메뉴 건너뛰기




Volumn 43, Issue 7, 2000, Pages 946-952

Non-esterified fatty acids and the liver: Why is insulin secreted into the portal vein?

Author keywords

Adipocyte; Central adiposity; Gluconeogenesis; Liver; Single gateway hypothesis

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN;

EID: 0033911870     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051474     Document Type: Review
Times cited : (111)

References (54)
  • 1
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR (1992) Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340: 925-929
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3    Bergman, R.N.4    Soeldner, J.S.5    Kahn, C.R.6
  • 2
    • 1842408448 scopus 로고    scopus 로고
    • Low insulin sensitivity is associated with clustering of cardiovascular risk factors
    • Mykkanen L, Haffner SM, Ronnemaa T, Bergman R, Laakso M (1997) Low insulin sensitivity is associated with clustering of cardiovascular risk factors. Am J Epidemiol 146: 315-321
    • (1997) Am J Epidemiol , vol.146 , pp. 315-321
    • Mykkanen, L.1    Haffner, S.M.2    Ronnemaa, T.3    Bergman, R.4    Laakso, M.5
  • 3
    • 0021928204 scopus 로고
    • Hyperinsulinemia: A link between hypertension, obesity, and glucose intolerance
    • Modan M, Halkin H, Almog S et al. (1985) Hyperinsulinemia: a link between hypertension, obesity, and glucose intolerance. J Clin Invest 75: 809-817
    • (1985) J Clin Invest , vol.75 , pp. 809-817
    • Modan, M.1    Halkin, H.2    Almog, S.3
  • 5
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease (Banting Lecture)
    • Reaven GM (1988) Role of insulin resistance in human disease (Banting Lecture). Diabetes 37: 1595-1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 6
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and Type II diabetes
    • Saltiel AR, Olefsky JM (1996) Thiazolidinediones in the treatment of insulin resistance and Type II diabetes. Diabetes 45: 1661-1669
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 7
    • 0029911503 scopus 로고    scopus 로고
    • Effect of troglitazone on insulin sensitivity and pancreatic β-cell function in women at high risk for NIDDM
    • Berkowitz K, Peters R, Kjos SL et al. (1996) Effect of troglitazone on insulin sensitivity and pancreatic β-cell function in women at high risk for NIDDM. Diabetes 45: 1572-1579
    • (1996) Diabetes , vol.45 , pp. 1572-1579
    • Berkowitz, K.1    Peters, R.2    Kjos, S.L.3
  • 8
    • 0032037738 scopus 로고    scopus 로고
    • PPAR-γ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes
    • Martin G, Schoonjans K, Staels B, Auwerx J (1998) PPAR-γ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes. Atherosclerosis 137: S75-S80
    • (1998) Atherosclerosis , vol.137
    • Martin, G.1    Schoonjans, K.2    Staels, B.3    Auwerx, J.4
  • 9
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • McGarry JD, Dobbins RL (1999) Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42: 128-138
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 10
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner A, Laurent D, Marcucci M et al. (1999) Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103: 253-259
    • (1999) J Clin Invest , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3
  • 11
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden M, Price TB, Perseghin G et al. (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97: 2859-2865
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 13
    • 17744405359 scopus 로고
    • Dose-response characteristics for effects of insulin on production and utilization of glucose in man
    • Rizza RA, Mandarino LJ, Gerich JE (1981) Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol 240: E630-E639
    • (1981) Am J Physiol , vol.240
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 14
    • 0019200193 scopus 로고
    • Control of hepatic glycogenolysis
    • Hems DA, Whitton PD (1980) Control of hepatic glycogenolysis. Physiol Rev 60: 1-50
