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Volumn , Issue , 2011, Pages 73-131

Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae

Author keywords

Adipokine production by adipose tissue novel target, treating metabolic syndrome and its sequelae; AMPK activation AMPK role, in regulating glucose and lipid metabolism; Relationship between MetS and cardiovascular disease risk

Indexed keywords


EID: 84872387730     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470910016.ch4     Document Type: Chapter
Times cited : (3)

References (481)
  • 1
    • 74049154021 scopus 로고    scopus 로고
    • The Metabolic Syndrome: Definition, Global Impact, And Pathophysiology
    • POTENZA, M.V., and J.I. MECHANICK. 2009. The metabolic syndrome: definition, global impact, and pathophysiology. Nutr Clin Pract 24:560-577.
    • (2009) Nutr Clin Pract , vol.24 , pp. 560-577
    • Potenza, M.V.1    Mechanick, J.I.2
  • 2
    • 39849099669 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and the metabolic syndrome: an update
    • RECTOR, R.S., J.P. THYFAULT, Y. WEI, and J.A. IBDAH. 2008. Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World J Gastroenterol 14:185-192.
    • (2008) World J Gastroenterol , vol.14 , pp. 185-192
    • Rector, R.S.1    Thyfault, J.P.2    Wei, Y.3    Ibdah, J.A.4
  • 3
    • 31744447164 scopus 로고    scopus 로고
    • How to best define the metabolic syndrome
    • MAGLIANO, D.J., J.E. SHAW, and P.Z. ZIMMET. 2006. How to best define the metabolic syndrome. Ann Med 38:34-41.
    • (2006) Ann Med , vol.38 , pp. 34-41
    • Magliano, D.J.1    Shaw, J.E.2    Zimmet, P.Z.3
  • 4
    • 4644279733 scopus 로고    scopus 로고
    • Increasing prevalence of the metabolic syndrome among U.S
    • FORD, E.S., W.H. GILES, and A.H. MOKDAD. 2004. Increasing prevalence of the metabolic syndrome among U.S. Adults. Diabetes Care 27:2444-2449.
    • (2004) Adults. Diabetes Care , vol.27 , pp. 2444-2449
    • Ford, E.S.1    Giles, W.H.2    Mokdad, A.H.3
  • 5
    • 33645467024 scopus 로고    scopus 로고
    • Characteristics and prevalence of the metabolic syndrome among three ethnic groups in Canada
    • LIU, J., A.J.HANLEY, T.K.YOUNG, S.B.HARRIS, and B. ZINMAN. 2006. Characteristics and prevalence of the metabolic syndrome among three ethnic groups in Canada. Int J Obes (Lond) 30:669-676.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 669-676
    • Liu, J.1    Anley, A.J.2    Oung, T.K.3    Arris, S.B.4    Zinman, B.5
  • 6
    • 33644845929 scopus 로고    scopus 로고
    • Insomnia
    • TJEPKEMA, M. 2005. Insomnia. Health Rep 17:9-25.
    • (2005) Health Rep , vol.17 , pp. 9-25
    • Tjepkema, M.1
  • 7
    • 0036719295 scopus 로고    scopus 로고
    • Epidemiology of the metabolic syndrome
    • MEIGS, J.B. 2002. Epidemiology of the metabolic syndrome. 2002. Am J Manag Care 8:S283-S292.
    • (2002) 2002. Am J Manag Care , vol.8
    • Meigs, J.B.1
  • 8
  • 10
    • 57749093663 scopus 로고    scopus 로고
    • "Sick fat," metabolic disease, and atherosclerosis
    • BAYS, H.E. 2009. "Sick fat," metabolic disease, and atherosclerosis. Am J Med 122:S26-S37.
    • (2009) Am J Med , vol.122
    • Bays, H.E.1
  • 11
    • 68849132248 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity
    • BLUHER,M. 2009. Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 117:241-250.
    • (2009) Exp Clin Endocrinol Diabetes , vol.117 , pp. 241-250
    • Bluher, M.1
  • 12
    • 58049219012 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
    • HAJER, G.R., T.W. VAN HAEFTEN, and F.L. VISSEREN. 2008. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29:2959-2971.
    • (2008) Eur Heart J , vol.29 , pp. 2959-2971
    • Hajer, G.R.1    Van Haeften, T.W.2    Visseren, F.L.3
  • 13
    • 4043052139 scopus 로고    scopus 로고
    • A burst of energy in metabolic disease research
    • SETHI, J.K. 2004. A burst of energy in metabolic disease research. Genome Biol 5:327.
    • (2004) Genome Biol , vol.5 , pp. 327
    • Sethi, J.K.1
  • 14
    • 0033789518 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • AHIMA, R.S., and J.S. FLIER. 2000. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11:327-332.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 327-332
    • Ahima, R.S.1    Flier, J.S.2
  • 17
    • 0000828672 scopus 로고
    • Diet-induced adipocyte number increase in adult rats: a new model of obesity
    • FAUST, I.M., P.R. JOHNSON, J.S. STERN, and J.HIRSCH. 1978. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol 235:E279-E286.
    • (1978) Am J Physiol , vol.235
    • Faust, I.M.1    Johnson, P.R.2    Stern, J.S.3    Hirsch, J.4
  • 18
    • 0017162520 scopus 로고
    • Adipose tissue cellularity in human obesity
    • HIRSCH, J., and B. BATCHELOR. 1976. Adipose tissue cellularity in human obesity. Clin Endocrinol Metab 5:299-311.
    • (1976) Clin Endocrinol Metab , vol.5 , pp. 299-311
    • Hirsch, J.1    Batchelor, B.2
  • 19
    • 17844393870 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT
    • BRUUN, J.M., A.S. LIHN, S.B. PEDERSEN, and B. RICHELSEN. 2005. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 90:2282-2289.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2282-2289
    • Bruun, J.M.1    Lihn, A.S.2    Pedersen, S.B.3    Richelsen, B.4
  • 21
    • 33748742519 scopus 로고    scopus 로고
    • Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue
    • CANCELLO, R., and K. CLEMENT. 2006. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 113:1141-1147.
    • (2006) BJOG , vol.113 , pp. 1141-1147
    • Cancello, R.1    Clement, K.2
  • 25
    • 29244439590 scopus 로고    scopus 로고
    • White Adipose Tissue And Cardiovascular Disease
    • MATSUZAWA,Y. 2005. White adipose tissue and cardiovascular disease. Best Pract Res Clin Endocrinol Metab 19:637-647.
    • (2005) Best Pract Res Clin Endocrinol Metab , vol.19 , pp. 637-647
    • Matsuzawa, Y.1
  • 26
    • 52449114737 scopus 로고    scopus 로고
    • Vascular Cells Contribute To Atherosclerosis By Cytokine- And Innate-Immunity-Related Inflammatory Mechanisms
    • LOPPNOW, H., K. WERDAN, and M. BUERKE. 2008. Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms. Innate Immun 14:63-87.
    • (2008) Innate Immun , vol.14 , pp. 63-87
    • Loppnow, H.1    Werdan, K.2    Buerke, M.3
  • 27
    • 18344404423 scopus 로고    scopus 로고
    • The Adipose Tissue As A Source Of Vasoactive Factors
    • FRUHBECK, G. 2004. The adipose tissue as a source of vasoactive factors. Curr Med Chem Cardiovasc Hematol Agents 2:197-208.
    • (2004) Curr Med Chem Cardiovasc Hematol Agents , vol.2 , pp. 197-208
    • Fruhbeck, G.1
  • 28
    • 0038341767 scopus 로고    scopus 로고
    • Do Regional Differences In Adipocyte Biology Provide New Pathophysiological Insights
    • LAFONTAN, M., and M. BERLAN. 2003. Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci 24:276-283.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 276-283
    • Lafontan, M.1    Berlan, M.2
  • 29
    • 52049097577 scopus 로고    scopus 로고
    • The Link Between Abdominal Obesity And The Metabolic Syndrome
    • PHILLIPS, L.K., and J.B. PRINS. 2008. The link between abdominal obesity and the metabolic syndrome. Curr Hypertens Rep 10:156-164.
    • (2008) Curr Hypertens Rep , vol.10 , pp. 156-164
    • Phillips, L.K.1    Prins, J.B.2
  • 31
    • 52949130244 scopus 로고    scopus 로고
    • The Concept Of Cardiometabolic Risk: Bridging The Fields Of Diabetology And Cardiology
    • DESPRES, J.P., A. CARTIER, M. COTE, and B.J. ARSENAULT. 2008. The concept of cardiometabolic risk: bridging the fields of diabetology and cardiology. Ann Med 40:514-523.
    • (2008) Ann Med , vol.40 , pp. 514-523
    • Despres, J.P.1    Cartier, A.2    Cote, M.3    Arsenault, B.J.4
  • 32
    • 0033911870 scopus 로고    scopus 로고
    • Non-Esterified Fatty Acids And The Liver: Why Is Insulin Secreted Into The Portal Vein
    • BERGMAN, R.N. 2000. Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein? Diabetologia 43:946-952.
    • (2000) Diabetologia , vol.43 , pp. 946-952
    • Bergman, R.N.1
  • 33
    • 34447560040 scopus 로고    scopus 로고
    • Visceral And Subcutaneous Adiposity: Are Both Potential Therapeutic Targets For Tackling The Metabolic Syndrome
    • RODRIGUEZ, A., V. CATALAN, J. GOMEZ-AMBROSI, and G. FRUHBECK. 2007. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des 13:2169-2175.
    • (2007) Curr Pharm Des , vol.13 , pp. 2169-2175
    • Rodriguez, A.1    Catalan, V.2    Gomez-Ambrosi, J.3    Fruhbeck, G.4
  • 36
    • 2042480671 scopus 로고    scopus 로고
    • Comparison Of The Release Of Adipokines By Adipose Tissue, Adipose Tissue Matrix, And Adipocytes From Visceral And Subcutaneous Abdominal Adipose Tissues Of Obese Humans
    • FAIN, J.N., A.K.MADAN, M.L. HILER, P. CHEEMA, and S.W. BAHOUTH. 2004. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145:2273-2282.
    • (2004) Endocrinology , vol.145 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3    Cheema, P.4    Bahouth, S.W.5
  • 37
    • 0031762908 scopus 로고    scopus 로고
    • Omental And Subcutaneous Adipose Tissues Of Obese Subjects Release Interleukin-6: Depot Difference And Regulation By Glucocorticoid
    • FRIED, S.K., D.A. BUNKIN, and A.S. GREENBERG. 1998. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 38
    • 0033991458 scopus 로고    scopus 로고
    • Differences Inmrnaexpression Of The Proteins Secreted By The Adipocytes In Human Subcutaneous And Visceral Adipose Tissues
    • DUSSERRE, E., P.MOULIN, and H.VIDAL. 2000. Differences inmRNAexpression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim Biophys Acta 1500:88-96.
    • (2000) Biochim Biophys Acta , vol.1500 , pp. 88-96
    • Dusserre, E.1    Moulin, P.2    Vidal, H.3
  • 41
    • 0032558725 scopus 로고    scopus 로고
    • Leptin And The Regulation Of Body Weight In Mammals
    • FRIEDMAN, J.M., and J.L.HALAAS. 1998. Leptin and the regulation of body weight in mammals. Nature 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 42
    • 2142748041 scopus 로고    scopus 로고
    • Stimulatory Effect Of Leptin On Nitric Oxide Production Is Impaired In Dietary-Induced Obesity
    • BELTOWSKI, J., G. WOJCICKA, and A. JAMROZ. 2003. Stimulatory effect of leptin on nitric oxide production is impaired in dietary-induced obesity. Obes Res 11:1571-1580.
    • (2003) Obes Res , vol.11 , pp. 1571-1580
    • Beltowski, J.1    Wojcicka, G.2    Jamroz, A.3
  • 43
    • 21344432100 scopus 로고    scopus 로고
    • Role Of Selective Leptin Resistance In Diet-Induced Obesity Hypertension
    • RAHMOUNI, K., D.A. MORGAN, G.M. MORGAN, A.L. MARK, and W.G. HAYNES. 2005. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54:2012-2018.
    • (2005) Diabetes , vol.54 , pp. 2012-2018
    • Rahmouni, K.1    Morgan, D.A.2    Morgan, G.M.3    Mark, A.L.4    Haynes, W.G.5
  • 44
    • 33749487087 scopus 로고    scopus 로고
    • Role Of Leptin In The Cardiovascular And Endocrine Complications Of Metabolic Syndrome
    • CORREIA, M.L., and K. RAHMOUNI. 2006. Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes Obes Metab 8:603-610.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 603-610
    • Correia, M.L.1    Rahmouni, K.2
  • 45
    • 39149143637 scopus 로고    scopus 로고
    • Adipokines: The Missing Link Between Insulin Resistance And Obesity
    • ANTUNA-PUENTE, B., B. FEVE, S. FELLAHI, and J.P. BASTARD. 2008. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab 34:2-11.
    • (2008) Diabetes Metab , vol.34 , pp. 2-11
    • Antuna-Puente, B.1    Feve, B.2    Fellahi, S.3    Bastard, J.P.4
  • 48
    • 0037119375 scopus 로고    scopus 로고
    • Oligomerization State-Dependent Activation Of Nf-Kappa B Signaling Pathway By Adipocyte Complement-Related Protein Of 30 Kda (Acrp30)
    • TSAO, T.S., H.E.MURREY, C. HUG, D.H. LEE, and H.F. LODISH. 2002. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 277:29359-29362.
    • (2002) J Biol Chem , vol.277 , pp. 29359-29362
    • Tsao, T.S.1    Murrey, H.E.2    Hug, C.3    Lee, D.H.4    Lodish, H.F.5
  • 49
    • 24044479055 scopus 로고    scopus 로고
    • Testosterone Selectively Reduces The High Molecular Weight Form Of Adiponectin By Inhibiting Its Secretion From Adipocytes
    • XU, A., K.W. CHAN, R.L.HOO, Y.WANG, K.C. TAN, J.ZHANG, B. CHEN, M.C. LAM, C.TSE, G.J. COOPER, and K.S. LAM. 2005. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem 280:18073-18080.
    • (2005) J Biol Chem , vol.280 , pp. 18073-18080
    • Xu, A.1    Chan, K.W.2    Hoo, R.L.3    Wang, Y.4    Tan, K.C.5    Zhang, J.6    Chen, B.7    Lam, M.C.8    Tse, C.9    Cooper, G.J.10    Lam, K.S.11
  • 52
    • 2942687834 scopus 로고    scopus 로고
    • Adiponectin: A Novel Adipokine Linking Adipocytes And Vascular Function
    • GOLDSTEIN, B.J., and R. SCALIA. 2004. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 89:2563-2568.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2563-2568
    • Goldstein, B.J.1    Scalia, R.2
  • 53
    • 0037126526 scopus 로고    scopus 로고
    • Third Report Of The National Cholesterol Education Program (Ncep) Expert Panel On Detection, Evaluation, And Treatment Of High Blood Cholesterol In Adults (Adult Treatment Panel Iii) Final Report
    • National Cholesterol Education Program (Ncep) Expert Panel On Detection, Evaluation, And Treatment Of High Blood Cholesterol In Adults (Adult Treatment Panel Iii).
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). 2002. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 106:3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 58
    • 35248847979 scopus 로고    scopus 로고
    • Plasma Adiponectin Distribution In A Mediterranean Population And Its Association With Cardiovascular Risk Factors And Metabolic Syndrome
    • SALAS-SALVADO, J., M. GRANADA, M. BULLO, A. COROMINAS, P. CASAS, and M. FOZ. 2007. Plasma adiponectin distribution in a Mediterranean population and its association with cardiovascular risk factors and metabolic syndrome. Metabolism 56:1486-1492.
    • (2007) Metabolism , vol.56 , pp. 1486-1492
    • Salas-Salvado, J.1    Granada, M.2    Bullo, M.3    Corominas, A.4    Casas, P.5    Foz, M.6
  • 62
    • 1642299047 scopus 로고    scopus 로고
    • Adipose Tissue Adiponectin Production And Adiponectin Serum Concentration In Human Obesity And Insulin Resistance
    • HOFFSTEDT, J., E. ARVIDSSON, E. SJOLIN, K. WAHLEN, and P. ARNER. 2004. Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance. J Clin Endocrinol Metab 89:1391-1396.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1391-1396
    • Hoffstedt, J.1    Arvidsson, E.2    Sjolin, E.3    Wahlen, K.4    Arner, P.5
  • 63
    • 0036930844 scopus 로고    scopus 로고
    • Differential Regulation Of Adiponectin Secretion From Cultured Human Omental And Subcutaneous Adipocytes: Effects Of Insulin And Rosiglitazone
    • MOTOSHIMA, H., X. WU, M.K. SINHA, V.E. HARDY, E.L. ROSATO, D.J. BARBOT, F.E. ROSATO, and B.J. GOLDSTEIN. 2002. Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J Clin Endocrinol Metab 87:5662-5667.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5662-5667
    • Motoshima, H.1    Wu, X.2    Sinha, M.K.3    Hardy, V.E.4    Rosato, E.L.5    Barbot, D.J.6    Rosato, F.E.7    Goldstein, B.J.8
  • 67
    • 0038359739 scopus 로고    scopus 로고
    • Body Fat Mass And Macronutrient Intake In Relation To Circulating Soluble Leptin Receptor, Free Leptin Index, Adiponectin, And Resistin Concentrations In Healthy Humans
    • YANNAKOULIA, M., N.YIANNAKOURIS, S. BLUHER, A.L.MATALAS,D.KLIMIS-ZACAS, and C.S.MANTZOROS. 2003. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab 88:1730-1736.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1730-1736
    • Yannakoulia, M.1    Yiannakouris, N.2    Bluher, S.3    Matalas, A.L.4    Klimis-Zacas, D.5    Mantzoros, C.S.6
  • 70
    • 0036134187 scopus 로고    scopus 로고
    • Resistin And Obesity-Associated Insulin Resistance
    • STEPPAN, C.M., and M.A. LAZAR. 2002. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 13:18-23.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 18-23
    • Steppan, C.M.1    Lazar, M.A.2
  • 71
    • 0035930998 scopus 로고    scopus 로고
    • Suppressed Gene Expression Of Adipocyte Resistin In An Insulin-Resistant Rat Model Probably By Elevated Free Fatty Acids
    • JUAN, C.C., L.C.AU,V.S. FANG, S.F.KANG,Y.H.KO, S.F.KUO, Y.P. HSU, C.F.KWOK, and L.T.HO. 2001. Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids. Biochem Biophys Res Commun 289:1328-1333.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 1328-1333
    • Juan, C.C.1    Au, L.C.2    Fang, V.S.3    Kang, S.F.4    Ko, Y.H.5    Kuo, S.F.6    Hsu, Y.P.7    Kwok, C.F.8    Ho, L.T.9
  • 72
    • 0035914057 scopus 로고    scopus 로고
    • Inhibition By Insulin Of Resistin Gene Expression In 3T3-L1 Adipocytes
    • HAUGEN, F., A. JORGENSEN, C.A. DREVON, and P. TRAYHURN. 2001. Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes. FEBS Lett 507:105-108.
    • (2001) Febs Lett , vol.507 , pp. 105-108
    • Haugen, F.1    Jorgensen, A.2    Drevon, C.A.3    Trayhurn, P.4
  • 73
    • 1842506529 scopus 로고    scopus 로고
    • The Current Biology Of Resistin
    • STEPPAN, C.M., and M.A. LAZAR. 2004. The current biology of resistin. J Intern Med 255:439-447.
    • (2004) J Intern Med , vol.255 , pp. 439-447
    • Steppan, C.M.1    Lazar, M.A.2
  • 76
    • 0035908632 scopus 로고    scopus 로고
    • C-Reactive Protein, Interleukin 6, And Risk Of Developing Type 2 Diabetes Mellitus
    • PRADHAN, A.D., J.E. MANSON, N. RIFAI, J.E. BURING, and P.M. RIDKER. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334.
