Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute family heart study

Hypertension

Volumn 53, Issue 3, 2009, Pages 473-479

  Ma, Duanduan ^a   Feitosa, Mary F ^a   Wilk, Jemma B ^b   Laramie, Jason M ^b   Yu, Kai ^c   Leiendecker Foster, Catherine ^d   Myers, Richard H ^b   Province, Michael A ^a   Borecki, Ingrid B ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Association; Blood pressure; Gender; Hypertension; Leptin

Indexed keywords

LEPTIN;

ADULT; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD PRESSURE VARIABILITY; CONTROLLED STUDY; FEMALE; GENE LOCATION; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; HEALTH CENTER; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; BLOOD; BLOOD PRESSURE; CLINICAL TRIAL; COMPARATIVE STUDY; GENETICS; HAPLOTYPE; MALE; MIDDLE AGED; MULTICENTER STUDY; NATIONAL HEALTH ORGANIZATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROMOTER REGION; SEXUAL DEVELOPMENT; UNITED STATES;

ADULT; BLOOD PRESSURE; FEMALE; HAPLOTYPES; HUMANS; HYPERTENSION; LEPTIN; MALE; MIDDLE AGED; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SEX CHARACTERISTICS; UNITED STATES;

EID: 61749084673     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.118133     Document Type: Article

References (43)