    • (1980) Physiol Rev , vol.60 , pp. 1-50
    • Hems, D.A.1    Whitton, P.D.2
  • 15
    • 0020972416 scopus 로고
    • Gluconeogenesis and related aspects of glycolysis
    • Hers HG, Hue L (1983) Gluconeogenesis and related aspects of glycolysis. Annu Rev Biochem 52: 617-653
    • (1983) Annu Rev Biochem , vol.52 , pp. 617-653
    • Hers, H.G.1    Hue, L.2
  • 16
    • 0001563150 scopus 로고
    • The relation of insulin to liver metabolism
    • Levine R, Fritz IB (1956) The relation of insulin to liver metabolism. Diabetes 5: 209-219
    • (1956) Diabetes , vol.5 , pp. 209-219
    • Levine, R.1    Fritz, I.B.2
  • 17
    • 0027526476 scopus 로고
    • Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo
    • Bradley DC, Poulin RA, Bergman RN (1992) Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes 42: 296-306
    • (1992) Diabetes , vol.42 , pp. 296-306
    • Bradley, D.C.1    Poulin, R.A.2    Bergman, R.N.3
  • 19
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin K, Steil GM, Getty L, Bergman RN (1995) Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44: 1038-1045
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 20
    • 0022500793 scopus 로고
    • In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
    • Prager R, Wallace P, Olefsky JM (1986) In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest 78: 472-481
    • (1986) J Clin Invest , vol.78 , pp. 472-481
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 21
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood DT, Bergman RN, Vranic M (1987) Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36: 914-924
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 22
    • 0022857823 scopus 로고
    • 3H]-glucose: Differences in the apparent pattern of insulin resistance depending on the isotope used
    • 3H]-glucose: differences in the apparent pattern of insulin resistance depending on the isotope used. J Clin Invest 78: 1479-1486
    • (1986) J Clin Invest , vol.78 , pp. 1479-1486
    • Bell, P.M.1    Firth, R.G.2    Rizza, R.A.3
  • 24
    • 0024265025 scopus 로고
    • Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps
    • Finegood DT, Bergman RN, Vranic M (1988) Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37: 1025-1034
    • (1988) Diabetes , vol.37 , pp. 1025-1034
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 26
    • 0028847791 scopus 로고
    • The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues
    • Turk D, Alzaid A, Dinneen S, Nair KS, Rizza R (1995) The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues. J Clin Invest 95: 755-762
    • (1995) J Clin Invest , vol.95 , pp. 755-762
    • Turk, D.1    Alzaid, A.2    Dinneen, S.3    Nair, K.S.4    Rizza, R.5
  • 27
    • 0025734838 scopus 로고
    • Scintigraphic studies in rats: Kinetics of insulin analogues covering wide range of receptor affinities
    • Jensen I, Kruse V, Larsen UD (1991) Scintigraphic studies in rats: kinetics of insulin analogues covering wide range of receptor affinities. Diabetes 40: 628-632
    • (1991) Diabetes , vol.40 , pp. 628-632
    • Jensen, I.1    Kruse, V.2    Larsen, U.D.3
  • 28
    • 0030630131 scopus 로고    scopus 로고
    • New concepts in extracellular signaling for insulin action: The single gateway hypothesis
    • Bergman RN (1997) New concepts in extracellular signaling for insulin action: the single gateway hypothesis. Recent Prog Horm Res 42: 359-385
    • (1997) Recent Prog Horm Res , vol.42 , pp. 359-385
    • Bergman, R.N.1
  • 29
    • 0025297310 scopus 로고
    • Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
    • Ader M, Bergman RN (1990) Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 258: E1020-E1032
    • (1990) Am J Physiol , vol.258
    • Ader, M.1    Bergman, R.N.2
  • 30
    • 0029861999 scopus 로고    scopus 로고
    • Causal linkage between insulin regulation of lipolysis and liver glucose output
    • Rebrin K, Steil GM, Mittelman S, Bergman RN (1996) Causal linkage between insulin regulation of lipolysis and liver glucose output. J Clin Invest 98: 741-749