    • (2001) Jama , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 77
    • 0035023128 scopus 로고    scopus 로고
    • Adipose Tissue Tumor Necrosis Factor And Interleukin-6 Expression In Human Obesity And Insulin Resistance
    • KERN, P.A., S. RANGANATHAN, C. LI, L. WOOD, and G. RANGANATHAN. 2001. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 79
    • 0348222671 scopus 로고    scopus 로고
    • Inflammation: The Link Between Insulin Resistance, Obesity And Diabetes
    • DANDONA, P., A. ALJADA, and A. BANDYOPADHYAY. 2004. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25:4-7.
    • (2004) Trends Immunol , vol.25 , pp. 4-7
    • Dandona, P.1    Aljada, A.2    Bandyopadhyay, A.3
  • 80
    • 0035403205 scopus 로고    scopus 로고
    • Circulating Interleukin-6 In Relation To Adiposity, Insulin Action, And Insulin Secretion
    • VOZAROVA, B., C. WEYER, K. HANSON, P.A. TATARANNI, C. BOGARDUS, and R.E. PRATLEY. 2001. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 9:414-417.
    • (2001) Obes Res , vol.9 , pp. 414-417
    • Vozarova, B.1    Weyer, C.2    Hanson, K.3    Tataranni, P.A.4    Bogardus, C.5    Pratley, R.E.6
  • 81
    • 33845225690 scopus 로고    scopus 로고
    • Inflammatory Peptides Derived From Adipose Tissue
    • RUDIN, E., and N. BARZILAI. 2005. Inflammatory peptides derived from adipose tissue. Immun Ageing 2:1.
    • (2005) Immun Ageing , vol.2 , pp. 1
    • Rudin, E.1    Barzilai, N.2
  • 82
    • 15244350133 scopus 로고    scopus 로고
    • Circulating Tumor Necrosis Factor Alpha Is Higher In Non-Obese, Non-Diabetic Mexican Americans Compared To Non-Hispanic White Adults
    • HO, R.C., K.P. DAVY, M.S. HICKEY, and C.L. MELBY. 2005. Circulating tumor necrosis factor alpha is higher in non-obese, non-diabetic Mexican Americans compared to non-Hispanic white adults. Cytokine 30:14-21.
    • (2005) Cytokine , vol.30 , pp. 14-21
    • Ho, R.C.1    Davy, K.P.2    Hickey, M.S.3    Melby, C.L.4
  • 83
    • 3042618753 scopus 로고    scopus 로고
    • Serum Tumor Necrosis Factor-Alpha Levels And Components Of The Metabolic Syndrome In Obese Adolescents
    • MOON, Y.S., D.H. KIM, and D.K. SONG. 2004. Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents. Metabolism 53:863-867.
    • (2004) Metabolism , vol.53 , pp. 863-867
    • Moon, Y.S.1    Kim, D.H.2    Song, D.K.3
  • 84
    • 34047155003 scopus 로고    scopus 로고
    • Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation In Obese Humans
    • FONTANA, L., J.C. EAGON, M.E. TRUJILLO, P.E. SCHERER, and S. KLEIN. 2007. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010-1013.
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 85
    • 20344397446 scopus 로고    scopus 로고
    • Is Angiotensin-Ii An Endogenous Pro-Inflammatory Molecule
    • DAS, U.N. 2005. Is angiotensin-II an endogenous pro-inflammatory molecule? Med Sci Monit 11: RA155-RA162.
    • (2005) Med Sci Monit , vol.11
    • Das, U.N.1
  • 87
    • 17944364171 scopus 로고    scopus 로고
    • Angiotensinogen-Deficient Mice Exhibit Impairment Of Diet-Induced Weight Gain With Alteration In Adipose Tissue Development And Increased Locomotor Activity
    • MASSIERA, F., J. SEYDOUX, A. GELOEN, A. QUIGNARD-BOULANGE, S. TURBAN, P. SAINT-MARC, A. FUKAMIZU, R. NEGREL, G. AILHAUD, and M. TEBOUL. 2001. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology 142:5220-5225.
    • (2001) Endocrinology , vol.142 , pp. 5220-5225
    • Massiera, F.1    Seydoux, J.2    Geloen, A.3    Quignard-Boulange, A.4    Turban, S.5    Saint-Marc, P.6    Fukamizu, A.7    Negrel, R.8    Ailhaud, G.9    Teboul, M.10
  • 89
    • 0344442670 scopus 로고    scopus 로고
    • Echocardiographic Epicardial Adipose Tissue Is Related To Anthropometric And Clinical Parameters Of Metabolic Syndrome: A New Indicator Of Cardiovascular Risk
    • IACOBELLIS, G., M.C. RIBAUDO, F. ASSAEL, E. VECCI, C. TIBERTI, A. ZAPPATERRENO, U. DI MARIO, and F. LEONETTI. 2003. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 88:5163-5168.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5163-5168
    • Iacobellis, G.1    Ribaudo, M.C.2    Assael, F.3    Vecci, E.4    Tiberti, C.5    Zappaterreno, A.6    Di Mario, U.7    Leonetti, F.8
  • 94
    • 39449083892 scopus 로고    scopus 로고
    • Adipocytokines And Proinflammatory Mediators From Abdominal And Epicardial Adipose Tissue In Patients With Coronary Artery Disease
    • CHENG, K.H., C.S. CHU, K.T. LEE, T.H. LIN, C.C. HSIEH, C.C. CHIU, W.C. VOON, S.H. SHEU, and W.T. LAI. 2008. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes (Lond) 32:268-274.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 268-274
    • Cheng, K.H.1    Chu, C.S.2    Lee, K.T.3    Lin, T.H.4    Hsieh, C.C.5    Chiu, C.C.6    Voon, W.C.7    Sheu, S.H.8    Lai, W.T.9
  • 96
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis: Summary Of An Aasld Single Topic Conference
    • NEUSCHWANDER-TETRI, B.A., and S.H. CALDWELL. 2003. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37:1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 98
    • 1042277044 scopus 로고    scopus 로고
    • Non-Alcoholic Fatty Liver Disease: An Emerging Pathological Spectrum
    • ZAFRANI, E.S. 2004. Non-alcoholic fatty liver disease: an emerging pathological spectrum. Virchows Arch 444:3-12.
    • (2004) Virchows Arch , vol.444 , pp. 3-12
    • Zafrani, E.S.1
  • 99
    • 0034068984 scopus 로고    scopus 로고
    • Non-Alcoholic Steatohepatitis: Association With Obesity And Insulin Resistance, And Influence Of Weight Loss
    • LUYCKX, F.H., P.J. LEFEBVRE, and A.J. SCHEEN. 2000. Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. Diabetes Metab 26:98-106.
    • (2000) Diabetes Metab , vol.26 , pp. 98-106
    • Luyckx, F.H.1    Lefebvre, P.J.2    Scheen, A.J.3
  • 100
    • 0141890172 scopus 로고    scopus 로고
    • Non-Alcoholic Fatty Liver: A Common Manifestation Of A Metabolic Disorder
    • MALNICK, S.D., M. BEERGABEL, and H. KNOBLER. 2003. Non-alcoholic fatty liver: a common manifestation of a metabolic disorder. QJM 96:699-709.
    • (2003) Qjm , vol.96 , pp. 699-709
    • Malnick, S.D.1    Beergabel, M.2    Knobler, H.3
  • 101
    • 0025260531 scopus 로고
    • Fatty Liver Hepatitis (Steatohepatitis) And Obesity: An Autopsy Study With Analysis Of Risk Factors
    • WANLESS, I.R., and J.S. LENTZ. 1990. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12:1106-1110.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 103
    • 0141615879 scopus 로고    scopus 로고
    • Fatty Liver In Type 2 Diabetes Mellitus: Relation To Regional Adiposity, Fatty Acids, And Insulin Resistance
    • KELLEY, D.E., T.M.MCKOLANIS, R.A.HEGAZI, L.H.KULLER, and S.C.KALHAN. 2003. Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 285:E906-E916.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Kelley, D.E.1    Mckolanis, T.M.2    Hegazi, R.A.3    Kuller, L.H.4    Kalhan, S.C.5
  • 106
    • 0942268772 scopus 로고    scopus 로고
    • Insulin Resistance And Ferritin As Major Determinants Of Nonalcoholic Fatty Liver Disease In Apparently Healthy Obese Patients
    • HSIAO, T.J., J.C. CHEN, and J.D. WANG. 2004. Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients. Int J Obes Relat Metab Disord 28:167-172.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 167-172
    • Hsiao, T.J.1    Chen, J.C.2    Wang, J.D.3
  • 107
    • 33744532392 scopus 로고    scopus 로고
    • Association Of Cardiorespiratory Fitness, Body Mass Index, And Waist Circumference To Nonalcoholic Fatty Liver Disease
    • CHURCH, T.S., J.L. KUK, R. ROSS, E.L. PRIEST, E. BILTOFT, and S.N. BLAIR. 2006. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 130:2023-2030.
    • (2006) Gastroenterology , vol.130 , pp. 2023-2030
    • Church, T.S.1    Kuk, J.L.2    Ross, R.3    Priest, E.L.4    Biltoft, E.5    Blair, S.N.6
  • 108
    • 38149030206 scopus 로고    scopus 로고
    • Liver Fat Is Increased In Type 2 Diabetic Patients And Underestimated By Serum Alanine Aminotransferase Compared With Equally Obese Nondiabetic Subjects
    • KOTRONEN, A., L. JUURINEN, A. HAKKARAINEN, J. WESTERBACKA, A. CORNER, R. BERGHOLM, and H. YKI-JARVINEN. 2008. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care 31:165-169.
    • (2008) Diabetes Care , vol.31 , pp. 165-169
    • Kotronen, A.1    Juurinen, L.2    Hakkarainen, A.3    Westerbacka, J.4    Corner, A.5    Bergholm, R.6    Yki-Jarvinen, H.7
  • 109
    • 69249213467 scopus 로고    scopus 로고
    • Hepatic Insulin Resistance, Metabolic Syndrome And Cardiovascular Disease
    • MESHKANI, R., and K.ADELI. 2009. Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem 42:1331-1346.
    • (2009) Clin Biochem , vol.42 , pp. 1331-1346
    • Meshkani, R.1    Adeli, K.2
  • 110
    • 33745804103 scopus 로고    scopus 로고
    • Is Visceral Fat Involved In The Pathogenesis Of The Metabolic Syndrome? Human model
    • JENSEN, M.D. 2006. Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. Obesity (Silver Spring) 14 (Suppl 1): 20S-24S.
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 1
    • Jensen, M.D.1
  • 111
    • 56149127703 scopus 로고    scopus 로고
    • Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome
    • BERK, P.D. 2008. Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatology 48:1362-1376.
    • (2008) Hepatology , vol.48 , pp. 1362-1376
    • Berk, P.D.1
  • 112
    • 33745107554 scopus 로고    scopus 로고
    • Mechanisms Of Disease: Hepatic Steatosis In Type 2 Diabetes-Pathogenesis And Clinical Relevance
    • RODEN, M. 2006. Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab 2:335-348.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 335-348
    • Roden, M.1
  • 113
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation And Metabolic Disorders
    • HOTAMISLIGIL, G.S. 2006. Inflammation and metabolic disorders. Nature 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 114
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin And Adiponectin Receptors
    • KADOWAKI, T., and T. YAMAUCHI. 2005. Adiponectin and adiponectin receptors. Endocr Rev 26:439-451.
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 115
    • 33749135225 scopus 로고    scopus 로고
    • The Relationships Of Plasma Adiponectin With A Favorable Lipid Profile, Decreased Inflammation, And Less Ectopic Fat Accumulation Depend On Adiposity
    • KANTARTZIS, K., K. RITTIG, B. BALLETSHOFER, J. MACHANN, F. SCHICK, K. PORUBSKA, A. FRITSCHE, H.U. HARING, and N. STEFAN. 2006. The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposity. Clin Chem 52:1934-1942.
    • (2006) Clin Chem , vol.52 , pp. 1934-1942
    • Kantartzis, K.1    Rittig, K.2    Balletshofer, B.3    Machann, J.4    Schick, F.5    Porubska, K.6    Fritsche, A.7    Haring, H.U.8    Stefan, N.9
  • 118
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines In Alcoholic And Nonalcoholic Steatohepatitis
    • TILG, H., and A.M.DIEHL. 2000. Cytokines in alcoholic and nonalcoholic steatohepatitis.NEngl J Med 343:1467-1476.
    • (2000) Nengl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 119
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics And Antibodies To Tnf Inhibit Inflammatory Activity And Improve Nonalcoholic Fatty Liver Disease
    • LI, Z., S.YANG, H.LIN, J. HUANG, P.A.WATKINS, A.B.MOSER, C.DESIMONE, X.Y. SONG, and A.M.DIEHL. 2003. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37:343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4    Watkins, P.A.5    Moser, A.B.6    Desimone, C.7    Song, X.Y.8    Diehl, A.M.9
  • 120
    • 0037631831 scopus 로고    scopus 로고
    • Insulin Resistance And Chronic Cardiovascular Inflammatory Syndrome
    • FERNANDEZ-REAL, J.M., and W. RICART. 2003. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24:278-301.
    • (2003) Endocr Rev , vol.24 , pp. 278-301
    • Fernandez-Real, J.M.1    Ricart, W.2
  • 121
    • 0041302377 scopus 로고    scopus 로고
    • The Fat-Derived Hormone Adiponectin Alleviates Alcoholic And Nonalcoholic Fatty Liver Diseases In Mice
    • XU, A., Y. WANG, H. KESHAW, L.Y. XU, K.S. LAM, and G.J. COOPER. 2003. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112:91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 124
    • 28844440050 scopus 로고    scopus 로고
    • Decreased Serum Adiponectin: An Early Event In Pediatric Nonalcoholic Fatty Liver Disease
    • LOUTHAN, M.V., S. BARVE, C.J.MCCLAIN, and S. JOSHI-BARVE. 2005. Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. J Pediatr 147:835-838.
    • (2005) J Pediatr , vol.147 , pp. 835-838
    • Louthan, M.V.1    Barve, S.2    Mcclain, C.J.3    Joshi-Barve, S.4
  • 125
    • 27744452634 scopus 로고    scopus 로고
    • Serum Adiponectin, Resistin Levels And Nonalcoholic Fatty Liver Disease In Obese Children
    • ZOU, C.C., L. LIANG, F.HONG, J.F. FU, and Z.Y. ZHAO. 2005. Serum adiponectin, resistin levels and nonalcoholic fatty liver disease in obese children. Endocr J 52:519-524.
    • (2005) Endocr J , vol.52 , pp. 519-524
    • Zou, C.C.1    Liang, L.2    Hong, F.3    Fu, J.F.4    Zhao, Z.Y.5
  • 131
    • 52649142089 scopus 로고    scopus 로고
    • Loss Of Resistin Ameliorates Hyperlipidemia And Hepatic Steatosis In Leptin-Deficient Mice
    • SINGHAL, N.S., R.T. PATEL, Y. QI, Y.S. LEE, and R.S. AHIMA. 2008. Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol Endocrinol Metab 295: E331-E338.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Singhal, N.S.1    Patel, R.T.2    Qi, Y.3    Lee, Y.S.4    Ahima, R.S.5
  • 132
    • 48349147074 scopus 로고    scopus 로고
    • The Role Of Adipokines In Liver Fibrosis
    • BERTOLANI, C., and F. MARRA. 2008. The role of adipokines in liver fibrosis. Pathophysiology 15:91-101.
    • (2008) Pathophysiology , vol.15 , pp. 91-101
    • Bertolani, C.1    Marra, F.2
  • 137
    • 48649092057 scopus 로고    scopus 로고
    • Pancreatic Fat Content And Beta-Cell Function In Men With And Without Type 2 Diabetes: Response To Tushuizen Et Al
    • Author Reply E39
    • SAISHO, Y., A.E. BUTLER, and P.C. BUTLER. 2008. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al. Diabetes Care 31:e38; author reply e39.
    • (2008) Diabetes Care , vol.31
    • Saisho, Y.1    Butler, A.E.2    Butler, P.C.3
  • 139
    • 35948980834 scopus 로고    scopus 로고
    • Pancreas Volumes In Humans From Birth To Age One Hundred Taking Into Account Sex, Obesity, And Presence Of Type-2 Diabetes
    • SAISHO, Y., A.E. BUTLER, J.J.MEIER, T. MONCHAMP,M. ALLEN-AUERBACH, R.A. RIZZA, and P.C. BUTLER. 2007. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 20:933-942.
    • (2007) Clin Anat , vol.20 , pp. 933-942
    • Saisho, Y.1    Butler, A.E.2    Meier, J.J.3    Monchamp, T.4    Allen-Auerbach, M.5    Rizza, R.A.6    Butler, P.C.7
  • 143
    • 45549096742 scopus 로고    scopus 로고
    • Serum Adiponectin And Leptin Concentrations In Patients With Chronic Pancreatitis Of Alcoholic And Nonalcoholic Origin
    • ADRYCH, K., M. SMOCZYNSKI, E. STELMANSKA, J. KORCZYNSKA, E. GOYKE, and J. SWIERCZYNSKI. 2008. Serum adiponectin and leptin concentrations in patients with chronic pancreatitis of alcoholic and nonalcoholic origin. Pancreas 36:120-124.
    • (2008) Pancreas , vol.36 , pp. 120-124
    • Adrych, K.1    Smoczynski, M.2    Stelmanska, E.3    Korczynska, J.4    Goyke, E.5    Swierczynski, J.6
  • 145
    • 48749108892 scopus 로고    scopus 로고
    • Role Of Islet-, Gut-, And Adipocytederived Hormones In The Central Control Of Food Intake And Body Weight: Implications For An Integrated Neurohormonal Approach To Obesity Pharmacotherapy
    • CHEN, H.C., J.D. ROTH, B.E. SCHROEDER, and C. WEYER. 2008. Role of islet-, gut-, and adipocytederived hormones in the central control of food intake and body weight: implications for an integrated neurohormonal approach to obesity pharmacotherapy. Curr Diabetes Rev 4:79-91.
    • (2008) Curr Diabetes Rev , vol.4 , pp. 79-91
    • Chen, H.C.1    Roth, J.D.2    Schroeder, B.E.3    Weyer, C.4
  • 148
    • 49749107875 scopus 로고    scopus 로고
    • Disruption In The Leptin-Npy Link Underlies The Pandemic Of Diabetes And Metabolic Syndrome: New Therapeutic Approaches
    • KALRA, S.P. 2008. Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 24:820-826.
    • (2008) Nutrition , vol.24 , pp. 820-826
    • Kalra, S.P.1
  • 149
    • 36248961170 scopus 로고    scopus 로고
    • Global Life-Long Health Benefits Of Repression Of Hypothalamic Npy System By Central Leptin Gene Therapy
    • KALRA, S.P. 2007. Global life-long health benefits of repression of hypothalamic NPY system by central leptin gene therapy. Curr Top Med Chem 7:1675-1681.
    • (2007) Curr Top Med Chem , vol.7 , pp. 1675-1681
    • Kalra, S.P.1
  • 150
    • 34547126211 scopus 로고    scopus 로고
    • Disruption Of Peripheral Leptin Signaling In Mice Results In Hyperleptinemia Without Associated Metabolic Abnormalities
    • GUO, K., J.E. MCMINN, T. LUDWIG, Y.H. YU, G. YANG, L. CHEN, D. LOH, C. LI, S. CHUA, JR., AND Y. ZHANG. 2007.DISRUPTION OF PERIPHERAL LEPTIN SIGNALING IN MICE RESULTS IN HYPERLEPTINEMIA WITHOUT ASSOCIATED METABOLIC ABNORMALITIES. ENDOCRINOLOGY 148:3987-3997.
    • (2007) Endocrinology , vol.148 , pp. 3987-3997
    • Guo, K.1    Mcminn, J.E.2    Ludwig, T.3    Yu, Y.H.4    Yang, G.5    Chen, L.6    Loh, D.7    Li, C.8    Chua Jr, S.9    Zhang, Y.10
  • 151
    • 44949158893 scopus 로고    scopus 로고
    • The Long Reach Of Leptin
    • MARATOS-FLIER, E. 2008. The long reach of leptin. Nat Med 14:604-606.
