Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice

Biochemical and Biophysical Research Communications

Volumn 286, Issue 4, 2001, Pages 735-741

  Moore, Gary B T ^a   Chapman, Helen ^a   Holder, Julie C ^a   Lister, Carolyn A ^a   Piercy, Valerie ^a   Smith, Stephen A ^a   Clapham, John C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Adiponectin; Adipose; Db db; PPAR ; RELM ; Resistin; Rosiglitazone; TaqMan; TNF ; 3 adrenoceptor

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; ADIPOCYTOKINE; ADIPONECTIN; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLOPHILIN; CYTOKINE; MESSENGER RNA; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIRINIXIC ACID; POLYPEPTIDE; RESISTIN; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; METABOLIC REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 0034806965     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5460     Document Type: Article

References (38)

1. Enhancing insulin action: From chemical elements to thiazolidinediones
2. The pleiotropic functions of peroxisome proliferator-activated receptor gamma
3. mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer
4. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones
5. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
6. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
7. Leptin impairs metabolic actions of insulin in isolated rat adipocytes
8. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
9. PPARgamma: An essential regulator of adipogenesis and modulator of fat cell function
10. Enhancement of adipocyte differentiation by an insulin-sensitizing agent
11. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
12. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance
13. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
14. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
15. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
16. The hormone resistin links obesity to diabetes
17. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
18. A family of tissue-specific resistin-like molecules
19. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
20. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by PPAR{gamma} agonists
21. Effects of BRL 35135, a beta-adrenoceptor agonist with novel selectivity, on glucose tolerance and insulin sensitivity in obese subjects
22. Metabolic alterations associated with the antidiabetic effect of beta 3-adrenergic receptor agonists in obese mice
23. Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA
24. Tumor necrosis factor-alpha in sera of obese patients: Fall with weight loss
25. The role of TNFalpha and TNF receptors in obesity and insulin resistance
26. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
27. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
28. Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese
29. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents
30. Alteration in expression profiles of a series of diabetes-related genes in db/db mice following treatment with thiazolidinediones
31. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
32. AdipoQ is a novel adipose-specific gene dysregulated in obesity
33. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
34. Influences of ionomycin, dibutyryl-cycloAMP and tumour necrosis factor-alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes
35. Identification and characterization of the human adipocyte apM-1 promoter
36. Regulation of gelatin-binding protein 28 (GBP28) gene expression by C/EBP
37. Functional antagonism between CCAAT/enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter
38. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation