Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1

FEBS Letters

Volumn 583, Issue 15, 2009, Pages 2457-2463

  Nakamura, Nobuhisa ^a   Naruse, Keiko ^a,b   Matsuki, Takashi ^a   Hamada, Yoji ^c   Nakashima, Eitaro ^a   Kamiya, Hideki ^a   Matsubara, Tatsuaki ^b   Enomoto, Atsushi ^a   Takahashi, Masahide ^a   Oiso, Yutaka ^a   Nakamura, Jiro ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adiponectin; Cdc42; Endothelial progenitor cell; Migration; Rac1

Indexed keywords

ADIPONECTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN KINASE B; RAC1 PROTEIN; SMALL INTERFERING RNA;

ANGIOGENESIS; ARTICLE; CELL ACTIVITY; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ADIPONECTIN; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FEMALE; FETAL BLOOD; HUMANS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RECEPTORS, ADIPONECTIN; RNA, SMALL INTERFERING; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67849118458     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.07.011     Document Type: Article

References (37)

1. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., and Matsubara K. CDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. 221 (1996) 286-289
2. Pajvani U.B., et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J. Biol. Chem. 278 (2003) 9073-9085
3. Yamauchi T., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7 (2001) 941-946
4. Arita Y., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257 (1999) 79-83
5. Koenig W., Khuseyinova N., Baumert J., Meisinger C., and Lowel H. Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany. J. Am. Coll. Cardiol. 48 (2006) 1369-1377
6. Qi L., Doria A., Manson J.E., Meigs J.B., Hunter D., Mantzoros C.S., and Hu F.B. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes 55 (2006) 1512-1516
7. Yamamoto Y., Hirose H., Saito I., Nishikai K., and Saruta T. Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population. J. Clin. Endocrinol. Metab. 89 (2004) 87-90
8. Yatagai T., Nagasaka S., Taniguchi A., Fukushima M., Nakamura T., Kuroe A., Nakai Y., and Ishibashi S. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism 52 (2003) 1274-1278
9. Kubota N., et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 277 (2002) 25863-25866
10. Yamauchi T., et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J. Biol. Chem. 278 (2003) 2461-2468
11. Shibata R., Ouchi N., Kihara S., Sato K., Funahashi T., and Walsh K. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J. Biol. Chem. 279 (2004) 28670-28674
12. Ouchi N., Kobayashi H., Kihara S., Kumada M., Sato K., Inoue T., Funahashi T., and Walsh K. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279 (2004) 1304-1309
13. Asahara T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275 (1997) 964-967
14. Amrani D.L., and Port S. Cardiovascular disease: potential impact of stem cell therapy. Expert Rev. Cardiovasc. Ther. 1 (2003) 453-461
15. Kalka C., et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc. Natl. Acad. Sci. USA 97 (2000) 3422-3427
16. Murohara T. Therapeutic vasculogenesis using human cord blood-derived endothelial progenitors. Trends Cardiovasc. Med. 11 (2001) 303-307
17. Naruse K., et al. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes 54 (2005) 1823-1828
18. Asahara T., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85 (1999) 221-228
19. Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., Bohm M., and Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N. Engl. J. Med. 353 (2005) 999-1007
20. Loomans C.J., et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53 (2004) 195-199
21. Tepper O.M., Galiano R.D., Capla J.M., Kalka C., Gagne P.J., Jacobowitz G.R., Levine J.P., and Gurtner G.C. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106 (2002) 2781-2786
22. Shibata R., et al. Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett. 582 (2008) 1607-1612
23. Werner C., Kamani C.H., Gensch C., Bohm M., and Laufs U. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance. Diabetes 56 (2007) 2609-2615
24. Enomoto A., et al. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev. Cell 9 (2005) 389-402
25. Balestrieri M.L., et al. High glucose downregulates endothelial progenitor cell number via SIRT1. Biochim. Biophys. Acta 1784 (2008) 936-945
26. Ouedraogo R., et al. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J. Clin. Invest. 117 (2007) 1718-1726
27. Shaw L.M., Rabinovitz I., Wang H.H., Toker A., and Mercurio A.M. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91 (1997) 949-960
28. Sotsios Y., and Ward S.G. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines. Immunol. Rev. 177 (2000) 217-235
29. Hattori Y., Suzuki M., Hattori S., and Kasai K. Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 46 (2003) 1543-1549
30. Xi W., Satoh H., Kase H., Suzuki K., and Hattori Y. Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: vasorelaxation in response to globular adiponectin. Biochem. Biophys. Res. Commun. 332 (2005) 200-205
31. Higuchi M., Masuyama N., Fukui Y., Suzuki A., and Gotoh Y. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr. Biol. 11 (2001) 1958-1962
32. Liu H., Radisky D.C., Wang F., and Bissell M.J. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J. Cell Biol. 164 (2004) 603-612
33. Morales-Ruiz M., Fulton D., Sowa G., Languino L.R., Fujio Y., Walsh K., and Sessa W.C. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ. Res. 86 (2000) 892-896
34. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
35. Aoki K., Nakamura T., Fujikawa K., and Matsuda M. Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol. Biol. Cell 16 (2005) 2207-2217
36. Huang Q., Shen H.M., and Ong C.N. Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway. Cell. Mol. Life Sci. 62 (2005) 1167-1175
37. Ladwein M., and Rottner K. On the Rho'd: the regulation of membrane protrusions by Rho-GTPases. FEBS Lett. 582 (2008) 2066-2074