    • (2008) Nat Med , vol.14 , pp. 604-606
    • Maratos-Flier, E.1
  • 153
    • 46349110307 scopus 로고    scopus 로고
    • Signal Transducer And Activator Of Transcription-3 Is Required In Hypothalamic Agouti-Related Protein/Neuropeptide Y Neurons For Normal Energy Homeostasis
    • GONG, L., F. YAO, K. HOCKMAN, H.H. HENG, G.J. MORTON, K. TAKEDA, S. AKIRA, M.J. LOW, M. RUBINSTEIN, and R.G. MACKENZIE. 2008. Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology 149:3346-3354.
    • (2008) Endocrinology , vol.149 , pp. 3346-3354
    • Gong, L.1    Yao, F.2    Hockman, K.3    Heng, H.H.4    Morton, G.J.5    Takeda, K.6    Akira, S.7    Low, M.J.8    Rubinstein, M.9    Mackenzie, R.G.10
  • 154
    • 54349083339 scopus 로고    scopus 로고
    • Biological Specificity Of Visceral Adipose Tissue And Therapeutic Intervention
    • PERRINI, S., A. LEONARDINI, L. LAVIOLA, and F. GIORGINO. 2008. Biological specificity of visceral adipose tissue and therapeutic intervention. Arch Physiol Biochem 114:277-286.
    • (2008) Arch Physiol Biochem , vol.114 , pp. 277-286
    • Perrini, S.1    Leonardini, A.2    Laviola, L.3    Giorgino, F.4
  • 155
    • 53249093794 scopus 로고    scopus 로고
    • Endocannabinoids, Metabolic Regulation, And The Role Of Diet
    • CARR, T.P., E.D. JESCH, and A.W. BROWN. 2008. Endocannabinoids, metabolic regulation, and the role of diet. Nutr Res 28:641-650.
    • (2008) Nutr Res , vol.28 , pp. 641-650
    • Carr, T.P.1    Jesch, E.D.2    Brown, A.W.3
  • 156
    • 48149101434 scopus 로고    scopus 로고
    • The Endocannabinoid System In Obesity And Type 2 Diabetes
    • DI MARZO, V. 2008. The endocannabinoid system in obesity and type 2 diabetes. Diabetologia 51:1356-1367.
    • (2008) Diabetologia , vol.51 , pp. 1356-1367
    • Di Marzo, V.1
  • 158
    • 31044456243 scopus 로고    scopus 로고
    • The Cannabinoid Cb1 Receptor Antagonist Rimonabant (Sr141716) Inhibits Cell Proliferation And Increases Markers Of Adipocyte Maturation In Cultured Mouse 3T3 F442A Preadipocytes
    • GARY-BOBO, M., G. ELACHOURI, B. SCATTON, G. LE FUR, F. OURY-DONAT, and M. BENSAID. 2006. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes. Mol Pharmacol 69:471-478.
    • (2006) Mol Pharmacol , vol.69 , pp. 471-478
    • Gary-Bobo, M.1    Elachouri, G.2    Scatton, B.3    Le Fur, G.4    Oury-Donat, F.5    Bensaid, M.6
  • 161
    • 67649419169 scopus 로고    scopus 로고
    • The Dysregulation Of The Endocannabinoid System In Diabesity- A Tricky Problem
    • SCHERER, T., and C. BUETTNER. 2009. The dysregulation of the endocannabinoid system in diabesity- a tricky problem. J Mol Med 87:663-668.
    • (2009) J Mol Med , vol.87 , pp. 663-668
    • Scherer, T.1    Buettner, C.2
  • 162
    • 1842866963 scopus 로고    scopus 로고
    • Cb1 Cannabinoid Receptor Knockout In Mice Leads To Leanness, Resistance To Diet-Induced Obesity And Enhanced Leptin Sensitivity
    • RAVINET TRILLOU, C., C. DELGORGE, C. MENET, M. ARNONE, and P. SOUBRIE. 2004. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 28:640-648.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 640-648
    • Ravinet Trillou, C.1    Delgorge, C.2    Menet, C.3    Arnone, M.4    Soubrie, P.5
  • 163
    • 33751019428 scopus 로고    scopus 로고
    • Rimonabant: Endocannabinoid Inhibition For The Metabolic Syndrome
    • WIERZBICKI, A.S. 2006. Rimonabant: endocannabinoid inhibition for the metabolic syndrome. Int J Clin Pract 60:1697-1706.
    • (2006) Int J Clin Pract , vol.60 , pp. 1697-1706
    • Wierzbicki, A.S.1
  • 164
    • 0037407403 scopus 로고    scopus 로고
    • Ncep-Defined Metabolic Syndrome, Diabetes, And Prevalence Of Coronary Heart Disease Among Nhanes Iii Participants Age 50 Years And Older
    • Third National Health And Nutrition Examination Survey (Nhanes Iii), And National Cholesterol Education Program (Ncep)
    • ALEXANDER, C.M., P.B. LANDSMAN, S.M. TEUTSCH, S.M.HAFFNER, Third National Health and Nutrition Examination Survey (NHANES III), and National Cholesterol Education Program (NCEP). 2003. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 52:1210-1214.
    • (2003) Diabetes , vol.52 , pp. 1210-1214
    • Alexander, C.M.1    Landsman, P.B.2    Teutsch, S.M.3    Haffner, S.M.4
  • 165
    • 66349086461 scopus 로고    scopus 로고
    • Diabetes And Atherosclerosis: Is There A Role For Hyperglycemia
    • CHAIT, A., and K.E. BORNFELDT. 2009. Diabetes and atherosclerosis: is there a role for hyperglycemia? J Lipid Res 50 (Suppl): S335-S339.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL
    • Chait, A.1    Bornfeldt, K.E.2
  • 166
    • 0033889962 scopus 로고    scopus 로고
    • Management Of Coronary Artery Disease: Therapeutic Options In Patients With Diabetes
    • HAMMOUD, T., J.F. TANGUAY, and M.G. BOURASSA. 2000. Management of coronary artery disease: therapeutic options in patients with diabetes. J Am Coll Cardiol 36:355-365.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 355-365
    • Hammoud, T.1    Tanguay, J.F.2    Bourassa, M.G.3
  • 168
    • 55949127411 scopus 로고    scopus 로고
    • Targeting abdominal obesity in cardiology: can we be effective?
    • POIRIER, P. 2008. Targeting abdominal obesity in cardiology: can we be effective? Can J Cardiol 24 (Suppl D): 13D-17D.
    • (2008) Can J Cardiol , vol.24 , Issue.SUPPL. D
    • Poirier, P.1
  • 169
    • 70349566488 scopus 로고    scopus 로고
    • Beneficial effects of intravenously administered N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a prospective randomized study
    • HEIDT, M.C., M. VICIAN, S.K. STRACKE, T. STADLBAUER, M.T. GREBE, A. BOENING, P.R. VOGT, and A. ERDOGAN. 2009. Beneficial effects of intravenously administered N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a prospective randomized study. Thorac Cardiovasc Surg 57:276-280.
    • (2009) Thorac Cardiovasc Surg , vol.57 , pp. 276-280
    • Heidt, M.C.1    Vician, M.2    Stracke, S.K.3    Stadlbauer, T.4    Grebe, M.T.5    Boening, A.6    Vogt, P.R.7    Erdogan, A.8
  • 173
  • 175
    • 34247325960 scopus 로고    scopus 로고
    • Adipose Tissue And Atherosclerosis: Exploring The Connection
    • FANTUZZI, G., and T. MAZZONE. 2007. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol 27:996-1003.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 996-1003
    • Fantuzzi, G.1    Mazzone, T.2
  • 177
    • 36949025455 scopus 로고    scopus 로고
    • Adipose Tissue And The Vessel Wall
    • MAZZONE, T. 2007. Adipose tissue and the vessel wall. Curr Drug Targets 8:1190-1195.
    • (2007) Curr Drug Targets , vol.8 , pp. 1190-1195
    • Mazzone, T.1
  • 178
    • 0015792424 scopus 로고
    • Effects Of Parabiosis Of Obese With Diabetes And Normal Mice
    • COLEMAN, D.L. 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9:294-298.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 181
    • 0034852245 scopus 로고    scopus 로고
    • Expression Of Leptin (Ob) And Leptin Receptor (Ob-R) In Human Fibroblasts: Regulation Of Leptin Secretion By Insulin
    • GLASOW, A.,W. KIESS, U. ANDEREGG, A. BERTHOLD, A.BOTTNER, and J. KRATZSCH. 2001. Expression of leptin (Ob) and leptin receptor (Ob-R) in human fibroblasts: regulation of leptin secretion by insulin. J Clin Endocrinol Metab 86:4472-4479.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4472-4479
    • Glasow, A.1    Kiess, W.2    Anderegg, U.3    Berthold, A.4    Bottner, A.5    Kratzsch, J.6
  • 183
    • 45949097987 scopus 로고    scopus 로고
    • Identification Of Leptin Gene Expression In Sinusoidal Endothelial Rat Liver Cells
    • REYES, M.R., B. LAZALDE, F.A. POSADAS DEL RIO, and B. ESCALANTE. 2008. Identification of leptin gene expression in sinusoidal endothelial rat liver cells. Endothelium 15:121-125.
    • (2008) Endothelium , vol.15 , pp. 121-125
    • Reyes, M.R.1    Lazalde, B.2    Posadas Del Rio, F.A.3    Escalante, B.4
  • 186
    • 34249072804 scopus 로고    scopus 로고
    • Leptin And Vascular Smooth Muscle
    • ZEIDAN, A., and M. KARMAZYN. 2006. Leptin and vascular smooth muscle. Curr Vasc Pharmacol 4:383-393.
    • (2006) Curr Vasc Pharmacol , vol.4 , pp. 383-393
    • Zeidan, A.1    Karmazyn, M.2
  • 187
    • 55249108435 scopus 로고    scopus 로고
    • Leptin Receptor Is Elevated In Carotid Plaques From Neurologically Symptomatic Patients And Positively Correlated With Augmented Macrophage Density
    • SCHNEIDERMAN, J., A.J. SIMON, M.R. SCHROETER, M.Y. FLUGELMAN, S. KONSTANTINIDES, and K. SCHAEFER. 2008. Leptin receptor is elevated in carotid plaques from neurologically symptomatic patients and positively correlated with augmented macrophage density. J Vasc Surg 48:1146-1155.
    • (2008) J Vasc Surg , vol.48 , pp. 1146-1155
    • Schneiderman, J.1    Simon, A.J.2    Schroeter, M.R.3    Flugelman, M.Y.4    Konstantinides, S.5    Schaefer, K.6
  • 188
    • 62549122501 scopus 로고    scopus 로고
    • Update On The Metabolic Syndrome: Hypertension
    • REYNOLDS, K., and R.P. WILDMAN. 2009. Update on the metabolic syndrome: hypertension. Curr Hypertens Rep 11:150-155.
    • (2009) Curr Hypertens Rep , vol.11 , pp. 150-155
    • Reynolds, K.1    Wildman, R.P.2
  • 189
    • 70349695858 scopus 로고    scopus 로고
    • Long-Term Weight Loss From Lifestyle Intervention Benefits Blood Pressure?: A Systematic Review
    • AUCOTT, L., H. ROTHNIE, L. MCINTYRE, M. THAPA, C. WAWERU, and D. GRAY. 2009. Long-term weight loss from lifestyle intervention benefits blood pressure?: a systematic review. Hypertension 54:756-762.
    • (2009) Hypertension , vol.54 , pp. 756-762
    • Aucott, L.1    Rothnie, H.2    Mcintyre, L.3    Thapa, M.4    Waweru, C.5    Gray, D.6
  • 190
    • 67649710357 scopus 로고    scopus 로고
    • Circulating Levels Of Adiponectin, Leptin, And Tumour Necrosis Factor Alpha In Hypertension
    • PATEL, J.V., H.S. LIM, K. DUBB, E.A. HUGHES, and G.Y. LIP. 2009. Circulating levels of adiponectin, leptin, and tumour necrosis factor alpha in hypertension. Ann Med 41:291-300.
    • (2009) Ann Med , vol.41 , pp. 291-300
    • Patel, J.V.1    Lim, H.S.2    Dubb, K.3    Hughes, E.A.4    Lip, G.Y.5
  • 191
    • 44249094622 scopus 로고    scopus 로고
    • Overview Of Human Obesity And Central Mechanisms Regulating Energy Homeostasis
    • CROWLEY, V.E. 2008. Overview of human obesity and central mechanisms regulating energy homeostasis. Ann Clin Biochem 45:245-255.
    • (2008) Ann Clin Biochem , vol.45 , pp. 245-255
    • Crowley, V.E.1
  • 192
    • 0038460863 scopus 로고    scopus 로고
    • Neural Regulation Of Blood Pressure By Leptin And The Related Peptides
    • MATSUMURA, K., T. TSUCHIHASHI, K. FUJII, and M. IIDA. 2003. Neural regulation of blood pressure by leptin and the related peptides. Regul Pept 114:79-86.
    • (2003) Regul Pept , vol.114 , pp. 79-86
    • Matsumura, K.1    Tsuchihashi, T.2    Fujii, K.3    Iida, M.4
  • 194
    • 0041621613 scopus 로고    scopus 로고
    • Activation Of The Renal Sympathetic Nerve By Leptin Microinjection Into The Ventromedial Hypothalamus In Rats
    • TANIDA, M., K. NAGAI, and H. KANEKO. 2003. Activation of the renal sympathetic nerve by leptin microinjection into the ventromedial hypothalamus in rats. In Vivo 17:213-217.
    • (2003) In Vivo , vol.17 , pp. 213-217
    • Tanida, M.1    Nagai, K.2    Kaneko, H.3
  • 195
    • 54249165852 scopus 로고    scopus 로고
    • Multiple Roles Of Leptin In Blood Pressure Regulation, From Central To Peripheral Mechanisms
    • POLAK, J. 2008. Multiple roles of leptin in blood pressure regulation, from central to peripheral mechanisms. Am J Hypertens 21:1172.
    • (2008) Am J Hypertens , vol.21 , pp. 1172
    • Polak, J.1
  • 196
    • 27744518880 scopus 로고    scopus 로고
    • Leptin Induces Vascular Smooth Muscle Cell Hypertrophy ThroughAngiotensin Ii- And Endothelin-1-Dependent Mechanisms And Mediates Stretch-Induced Hypertrophy
    • Andm.Karmazyn
    • ZEIDAN,A.,D.M.PURDHAM,V.RAJAPUROHITAM,S.JAVADOV,S.CHAKRABARTI,andM.KARMAZYN.2005.Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. J Pharmacol Exp Ther 315:1075-1084.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1075-1084
    • Zeidan, A.1    Purdham, D.M.2    Rajapurohitam, V.3    Javadov, S.4    Chakrabarti, S.5
  • 197
    • 0035206659 scopus 로고    scopus 로고
    • Leptin Stimulates Rat Aortic Smooth Muscle Cell Proliferation And Migration
    • ODA, A., T. TANIGUCHI, and M. YOKOYAMA. 2001. Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J Med Sci 47:141-150.
    • (2001) Kobe J Med Sci , vol.47 , pp. 141-150
    • Oda, A.1    Taniguchi, T.2    Yokoyama, M.3
  • 199
    • 67651162132 scopus 로고    scopus 로고
    • Leptin-Stimulated Endothelial Nitric-Oxide Synthase Via An Adenosine 50-Monophosphate- Activated Protein Kinase/Akt Signaling Pathway Is Attenuated By Interaction With C-Reactive Protein
    • PROCOPIO, C., F.ANDREOZZI, E. LARATTA,A. CASSESE, F. BEGUINOT, F.ARTURI, M.L.HRIBAL, F. PERTICONE, and G. SESTI. 2009. Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 50-monophosphate- activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein. Endocrinology 150:3584-3593.
    • (2009) Endocrinology , vol.150 , pp. 3584-3593
    • Procopio, C.1    Andreozzi, F.2    Laratta, E.3    Cassese, A.4    Beguinot, F.5    Arturi, F.6    Hribal, M.L.7    Perticone, F.8    Sesti, G.9
  • 200
    • 33746733607 scopus 로고    scopus 로고
    • The Inhibitory Effect Of Leptin On Angiotensin Ii-Induced Vasoconstriction Is Blunted In Spontaneously Hypertensive Rats
    • RODRIGUEZ, A., G. FRUHBECK, J. GOMEZ-AMBROSI, V. CATALAN, N. SAINZ, J. DIEZ, G. ZALBA, and A. FORTUNO. 2006. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats. J Hypertens 24:1589-1597.
    • (2006) J Hypertens , vol.24 , pp. 1589-1597
    • Rodriguez, A.1    Fruhbeck, G.2    Gomez-Ambrosi, J.3    Catalan, V.4    Sainz, N.5    Diez, J.6    Zalba, G.7    Fortuno, A.8
  • 201
    • 33845914627 scopus 로고    scopus 로고
    • The Inhibitory Effect Of Leptin On Angiotensin Ii-Induced Vasoconstriction In Vascular Smooth Muscle Cells Is Mediated Via A Nitric Oxide-Dependent Mechanism
    • RODRIGUEZ, A., A. FORTUNO, J. GOMEZ-AMBROSI, G. ZALBA, J. DIEZ, and G. FRUHBECK. 2007. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology 148:324-331.
    • (2007) Endocrinology , vol.148 , pp. 324-331
    • Rodriguez, A.1    Fortuno, A.2    Gomez-Ambrosi, J.3    Zalba, G.4    Diez, J.5    Fruhbeck, G.6
  • 203
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial Nitric Oxide Synthase In Vascular Disease: From Marvel To Menace
    • FORSTERMANN, U., and T. MUNZEL. 2006. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113:1708-1714.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 204
    • 61749084673 scopus 로고    scopus 로고
    • Leptin Is Associated With Blood Pressure And Hypertension In Women From The National Heart, Lung, And Blood Institute Family Heart Study
    • MA, D., M.F. FEITOSA, J.B. WILK, J.M. LARAMIE, K. YU, C. LEIENDECKER-FOSTER, R.H. MYERS, M.A. PROVINCE, and I.B.BORECKI. 2009. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension 53:473-479.
    • (2009) Hypertension , vol.53 , pp. 473-479
    • Ma, D.1    Feitosa, M.F.2    Wilk, J.B.3    Laramie, J.M.4    Yu, K.5    Leiendecker-Foster, C.6    Myers, R.H.7    Province, M.A.8    Borecki, I.B.9
  • 206
  • 207
    • 33846108745 scopus 로고    scopus 로고
    • Sympathetic Overdrive And Cardiovascular Risk In The Metabolic Syndrome
    • GRASSI, G. 2006. Sympathetic overdrive and cardiovascular risk in the metabolic syndrome. Hypertens Res 29:839-847.
    • (2006) Hypertens Res , vol.29 , pp. 839-847
    • Grassi, G.1
  • 209
    • 70449706328 scopus 로고    scopus 로고
    • Leptin Impairs Cardiovagal Baroreflex Function At The Level Of The Solitary Tract Nucleus
    • ARNOLD, A.C., H.A. SHALTOUT, P.E. GALLAGHER, and D.I. DIZ. 2009. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension 54:1001-1008.
    • (2009) Hypertension , vol.54 , pp. 1001-1008
    • Arnold, A.C.1    Shaltout, H.A.2    Gallagher, P.E.3    Diz, D.I.4
  • 210
    • 23944484926 scopus 로고    scopus 로고
    • Leptin Resistance Extends To The Coronary Vasculature In Prediabetic Dogs And Provides A Protective Adaptation Against Endothelial Dysfunction
    • KNUDSON, J.D., U.D. DINCER, G.M. DICK, H. SHIBATA, R. AKAHANE, M. SAITO, and J.D. TUNE. 2005. Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction. Am J Physiol Heart Circ Physiol 289: H1038-H1046.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Knudson, J.D.1    Dincer, U.D.2    Dick, G.M.3    Shibata, H.4    Akahane, R.5    Saito, M.6    Tune, J.D.7
  • 211
    • 33845863407 scopus 로고    scopus 로고
    • Regulation Of Smooth Muscle Cells In Development And Vascular Disease: Current Therapeutic Strategies
    • CAI, X. 2006. Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies. Expert Rev Cardiovasc Ther 4:789-800.