    • (1996) J Clin Invest , vol.98 , pp. 741-749
    • Rebrin, K.1    Steil, G.M.2    Mittelman, S.3    Bergman, R.N.4
  • 31
    • 0031467268 scopus 로고    scopus 로고
    • Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia
    • Mittelman SD, Fu YH, Rebrin K, Steil G, Bergman RN (1997) Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest 100: 3121-3130
    • (1997) J Clin Invest , vol.100 , pp. 3121-3130
    • Mittelman, S.D.1    Fu, Y.H.2    Rebrin, K.3    Steil, G.4    Bergman, R.N.5
  • 32
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca A, Fisher S, Shi ZQ, Gupta R, Lickley HL, Vranic M (1992) Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90: 1769-1777
    • (1992) J Clin Invest , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.2    Shi, Z.Q.3    Gupta, R.4    Lickley, H.L.5    Vranic, M.6
  • 33
    • 0029936779 scopus 로고    scopus 로고
    • Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans
    • Lewis GF, Zinman B, Groenewoud Y, Vranic M, Steiner G, Giacca A (1996) Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes 45: 454-462
    • (1996) Diabetes , vol.45 , pp. 454-462
    • Lewis, G.F.1    Zinman, B.2    Groenewoud, Y.3    Vranic, M.4    Steiner, G.5    Giacca, A.6
  • 34
    • 0030975131 scopus 로고    scopus 로고
    • Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    • Lewis GF, Vranic M, Harley P, Giacca A (1997) Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes 46: 1111-1119
    • (1997) Diabetes , vol.46 , pp. 1111-1119
    • Lewis, G.F.1    Vranic, M.2    Harley, P.3    Giacca, A.4
  • 35
    • 0030932918 scopus 로고    scopus 로고
    • Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans
    • Lewis GF, Vranic M, Giacca A (1997) Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans. Am J Physiol 272: E371-E378
    • (1997) Am J Physiol , vol.272
    • Lewis, G.F.1    Vranic, M.2    Giacca, A.3
  • 36
    • 0032972425 scopus 로고    scopus 로고
    • Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with Type 2 diabetes
    • Lewis GF, Carpentier A, Vranic M, Giacca A (1999) Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with Type 2 diabetes. Diabetes 48: 570-576
    • (1999) Diabetes , vol.48 , pp. 570-576
    • Lewis, G.F.1    Carpentier, A.2    Vranic, M.3    Giacca, A.4
  • 37
    • 0014670390 scopus 로고
    • Control of gluconeogenesis in liver: IV. Differential effects of fatty acids and glucagon on ketogenesis and gluconeogenesis in the perfused rat liver
    • Exton JH, Corbin JG, Park CR (1969) Control of gluconeogenesis in liver: IV. Differential effects of fatty acids and glucagon on ketogenesis and gluconeogenesis in the perfused rat liver. J Biol Chem 244: 4095-4102
    • (1969) J Biol Chem , vol.244 , pp. 4095-4102
    • Exton, J.H.1    Corbin, J.G.2    Park, C.R.3
  • 39
    • 0014495408 scopus 로고
    • Intrinsic regulation of glucose output by rat liver
    • Glinsmann WH, Hern EP, Lynch A (1969) Intrinsic regulation of glucose output by rat liver. Am J Physiol 216: 698-703
    • (1969) Am J Physiol , vol.216 , pp. 698-703
    • Glinsmann, W.H.1    Hern, E.P.2    Lynch, A.3
  • 42
    • 0033826669 scopus 로고    scopus 로고
    • Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin
    • in press
    • Mittelman SD, Bergman RN (2000) Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am J Physiol (in press)
    • (2000) Am J Physiol
    • Mittelman, S.D.1    Bergman, R.N.2
  • 43
    • 0032905885 scopus 로고    scopus 로고
    • The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
    • Chen X, Iqbal N, Boden G (1999) The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest 103: 365-372
    • (1999) J Clin Invest , vol.103 , pp. 365-372
    • Chen, X.1    Iqbal, N.2    Boden, G.3
  • 44
    • 0025911738 scopus 로고
    • Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men
    • Clore JN, Glickman PS, Helm ST, Nestler JE, Blackard WG (1991) Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men. Diabetes 40: 1033-1040
