Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 20, 2008, Pages 7257-7262

  Roth, Jonathan D ^a   Roland, Barbara L ^a   Cole, Rebecca L ^a   Trevaskis, James L ^a   Weyer, Christian ^a   Koda, Joy E ^a   Anderson, Christen M ^a   Parkes, David G ^a   Baron, Alain D ^a  

^a AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

Adiposity; Leptin resistance; Metreleptin; Pramlintide; Synergy

Indexed keywords

AMYLIN; ANOREXIGENIC AGENT; LEPTIN; METRELEPTIN; PRAMLINTIDE; RECOMBINANT HUMAN LEPTIN; STAT3 PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; EVENING DOSAGE; FEMALE; FOOD INTAKE; HORMONE RESPONSE; HUMAN; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; MULTICENTER STUDY; NONHUMAN; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; WEIGHT REDUCTION;

ADIPOSE TISSUE; AMYLOID; ANIMALS; BODY WEIGHT; CALORIC RESTRICTION; DISEASE MODELS, ANIMAL; HORMONES; HYPOTHALAMUS; LEPTIN; MODELS, BIOLOGICAL; OBESITY; OXYGEN CONSUMPTION; RATS;

RATTUS;

EID: 44449175729     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0706473105     Document Type: Article

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