Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: A new link between obesity and heart disease

Circulation Research

Volumn 105, Issue 4, 2009, Pages 326-334

  Lamounier Zepter, Valéria ^a   Look, Christiane ^a   Alvarez, Julio ^b   Christ, Torsten ^a   Ravens, Ursula ^a   Schunck, Wolf Hagen ^c   Ehrhart Bornstein, Monika ^a   Bornstein, Stefan R ^a   Morano, Ingo ^c,d  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b Institute of Cardiology   (Cuba)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Adipocytes; FABP4; Heart failure; Metabolic syndrome

Indexed keywords

CALCIUM ION; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 3; FATTY ACID BINDING PROTEIN 4; UNCLASSIFIED DRUG; CALCIUM; FABP4 PROTEIN, HUMAN; FABP4 PROTEIN, RAT;

ACTION POTENTIAL; ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HEART CONTRACTION; HEART DISEASE; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MASS SPECTROMETRY; OBESITY; PRIORITY JOURNAL; PROTEIN SECRETION; WESTERN BLOTTING; ADIPOCYTE; ANIMAL; ATHEROSCLEROSIS; CALCIUM SIGNALING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; ISOLATION AND PURIFICATION; MALE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; RAT; SECRETION; WISTAR RAT;

ACTION POTENTIALS; ADIPOCYTES; ADULT; AGED; ANIMALS; ATHEROSCLEROSIS; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID-BINDING PROTEINS; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OBESITY; RATS; RATS, WISTAR;

EID: 70349260934     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.200501     Document Type: Article

References (31)

1. Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med. 2001;161:996-1002.
2. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305-313.
3. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113:898-918.
4. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548-2556.
5. Lamounier-Zepter V, Ehrhart-Bornstein M, Karczewski P, Haase H, Bornstein SR, Morano I. Human adipocytes attenuate cardiomyocyte contraction: characterization of an adipocyte-derived negative inotropic activity. FASEB J. 2006;20:1653-1659.
6. Hertzel AV, Bernlohr DA. The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function. Trends Endocrinol Metab. 2000;11:175-180.
7. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. Biochemistry. 1989;28:8683-8690.
8. Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008;118:2640-2650.
9. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science. 1996;274:1377-1379.
10. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 2000;141:3388-3396.
11. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci U S A. 2006;103:6970-6975.
12. Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, Lam KS. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem. 2006;52:405-413.
13. Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, Langenbach J, Willenberg HS, Barthel A, Hauner H, McCann SM, Scherbaum WA, Bornstein SR. Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci U S A. 2003;100:14211-14216.
14. Alvarez J, Hamplova J, Hohaus A, Morano I, Haase H, Vassort G. Calcium current in rat cardiomyocytes is modulated by the carboxylterminal ahnak domain. J Biol Chem. 2004;279:12456-12461.
15. Shevchenko A, Tomas H, Havlis J, Olsen JV, Mann M. Ingel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc. 2006;1:2856-2860.
16. Waridel P, Frank A, Thomas H, Surendranath V, Sunyaev S, Pevzner P, Shevchenko A. Sequence similarity-driven proteomics in organisms with unknown genomes by LC-MS/MS and automated de novo sequencing. Proteomics. 2007;7:2318-2329.
17. Bendtsen JD, Nielsen H, von Heijne G, Brunak S. Improved prediction of signal peptides: SignalP 3.0. J Mol Biol. 2004;340:783-795.
18. Bendtsen JD, Jensen LJ, Blom N, von Heijne G, Brunak S. Feature-based prediction of non-classical and leaderless protein secretion. Protein Eng Des Sel. 2004;17:349-356.
19. Aoki N, Jin-no S, Nakagawa Y, Asai N, Arakawa E, Tamura N, Tamura T, Matsuda T. Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology. 2007;148:3850-3862.
20. Makowski L, Hotamisligil GS. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol. 2005;16: 543-548.
21. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med. 2001;7:699-705.
22. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 2004;110:1492-1498.
23. Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 2007;447:959-965.
24. Vural B, Atalar F, Ciftci C, Demirkan A, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS. Presence of fatty-acidbinding protein 4 expression in human epicardial adipose tissue in metabolic syndrome. Cardiovasc Pathol. 2008;17:392-398.
25. Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab. 2005;90:6300-6302.
26. Iacobellis G, Sharma AM. Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome. Curr Pharm Des. 2007;13:2180-2184.
27. Sacks HS, Fain JN. Human epicardial adipose tissue: a review. Am Heart J. 2007;153:907-917.
28. Wier WG. Gain and cardiac EC coupling. Revisited and revised. Circ Res. 2007;101:533-535.
29. Gómez AM, Guatimosim S, Dilly KW, Vassort G, Lederer WJ. Heart failure after myocardial infarction: altered excitation-contraction coupling. Circulation. 2001;104:688-693.
30. Gómez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitationcontraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997;276:800-806.
31. Burton PB, Hogben CE, Joannou CL, Clark AG, Hsuan JJ, and Totty NF, Sorensen C, Evans RW, Tynan MJ. Heart fatty acid binding protein is a novel regulator of cardiac myocyte hypertrophy. Biochem Biophys Res Commun. 1994;205:1822-1828.