    • (2006) Expert Rev Cardiovasc Ther , vol.4 , pp. 789-800
    • Cai, X.1
  • 215
    • 33847625379 scopus 로고    scopus 로고
    • Leptin Regulates Neointima Formation After Arterial Injury Through Mechanisms Independent Of Blood Pressure And The Leptin Receptor/Stat3 Signaling Pathways Involved In Energy Balance
    • BODARY, P.F., Y. SHEN, M. OHMAN, K.L. BAHROU, F.B. VARGAS, S.S. CUDNEY, K.J. WICKENHEISER, M.G. MYERS, JR., AND D.T. EITZMAN. 2007. LEPTIN REGULATES NEOINTIMA FORMATION AFTER ARTERIAL INJURY THROUGH MECHANISMS INDEPENDENT OF BLOOD PRESSURE AND THE LEPTIN RECEPTOR/STAT3 SIGNALING PATHWAYS INVOLVED IN ENERGY BALANCE. ARTERIOSCLER THROMB VASC BIOL 27:70-76.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 70-76
    • Bodary, P.F.1    Shen, Y.2    Ohman, M.3    Bahrou, K.L.4    Vargas, F.B.5    Cudney, S.S.6    Wickenheiser, K.J.7    Myers Jr, M.G.8    Eitzman, D.T.9
  • 216
    • 33845589430 scopus 로고    scopus 로고
    • Role Of Leptin In Atherogenesis
    • DUBEY, L., and Z. HESONG. 2006. Role of leptin in atherogenesis. Exp Clin Cardiol 11:269-275.
    • (2006) Exp Clin Cardiol , vol.11 , pp. 269-275
    • Dubey, L.1    Hesong, Z.2
  • 217
    • 0141459376 scopus 로고    scopus 로고
    • C-Reactive Protein In Young, Apparently Healthy Men: Associations With Serum Leptin, Qtc Interval, And High-Density Lipoprotein-Cholesterol
    • KAZUMI, T., A. KAWAGUCHI, T. HIRANO, and G. YOSHINO. 2003. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. Metabolism 52:1113-1116.
    • (2003) Metabolism , vol.52 , pp. 1113-1116
    • Kazumi, T.1    Kawaguchi, A.2    Hirano, T.3    Yoshino, G.4
  • 218
    • 33845456339 scopus 로고    scopus 로고
    • Vascular C-Reactive Protein In The Pathogenesis Of Coronary Artery Disease: Role Of Vascular Inflammation And Oxidative Stress
    • INOUE, N. 2006. Vascular C-reactive protein in the pathogenesis of coronary artery disease: role of vascular inflammation and oxidative stress. Cardiovasc Hematol Disord Drug Targets 6:227-231.
    • (2006) Cardiovasc Hematol Disord Drug Targets , vol.6 , pp. 227-231
    • Inoue, N.1
  • 219
    • 57349111713 scopus 로고    scopus 로고
    • Leptin, Obesity And Platelet Responsiveness: Another Piece In The Puzzle
    • CORSONELLO, A., and F. CORICA. 2008. Leptin, obesity and platelet responsiveness: another piece in the puzzle. Thromb Haemost 100:960-961.
    • (2008) Thromb Haemost , vol.100 , pp. 960-961
    • Corsonello, A.1    Corica, F.2
  • 220
    • 0032971218 scopus 로고    scopus 로고
    • Leptin Promotes Aggregation Of Human Platelets Via The Long Form Of Its Receptor
    • NAKATA, M., T. YADA, N. SOEJIMA, and I. MARUYAMA. 1999. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 48:426-429.
    • (1999) Diabetes , vol.48 , pp. 426-429
    • Nakata, M.1    Yada, T.2    Soejima, N.3    Maruyama, I.4
  • 222
    • 57349151521 scopus 로고    scopus 로고
    • Absence Of Leptin Resistance In Platelets From Morbidly Obese Individuals May Contribute To The Increased Thrombosis Risk In Obesity
    • DELLAS, C., K. SCHAFER, I. ROHM, M. LANKEIT, T. ELLROTT, V. FAUSTIN, J. RIGGERT, G. HASENFUSS, and S. KONSTANTINIDES. 2008. Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost 100:1123-1129.
    • (2008) Thromb Haemost , vol.100 , pp. 1123-1129
    • Dellas, C.1    Schafer, K.2    Rohm, I.3    Lankeit, M.4    Ellrott, T.5    Faustin, V.6    Riggert, J.7    Hasenfuss, G.8    Konstantinides, S.9
  • 225
    • 0035973147 scopus 로고    scopus 로고
    • Potential Role Of Leptin In Angiogenesis: Leptin Induces Endothelial Cell Proliferation And Expression Of Matrix Metalloproteinases In Vivo And In Vitro
    • PARK, H.Y., H.M. KWON, H.J. LIM, B.K. HONG, J.Y. LEE, B.E. PARK, Y. JANG, S.Y. CHO, and H.S. KIM. 2001. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33:95-102.
    • (2001) Exp Mol Med , vol.33 , pp. 95-102
    • Park, H.Y.1    Kwon, H.M.2    Lim, H.J.3    Hong, B.K.4    Lee, J.Y.5    Park, B.E.6    Jang, Y.7    Cho, S.Y.8    Kim, H.S.9
  • 226
    • 70349484670 scopus 로고    scopus 로고
    • Mechanisms Of Obesity And Related Pathologies: The Macro- And Microcirculation Of Adipose Tissue
    • RUTKOWSKI, J.M., K.E.DAVIS, and P.E. SCHERER. 2009. Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue. FEBS J 276:5738-5746.
    • (2009) Febs J , vol.276 , pp. 5738-5746
    • Rutkowski, J.M.1    Davis, K.E.2    Scherer, P.E.3
  • 232
    • 34548673078 scopus 로고    scopus 로고
    • Adiponectin Receptors, With Special Focus On The Role Of The Third Receptor, T-Cadherin, In Vascular Disease
    • TAKEUCHI, T.,Y.ADACHI, Y.OHTSUKI, and M. FURIHATA. 2007. Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease. Med Mol Morphol 40:115-120.
    • (2007) Med Mol Morphol , vol.40 , pp. 115-120
    • Takeuchi, T.1    Adachi, Y.2    Ohtsuki, Y.3    Furihata, M.4
  • 233
    • 58849159550 scopus 로고    scopus 로고
    • Overexpression Of Adiponectin Receptors Potentiates The Antiinflammatory Action Of Subeffective Dose Of Globular Adiponectin In Vascular Endothelial Cells
    • ZHANG, P., Y. WANG, Y. FAN, Z. TANG, and N. WANG. 2009. Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arterioscler Thromb Vasc Biol 29:67-74.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 67-74
    • Zhang, P.1    Wang, Y.2    Fan, Y.3    Tang, Z.4    Wang, N.5
  • 234
    • 58149250329 scopus 로고    scopus 로고
    • Upregulation Of Heme Oxygenase-1 Combined With Increased Adiponectin Lowers Blood Pressure In Diabetic Spontaneously Hypertensive Rats Through A Reduction In Endothelial Cell Dysfunction, Apoptosis And Oxidative Stress
    • CAO, J., G. DRUMMOND, K. INOUE, K. SODHI, X.Y. LI, and S. OMURA. 2008. Upregulation of heme oxygenase-1 combined with increased adiponectin lowers blood pressure in diabetic spontaneously hypertensive rats through a reduction in endothelial cell dysfunction, apoptosis and oxidative stress. Int J Mol Sci 9:2388-2406.
    • (2008) Int J Mol Sci , vol.9 , pp. 2388-2406
    • Cao, J.1    Drummond, G.2    Inoue, K.3    Sodhi, K.4    Li, X.Y.5    Omura, S.6
  • 236
    • 34447324638 scopus 로고    scopus 로고
    • Regulation Of Vascular Function And Insulin Sensitivity By Adipose Tissue: Focus On Perivascular Adipose Tissue
    • ERINGA, E.C., W. BAKKER, Y.M. SMULDERS, E.H. SERNE, J.S. YUDKIN, and C.D. STEHOUWER. 2007. Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissue. Microcirculation 14:389-402.
    • (2007) Microcirculation , vol.14 , pp. 389-402
    • Eringa, E.C.1    Bakker, W.2    Smulders, Y.M.3    Serne, E.H.4    Yudkin, J.S.5    Stehouwer, C.D.6
  • 237
    • 55449093720 scopus 로고    scopus 로고
    • A reduction in the amount and anticontractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats
    • GALVEZ-PRIETO, B., G. DUBROVSKA, M.V. CANO, M. DELGADO, I. ARANGUEZ, M.C. GONZALEZ, M. RUIZGAYO, M. GOLLASCH, and M.S. FERNANDEZ-ALFONSO. 2008. A reduction in the amount and anticontractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats. Hypertens Res 31:1415-1423.
    • (2008) Hypertens Res , vol.31 , pp. 1415-1423
    • Galvez-Prieto, B.1    Dubrovska, G.2    Cano, M.V.3    Delgado, M.4    Aranguez, I.5    Gonzalez, M.C.6    Ruizgayo, M.7    Gollasch, M.8    Fernandez-Alfonso, M.S.9
  • 240
    • 65649109726 scopus 로고    scopus 로고
    • Adiponectin and cardiovascular disease
    • SHIBATA, R., N. OUCHI, and T. MUROHARA. 2009. Adiponectin and cardiovascular disease. Circ J 73:608-614.
    • (2009) Circ J , vol.73 , pp. 608-614
    • Shibata, R.1    Ouchi, N.2    Murohara, T.3
  • 242
    • 69349102944 scopus 로고    scopus 로고
    • Antiatherosclerotic and anti-insulin resistance effects of adiponectin: basic and clinical studies
    • HAN, S.H., I. SAKUMA, E.K. SHIN, and K.K. KOH. 2009. Antiatherosclerotic and anti-insulin resistance effects of adiponectin: basic and clinical studies. Prog Cardiovasc Dis 52:126-140.
    • (2009) Prog Cardiovasc Dis , vol.52 , pp. 126-140
    • Han, S.H.1    Sakuma, I.2    Shin, E.K.3    Koh, K.K.4
  • 243
    • 33748310586 scopus 로고    scopus 로고
    • Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway
    • OUEDRAOGO, R., X.WU, S.Q.XU, L. FUCHSEL,H.MOTOSHIMA,K.MAHADEV,K.HOUGH, R. SCALIA, and B. J. GOLDSTEIN. 2006. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55:1840-1846.
    • (2006) Diabetes , vol.55 , pp. 1840-1846
    • Ouedraogo, R.1    Wu, X.2    Xu, S.Q.3    Fuchsel, L.4    Motoshima, H.5    Mahadev, K.6    Hough, K.7    Scalia, R.8    Goldstein, B.J.9
  • 245
    • 69049095976 scopus 로고    scopus 로고
    • PON1 is a longevity gene: results of a metaanalysis
    • LESCAI, F., F. MARCHEGIANI, and C. FRANCESCHI. 2009. PON1 is a longevity gene: results of a metaanalysis. Ageing Res Rev 8:277-284.
    • (2009) Ageing Res Rev , vol.8 , pp. 277-284
    • Lescai, F.1    Marchegiani, F.2    Franceschi, C.3
  • 247
    • 74249096153 scopus 로고    scopus 로고
    • Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS pathway
    • DENG, G., Y. LONG, Y.R. YU, and M.R. LI. 2010. Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS pathway. Int J Obes (Lond) 34:165-171.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 165-171
    • Deng, G.1    Long, Y.2    Yu, Y.R.3    Li, M.R.4
  • 248
    • 46349086870 scopus 로고    scopus 로고
    • Vascular system: role of nitric oxide in cardiovascular diseases
    • BIAN, K., M.F. DOURSOUT, and F.MURAD. 2008. Vascular system: role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich) 10:304-310.
    • (2008) J Clin Hypertens (Greenwich) , vol.10 , pp. 304-310
    • Bian, K.1    Doursout, M.F.2    Murad, F.3
  • 249
    • 39549094717 scopus 로고    scopus 로고
    • Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention
    • ZHU,W., K.K. CHENG, P.M. VANHOUTTE, K.S. LAM, and A. XU. 2008. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) 114:361-374.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 361-374
    • Zhu, W.1    Cheng, K.K.2    Vanhoutte, P.M.3    Lam, K.S.4    Xu, A.5
  • 250
    • 68249150893 scopus 로고    scopus 로고
    • Adiponectin inhibits insulin-like growth factor-1- induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells
    • MOTOBAYASHI, Y., Y. IZAWA-ISHIZAWA, K. ISHIZAWA, S. ORINO, K.YAMAGUCHI, K.KAWAZOE, S.HAMANO, K. TSUCHIYA, S. TOMITA, and T. TAMAKI. 2009. Adiponectin inhibits insulin-like growth factor-1- induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells. Hypertens Res 32:188-193.
    • (2009) Hypertens Res , vol.32 , pp. 188-193
    • Motobayashi, Y.Y.1    Izawa-Ishizawa, K.2    Ishizawa, S.3    Orino, K.4    Yamaguchi, K.5    Kawazoe, S.6    Hamano, S.7    Tsuchiya, K.8    Tomita, S.9    Tamaki, T.10
  • 253
    • 68949158625 scopus 로고    scopus 로고
    • Development of arterial calcification in adiponectin-deficient mice: adiponectin regulates arterial calcification
    • LUO, X.H., L.L. ZHAO, L.Q. YUAN, M. WANG, H. XIE, and E.Y. LIAO. 2009. Development of arterial calcification in adiponectin-deficient mice: adiponectin regulates arterial calcification. J Bone Miner Res 24:1461-1468.
    • (2009) J Bone Miner Res , vol.24 , pp. 1461-1468
    • Luo, X.H.1    Zhao, L.L.2    Yuan, L.Q.3    Wang, M.4    Xie, H.5    Liao, E.Y.6
  • 257
    • 45149117343 scopus 로고    scopus 로고
    • The proinflammatory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponectin
    • NATAL, C., P.RESTITUTO, C. INIGO, I.COLINA, J.DIEZ, and N.VARO. 2008. The proinflammatory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponectin. J Clin Endocrinol Metab 93:2319-2327.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2319-2327
    • Natal, C.1    Restituto, P.2    Inigo, C.3    Colina, I.4    Diez, J.5    Varo, N.6
  • 258
    • 43749115532 scopus 로고    scopus 로고
    • Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex
    • RIBA, R., C.E. HUGHES, A. GRAHAM, S.P. WATSON, and K.M. NASEEM. 2008. Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. J Thromb Haemost 6:1012-1020.
    • (2008) J Thromb Haemost , vol.6 , pp. 1012-1020
    • Riba, R.1    Hughes, C.E.2    Graham, A.3    Watson, S.P.4    Naseem, K.M.5
  • 260
    • 34247176774 scopus 로고    scopus 로고
    • High serum levels of adiponectin improve coronary collateral development in patients with coronary artery disease
    • SOYDINC, S., V. DAVUTOGLU, and I. SARI. 2007. High serum levels of adiponectin improve coronary collateral development in patients with coronary artery disease. Tohoku J Exp Med 211:347-352.
    • (2007) Tohoku J Exp Med , vol.211 , pp. 347-352
    • Soydinc, S.1    Davutoglu, V.2    Sari, I.3
  • 261
    • 42149117692 scopus 로고    scopus 로고
    • Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells
    • MAHADEV, K., X. WU, S. DONNELLY, R. OUEDRAOGO, A.D. ECKHART, and B.J. GOLDSTEIN. 2008. Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc Res 78:376-384.
    • (2008) Cardiovasc Res , vol.78 , pp. 376-384
    • Mahadev, K.1    Wu, X.2    Donnelly, S.3    Ouedraogo, R.4    Eckhart, A.D.5    Goldstein, B.J.6
  • 262
  • 263
    • 59449094091 scopus 로고    scopus 로고
    • Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase
    • KONDO, M., R. SHIBATA, R. MIURA, M. SHIMANO, K. KONDO, P. LI, T. OHASHI, S. KIHARA, N.MAEDA, K. WALSH, N. OUCHI, and T. MUROHARA. 2009. Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem 284:1718-1724.
    • (2009) J Biol Chem , vol.284 , pp. 1718-1724
    • Kondo, M.1    Shibata, R.2    Miura, R.3    Shimano, M.4    Kondo, K.5    Li, P.6    Ohashi, T.7    Kihara, S.8    Maeda, N.9    Walsh, K.10    Ouchi, N.11    Murohara, T.12
  • 267
    • 70549108877 scopus 로고    scopus 로고
    • Regulation Of Resistin By Cyclic Mechanical Stretch In Cultured Rat Vascular Smooth Muscle Cell
    • WANG, B.W., H. CHANG, and K.G. SHYU. 2009. Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cell. Clin Sci (Lond) 118 (3): 221-230.
    • (2009) Clin Sci (Lond) , vol.118 , Issue.3 , pp. 221-230
    • Wang, B.W.1    Chang, H.2    Shyu, K.G.3
  • 268
    • 59849088990 scopus 로고    scopus 로고
    • The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia
    • HUNG, H.F., B.W. WANG, H. CHANG, and K.G. SHYU. 2008. The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia. J Hypertens 26:2349-2360.
    • (2008) J Hypertens , vol.26 , pp. 2349-2360
    • Hung, H.F.1    Wang, B.W.2    Chang, H.3    Shyu, K.G.4
  • 271
    • 70349972139 scopus 로고    scopus 로고
    • The role of resistin as a regulator of inflammation: implications for various human pathologies
    • FILKOVA, M., M. HALUZIK, S. GAY, and L. SENOLT. 2009. The role of resistin as a regulator of inflammation: implications for various human pathologies. Clin Immunol 133:157-170.
    • (2009) Clin Immunol , vol.133 , pp. 157-170
    • Filkova, M.1    Haluzik, M.2    Gay, S.3    Senolt, L.4
  • 276
    • 67349174221 scopus 로고    scopus 로고
    • Relationship between serum retinol-binding protein 4 and visfatin and the metabolic syndrome
    • LIN, C.C., M.M. LAI, T.C. LI, C.I. LI, C.S. LIU, C.C. CHEN, and M.T.WU. 2009. Relationship between serum retinol-binding protein 4 and visfatin and the metabolic syndrome. Diabetes Res Clin Pract 85:24-29.
    • (2009) Diabetes Res Clin Pract , vol.85 , pp. 24-29
    • Lin, C.C.1    Lai, M.M.2    Li, T.C.3    Li, C.I.4    Liu, C.S.5    Chen, C.C.6    Wu, M.T.7
  • 278
    • 63149089930 scopus 로고    scopus 로고
    • The NADWorld: a new systemic regulatory network for metabolism and aging-Sirt1, systemic NAD biosynthesis, and their importance
    • IMAI, S. 2009. The NADWorld: a new systemic regulatory network for metabolism and aging-Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys 53:65-74.
    • (2009) Cell Biochem Biophys , vol.53 , pp. 65-74
    • Imai, S.1
  • 281
  • 284
    • 57549107880 scopus 로고    scopus 로고
    • Apelin, a novel adipocytokine, in relation to endothelial function and inflammation in kidney allograft recipients
    • MALYSZKO, J., J.S. MALYSZKO, K. PAWLAK, S. WOLCZYNSKI, and M. MYSLIWIEC. 2008. Apelin, a novel adipocytokine, in relation to endothelial function and inflammation in kidney allograft recipients. Transplant Proc 40:3466-3469.
    • (2008) Transplant Proc , vol.40 , pp. 3466-3469
    • Malyszko, J.1    Malyszko, J.S.2    Pawlak, K.3    Wolczynski, S.4    Mysliwiec, M.5
  • 285
    • 34548382056 scopus 로고    scopus 로고
    • Diabetes Mellitus And Macrovascular Disease: Mechanisms And Mediators
    • BOYLE, P.J. 2007. Diabetes mellitus and macrovascular disease: mechanisms and mediators.AmJ Med 120:S12-S17.
    • (2007) Amj Med , vol.120
    • Boyle, P.J.1
  • 286
    • 50949099615 scopus 로고    scopus 로고
    • Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis
    • EYRIES, M., G. SIEGFRIED, M. CIUMAS, K.MONTAGNE, M. AGRAPART, F. LEBRIN, and F. SOUBRIER. 2008. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ Res 103:432-440.
