Making insulin-deficient type 1 diabetic rodents thrive without insulin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 37, 2008, Pages 14070-14075

  Yu, Xinxin ^a   Park, Byung Hyun ^c   Wang, May Yun ^a   Wang, Zhao V ^a   Unger, Roger H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^c Chonbuk National University Medical School   (South Korea)

Author keywords

Glucagon suppression; Hyperglucagonemia; IGF 1 upregulation; Insulinomimetic; Leptin

Indexed keywords

ADENOVIRUS VECTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCAGON; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; ISOPHANE INSULIN; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CELL DESTRUCTION; CONTROLLED STUDY; DYING; ENZYME PHOSPHORYLATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HYPERGLUCAGONEMIA; HYPERGLYCEMIA; HYPERLEPTINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KETOACIDOSIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SKELETAL MUSCLE; UPREGULATION;

ALLOXAN; ANIMALS; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DOWN-REGULATION; GLUCAGON; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIVER; MICE; RATS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STREPTOZOCIN;

ANIMALIA; RODENTIA;

EID: 52949140814     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806993105     Document Type: Article

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