    • (1991) Diabetes , vol.40 , pp. 1033-1040
    • Clore, J.N.1    Glickman, P.S.2    Helm, S.T.3    Nestler, J.E.4    Blackard, W.G.5
  • 45
    • 0025994801 scopus 로고
    • No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients
    • Puhakainen I, Koivisto VA, Yki-Jarvinen H (1991) No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients. Diabetes 40: 1319-1327
    • (1991) Diabetes , vol.40 , pp. 1319-1327
    • Puhakainen, I.1    Koivisto, V.A.2    Yki-Jarvinen, H.3
  • 46
    • 0031972509 scopus 로고    scopus 로고
    • Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats
    • Massillon D, Chen W, Barzilai N et al. (1998) Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats. J Biol Chem 273: 228-234
    • (1998) J Biol Chem , vol.273 , pp. 228-234
    • Massillon, D.1    Chen, W.2    Barzilai, N.3
  • 47
    • 4243383394 scopus 로고    scopus 로고
    • Insulin suppresses glucose production by inhibiting glucose-6-phosphatase
    • Dea MK, Kim SP, Kabir M, Youn JH, Bergman RN (2000) Insulin suppresses glucose production by inhibiting glucose-6-phosphatase. Diabetes 49 [Suppl 1]: A282
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Dea, M.K.1    Kim, S.P.2    Kabir, M.3    Youn, J.H.4    Bergman, R.N.5
  • 48
    • 0033656589 scopus 로고    scopus 로고
    • The longitudinal compensation for fat induced insulin resistance includes reduced insulin clearance and enhanced B-cell response
    • in press
    • Mittelman SD, van Citters GW, Kim SP, Davis DA, Dea MK, Bergman RN (2000) The longitudinal compensation for fat induced insulin resistance includes reduced insulin clearance and enhanced B-cell response. Diabetes (in press)
    • (2000) Diabetes
    • Mittelman, S.D.1    Van Citters, G.W.2    Kim, S.P.3    Davis, D.A.4    Dea, M.K.5    Bergman, R.N.6
  • 49
    • 0019810028 scopus 로고
    • Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose
    • Bergman RN, Phillips LS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68: 1456-1467
    • (1981) J Clin Invest , vol.68 , pp. 1456-1467
    • Bergman, R.N.1    Phillips, L.S.2    Cobelli, C.3
  • 50
    • 0024834748 scopus 로고
    • Toward physiological understanding of glucose tolerance: Minimal-model approach (Lilly Lecture)
    • Bergman RN (1989) Toward physiological understanding of glucose tolerance: minimal-model approach (Lilly Lecture). Diabetes 38: 1512-1527
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 51
    • 0026341637 scopus 로고
    • Fatty acids in the portal vein of the rat regulate hepatic insulin clearance
    • Svedberg J, Stromblad G, Wirth A, Smith U, Bjorntorp P (1991) Fatty acids in the portal vein of the rat regulate hepatic insulin clearance. J Clin Invest 88: 2054-2058
    • (1991) J Clin Invest , vol.88 , pp. 2054-2058
    • Svedberg, J.1    Stromblad, G.2    Wirth, A.3    Smith, U.4    Bjorntorp, P.5
  • 52
    • 0032999369 scopus 로고    scopus 로고
    • Free fatty acids impair hepatic insulin extraction in vivo
    • Wiesenthal SR, Sandhu H, McCall RH et al. (1999) Free fatty acids impair hepatic insulin extraction in vivo. Diabetes 48: 766-774
    • (1999) Diabetes , vol.48 , pp. 766-774
    • Wiesenthal, S.R.1    Sandhu, H.2    McCall, R.H.3
  • 53
    • 0025800354 scopus 로고
    • Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects
    • Arner P, Pollare T, Lithell H (1991) Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia 34: 483-487
    • (1991) Diabetologia , vol.34 , pp. 483-487
    • Arner, P.1    Pollare, T.2    Lithell, H.3
  • 54
    • 0031944785 scopus 로고    scopus 로고
    • The metabolically obese, normal-weight individual revisited
    • Ruderman N, Chisholm D, Pi-Sunyer X, Schneider U (1998) The metabolically obese, normal-weight individual revisited. Diabetes 47: 699-713
    • (1998) Diabetes , vol.47 , pp. 699-713
    • Ruderman, N.1    Chisholm, D.2    Pi-Sunyer, X.3    Schneider, U.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.