Antiobesity activity of aqueous extracts of rhizoma dioscoreae tokoronis on high-fat diet-induced obesity in mice

Journal of Medicinal Food

Volumn 12, Issue 2, 2009, Pages 304-309

  Song, Mi Young ^a   Lv, Na ^a   Kim, Eun Kyung ^a   Kwon, Keun Sang ^a,b   Yoo, Young Bum ^c   Kim, Jin Hang ^d   Lee, Si Woo ^e   Song, Je Ho ^f   Lee, Jung Han ^g   Lee, Su Kyung ^g   Shin, Byung Cheul ^g   Ryu, Do Gon ^g   Park, Byung Hyun ^a   Kwon, Kang Beom ^g  

^a Medical School   (South Korea)

^b Chonbuk National University   (South Korea)

^c Konkuk University School of Medicine   (South Korea)

^d Hanyang University   (South Korea)

^e Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^f Wonkwang University   (South Korea)

^g Wonkwang University   (South Korea)

Author keywords

Antiobesity; High fat diet; Lipogenesis; Rhizoma Dioscoreae Tokoronis

Indexed keywords

ADIPONECTIN; ANTIOBESITY AGENT; FATTY ACID SYNTHASE; GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; RHIZOMA DIOSCOREAE TOKORONIS EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; EPIDIDYMIS FAT; FATTY LIVER; LIPID BLOOD LEVEL; LIPID DIET; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHIZOMA DIOSCOREAE TOKORONIS; RHIZOME; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; DIETARY FATS; DIOSCOREA; EPIDIDYMIS; FATTY ACID SYNTHETASE COMPLEX; FATTY LIVER; GENE EXPRESSION; LEPTIN; MALE; MICE; MICE, INBRED C57BL; OBESITY; ORGAN SIZE; PHYTOTHERAPY; PLANT EXTRACTS; RHIZOME; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 67649526476     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2008.1010     Document Type: Article

References (16)

1. Unger RH: Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol Meta 2003;14: 398-403.
2. Hofbauer KG, Nicholson JR, Boss O: The obesity epidemic: current and future pharmacological treatments. Annu Rev Pharmacol Toxicol 2007;47:565-592.
3. Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F: SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 2004;86:839-848.
4. Foretz M, Guichard C, Ferre P, Foufelle F: Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A 1999;96:12737-12742.
5. Horton JD, Goldstein JL, Brown MS: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002;109:1125-1131.
6. Horton JD, Shimomura I, Brown MS, et al.: Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 1998;101:2331-2339.
7. Horton JD, Shimomura I, Ikemoto S, Bashmakov Y, Hammer RE: Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J Biol Chem 2003;278:36652-36660.
8. Shimano H, Horton JD, Hammer RE, et al.: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 1996;98:1575-1584.
9. Laclaustra M, Corella D, Ordovas JM: Metabolic syndrome pathophysiology: the role of adipose tissue. Nutr Metab Cardiovasc Dis 2007;17:125-139.
10. Moon YS, Latasa MJ, Griffin MJ, Sul HS: Suppression of fatty acid synthase promoter by polyunsaturated fatty acids. J Lipid Res 2002;43:691-698.
11. Fasshauer M, Klein J, Krahlisch S, et al.: GH is a positive regulator of tumor necrosis factor α-induced adipose related protein in 3T3-L1 adipocytes. J Endocrinol 2003;178:523-531.
12. Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
13. Maffei M, Halaas J, Ravussin E, et al.: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-1161.
14. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE: The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-953.
15. Yamauchi T, Kamon J, Waki H, et al.: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-946.
16. Oda N, Imamura S, Fujita T, et al.: The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism 2008;57:268-273.