1. Francischetti EA, Genelhu VA. Obesity-hypertension: an ongoing pandemic. Int J Clin Pract. 2007;61:269-280.
2. Kagan A, Faibel H, Ben-Arie G, Granevitze Z, Rapoport J. Gender differences in ambulatory blood pressure monitoring profile in obese, overweight and normal subjects. J Hum Hypertens. 2006;21:128-134.
3. Wilsgaard T, Schirmer H, Arnesen E. Impact of body weight on blood pressure with a focus on sex differences: the Tromso Study, 1986-1995. Arch Intern Med. 2000;160:2847-2853.
4. Hunt SC, Ellison C, Atwood LD, Pankow JS, Province MA, Leppert MF. Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension. 2002;40:1-6.
5. Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J. Genome-wide mapping of human loci for essential hypertension. Lancet. 2003;361:2118-2123.
6. Mitchell GF, DeStefano AL, Larson MG, Benjamin EJ, Chen MH, Vasan RS, Vita JA, Levy D. Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study. Circulation. 2005;112:194-199.
7. Shmulewitz D, Heath SC. Blundell ML, Han Z, Sharma Ratnendra, Salit J, Auerbach SB, Signorini S, Breslow JL, Stoffel M, Friedman JM. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proc Natl Acad Sci USA. 2006;103:3502-3509.
8. van Dijk G. The role of leptin in the regulation of energy balance and adiposity. J Neuroendocrinol. 2001;13:913-921.
9. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension. 1998;31:409-414.
10. Hall JE, Hildebrandt DA, Kuo J. Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens. 2001;14:103S-115S.
11. Satoh N, Ogawa Y, Katsuura G, Numata Y, Tsuji T, Hayase M, Ebihara K, Masuzaki H, Hosoda K, Yoshimasa Y, Nakao K. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes. 1999;48:1787-1793.
12. Hickey MS, Israel RG, Gardiner SN, Considine RV, McCammon MR, Tyndall GL, Houmard JA, Marks RHL, Caro JF. Gender differences in serum leptin levels in humans. Biochem Mol Med. 1996;59:1-6.
13. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab. 1996;81: 3424-3427.
14. Flanagan DE, Vaile JC. Petley GW, Phillips DI, Godsland IF, Owens P, Moore VM, Cockington RA, Robinson JS. Gender differences in the relationship between leptin, insulin resistance and the autonomic nervous system. Regul Pept. 2007;140:37-42.
15. Gaukrodger N, Mayosi BM, Imrie H, Avery P, Baker M, Connell JMC. Watkins H, Farrall M, Keavney B. A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families. J Med Genet. 2005;42: 474-478.
16. Han HR, Ryu HJ, Cha HS, Go MJ, Ahn Y, Koo BK, Cho YM, Lee HK, Cho NH, Shin C, Shin HD, Kimm K, Kim HL, Oh B, Park KS. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. Clinical Genet. 2008;74:105-115.
17. Suter PM, Locher R, Hasler E, Vetter W. Is there a role for the ob gene product Leptin in essential hypertension? Am J Hypertens. 1998;11: 1305-1311.
18. Hu FB, Chen C, Wang B, Stampfer MJ, Xu X. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes Relate Metab Dixord. 2001;25:121-125.
19. El-Gharbawy AH, Kotchen JM, Grim CE, Kaldunski M. Hoffmann RG. Pausova Z, Hamet P, Kotchen TA. Gender-specific correlates of Leptin with hypertension-related phenotypes in African Americans. Am J Hypertens. 2002;15:989-993.
20. Jiang Y, Wilk JB, Borecki I, Williamson S, DeStefano AL, Xu G, Liu J, Ellison RC, Province M, Myers RH. Common variants in the 5′ region of the Leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet. 2004;75:220-230.
21. Feitosa MF, Borecki IB, Rich SS, Arnett DK, Sholinsky P, Myers RH, Leppert M, Province MA. Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart. Lung, and Blood Institute Family Heart Study. Am J Hum Genet. 2002;70:72-82.
22. Abecasis GR, Cherny SS, Cookson WOC, Cardon LR. GRR: graphical representation of relationship errors. Bioinformatics. 2001;17:742-743.
23. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene How trees. Nat Genet. 2002;30:97-101.
24. Abecasis GR, Cardon LR, Cookson WOC. A general test of association for quantitative traits in nuclear families. Am J Hum Genet. 2000;66: 279-292.
25. Abecasis GR, Cookson WOC, Cardon LR. Pedigree tests of transmission disequilibrium. Eur J Hum Genet. 2000;8:545-551.
26. Clayton D. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet. 1999;65:1170-1177.
27. Clayton D, Jones H. Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet. 1999;65:1161-1169.
28. Yu K, Zhang SL, Borecki I, Kraja A, Xiong C, Myers R, Province M. A haplotype similarity based transmission/disequilibrium test under founder heterogeneity. Ann Hum Genet. 2005;69:455-467.
29. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension. 1997;30:619-623.
30. Reaven GM, Lithell H, Landberg L. Hypertension and associated metabolic abnormalities-the role of insulin resistance and the sympathoadrenal system. N Engl J Med. 1996;334:374-381.
31. Tuominen JA, Ebeling P, Laquier FW. Serum leptin concentration and fuel homeostasis in healthy man. Eur J Clin Invest. 1997;27:206-211.
32. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, Corvol P. Molecular basis of human hypertension: role of angiotensinogen. Cell. 1992;71:169-180.
33. Tamura K, Umemura S, Iwamoto T, Yamaguchi S, Kobayashi S, Takeda K, Tokita Y, Takagi N, Murakami K, Fukamizu A. Molecular mechanism of adipogenic activation of the angiotensinogen gene. Hypertension. 1994;23:364-368.
34. Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway-a link between adipose tissue mass and central neural networks. Horm Metab Res. 1996;28:619-632.
35. Campfield LA, Smith FJ, Burn P. OB protein: a hormonal controller of central neural networks mediating behavioral, metabolic and neuroendocrine responses. Endocrinol Metab. 1997;4:81-102.
36. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45:1455-1462.
37. Wolf G. Neuropeptides responding to leptin. Nutr Rev. 1997;55:85-88.
38. Quilliot D, Bohme P, Zannad F, and Ziegler O. Sympathetic-leptin relationship in obesity: effect of weight loss. Metabolism. 2008;57: 555-562.
39. Tena-Sempere M, Manna PR, Zhang FP, Pinilla L, Gonzalez LC, Dieguez C, Huhtaniemi I, Aguilar E. Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression. J Endocrinol. 2001;170:413-423.
40. Martin LJ, Mahaney MC, Almasy L, MacCluer JW, Blangero J, Jaquish CE, Comuzzie AG. Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone. Obes Res. 2002;10:14-21.
41. Elbers JM, Asscheman H, Seidell JC, Frolich M, Meinders AE, Gooren LJ. Reversal of the sex differences in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab. 1997; 82:3267-3270.
42. Matera C, Wardlaw SL. Aromatization is not required for androgen induced changes in the proopiomelanocortin gene expression in the hypothalamus. Mol Brain Res. 1994;27:275-280.
43. Majdoubi ME, Ramaswamy S, Sahu A, Plant TM. Effects of orchidectomy on levels of mRNAs encoding gonadotropin-releasing hormone and other hypothalamic peptides in the adult male rhesus monkey (Macaca mulatta). J Neuroendocrinol. 2000;12:167-176.