    • (2008) Circ Res , vol.103 , pp. 432-440
    • Eyries, M.1    Siegfried, G.2    Ciumas, M.3    Montagne, K.4    Agrapart, M.5    Lebrin, F.6    Soubrier, F.7
  • 289
    • 42649096311 scopus 로고    scopus 로고
    • The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential
    • JAPP, A.G., and D.E.NEWBY. 2008. The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential. Biochem Pharmacol 75:1882-1892.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1882-1892
    • Japp, A.G.1    Newby, D.E.2
  • 292
    • 34548329794 scopus 로고    scopus 로고
    • The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns
    • WANG, J., S.RUOTSALAINEN, L.MOILANEN, P. LEPISTO, M. LAAKSO, and J.KUUSISTO. 2007. The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns. Eur Heart J 28:857-864.
    • (2007) Eur Heart J , vol.28 , pp. 857-864
    • Wang, J.1    Ruotsalainen, S.2    Moilanen, L.3    Lepisto, P.4    Laakso, M.5    Kuusisto, J.6
  • 293
    • 67650330454 scopus 로고    scopus 로고
    • Unraveling the paradoxical link between obesity and heart failure: the role of adipocytokines
    • PATEL, J.V., I. TRACEY, E.A. HUGHES, and G.Y. LIP. 2009. Unraveling the paradoxical link between obesity and heart failure: the role of adipocytokines. Expert Rev Cardiovasc Ther 7:337-340.
    • (2009) Expert Rev Cardiovasc Ther , vol.7 , pp. 337-340
    • Patel, J.V.1    Tracey, I.2    Hughes, E.A.3    Lip, G.Y.4
  • 294
    • 58149484949 scopus 로고    scopus 로고
    • Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study
    • Lipid Study Investigators
    • SODERBERG, S., D.COLQUHOUN, A. KEECH, J. YALLOP, E.H. BARNES, C. POLLICINO, J.SIMES, A.M. TONKIN, P. NESTEL, and LIPID Study Investigators. 2009. Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study. Int J Obes (Lond) 33:123-130.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 123-130
    • Soderberg, S.1    Colquhoun, D.2    Keech, A.3    Yallop, J.4    Barnes, E.H.5    Pollicino, C.6    Simes, J.7    Tonkin, A.M.8    Nestel, P.9
  • 295
    • 0037119410 scopus 로고    scopus 로고
    • Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylasemalonyl- CoA axis
    • ATKINSON, L.L., M.A. FISCHER, and G. D. LOPASCHUK. 2002. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylasemalonyl- CoA axis. J Biol Chem 277:29424-29430.
    • (2002) J Biol Chem , vol.277 , pp. 29424-29430
    • Atkinson, L.L.1    Fischer, M.A.2    Lopaschuk, G.D.3
  • 296
    • 0142025119 scopus 로고    scopus 로고
    • Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes
    • HINTZ, K.K., N.S. ABERLE, and J. REN. 2003. Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes. Int J Obes Relat Metab Disord 27:1196-1203.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 1196-1203
    • Hintz, K.K.1    Aberle, N.S.2    Ren, J.3
  • 297
    • 34250891864 scopus 로고    scopus 로고
    • Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation
    • ABE, Y., K. ONO, T. KAWAMURA, H. WADA, T. KITA, A. SHIMATSU, and K. HASEGAWA. 2007. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. Am J Physiol Heart Circ Physiol 292:H2387-H2396.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Abe, Y.1    Ono, K.2    Kawamura, T.3    Wada, H.4    Kita, T.5    Shimatsu, A.6    Hasegawa, K.7
  • 299
    • 34547828051 scopus 로고    scopus 로고
    • Fitness or fatness-the debate continues for the role of leptin in obesityassociated heart dysfunction
    • DONG, F., and J. REN. 2007. Fitness or fatness-the debate continues for the role of leptin in obesityassociated heart dysfunction. Curr Diabetes Rev 3:159-164.
    • (2007) Curr Diabetes Rev , vol.3 , pp. 159-164
    • Dong, F.1    Ren, J.2
  • 300
    • 34447643051 scopus 로고    scopus 로고
    • Leptin as a cardiac hypertrophic factor: a potential target for therapeutics
    • KARMAZYN, M., D.M. PURDHAM, V. RAJAPUROHITAM, and A. ZEIDAN. 2007. Leptin as a cardiac hypertrophic factor: a potential target for therapeutics. Trends Cardiovasc Med 17:206-211.
    • (2007) Trends Cardiovasc Med , vol.17 , pp. 206-211
    • Karmazyn, M.1    Purdham, D.M.2    Rajapurohitam, V.3    Zeidan, A.4
  • 304
    • 34547761805 scopus 로고    scopus 로고
    • Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure
    • TSUTAMOTO, T., T. TANAKA, H. SAKAI, C. ISHIKAWA, M. FUJII, T. YAMAMOTO, and M. HORIE. 2007. Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J 28:1723-1730.
    • (2007) Eur Heart J , vol.28 , pp. 1723-1730
    • Tsutamoto, T.1    Tanaka, T.2    Sakai, H.3    Ishikawa, C.4    Fujii, M.5    Yamamoto, T.6    Horie, M.7
  • 306
    • 46749104513 scopus 로고    scopus 로고
    • Impact of adiponectin on left ventricular mass index in non-complicated obese subjects
    • EBINC, H., F.A. EBINC, Z.N. OZKURT, M.T. DOGRU, M. TULMAC, M. YILMAZ, and O. CAGLAYAN. 2008. Impact of adiponectin on left ventricular mass index in non-complicated obese subjects. Endocr J 55:523-528.
    • (2008) Endocr J , vol.55 , pp. 523-528
    • Ebinc, H.1    Ebinc, F.A.2    Ozkurt, Z.N.3    Dogru, M.T.4    Tulmac, M.5    Yilmaz, M.6    Caglayan, O.7
  • 309
    • 41149094470 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide
    • GONON, A.T., U.WIDEGREN, A.BULHAK, F. SALEHZADEH, J. PERSSON, P.O. SJOQUIST, and J. PERNOW. 2008. Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide. Cardiovasc Res 78:116-122.
    • (2008) Cardiovasc Res , vol.78 , pp. 116-122
    • Gonon, A.T.1    Widegren, U.2    Bulhak, A.3    Salehzadeh, F.4    Persson, J.5    Sjoquist, P.O.6    Pernow, J.7
  • 310
    • 61949363051 scopus 로고    scopus 로고
    • AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin
    • WANG, Y., E. GAO, L. TAO,W.B. LAU, Y. YUAN, B.J.GOLDSTEIN, B.L. LOPEZ, T.A. CHRISTOPHER, R. TIAN, W. KOCH, and X.L. MA. 2009. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation 119:835-844.
    • (2009) Circulation , vol.119 , pp. 835-844
    • Wang, Y.1    Gao, E.2    Tao, L.3    Lau, W.B.4    Yuan, Y.5    Goldstein, B.J.6    Lopez, B.L.7    Christopher, T.A.8    Tian, R.9    Koch, W.10    Ma, X.L.11
  • 311
    • 39749087544 scopus 로고    scopus 로고
    • HYPOXIA INDUCIBLE FACTOR-1 UPREGULATES ADIPONECTIN IN DIABETIC MOUSE HEARTS AND ATTENUATES POST-ISCHEMIC INJURY
    • NATARAJAN, R., F.N. SALLOUM, B.J. FISHER, R.C. KUKREJA, and A.A. FOWLER 3RD. 2008. HYPOXIA INDUCIBLE FACTOR-1 UPREGULATES ADIPONECTIN IN DIABETIC MOUSE HEARTS AND ATTENUATES POST-ISCHEMIC INJURY. J CARDIOVASC PHARMACOL 51:178-187.
    • (2008) J CARDIOVASC PHARMACOL , vol.51 , pp. 178-187
    • Natarajan, R.1    Salloum, F.N.2    Fisher, B.J.3    Kukreja, R.C.4    Fowler, A.A.5
  • 315
    • 48749091951 scopus 로고    scopus 로고
    • Plasma resistin associated with myocardium injury in patients with acute coronary syndrome
    • CHU, S., W. DING, K. LI, Y. PANG, and C. TANG. 2008. Plasma resistin associated with myocardium injury in patients with acute coronary syndrome. Circ J 72:1249-1253.
    • (2008) Circ J , vol.72 , pp. 1249-1253
    • Chu, S.1    Ding, W.2    Li, K.3    Pang, Y.4    Tang, C.5
  • 316
    • 35348979137 scopus 로고    scopus 로고
    • Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha
    • WANG, B.W., H.F. HUNG, H. CHANG, P.KUAN, and K.G. SHYU. 2007. Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol 293:H2305-H2312.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Wang, B.W.1    Hung, H.F.2    Chang, H.3    Kuan, P.4    Shyu, K.G.5
  • 318
    • 35348857484 scopus 로고    scopus 로고
    • Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury
    • SIMPKIN, J.C., D.M. YELLON, S.M. DAVIDSON, S.Y. LIM, A.M.WYNNE, and C.C. SMITH. 2007. Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury. Basic Res Cardiol 102:518-528.
    • (2007) Basic Res Cardiol , vol.102 , pp. 518-528
    • Simpkin, J.C.1    Yellon, D.M.2    Davidson, S.M.3    Lim, S.Y.4    Wynne, A.M.5    Smith, C.C.6
  • 321
    • 66949157990 scopus 로고    scopus 로고
    • Interventions to increase adiponectin may be associated with increased coronary heart disease in older adults
    • WANNAMETHEE, S.G. 2009. Interventions to increase adiponectin may be associated with increased coronary heart disease in older adults. Future Cardiol 5:19-22.
    • (2009) Future Cardiol , vol.5 , pp. 19-22
    • Wannamethee, S.G.1
  • 322
    • 70349976936 scopus 로고    scopus 로고
    • Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs
    • GERMAN, A.J., M. HERVERA, L. HUNTER, S.L. HOLDEN, P.J.MORRIS, V. BIOURGE, and P. TRAYHURN. 2009. Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domest Anim Endocrinol 37:214-226.
    • (2009) Domest Anim Endocrinol , vol.37 , pp. 214-226
    • German, A.J.1    Hervera, M.2    Hunter, L.3    Holden, S.L.4    Morris, P.J.5    Biourge, V.6    Trayhurn, P.7
  • 324
    • 67651092387 scopus 로고    scopus 로고
    • Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women
    • VARADY, K.A., L. TUSSING, S. BHUTANI, and C.L. BRAUNSCHWEIG. 2009. Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism 58:1096-1101.
    • (2009) Metabolism , vol.58 , pp. 1096-1101
    • Varady, K.A.1    Tussing, L.2    Bhutani, S.3    Braunschweig, C.L.4
  • 325
    • 20544431563 scopus 로고    scopus 로고
    • Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin
    • BALLANTYNE, G.H., A. GUMBS, and I.M. MODLIN. 2005. Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. Obes Surg 15:692-699.
    • (2005) Obes Surg , vol.15 , pp. 692-699
    • Ballantyne, G.H.1    Gumbs, A.2    Modlin, I.M.3
  • 326
    • 18044370830 scopus 로고    scopus 로고
    • Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss
    • GUMBS, A.A., I.M. MODLIN, and G.H. BALLANTYNE. 2005. Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes Surg 15:462-473.
    • (2005) Obes Surg , vol.15 , pp. 462-473
    • Gumbs, A.A.1    Modlin, I.M.2    Ballantyne, G.H.3
  • 329
    • 34447098919 scopus 로고    scopus 로고
    • Dissociation Between Adipose Tissue Expression And Serum Levels Of Adiponectin During And After Diet-Induced Weight Loss In Obese Subjects With And Without The Metabolic Syndrome
    • BEHRE, C.J., A. GUMMESSON, M. JERNAS, T.C. LYSTIG, B. FAGERBERG, B. CARLSSON, and L.M. CARLSSON. 2007. Dissociation between adipose tissue expression and serum levels of adiponectin during and after diet-induced weight loss in obese subjects with and without the metabolic syndrome. Metabolism 56:1022-1028.
    • (2007) Metabolism , vol.56 , pp. 1022-1028
    • Behre, C.J.1    Gummesson, A.2    Jernas, M.3    Lystig, T.C.4    Fagerberg, B.5    Carlsson, B.6    Carlsson, L.M.7
  • 330
    • 36049007478 scopus 로고    scopus 로고
    • Effect Of Weight Loss Onldland Hdlkinetics In The Metabolic Syndrome: Associations With Changes In Plasma Retinol-Binding Protein- 4 And Adiponectin Levels
    • NG, T.W., G.F.WATTS, P.H.BARRETT, K.A.RYE, and D.C.CHAN. 2007. Effect of weight loss onLDLand HDLkinetics in the metabolic syndrome: associations with changes in plasma retinol-binding protein- 4 and adiponectin levels. Diabetes Care 30:2945-2950.
    • (2007) Diabetes Care , vol.30 , pp. 2945-2950
    • Ng, T.W.1    Watts, G.F.2    Barrett, P.H.3    Rye, K.A.4    Chan, D.C.5
  • 331
    • 0037840403 scopus 로고    scopus 로고
    • Effect Of Weight Loss And Lifestyle Changes On Vascular Inflammatory Markers In Obese Women: A Randomized Trial
    • ESPOSITO, K., A. PONTILLO, C. DI PALO, G.GIUGLIANO, M. MASELLA, R. MARFELLA, and D. GIUGLIANO. 2003. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289:1799-1804.
    • (2003) Jama , vol.289 , pp. 1799-1804
    • Esposito, K.1    Pontillo, A.2    Di Palo, C.3    Giugliano, G.4    Masella, M.5    Marfella, R.6    Giugliano, D.7
  • 332
    • 34548080951 scopus 로고    scopus 로고
    • Lifestyle Plus Exercise Intervention Improves Metabolic Syndrome Markers Without Change In Adiponectin In Obese Girls
    • PARK, T.G., H.R. HONG, J. LEE, and H.S. KANG. 2007. Lifestyle plus exercise intervention improves metabolic syndrome markers without change in adiponectin in obese girls. Ann Nutr Metab 51:197-203.
    • (2007) Ann Nutr Metab , vol.51 , pp. 197-203
    • Park, T.G.1    Hong, H.R.2    Lee, J.3    Kang, H.S.4
  • 334
    • 58149499174 scopus 로고    scopus 로고
    • Physiological And Pathophysiological Roles Of Adiponectin And Adiponectin Receptors In The Integrated Regulation Of Metabolic And Cardiovascular Diseases
    • YAMAUCHI, T., and T. KADOWAKI. 2008. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes (Lond) 32 (Suppl 7): S13-S18.
    • (2008) Int J Obes (Lond) , vol.32 SUPPL , Issue.7
    • Yamauchi, T.1    Kadowaki, T.2
  • 335
    • 40949127502 scopus 로고    scopus 로고
    • Hypoadiponectinemia As A Marker Of Adipocyte Dysfunction-Part Ii: The Functional Significance Of Low Adiponectin Secretion
    • STERN, N., E. OSHER, and Y. GREENMAN. 2007. Hypoadiponectinemia as a marker of adipocyte dysfunction-part II: the functional significance of low adiponectin secretion. J Cardiometab Syndr 2:288-294.
    • (2007) J Cardiometab Syndr , vol.2 , pp. 288-294
    • Stern, N.1    Osher, E.2    Greenman, Y.3
  • 336
    • 70349486032 scopus 로고    scopus 로고
    • The Look Ahead Adipose Research Group. Differential Effect Of Weight Loss On Adipocyte Size Subfractions In Patients With Type 2 Diabetes
    • PASARICA, M., Y.D. TCHOUKALOVA, L.K. HEILBRONN, X. FANG, J.B. ALBU, D.E. KELLEY, S.R. SMITH, E. RAVUSSIN, and The Look AHEAD Adipose Research Group. 2009. Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes. Obesity (Silver Spring) 17:1976-1978.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1976-1978
    • Pasarica, M.1    Tchoukalova, Y.D.2    Heilbronn, L.K.3    Fang, X.4    Albu, J.B.5    Kelley, D.E.6    Smith, S.R.7    Ravussin, E.8
  • 337
    • 70350566702 scopus 로고    scopus 로고
    • Lifestyle Intervention In Obese Children Is Associated With A Decrease Of The Metabolic Syndrome Prevalence
    • REINEHR, T., M. KLEBER, and A.M. TOSCHKE. 2009. Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence. Atherosclerosis 207:174-180.
    • (2009) Atherosclerosis , vol.207 , pp. 174-180
    • Reinehr, T.1    Kleber, M.2    Toschke, A.M.3
  • 338
    • 64249092904 scopus 로고    scopus 로고
    • Effects Of Exercise And Caloric Restriction On Insulin Resistance And Cardiometabolic Risk Factors In Older Obese Adults-A Randomized Clinical Trial
    • YASSINE, H.N., C.M. MARCHETTI, R.K. KRISHNAN, T.R. VROBEL, F. GONZALEZ, and J.P. KIRWAN. 2009. Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults-a randomized clinical trial. J Gerontol A Biol Sci Med Sci 64:90-95.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 90-95
    • Yassine, H.N.1    Marchetti, C.M.2    Krishnan, R.K.3    Vrobel, T.R.4    Gonzalez, F.5    Kirwan, J.P.6
  • 340
    • 73249123598 scopus 로고    scopus 로고
    • Low-Fat Versus Low-Carbohydrate Weight Reduction Diets: Effects On Weight Loss, Insulin Resistance And Cardiovascular Risk: A Randomised Control Trial
    • BRADLEY, U., M. SPENCE, C.H. COURTNEY, M.C.MCKINLEY, C.N. ENNIS, D.R.MCCANCE, J. MCENENY, P. M. BELL, I.S.YOUNG, and S.J.HUNTER. 2009. Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance and cardiovascular risk: a randomised control trial. Diabetes 58:2741-2748.
    • (2009) Diabetes , vol.58 , pp. 2741-2748
    • Bradley, U.1    Spence, M.2    Courtney, C.H.3    Mckinley, M.C.4    Ennis, C.N.5    Mccance, D.R.6    Mceneny, J.7    Bell, P.M.8    Young, I.S.9    Hunter, S.J.10
  • 341
    • 67649126552 scopus 로고    scopus 로고
    • Chardonnay Grape Seed Procyanidin Extract Supplementation Prevents High-Fat Diet-Induced Obesity In Hamsters By Improving Adipokine Imbalance And Oxidative Stress Markers
    • DECORDE, K., P.L. TEISSEDRE, T.SUTRA, E.VENTURA, J.P.CRISTOL, and J.M.ROUANET. 2009. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Mol Nutr Food Res 53:659-666.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 659-666
    • Decorde, K.1    Teissedre, P.L.2    Sutra, T.3    Ventura, E.4    Cristol, J.P.5    Rouanet, J.M.6
  • 343
    • 60949087943 scopus 로고    scopus 로고
    • Long-Term Resveratrol Administration Reduces Metabolic Disturbances And Lowers Blood Pressure In Obese Zucker Rats
    • RIVERA, L., R. MORON, A. ZARZUELO, and M. GALISTEO. 2009. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77:1053-1063.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1053-1063
    • Rivera, L.1    Moron, R.2    Zarzuelo, A.3    Galisteo, M.4
  • 345
    • 60249098019 scopus 로고    scopus 로고
    • Dietary L-Arginine Supplementation Reduces White Fat Gain And Enhances Skeletal Muscle And Brown Fat Masses In Diet-Induced Obese Rats
    • JOBGEN, W., C.J. MEININGER, S.C. JOBGEN, P. LI, M.J. LEE, S.B. SMITH, T.E. SPENCER, S.K. FRIED, and G.WU. 2009. Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr 139:230-237.
