-
(2006)
Oncogene
, vol.25
, pp. 6101-6112
-
-
Zhang, H.1
Ozaki, I.2
Mizuta, T.3
-
36
-
-
0942301280
-
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR
-
Vella MC, Choi E-Y, Lin S-Y, Reinert K, Slack FJ. The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR. Genes Dev 2004;18:132-7.
-
(2004)
Genes Dev
, vol.18
, pp. 132-137
-
-
Vella, M.C.1
Choi, E.-Y.2
Lin, S.-Y.3
Reinert, K.4
Slack, F.J.5
-
37
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
-
Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
-
(1990)
Cell
, vol.63
, pp. 1129-1136
-
-
Scheffner, M.1
Werness, B.A.2
Huibregtse, J.M.3
Levine, A.J.4
Howley, P.M.5
-
38
-
-
22744459472
-
TAp63a induces apoptosis by activating signaling via death receptors and mitochondria
-
Gressner O, Schilling T, Lorenz K, et al. TAp63a induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J 2005;24:2458-71.
-
(2005)
EMBO J
, vol.24
, pp. 2458-2471
-
-
Gressner, O.1
Schilling, T.2
Lorenz, K.3
-
39
-
-
33846821915
-
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007;11:175-89.
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
40
-
-
4344696621
-
Convergence of p53 and TGF-β signaling networks
-
Dupont S, Zacchigna L, Adorno M, et al. Convergence of p53 and TGF-β signaling networks. Cancer Lett 2004;213:129-38.
-
(2004)
Cancer Lett
, vol.213
, pp. 129-138
-
-
Dupont, S.1
Zacchigna, L.2
Adorno, M.3
-
41
-
-
0038274163
-
Links between tumor suppressors: P53 is required for TGF-β gene responses by cooperating with Smads
-
Cordenonsi M, Dupont S, Maretto S, Insinga A, Imbriano C, Piccolo S. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 2003;113:301-14.
-
(2003)
Cell
, vol.113
, pp. 301-314
-
-
Cordenonsi, M.1
Dupont, S.2
Maretto, S.3
Insinga, A.4
Imbriano, C.5
Piccolo, S.6
-
42
-
-
34247115576
-
Convergence of p53 and transforming growth factor β (TGFβ) signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells
-
Wang SE, Narasanna A, Whitell CW, Wu FY, Friedman DB, Arteaga CL. Convergence of p53 and transforming growth factor β (TGFβ) signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells. J Biol Chem 2007;282:5661-9.
-
(2007)
J Biol Chem
, vol.282
, pp. 5661-5669
-
-
Wang, S.E.1
Narasanna, A.2
Whitell, C.W.3
Wu, F.Y.4
Friedman, D.B.5
Arteaga, C.L.6
-
43
-
-
34548012848
-
The let-7 MicroRNA represses cell proliferation pathways in human cells
-
Johnson CD, Esquela-Kerscher A, Stefani G, et al. The let-7 MicroRNA represses cell proliferation pathways in human cells. Cancer Res 2007;67:7713-22.
-
(2007)
Cancer Res
, vol.67
, pp. 7713-7722
-
-
Johnson, C.D.1
Esquela-Kerscher, A.2
Stefani, G.3
-
44
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
|