    • (2009) J Nutr , vol.139 , pp. 230-237
    • Jobgen, W.1    Meininger, C.J.2    Jobgen, S.C.3    Li, P.4    Lee, M.J.5    Smith, S.B.6    Spencer, T.E.7    Fried, S.K.8    Wu, G.9
  • 349
    • 67349191562 scopus 로고    scopus 로고
    • Dietary Supplementation With Chitosan Derived From Mushrooms Changes Adipocytokine Profile In Diet-Induced Obese Mice, A Phenomenon Linked To Its Lipid-Lowering Action
    • NEYRINCK, A.M., L.B. BINDELS, F. DE BACKER, B.D. PACHIKIAN, P.D. CANI, and N.M. DELZENNE. 2009. Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action. Int Immunopharmacol 9:767-773.
    • (2009) Int Immunopharmacol , vol.9 , pp. 767-773
    • Neyrinck, A.M.1    Bindels, L.B.2    De Backer, F.F.3    Pachikian, B.D.4    Cani, P.D.5    Delzenne, N.M.6
  • 350
    • 67650729972 scopus 로고    scopus 로고
    • Alaska Pollack Protein Prevents The Accumulation Of Visceral Fat In Rats Fed A High Fat Diet
    • OISHI, Y., and N. DOHMOTO. 2009. Alaska pollack protein prevents the accumulation of visceral fat in rats fed a high fat diet. J Nutr Sci Vitaminol (Tokyo) 55:156-161.
    • (2009) J Nutr Sci Vitaminol (Tokyo) , vol.55 , pp. 156-161
    • Oishi, Y.1    Dohmoto, N.2
  • 351
    • 33646790507 scopus 로고    scopus 로고
    • From Big Fat Cells To High Blood Pressure: A Pathway To Obesity-Associated Hypertension
    • PAUSOVA, Z. 2006. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens 15:173-178.
    • (2006) Curr Opin Nephrol Hypertens , vol.15 , pp. 173-178
    • Pausova, Z.1
  • 353
    • 70149108937 scopus 로고    scopus 로고
    • Effects Of High-Calcium Diets With Different Whey Proteins On Weight Loss And Weight Regain In High-Fat-Fed C57Bl/6J Mice
    • PILVI, T.K., S. HARALA, R. KORPELA, and E.M. MERVAALA. 2009. Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice. Br J Nutr 102:337-341.
    • (2009) Br J Nutr , vol.102 , pp. 337-341
    • Pilvi, T.K.1    Harala, S.2    Korpela, R.3    Mervaala, E.M.4
  • 354
    • 41349090882 scopus 로고    scopus 로고
    • Anti-Obesity And Hypolipidemic Effects Of A Proprietary Herb And Fiber Combination (S&Spwh) In Rats Fed High-Fat Diets
    • WOO, M.N., S.H. BOK, M.K. LEE, H.J. KIM, S.M. JEON, G.M. DO, S.K. SHIN, T.Y. HA, and M.S. CHOI. 2008. Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&SPWH) in rats fed high-fat diets. J Med Food 11:169-178.
    • (2008) J Med Food , vol.11 , pp. 169-178
    • Woo, M.N.1    Bok, S.H.2    Lee, M.K.3    Kim, H.J.4    Jeon, S.M.5    Do, G.M.6    Shin, S.K.7    Ha, T.Y.8    Choi, M.S.9
  • 355
    • 33750691063 scopus 로고    scopus 로고
    • Supplementation Of Whole Persimmon Leaf Improves Lipid Profiles And Suppresses Body Weight Gain In Rats Fed High-Fat Diet
    • LEE, J.S., M.K. LEE, T.Y.HA, S.H. BOK, H.M. PARK, K.S. JEONG, M.N. WOO, G.M. DO, J.Y. YEO, and M.S. CHOI. 2006. Supplementation of whole persimmon leaf improves lipid profiles and suppresses body weight gain in rats fed high-fat diet. Food Chem Toxicol 44:1875-1883.
    • (2006) Food Chem Toxicol , vol.44 , pp. 1875-1883
    • Lee, J.S.1    Lee, M.K.2    Ha, T.Y.3    Bok, S.H.4    Park, H.M.5    Jeong, K.S.6    Woo, M.N.7    do, G.M.8    Yeo, J.Y.9    Choi, M.S.10
  • 356
    • 33645523785 scopus 로고    scopus 로고
    • Conjugated Linoleic Acid Reduces Hepatic Steatosis, Improves Liver Function, And Favorably Modifies Lipid Metabolism In Obese Insulin-Resistant Rats
    • NOTO, A., P. ZAHRADKA, N. YURKOVA, X. XIE, E. NITSCHMANN, M. OGBORN, and C.G. TAYLOR. 2006. Conjugated linoleic acid reduces hepatic steatosis, improves liver function, and favorably modifies lipid metabolism in obese insulin-resistant rats. Lipids 41:179-188.
    • (2006) Lipids , vol.41 , pp. 179-188
    • Noto, A.1    Zahradka, P.2    Yurkova, N.3    Xie, X.4    Nitschmann, E.5    Ogborn, M.6    Taylor, C.G.7
  • 357
    • 33645633309 scopus 로고    scopus 로고
    • Conjugated Linoleic Acid Supplementation For 1 Y Does Not Prevent Weight Or Body Fat Regain
    • LARSEN, T.M., S. TOUBRO, O. GUDMUNDSEN, and A. ASTRUP. 2006. Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. Am J Clin Nutr 83:606-612.
    • (2006) Am J Clin Nutr , vol.83 , pp. 606-612
    • Larsen, T.M.1    Toubro, S.2    Gudmundsen, O.3    Astrup, A.4
  • 358
    • 34248370966 scopus 로고    scopus 로고
    • Efficacy Of Conjugated Linoleic Acid For Reducing Fat Mass: A Meta-Analysis In Humans
    • WHIGHAM, L.D., A.C. WATRAS, and D.A. SCHOELLER. 2007. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 85:1203-1211.
    • (2007) Am J Clin Nutr , vol.85 , pp. 1203-1211
    • Whigham, L.D.1    Watras, A.C.2    Schoeller, D.A.3
  • 360
    • 3042803823 scopus 로고    scopus 로고
    • Conjugated Linoleic Acid Supplementation For 1 Y Reduces Body Fat Mass In Healthy Overweight Humans
    • GAULLIER, J.M., J. HALSE, K.HOYE, K.KRISTIANSEN, H. FAGERTUN, H.VIK, and O. GUDMUNDSEN. 2004. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 79:1118-1125.
    • (2004) Am J Clin Nutr , vol.79 , pp. 1118-1125
    • Gaullier, J.M.1    Halse, J.2    Hoye, K.3    Kristiansen, K.4    Fagertun, H.5    Vik, H.6    Gudmundsen, O.7
  • 361
    • 33845212465 scopus 로고    scopus 로고
    • Dietary Conjugated Linoleic Acid Preserves Pancreatic Function And Reduces Inflammatory Markers In Obese, Insulinresistant Rats
    • NOTO, A., P. ZAHRADKA, N.R. RYZ, N. YURKOVA, X. XIE, and C.G. TAYLOR. 2007. Dietary conjugated linoleic acid preserves pancreatic function and reduces inflammatory markers in obese, insulinresistant rats. Metabolism 56:142-151.
    • (2007) Metabolism , vol.56 , pp. 142-151
    • Noto, A.1    Zahradka, P.2    Ryz, N.R.3    Yurkova, N.4    Xie, X.5    Taylor, C.G.6
  • 362
    • 60249085577 scopus 로고    scopus 로고
    • Dietary Trans-10, Cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement And Elevated Renal Cyclooxygenase-2 Levels In Young Obese Fa/Fa Zucker Rats
    • DRURY, B., L.J. WARFORD-WOOLGAR, D.J. HERCHAK, N. BANKOVIC-CALIC, G. CROW, C.G. TAYLOR, P. ZAHRADKA, M.R. OGBORN, and H.M. AUKEMA. 2009. Dietary trans-10, cis-12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa zucker rats. J Nutr 139:285-290.
    • (2009) J Nutr , vol.139 , pp. 285-290
    • Drury, B.1    Warford-Woolgar, L.J.2    Herchak, D.J.3    Bankovic-Calic, N.4    Crow, G.5    Taylor, C.G.6    Zahradka, P.7    Ogborn, M.R.8    Aukema, H.M.9
  • 363
    • 35848968483 scopus 로고    scopus 로고
    • Dietary Conjugated Linoleic Acid Decreases Adipocyte Size And Favorably Modifies Adipokine Status And Insulin Sensitivity In Obese, Insulin-Resistant Rats
    • NOTO, A., P. ZAHRADKA, N. YURKOVA, X. XIE, H. TRUONG, E. NITSCHMANN, M.R. OGBORN, and C.G. TAYLOR. 2007. Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats. Metabolism 56:1601-1611.
    • (2007) Metabolism , vol.56 , pp. 1601-1611
    • Noto, A.1    Zahradka, P.2    Yurkova, N.3    Xie, X.4    Truong, H.5    Nitschmann, E.6    Ogborn, M.R.7    Taylor, C.G.8
  • 364
    • 0141793762 scopus 로고    scopus 로고
    • Conjugated Linoleic Acid Enhances Plasma Adiponectin Level And Alleviates Hyperinsulinemia And Hypertension In Zucker Diabetic Fatty (Fa/Fa) Rats
    • NAGAO, K., N. INOUE, Y.M. WANG, and T. YANAGITA. 2003. Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats. Biochem Biophys Res Commun 310:562-566.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 562-566
    • Nagao, K.1    Inoue, N.2    Wang, Y.M.3    Yanagita, T.4
  • 365
    • 56349141600 scopus 로고    scopus 로고
    • Trans-10, Cis-12-Conjugated Linoleic Acid Does Not Increase Body Fat Loss Induced By Energy Restriction
    • LASA, A., I. CHURRUCA, E. SIMON, A. FERNANDEZ-QUINTELA, V.M. RODRIGUEZ, and M.P. PORTILLO. 2008. Trans-10, cis-12-conjugated linoleic acid does not increase body fat loss induced by energy restriction. Br J Nutr 100:1245-1250.
    • (2008) Br J Nutr , vol.100 , pp. 1245-1250
    • Lasa, A.1    Churruca, I.2    Simon, E.3    Fernandez-Quintela, A.4    Rodriguez, V.M.5    Portillo, M.P.6
  • 368
    • 53149091637 scopus 로고    scopus 로고
    • Phytochemicals And Regulation Of The Adipocyte Life Cycle
    • RAYALAM, S., M.A. DELLA-FERA, and C.A. BAILE. 2008. Phytochemicals and regulation of the adipocyte life cycle. J Nutr Biochem 19:717-726.
    • (2008) J Nutr Biochem , vol.19 , pp. 717-726
    • Rayalam, S.1    Della-Fera, M.A.2    Baile, C.A.3
  • 369
    • 58849106396 scopus 로고    scopus 로고
    • Xanthohumol Influences Preadipocyte Differentiation: Implication Of Antiproliferative And Apoptotic Effects
    • MENDES, V., R. MONTEIRO, D. PESTANA, D. TEIXEIRA, C. CALHAU, and I. AZEVEDO. 2008. Xanthohumol influences preadipocyte differentiation: implication of antiproliferative and apoptotic effects. J Agric Food Chem 56:11631-11637.
    • (2008) J Agric Food Chem , vol.56 , pp. 11631-11637
    • Mendes, V.1    Monteiro, R.2    Pestana, D.3    Teixeira, D.4    Calhau, C.5    Azevedo, I.6
  • 371
    • 38049030825 scopus 로고    scopus 로고
    • Inhibitory Effect Of (-)-Epigallocatechin-3-Gallate On Lipid Accumulation Of 3T3-L1 Cells
    • MOON, H.S., C.S. CHUNG, H.G. LEE, T.G. KIM, Y.J. CHOI, and C.S. CHO. 2007. Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. Obesity (Silver Spring) 15:2571-2582.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 2571-2582
    • Moon, H.S.1    Chung, C.S.2    Lee, H.G.3    Kim, T.G.4    Choi, Y.J.5    Cho, C.S.6
  • 372
    • 39449104855 scopus 로고    scopus 로고
    • Guggulsterone Inhibits Adipocyte Differentiation And Induces Apoptosis In 3T3-L1 Cells
    • YANG, J.Y., M.A.DELLA-FERA, and C.A. BAILE. 2008. Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. Obesity (Silver Spring) 16:16-22.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 16-22
    • Yang, J.Y.1    Della-Fera, M.A.2    Baile, C.A.3
  • 373
    • 70349242054 scopus 로고    scopus 로고
    • The Inhibitory Effect Of Resveratrol On Leptin Secretion From Rat Adipocytes
    • SZKUDELSKA, K., L. NOGOWSKI, and T. SZKUDELSKI. 2009. The inhibitory effect of resveratrol on leptin secretion from rat adipocytes. Eur J Clin Invest 39:899-905.
    • (2009) Eur J Clin Invest , vol.39 , pp. 899-905
    • Szkudelska, K.1    Nogowski, L.2    Szkudelski, T.3
  • 375
    • 77950347503 scopus 로고    scopus 로고
    • Is The Use Of Resveratrol In The Treatment And Prevention Of Obesity Premature?
    • VAN DER SPUY,W.J., and E. PRETORIUS. 2009. Is the use of resveratrol in the treatment and prevention of obesity premature? Nutr Res Rev 1-7.
    • (2009) Nutr Res Rev , pp. 1-7
    • Van Der Spuy, W.J.1    Pretorius, E.2
  • 378
    • 0033580938 scopus 로고    scopus 로고
    • Novel Form Of Lipolysis Induced By Leptin
    • WANG, M.Y., Y. LEE, and R.H. UNGER. 1999. Novel form of lipolysis induced by leptin. J Biol Chem 274:17541-17544.
    • (1999) J Biol Chem , vol.274 , pp. 17541-17544
    • Wang, M.Y.1    Lee, Y.2    Unger, R.H.3
  • 379
    • 72449185147 scopus 로고    scopus 로고
    • Efficacy Of Leptin Therapy In The Different Forms Of Human Lipodystrophy
    • CHONG, A.Y., B.C. LUPSA, E.K. COCHRAN, and P. GORDEN. 2010. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia 53:27-35.
    • (2010) Diabetologia , vol.53 , pp. 27-35
    • Chong, A.Y.1    Lupsa, B.C.2    Cochran, E.K.3    Gorden, P.4
  • 380
    • 56649086772 scopus 로고    scopus 로고
    • Critical Role Of The Nadph Oxidase Subunit P47Phox On Vascular Tlr Expression And Neointimal Lesion Formation In High-Fat Diet-Induced Obesity
    • CHEN, J.X., and A. STINNETT. 2008. Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity. Lab Invest 88:1316-1328.
    • (2008) Lab Invest , vol.88 , pp. 1316-1328
    • Chen, J.X.1    Stinnett, A.2
  • 381
    • 63049125732 scopus 로고    scopus 로고
    • Short-Term Physiological Hyperleptinemia Decreases Arterial Blood Pressure
    • KNIGHT,W.D., R. SETH, J.BORON, and J.M. OVERTON. 2009. Short-term physiological hyperleptinemia decreases arterial blood pressure. Regul Pept 154:60-68.
    • (2009) Regul Pept , vol.154 , pp. 60-68
    • Knight, W.D.1    Seth, R.2    Boron, J.3    Overton, J.M.4
  • 382
    • 73949151936 scopus 로고    scopus 로고
    • Interaction Of Leptin And Amylin In The Long-Term Maintenance Of Weight Loss In Diet-Induced Obese Rats
    • TREVASKIS, J.L., C. LEI, J.E. KODA, C. WEYER, D.G. PARKES, and J.D. ROTH. 2010. Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats. Obesity (Silver Spring) 18:21-26.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 21-26
    • Trevaskis, J.L.1    Lei, C.2    Koda, J.E.3    Weyer, C.4    Parkes, D.G.5    Roth, J.D.6
  • 383
    • 17844389101 scopus 로고    scopus 로고
    • Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity In Male Wistar Rats
    • SATOH, H., M.T. NGUYEN, M. TRUJILLO, T. IMAMURA, I. USUI, P.E. SCHERER, and J.M. OLEFSKY. 2005. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes 54:1304-1313.
    • (2005) Diabetes , vol.54 , pp. 1304-1313
    • Satoh, H.1    Nguyen, M.T.2    Trujillo, M.3    Imamura, T.4    Usui, I.5    Scherer, P.E.6    Olefsky, J.M.7
  • 384
    • 67549142088 scopus 로고    scopus 로고
    • Inhibition Of New Vessel Growth In Mouse Model Of Laser-Induced Choroidal Neovascularization By Adiponectin Peptide Ii
    • LYZOGUBOV, V.V., R.G. TYTARENKO, S. THOTAKURA, T. VISWANATHAN, N.S. BORA, and P.S. BORA. 2009. Inhibition of new vessel growth in mouse model of laser-induced choroidal neovascularization by adiponectin peptide II. Cell Biol Int 33:765-771.
    • (2009) Cell Biol Int , vol.33 , pp. 765-771
    • Lyzogubov, V.V.1    Tytarenko, R.G.2    Thotakura, S.3    Viswanathan, T.4    Bora, N.S.5    Bora, P.S.6
  • 385
    • 0037241112 scopus 로고    scopus 로고
    • Adipose-Derived Resistin And Gut-Derived Resistin-Like Molecule-Beta Selectively Impair Insulin Action On Glucose Production
    • RAJALA,M.W., S.OBICI, P.E. SCHERER, and L.ROSSETTI. 2003. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111:225-230.
    • (2003) J Clin Invest , vol.111 , pp. 225-230
    • Rajala, M.W.1    Obici, S.2    Scherer, P.E.3    Rossetti, L.4
  • 386
    • 0842291596 scopus 로고    scopus 로고
    • Adiponectin Ameliorates Dyslipidemia Induced By The Human Immunodeficiency Virus Protease Inhibitor Ritonavir In Mice
    • XU, A., S. YIN, L. WONG, K.W. CHAN, and K.S. LAM. 2004. Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology 145:487-494.
    • (2004) Endocrinology , vol.145 , pp. 487-494
    • Xu, A.1    Yin, S.2    Wong, L.3    Chan, K.W.4    Lam, K.S.5
  • 388
    • 51449111911 scopus 로고    scopus 로고
    • Role Of Feed-Regulating Peptides On Pancreatic Exocrine Secretion
    • KAPICA, M., I. PUZIO, I.KATO, A.KUWAHARA, and R. ZABIELSKI. 2008. Role of feed-regulating peptides on pancreatic exocrine secretion. J Physiol Pharmacol 59 (Suppl 2): 145-159.
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL 2 , pp. 145-159
    • Kapica, M.1    Puzio, I.2    Kato, I.3    Kuwahara, A.4    Zabielski, R.5
  • 389
    • 58149229484 scopus 로고    scopus 로고
    • Resistin Increases Islet Blood Flow And Decreases Subcutaneous Adipose Tissue Blood Flow In Anaesthetized Rats
    • DANIELSSON, T., L. FREDRIKSSON, L. JANSSON, and J. HENRIKSNAS. 2009. Resistin increases islet blood flow and decreases subcutaneous adipose tissue blood flow in anaesthetized rats. Acta Physiol (Oxf) 195:283-288.
    • (2009) Acta Physiol (Oxf) , vol.195 , pp. 283-288
    • Danielsson, T.1    Fredriksson, L.2    Jansson, L.3    Henriksnas, J.4
  • 390
    • 52949140814 scopus 로고    scopus 로고
    • Making Insulin-Deficient Type 1 Diabetic Rodents Thrive Without Insulin
    • YU, X., B.H. PARK, M.Y. WANG, Z.V. WANG, and R.H. UNGER. 2008. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA 105:14070-14075.
    • (2008) Proc Natl Acad Sci Usa , vol.105 , pp. 14070-14075
    • Yu, X.1    Park, B.H.2    Wang, M.Y.3    Wang, Z.V.4    Unger, R.H.5
  • 391
    • 48249117609 scopus 로고    scopus 로고
    • Adiponectin Reduces Plasma Triglyceride By Increasing Vldl Triglyceride Catabolism
    • QIAO, L., C. ZOU, D.R. VAN DER WESTHUYZEN, and J. SHAO. 2008. Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes 57:1824-1833.
    • (2008) Diabetes , vol.57 , pp. 1824-1833
    • Qiao, L.1    Zou, C.2    Van Der Westhuyzen, D.R.3    Shao, J.4
  • 392
    • 29144456017 scopus 로고    scopus 로고
    • Effect Of Orlistat, Micronised Fenofibrate And Their Combination On Metabolic Parameters In Overweight And Obese Patients With The Metabolic Syndrome: The Fenorli Study
    • FILIPPATOS, T.D., D.N.KIORTSIS, E.N. LIBEROPOULOS,M.GEORGOULA, D.P.MIKHAILIDIS, and M.S. ELISAF. 2005. Effect of orlistat, micronised fenofibrate and their combination on metabolic parameters in overweight and obese patients with the metabolic syndrome: the FenOrli study. Curr Med Res Opin 21:1997-2006.
    • (2005) Curr Med Res Opin , vol.21 , pp. 1997-2006
    • Filippatos, T.D.1    Kiortsis, D.N.2    Liberopoulos, E.N.3    Georgoula, M.4    Mikhailidis, D.P.5    Elisaf, M.S.6
  • 393
    • 1842688305 scopus 로고    scopus 로고
    • Effect Of Short-Term Weight Loss On The Metabolic Syndrome And Conduit Vascular Endothelial Function In Overweight Adults
    • BROOK, R.D., R.L. BARD, L. GLAZEWSKI, C. KEHRER, P.F. BODARY, D.L. EITZMAN, and S. RAJAGOPALAN. 2004. Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults. Am J Cardiol 93:1012-1016.
    • (2004) Am J Cardiol , vol.93 , pp. 1012-1016
    • Brook, R.D.1    Bard, R.L.2    Glazewski, L.3    Kehrer, C.4    Bodary, P.F.5    Eitzman, D.L.6    Rajagopalan, S.7
  • 394
    • 44449111714 scopus 로고    scopus 로고
    • Physiological, Pharmacological, And Nutritional Regulation Of Circulating Adiponectin Concentrations In Humans
    • SWARBRICK, M.M., and P.J.HAVEL. 2008. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndr Relat Disord 6:87-102.
    • (2008) Metab Syndr Relat Disord , vol.6 , pp. 87-102
    • Swarbrick, M.M.1    Havel, P.J.2
  • 396
    • 67549134935 scopus 로고    scopus 로고
    • Targeting Heme Oxygenase: Therapeutic Implications For Diseases Of The Cardiovascular System
    • PETERSON, S.J., W.H. FRISHMAN, and N.G. ABRAHAM. 2009. Targeting heme oxygenase: therapeutic implications for diseases of the cardiovascular system. Cardiol Rev 17:99-111.
    • (2009) Cardiol Rev , vol.17 , pp. 99-111
    • Peterson, S.J.1    Frishman, W.H.2    Abraham, N.G.3
  • 397
    • 59449100515 scopus 로고    scopus 로고
    • Inhibition Of Rhoa Or Rac1? Mechanism Of Cholesterolindependent Beneficial Effects Of Statins
    • RIKITAKE, Y., and K. HIRATA. 2009. Inhibition of RhoA or Rac1? Mechanism of cholesterolindependent beneficial effects of statins. Circ J 73:231-232.
    • (2009) Circ J , vol.73 , pp. 231-232
    • Rikitake, Y.1    Hirata, K.2
  • 398
    • 0032823204 scopus 로고    scopus 로고
    • Both Wortmannin And Simvastatin Inhibit The Adipogenesis In 3T3-L1 Cells During The Late Phase Of Differentiation
    • TOMIYAMA, K., E. NISHIO, and Y. WATANABE. 1999. Both wortmannin and simvastatin inhibit the adipogenesis in 3T3-L1 cells during the late phase of differentiation. Jpn J Pharmacol 80:375-378.
    • (1999) Jpn J Pharmacol , vol.80 , pp. 375-378
    • Tomiyama, K.1    Nishio, E.2    Watanabe, Y.3
  • 399
    • 48749131386 scopus 로고    scopus 로고
    • Effects Of Atorvastatin And Pravastatin On Glucose Tolerance, Adipokine Levels And Inflammatorymarkers In Hypercholesterolaemic Patients
    • ANDO, H., K. SUGIMOTO, H. YANAGIHARA, S. TSURUOKA, T. SAITO, T. TAKAMURA, S. KANEKO, and A. FUJIMURA. 2008. Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatorymarkers in hypercholesterolaemic patients. ClinExpPharmacolPhysiol 35:1012-1017.
    • (2008) Clinexppharmacolphysiol , vol.35 , pp. 1012-1017
    • Ando, H.1    Sugimoto, K.2    Yanagihara, H.3    Tsuruoka, S.4    Saito, T.5    Takamura, T.6    Kaneko, S.7    Fujimura, A.8
  • 400
    • 67651152643 scopus 로고    scopus 로고
    • Simvastatin Suppresses Leptin Expression In 3T3-L1 Adipocytes Via Activation Of The Cyclic Amp-Pka Pathway Induced By Inhibition Of Protein Prenylation
    • MAEDA, T., and N.HORIUCHI. 2009. Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. J Biochem 145:771-781.
    • (2009) J Biochem , vol.145 , pp. 771-781
    • Maeda, T.1    Horiuchi, N.2
  • 401
    • 50649105705 scopus 로고    scopus 로고
    • Effects Of Pravastatin On Obesity, Diabetes, And Adiponectin In Diet-Induced Obese Mice
    • ARAKI, K., T. MASAKI, I. KATSURAGI, T. KAKUMA, and H. YOSHIMATSU. 2008. Effects of pravastatin on obesity, diabetes, and adiponectin in diet-induced obese mice. Obesity (Silver Spring) 16:2068-2073.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2068-2073
    • Araki, K.1    Masaki, T.2    Katsuragi, I.3    Kakuma, T.4    Yoshimatsu, H.5
  • 402
    • 67649816851 scopus 로고    scopus 로고
    • The Effect Of Anti-Inflammatory (Aspirin And/Or Statin) Therapy On Body Weight In Type 2 Diabetic Individuals: Eat, A Retrospective Study
    • BOAZ, M., L. LISY, G. ZANDMAN-GODDARD, and J. WAINSTEIN. 2009. The effect of anti-inflammatory (aspirin and/or statin) therapy on body weight in Type 2 diabetic individuals: EAT, a retrospective study. Diabet Med 26:708-713.
    • (2009) Diabet Med , vol.26 , pp. 708-713
    • Boaz, M.1    Lisy, L.2    Zandman-Goddard, G.3    Wainstein, J.4
  • 404
    • 61649116419 scopus 로고    scopus 로고
    • The Effects Of Pitavastatin, Eicosapentaenoic Acid And Combined Therapy On Platelet-Derived Microparticles And Adiponectin In Hyperlipidemic, Diabetic Patients
    • NOMURA, S., N. INAMI,A. SHOUZU, S.OMOTO,Y.KIMURA,N.TAKAHASHI,A.TANAKA, F.URASE,Y.MAEDA, H. OHTANI, and T. IWASAKA. 2009. The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients. Platelets 20:16-22.
    • (2009) Platelets , vol.20 , pp. 16-22
    • Nomura, S.1    Inami, N.2    Shouzu, A.3    Omoto, S.4    Kimura, Y.5    Takahashi, N.6    Tanaka, A.7    Urase, F.8    Maeda, Y.9    Ohtani, H.10    Iwasaka, T.11
  • 407
    • 67651174458 scopus 로고    scopus 로고
    • Effects Of Rosuvastatin And Colestimide On Metabolic Parameters And Urinary Monocyte Chemoattractant Protein-1 In Type 2 Diabetic Patients With Hyperlipidemia
    • TAKEBAYASHI, K., M. SUETSUGU, S. MATSUMOTO, Y. ASO, and T. INUKAI. 2009. Effects of rosuvastatin and colestimide on metabolic parameters and urinary monocyte chemoattractant protein-1 in type 2 diabetic patients with hyperlipidemia. South Med J 102:361-368.
    • (2009) South Med J , vol.102 , pp. 361-368
    • Takebayashi, K.1    Suetsugu, M.2    Matsumoto, S.3    Aso, Y.4    Inukai, T.5
  • 408
    • 67349224722 scopus 로고    scopus 로고
    • Differential Metabolic Effects Of Pravastatin And Simvastatin In Hypercholesterolemic Patients
    • KOH, K.K., M.J. QUON, S.H. HAN, Y. LEE, S.J. KIM, J.B. PARK, and E.K. SHIN. 2009. Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients. Atherosclerosis 204:483-490.
    • (2009) Atherosclerosis , vol.204 , pp. 483-490
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Lee, Y.4    Kim, S.J.5    Park, J.B.6    Shin, E.K.7
  • 409
    • 21644436821 scopus 로고    scopus 로고
    • Peroxisome Proliferatoractivated Receptor (Ppar)-Alpha: A Pharmacological Target With A Promising Future
    • VAN RAALTE, D.H., M. LI, P.H. PRITCHARD, and K.M. WASAN. 2004. Peroxisome proliferatoractivated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res 21:1531-1538.
    • (2004) Pharm Res , vol.21 , pp. 1531-1538
    • Van Raalte, D.H.1    Li, M.2    Pritchard, P.H.3    Wasan, K.M.4
  • 411
    • 67649659650 scopus 로고    scopus 로고
    • Fenofibrate Inhibits Adipocyte Hypertrophy And Insulin Resistance By Activating Adipose Pparalpha In High Fat Diet-Induced Obese Mice
    • JEONG, S., and M. YOON. 2009. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Exp Mol Med 41:397-405.
    • (2009) Exp Mol Med , vol.41 , pp. 397-405
    • Jeong, S.1    Yoon, M.2
  • 412
    • 19944379835 scopus 로고    scopus 로고
    • Beneficial Effects Of Fenofibrate To Improve Endothelial Dysfunction And Raise Adiponectin Levels In Patients With Primary Hypertriglyceridemia
    • KOH, K.K., S.H.HAN, M.J.QUON, J. YEALAHN, and E.K. SHIN. 2005. Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care 28:1419-1424.
    • (2005) Diabetes Care , vol.28 , pp. 1419-1424
    • Koh, K.K.1    Han, S.H.2    Quon, M.J.3    Yealahn, J.4    Shin, E.K.5
  • 413
    • 12344316682 scopus 로고    scopus 로고
    • Thiazolidinediones: A Reviewof Their Mechanisms Of Insulin Sensitization, Therapeutic Potential, Clinical Efficacy, And Tolerability
    • VASUDEVAN, A.R., and A.BALASUBRAMANYAM. 2004. Thiazolidinediones: a reviewof their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability. Diabetes Technol Ther 6:850-863.
    • (2004) Diabetes Technol Ther , vol.6 , pp. 850-863
    • Vasudevan, A.R.1    Balasubramanyam, A.2
  • 414
    • 54949138357 scopus 로고    scopus 로고
    • Pioglitazone Acutely Stimulates Adiponectin Secretion From Mouse And Human Adipocytes Via Activation Of The Phosphatidylinositol 30- Kinase
    • PEREIRA, R.I., J.W. LEITNER, C. ERICKSON, and B. DRAZNIN. 2008. Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 30- kinase. Life Sci 83:638-643.
    • (2008) Life Sci , vol.83 , pp. 638-643
    • Pereira, R.I.1    Leitner, J.W.2    Erickson, C.3    Draznin, B.4
  • 415
    • 34248578485 scopus 로고    scopus 로고
    • Thiazolidinediones Exhibit Different Effects On Preadipocytes Isolated From Rat Mesenteric Fat Tissue And Cell Line 3T3-L1 Cells Derived From Mice
    • MINEO, H., C. ODA, H. CHIJI, T. KAWADA, K. SHIMIZU, and T. TAIRA. 2007. Thiazolidinediones exhibit different effects on preadipocytes isolated from rat mesenteric fat tissue and cell line 3T3-L1 cells derived from mice. Cell Biol Int 31:703-710.
    • (2007) Cell Biol Int , vol.31 , pp. 703-710
    • Mineo, H.1    Oda, C.2    Chiji, H.3    Kawada, T.4    Shimizu, K.5    Taira, T.6
  • 416
    • 33748742272 scopus 로고    scopus 로고
    • Low-Dose Rosiglitazone Exertsanantiinflammatoryeffectwithanincrease Inadiponectinindependently Offreefatty Acid Fall And Insulin Sensitization In Obese Type 2 Diabetics
    • GHANIM, H., S. DHINDSA, A.ALJADA, A. CHAUDHURI, P. VISWANATHAN, and P.DANDONA. 2006. Low-dose rosiglitazone exertsanantiinflammatoryeffectwithanincrease inadiponectinindependently offreefatty acid fall and insulin sensitization in obese type 2 diabetics. J Clin Endocrinol Metab 91:3553-3558.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3553-3558
    • Ghanim, H.1    Dhindsa, S.2    Aljada, A.3    Chaudhuri, A.4    Viswanathan, P.5    Dandona, P.6
  • 418
    • 33646569668 scopus 로고    scopus 로고
    • Effects Of Rosiglitazone On Lipids, Adipokines, And Inflammatory Markers In Nondiabetic Patients With Low High-Density Lipoprotein Cholesterol And Metabolic Syndrome
    • SAMAHA, F.F., P.O. SZAPARY, N. IQBAL, M.M. WILLIAMS, L.T. BLOEDON, A. KOCHAR, M.L. WOLFE, and D.J. RADER. 2006. Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome. Arterioscler Thromb Vasc Biol 26:624-630.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 624-630
    • Samaha, F.F.1    Szapary, P.O.2    Iqbal, N.3    Williams, M.M.4    Bloedon, L.T.5    Kochar, A.6    Wolfe, M.L.7    Rader, D.J.8
  • 419
    • 34248571041 scopus 로고    scopus 로고
    • Adiponectin Is Associated With Improvement Of Endothelial Function After Rosiglitazone Treatment In Non-Diabetic Individuals With Metabolic Syndrome
    • BAHIA, L., L.G. AGUIAR, N.VILLELA, D. BOTTINO, A.F. GODOY-MATOS, B. GELONEZE,M. TAMBASCIA, and E. BOUSKELA. 2007. Adiponectin is associated with improvement of endothelial function after rosiglitazone treatment in non-diabetic individuals with metabolic syndrome. Atherosclerosis 195:138-146.
    • (2007) Atherosclerosis , vol.195 , pp. 138-146
    • Bahia, L.1    Aguiar, L.G.2    L.G.Villela, L.G.3    Bottino, D.4    Godoy-Matos, A.F.5    Geloneze, B.6    Tambascia, M.7    Bouskela, E.8
  • 422
    • 0037205499 scopus 로고    scopus 로고
    • Mechanisms Regulating Adipocyte Expression Of Resistin
    • HARTMAN, H.B., X. HU, K.X. TYLER, C.K. DALAL, and M.A. LAZAR. 2002. Mechanisms regulating adipocyte expression of resistin. J Biol Chem 277:19754-19761.
    • (2002) J Biol Chem , vol.277 , pp. 19754-19761
    • Hartman, H.B.1    Hu, X.2    Tyler, K.X.3    Dalal, C.K.4    Lazar, M.A.5
  • 424
    • 0036789137 scopus 로고    scopus 로고
    • The Effect Of Thiazolidinediones On Plasma Adiponectin Levels In Normal, Obese, And Type 2 Diabetic Subjects
    • YU, J.G., S. JAVORSCHI, A.L. HEVENER, Y.T. KRUSZYNSKA, R.A. NORMAN, M. SINHA, and J.M. OLEFSKY. 2002. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51:2968-2974.
    • (2002) Diabetes , vol.51 , pp. 2968-2974
    • Yu, J.G.1    Javorschi, S.2    Hevener, A.L.3    Kruszynska, Y.T.4    Norman, R.A.5    Sinha, M.6    Olefsky, J.M.7
  • 426
    • 36048940806 scopus 로고    scopus 로고
    • Adiponectin Concentrations Increase During Acute Ffa Elevation In Humans Treated With Rosiglitazone
    • KRZYZANOWSKA, K., F. MITTERMAYER, W. KRUGLUGER, M. RODEN, G. SCHERNTHANER, and M. WOLZT. 2007. Adiponectin concentrations increase during acute FFA elevation in humans treated with rosiglitazone. Horm Metab Res 39:769-772.
    • (2007) Horm Metab Res , vol.39 , pp. 769-772
    • Krzyzanowska, K.1    Mittermayer, F.2    Krugluger, W.3    Roden, M.4    Schernthaner, G.5    Wolzt, M.6
  • 430
    • 33644935649 scopus 로고    scopus 로고
    • Angiotensin Ii Infusion Decreases Plasma Adiponectin Level Via Its Type 1 Receptor In Rats: An Implication For Hypertension-Related Insulin Resistance
    • RAN, J., T. HIRANO, T. FUKUI, K. SAITO, H. KAGEYAMA, K. OKADA, and M. ADACHI. 2006. Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance. Metabolism 55:478-488.
    • (2006) Metabolism , vol.55 , pp. 478-488
    • Ran, J.1    Hirano, T.2    Fukui, T.3    Saito, K.4    Kageyama, H.5    Okada, K.6    Adachi, M.7
  • 431
    • 67649486849 scopus 로고    scopus 로고
    • Angiotensin Converting Enzyme Inhibition Lowers Body Weight And Improves Glucose Tolerance In C57Bl/6J Mice Maintained On A High Fat Diet
    • WEISINGER, R.S., T.K. STANLEY, D.P. BEGG, H.S.WEISINGER, K.J. SPARK, and M. JOIS. 2009. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. Physiol Behav 98:192-197.
    • (2009) Physiol Behav , vol.98 , pp. 192-197
    • Weisinger, R.S.1    Stanley, T.K.2    Begg, D.P.3    Weisinger, H.S.4    Spark, K.J.5    Jois, M.6
  • 433
    • 20844456215 scopus 로고    scopus 로고
    • Additive Beneficial Effects Of Losartan Combined With Simvastatin In The Treatment Of Hypercholesterolemic, Hypertensive Patients
    • KOH, K.K., M.J. QUON, S.H. HAN, W.J. CHUNG, J.Y. AHN, Y.H. SEO, M.H. KANG, T.H. AHN, I.S. CHOI, and E.K. SHIN. 2004. Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients. Circulation 110:3687-3692.
    • (2004) Circulation , vol.110 , pp. 3687-3692
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Chung, W.J.4    Ahn, J.Y.5    Seo, Y.H.6    Kang, M.H.7    Ahn, T.H.8    Choi, I.S.9    Shin, E.K.10
  • 434
    • 0038818552 scopus 로고    scopus 로고
    • Blockade Of The Renin-Angiotensin System Increases Adiponectin Concentrations In Patients With Essential Hypertension
    • FURUHASHI, M., N. URA, K. HIGASHIURA, H.MURAKAMI, M. TANAKA, N.MONIWA, D. YOSHIDA, and K. SHIMAMOTO. 2003. Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 42:76-81.
    • (2003) Hypertension , vol.42 , pp. 76-81
    • Furuhashi, M.1    Ura, N.2    Higashiura, K.3    Murakami, H.4    Tanaka, M.5    Moniwa, N.6    Yoshida, D.7    Shimamoto, K.8
  • 435
    • 1942536971 scopus 로고    scopus 로고
    • Increased Plasma Adiponectin In Losartan-Treated Type 1 Diabetic Patients. A Mediator Of Improved Insulin Sensitivity?
    • NIELSEN, S., A.S. LIHN, T. OSTERGAARD, C.E. MOGENSEN, and O. SCHMITZ. 2004. Increased plasma adiponectin in losartan-treated type 1 diabetic patients. A mediator of improved insulin sensitivity? Horm Metab Res 36:194-196.
    • (2004) Horm Metab Res , vol.36 , pp. 194-196
    • Nielsen, S.1    Lihn, A.S.2    Ostergaard, T.3    Mogensen, C.E.4    Schmitz, O.5
  • 437
    • 36749043046 scopus 로고    scopus 로고
    • Effects Of Renin-Angiotensin System Inhibition On End-Organ Protection: Can We Do Better?
    • WEIR, M.R. 2007. Effects of renin-angiotensin system inhibition on end-organ protection: can we do better? Clin Ther 29:1803-1824.
    • (2007) Clin Ther , vol.29 , pp. 1803-1824
    • Weir, M.R.1
  • 438
    • 51649094297 scopus 로고    scopus 로고
    • Effects Of Telmisartan On Adiponectin Levels And Body Weight In Hypertensive Patients With Glucose Intolerance
    • MAKITA, S., A. ABIKO, Y. NAGANUMA, Y. MORIAI, and M. NAKAMURA. 2008. Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance. Metabolism 57:1473-1478.
    • (2008) Metabolism , vol.57 , pp. 1473-1478
    • Makita, S.1    Abiko, A.2    Naganuma, Y.3    Moriai, Y.4    Nakamura, M.5
  • 439
    • 34247881925 scopus 로고    scopus 로고
    • Telmisartan Improves Lipid Metabolism And Adiponectin Production But Does Not Affect Glycemic Control In Hypertensive Patients With Type 2 Diabetes
    • MORI, Y., Y. ITOH, and N. TAJIMA. 2007. Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes. Adv Ther 24:146-153.
    • (2007) Adv Ther , vol.24 , pp. 146-153
    • Mori, Y.1    Itoh, Y.2    Tajima, N.3
  • 441
    • 73349086534 scopus 로고    scopus 로고
    • Combination Of An Ace Inhibitor And Indapamide Improves Blood Pressure Control, But Attenuates The Beneficial Effects Of Ace Inhibition On Plasma Adiponectin In Patients With Essential Hypertension
    • HUANG, S.S., T.C. WU, S.J. LIN, and J.W. CHEN. 2009. Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Circ J 73:2282-2287.
    • (2009) Circ J , vol.73 , pp. 2282-2287
    • Huang, S.S.1    Wu, T.C.2    Lin, S.J.3    Chen, J.W.4
  • 442
    • 34250803167 scopus 로고    scopus 로고
    • Indapamide Decreases Plasma Adiponectin Concentration In Patients With Essential Hypertension
    • PIECHA, G., M.ADAMCZAK, J. CHUDEK, and A.WIECEK. 2007. Indapamide decreases plasma adiponectin concentration in patients with essential hypertension. Kidney Blood Press Res 30:187-194.
    • (2007) Kidney Blood Press Res , vol.30 , pp. 187-194
    • Piecha, G.1    Adamczak, M.2    Chudek, J.3    Wiecek, A.4
  • 443
    • 36849061190 scopus 로고    scopus 로고
    • Targeting Ampactivated Protein Kinase As A Novel Therapeutic Approach For The Treatment Of Metabolic Disorders
    • VIOLLET, B., R.MOUNIER, J. LECLERC, A.YAZIGI, M. FORETZ, and F. ANDREELLI. 2007. Targeting AMPactivated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 33:395-402.
    • (2007) Diabetes Metab , vol.33 , pp. 395-402
    • Viollet, B.1    Mounier, R.2    Leclerc, J.3    Yazigi, A.4    Foretz, M.5    Andreelli, F.6
  • 444
    • 0036113811 scopus 로고    scopus 로고
    • Short-Term Treatment With Metformin Decreases Serum Leptin Concentration Without Affecting Body Weight And Body Fat Content In Normal-Weight Healthy Men
    • FRUEHWALD-SCHULTES, B., K.M. OLTMANNS, B. TOSCHEK, S. SOPKE, W. KERN, J. BORN, H.L. FEHM, and A. PETERS. 2002. Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metabolism 51:531-536.
    • (2002) Metabolism , vol.51 , pp. 531-536
    • Fruehwald-Schultes, B.1    Oltmanns, K.M.2    Toschek, B.3    Sopke, S.4    Kern, W.5    Born, J.6    Fehm, H.L.7    Peters, A.8
  • 445
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced Muscle Fat Oxidation And Glucose Transport By Acrp30 Globular Domain: Acetyl-Coa Carboxylase Inhibition And Amp-Activated Protein Kinase Activation
    • TOMAS, E., T.S. TSAO, A.K. SAHA, H.E. MURREY, C. ZHANG CC, S.I. ITANI, H.F. LODISH, and N.B. RUDERMAN. 2002. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 99:16309-16313.
    • (2002) Proc Natl Acad Sci Usa , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3    Murrey, H.E.4    Zhang Cc, C.5    Itani, S.I.6    Lodish, H.F.7    Ruderman, N.B.8
  • 447
    • 49649107800 scopus 로고    scopus 로고
    • Resistin Is Expressed In Human Hepatocytes And Induces Insulin Resistance
    • SHENG, C.H., J. DI, Y. JIN, Y.C. ZHANG, M.WU, Y. SUN, and G.Z. ZHANG. 2008. Resistin is expressed in human hepatocytes and induces insulin resistance. Endocrine 33:135-143.
    • (2008) Endocrine , vol.33 , pp. 135-143
    • Sheng, C.H.1    Di, J.2    Jin, Y.3    Zhang, Y.C.4    Wu, M.5    Sun, Y.6    Zhang, G.Z.7
  • 448
    • 33845673559 scopus 로고    scopus 로고
    • Endocannabinoids And The Control Of Energy Balance
    • MATIAS, I., and V. DI MARZO. 2007. Endocannabinoids and the control of energy balance. Trends Endocrinol Metab 18:27-37.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 27-37
    • Matias, I.1    Di Marzo, V.2
  • 450
    • 38449088457 scopus 로고    scopus 로고
    • The Endocannabinoid System: Novel Pathway For Cardiometabolic Risk-Factor Reduction
    • WOODS, S.C. 2007. The endocannabinoid system: novel pathway for cardiometabolic Risk-factor reduction. JAAPA Suppl Endocannabinoid: 7-10.
    • (2007) Jaapa Suppl Endocannabinoid , pp. 7-10
    • Woods, S.C.1
  • 454
    • 27844463517 scopus 로고    scopus 로고
    • Rimonabant In Obesity-Lipids Study Group. Effects Of Rimonabant On Metabolic Risk Factors In Overweight Patients With Dyslipidemia
    • DESPRES, J.P., A.GOLAY, L. SJOSTROM, and Rimonabant in Obesity-Lipids Study Group. 2005. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134.
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Despres, J.P.1    Golay, A.2    Sjostrom, L.3
  • 455
    • 0037374766 scopus 로고    scopus 로고
    • The Cannabinoid Cb1 Receptor Antagonist Sr141716 Increases Acrp30 Mrna Expression In Adipose Tissue Of Obese Fa/Fa Rats And In Cultured Adipocyte Cells
    • BENSAID, M., M.GARY-BOBO, A. ESCLANGON, J.P.MAFFRAND, G.LE FUR, F.OURY-DONAT, and P. SOUBRIE. 2003. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol 63:908-914.
    • (2003) Mol Pharmacol , vol.63 , pp. 908-914
    • Bensaid, M.1    Gary-Bobo, M.2    Esclangon, A.3    Maffrand, J.P.4    Le Fur, G.5    Oury-Donat, F.6    Soubrie, P.7
  • 456
    • 61549116530 scopus 로고    scopus 로고
    • Adagio-Lipids Investigators. Effect Of Rimonabant On The High-Triglyceride/Low-Hdl-Cholesterol Dyslipidemia, Intraabdominal Adiposity, And Liver Fat: The Adagio-Lipids Trial
    • DESPRES, J.P., R. ROSS, G. BOKA, N. ALMERAS, I. LEMIEUX, and ADAGIO-Lipids Investigators. 2009. Effect of rimonabant on the high-triglyceride/low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial. Arterioscler Thromb Vasc Biol 29:416-423.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 416-423
    • Despres, J.P.1    Ross, R.2    Boka, G.3    Almeras, N.4    Lemieux, I.5
  • 457
    • 33746490030 scopus 로고    scopus 로고
    • The Cannabinoid Cb1 Receptor Inverse Agonist, Rimonabant, Modifies Body Weight And Adiponectin Function In Diet-Induced Obese Rats As A Consequence Of Reduced Food Intake
    • THORNTON-JONES, Z.D., G.A. KENNETT, K.R. BENWELL, D.F. REVELL, A. MISRA, D.M. SELLWOOD, S.P. VICKERS, and P.G. CLIFTON. 2006. The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake. Pharmacol Biochem Behav 84:353-359.
    • (2006) Pharmacol Biochem Behav , vol.84 , pp. 353-359
    • Thornton-Jones, Z.D.1    Kennett, G.A.2    Benwell, K.R.3    Revell, D.F.4    Misra, A.5    Sellwood, D.M.6    Vickers, S.P.7    Clifton, P.G.8
  • 458
    • 41149130137 scopus 로고    scopus 로고
    • Efficacy And Safety Of Rimonabant For Improvement Of Multiple Cardiometabolic Risk Factors In Overweight/Obese Patients: Pooled 1-Year Data From The Rimonabant In Obesity (Rio) Program
    • VAN GAAL, L., X. PI-SUNYER, J.P. DESPRES, C. MCCARTHY, and A. SCHEEN. 2008. Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program. Diabetes Care 31 (Suppl 2): S229-S240.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL 2
    • Van Gaal, L.1    Pi-Sunyer, X.2    Despres, J.P.3    Mccarthy, C.4    Scheen, A.5
  • 459
    • 33751001942 scopus 로고    scopus 로고
    • Rio-Diabetes Study Group. Efficacy And Tolerability Of Rimonabant In Overweight Or Obese Patients With Type 2 Diabetes: A Randomised Controlled Study
    • SCHEEN, A.J., N. FINER, P.HOLLANDER, M.D. JENSEN, L.F. VAN GAAL, and RIO-Diabetes Study Group. 2006. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 368:1660-1672.
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 460
    • 33745768460 scopus 로고    scopus 로고
    • Opposing Crosstalk Between Leptin And Glucocorticoids Rapidly Modulates Synaptic Excitation Via Endocannabinoid Release
    • MALCHER-LOPES, R., S. DI, V.S. MARCHESELLI, F.J.WENG, C.T. STUART, N.G. BAZAN, and J.G. TASKER. 2006. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 26:6643-6650.
    • (2006) J Neurosci , vol.26 , pp. 6643-6650
    • Malcher-Lopes, R.1    Di, S.2    Marcheselli, V.S.3    Weng, F.J.4    Stuart, C.T.5    Bazan, N.G.6    Tasker, J.G.7
  • 461
    • 67649563560 scopus 로고    scopus 로고
    • The Endocannabinoid System As A Link Between Homoeostatic And Hedonic Pathways Involved In Energy Balance Regulation
    • DI MARZO, V., A. LIGRESTI, and L. CRISTINO. 2009. The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation. Int J Obes (Lond) 33 (Suppl 2): S18-S24.
    • (2009) Int J Obes Lond , vol.33 , Issue.SUPPL 2
    • Di Marzo, V.1    Ligresti, A.2    Cristino, L.3
  • 462
    • 67649881068 scopus 로고    scopus 로고
    • The Dietary Polyphenols Trans-Resveratrol And Curcumin Selectively Bind Human Cb1 Cannabinoid Receptors With Nanomolar Affinities And Function As Antagonists/Inverse Agonists
    • SEELY, K.A., M.S. LEVI, and P.L. PRATHER. 2009. The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists. J Pharmacol Exp Ther 330:31-39.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 31-39
    • Seely, K.A.1    Levi, M.S.2    Prather, P.L.3
  • 463
    • 48449106062 scopus 로고    scopus 로고
    • Intensive Glycemic Control And Cardiovascular Disease Observations From The Accord Study: Now What Can A Clinician Possibly Think?
    • CEFALU, W.T., and K. WATSON. 2008. Intensive glycemic control and cardiovascular disease observations from the ACCORD study: now what can a clinician possibly think? Diabetes 57: 1163-1165.
    • (2008) Diabetes , vol.57 , pp. 1163-1165
    • Cefalu, W.T.1    Watson, K.2
  • 464
    • 48949083974 scopus 로고    scopus 로고
    • Rofecoxib Impairs Adipose Tissue Development In A Murine Model Of Nutritionally Induced Obesity
    • LIJNEN, H.R., B. VAN HOEF, H.R. LU, and D.J. GALLACHER. 2008. Rofecoxib impairs adipose tissue development in a murine model of nutritionally induced obesity. Thromb Haemost 100:338-342.
    • (2008) Thromb Haemost , vol.100 , pp. 338-342
    • Lijnen, H.R.1    Van Hoef, B.2    Lu, H.R.3    Gallacher, D.J.4
  • 466
    • 0033775075 scopus 로고    scopus 로고
    • Eicosanoids As Endogenous Regulators Of Leptin Release And Lipolysis By Mouse Adipose Tissue In Primary Culture
    • FAIN, J.N., C.W. LEFFLER, and S.W. BAHOUTH. 2000. Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture. J Lipid Res 41:1689-1694.
    • (2000) J Lipid Res , vol.41 , pp. 1689-1694
    • Fain, J.N.1    Leffler, C.W.2    Bahouth, S.W.3
  • 469
    • 16544361808 scopus 로고    scopus 로고
    • Tissue-Specific Regulation Of Leptin Expression And Secretion By All-Trans Retinoic Acid
    • HOLLUNG, K., C.P. RISE, C.A. DREVON, and J.E. RESELAND. 2004. Tissue-specific regulation of leptin expression and secretion by all-trans retinoic acid. J Cell Biochem 92:307-315.
    • (2004) J Cell Biochem , vol.92 , pp. 307-315
    • Hollung, K.1    Rise, C.P.2    Drevon, C.A.3    Reseland, J.E.4
  • 470
    • 20444395444 scopus 로고    scopus 로고
    • Effects Of Retinoic Acid Administration And Dietary Vitamin A Supplementation On Leptin Expression In Mice: Lack Of Correlation With Changes Of Adipose Tissue Mass And Food Intake
    • FELIPE, F., J. MERCADER, J. RIBOT, A. PALOU, and M.L. BONET. 2005. Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake. Biochim Biophys Acta 1740:258-265.
    • (2005) Biochim Biophys Acta , vol.1740 , pp. 258-265
    • Felipe, F.1    Mercader, J.2    Ribot, J.3    Palou, A.4    Bonet, M.L.5
  • 471
    • 32844458264 scopus 로고    scopus 로고
    • Effects Of Retinoid Therapy On Insulin Sensitivity, Lipid Profile And Circulating Adipocytokines
    • ORBETTA, S., R. ANGIONI, A. CATTANEO, P. BECK-PECCOZ, and A. SPADA. 2006. Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines. Eur J Endocrinol 154:83-86.
    • (2006) Eur J Endocrinol , vol.154 , pp. 83-86
    • Orbetta, S.1    Angioni, R.2    Cattaneo, A.3    Beck-Peccoz, P.4    Spada, A.5
  • 472
    • 34248342234 scopus 로고    scopus 로고
    • 13-Cis- Retinoic Acid Therapy Induces Insulin Resistance, Regulates Inflammatory Parameters, And Paradoxically Increases Serum Adiponectin Concentration
    • HELIOVAARA, M.K., A. REMITZ, S. REITAMO, A.M. TEPPO, S.L. KARONEN, and P. EBELING. 2007. 13-cis- Retinoic acid therapy induces insulin resistance, regulates inflammatory parameters, and paradoxically increases serum adiponectin concentration. Metabolism 56:786-791.
    • (2007) Metabolism , vol.56 , pp. 786-791
    • Heliovaara, M.K.1    Remitz, A.2    Reitamo, S.3    Teppo, A.M.4    Karonen, S.L.5    Ebeling, P.6
  • 473
    • 31844445185 scopus 로고    scopus 로고
    • Paradoxical Rise In Serum Adiponectin Concentration In The Face Of Acid-Induced Insulin Resistance 13-Cis-Retinoic
    • KOISTINEN, H.A., A. REMITZ, V.A. KOIVISTO, and P. EBELING. 2006. Paradoxical rise in serum adiponectin concentration in the face of acid-induced insulin resistance 13-cis-retinoic. Diabetologia 49:383-386.
    • (2006) Diabetologia , vol.49 , pp. 383-386
    • Koistinen, H.A.1    Remitz, A.2    Koivisto, V.A.3    Ebeling, P.4
  • 474
    • 58449103893 scopus 로고    scopus 로고
    • Short Term 13-Cis-Retinoic Acid Treatment At Therapeutic Doses Elevates Expression Of Leptin, Glut4, Ppargamma And Ap2 In Rat Adipose Tissue
    • KRSKOVA-TYBITANCLOVA, K., D. MACEJOVA, J. BRTKO, M. BACULIKOVA, O. KRIZANOVA, and S. ZORAD. 2008. Short term 13-cis-retinoic acid treatment at therapeutic doses elevates expression of leptin, GLUT4, PPARgamma and aP2 in rat adipose tissue. J Physiol Pharmacol 59:731-743.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 731-743
    • Krskova-Tybitanclova, K.1    Macejova, D.2    Brtko, J.3    Baculikova, M.4    Krizanova, O.5    Zorad, S.6
  • 476
    • 42449154993 scopus 로고    scopus 로고
    • Cntf: A Target Therapeutic For Obesity-Related Metabolic Disease?
    • MATTHEWS, V.B., and M.A. FEBBRAIO. 2008. CNTF: a target therapeutic for obesity-related metabolic disease? J Mol Med 86:353-361.
    • (2008) J Mol Med , vol.86 , pp. 353-361
    • Matthews, V.B.1    Febbraio, M.A.2
  • 478
    • 7044272602 scopus 로고    scopus 로고
    • Ciliary Neurotrophic Factorax15 Alters Energy Homeostasis, Decreases Body Weight, And Improves Metabolic Control In Diet-Induced Obese And Ucp1-Dta Mice
    • BLUHER, S., S. MOSCHOS, J. BULLEN, JR., E. KOKKOTOU, E. MARATOS-FLIER, S.J. WIEGAND, M.W. SLEEMAN, AND C.S.MANTZOROS. 2004. CILIARY NEUROTROPHIC FACTORAX15 ALTERS ENERGY HOMEOSTASIS, DECREASES BODY WEIGHT, AND IMPROVES METABOLIC CONTROL IN DIET-INDUCED OBESE AND UCP1-DTA MICE. DIABETES 53:2787-2796.
    • (2004) Diabetes , vol.53 , pp. 2787-2796
    • Bluher, S.1    Moschos, S.2    Bullen Jr, J.3    Kokkotou, E.4    Maratos-Flier, E.5    Wiegand, S.J.6    Sleeman, M.W.7    Mantzoros, C.S.8
  • 479
    • 2442646665 scopus 로고    scopus 로고
    • for The Als Cntf Treatment Study Group. A Double-Blind Placebocontrolled Clinical Trial Of Subcutaneous Recombinant Human Ciliary Neurotrophic Factor (Rhcntf) In Amyotrophic Lateral Sclerosis
    • CEDARBAUM, J.M. for the ALS CNTF Treatment Study Group. 1996. A double-blind placebocontrolled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46:1244-1249.
    • (1996) Als Cntf Treatment Study Group. Neurology , vol.46 , pp. 1244-1249
    • Cedarbaum, J.M.1
  • 480
    • 43249094575 scopus 로고    scopus 로고
    • Altered Levels Of Adiponectin And Adiponectin Receptors May Underlie The Effect Of Ciliary Neurotrophic Factor (Cntf) To Enhance Insulin Sensitivity In Diet-Induced Obese Mice
    • BLUHER, S., J. BULLEN, and C.S. MANTZOROS. 2008. Altered levels of adiponectin and adiponectin receptors may underlie the effect of ciliary neurotrophic factor (CNTF) to enhance insulin sensitivity in diet-induced obese mice. Horm Metab Res 40:225-227.
    • (2008) Horm Metab Res , vol.40 , pp. 225-227
    • Bluher, S.1    Bullen, J.2    Mantzoros, C.S.3
  • 481
    • 42449158932 scopus 로고    scopus 로고
    • Metabolic Remodeling In Adipocytes Promotes Ciliary Neurotrophic Factor-Mediated Fat Loss In Obesity
    • CROWE, S., S.M. TURPIN, F.KE, B.E. KEMP, and M.J.WATT. 2008. Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity. Endocrinology 149:2546-2556.
    • (2008) Endocrinology , vol.149 , pp. 2546-2556
    • Crowe, S.1    Turpin, S.M.2    Ke, F.3    Kemp, B.E.4    Watt, M.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.