-
1
-
-
0037048669
-
Prevalence and trends in obesity among US adults, 1999-2000
-
Flegal KM, Carrol MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002;288:1723-7
-
(2002)
JAMA
, vol.288
, pp. 1723-1727
-
-
Flegal, K.M.1
Carrol, M.D.2
Ogden, C.L.3
Johnson, C.L.4
-
2
-
-
85069409891
-
Education levels, relative body weight and changes in their association over 10 years: An international perspective from the WHO MONICA Project
-
Molarius A, Seidell JC, Kuulasmaa K, et al. Education levels, relative body weight and changes in their association over 10 years: an international perspective from the WHO MONICA Project. J Epidemiol Commun Health 2000;51:1260-8
-
(2000)
J Epidemiol Commun Health
, vol.51
, pp. 1260-1268
-
-
Molarius, A.1
Seidell, J.C.2
Kuulasmaa, K.3
-
4
-
-
0027966932
-
Obesity, fat distribution and weight gain as risk factors for clinical diabetes in men
-
Chan MJ, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994;17:961-9
-
(1994)
Diabetes Care
, vol.17
, pp. 961-969
-
-
Chan, M.J.1
Rimm, E.B.2
Colditz, G.A.3
Stampfer, M.J.4
Willett, W.C.5
-
5
-
-
33845273560
-
ABC of obesity: Obesity and cancer
-
McMillan DC, Sattar N, McArdle CS. ABC of obesity: obesity and cancer. BMJ 2006;333:1109-11
-
(2006)
BMJ
, vol.333
, pp. 1109-1111
-
-
McMillan, D.C.1
Sattar, N.2
McArdle, C.S.3
-
7
-
-
34547774208
-
Obesity - The Policy Challenges
-
Department of Health and Children, Ireland: Department of Health and Children
-
Department of Health and Children. Obesity - The Policy Challenges. The Report of the National Taskforce on Obesity. Ireland: Department of Health and Children, 2005
-
(2005)
The Report of the National Taskforce on Obesity
-
-
-
8
-
-
0028851809
-
Physical Status: The Use and Interpretation of Anthropometry
-
WHO Expert Committee, 854. Geneva: WHO
-
WHO Expert Committee. Physical Status: the Use and Interpretation of Anthropometry. WHO Technical Report Series no. 854. Geneva: WHO, 1995
-
(1995)
WHO Technical Report Series no
-
-
-
9
-
-
0025748673
-
Metabolic implications of body fat distribution
-
Bjorntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991;14:1132-43
-
(1991)
Diabetes Care
, vol.14
, pp. 1132-1143
-
-
Bjorntorp, P.1
-
10
-
-
0030995569
-
Assessing obesity: Classification and epidemiology
-
Seidell JC, Flegal KM. Assessing obesity: classification and epidemiology. Br Med Bull 1997;53:238-52
-
(1997)
Br Med Bull
, vol.53
, pp. 238-252
-
-
Seidell, J.C.1
Flegal, K.M.2
-
11
-
-
44249123899
-
Measuring body composition in adults and children
-
Kopelman Caterson ID, Dietz WH, eds, 2nd edn. Oxford: Blackwell Publishing
-
Jebb S, Wells J. Measuring body composition in adults and children. In: Kopelman PG, Caterson ID, Dietz WH, eds. Clinical Obesity in Adults and Children. 2nd edn. Oxford: Blackwell Publishing, 2005:12-28
-
(2005)
Clinical Obesity in Adults and Children
, pp. 12-28
-
-
Jebb, S.1
Wells, J.2
-
13
-
-
18244387017
-
Centres for Disease Control and Prevention 2000 growth charts for the United States: Improvements to the 1977 National Centre for Health Statistics version
-
Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centres for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Centre for Health Statistics version. Paediatrics 2002;109:45-60
-
(2002)
Paediatrics
, vol.109
, pp. 45-60
-
-
Ogden, C.L.1
Kuczmarski, R.J.2
Flegal, K.M.3
-
15
-
-
84991084088
-
Prevalence of obesity in adults. The global epidemic
-
Gray GA, Bouchard C, eds, 2nd edn. New York: Marcel Dekker
-
Seidell JC, Rissanen AM. Prevalence of obesity in adults. The global epidemic. In: Gray GA, Bouchard C, eds. Handbook of Obesity: Etiology and Pathophysiology. 2nd edn. New York: Marcel Dekker, 2004:93-107
-
(2004)
Handbook of Obesity: Etiology and Pathophysiology
, pp. 93-107
-
-
Seidell, J.C.1
Rissanen, A.M.2
-
16
-
-
0030851214
-
An ecological approach to the obesity pandemic
-
Egger G, Swinburn B. An ecological approach to the obesity pandemic. BMJ 1997;315:477-80
-
(1997)
BMJ
, vol.315
, pp. 477-480
-
-
Egger, G.1
Swinburn, B.2
-
18
-
-
0345222490
-
Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Quebec family study
-
Rice T, Perusse L, Bouchard C, Rao DC. Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Quebec family study. Genet Epidemiol 1999;16:316-34
-
(1999)
Genet Epidemiol
, vol.16
, pp. 316-334
-
-
Rice, T.1
Perusse, L.2
Bouchard, C.3
Rao, D.C.4
-
19
-
-
0028588515
-
Investigation of obesity
-
Kopelman PG. Investigation of obesity. Clin Endocrinol 1994;41:703-8
-
(1994)
Clin Endocrinol
, vol.41
, pp. 703-708
-
-
Kopelman, P.G.1
-
21
-
-
0030820723
-
Obesity
-
Leibel RL. Obesity. N Engl J Med 1997;337:396-407
-
(1997)
N Engl J Med
, vol.337
, pp. 396-407
-
-
Leibel, R.L.1
-
22
-
-
84990756135
-
Hypothalamic lesions and adiposity in the rat
-
Hetherington AW, Ranson SW. Hypothalamic lesions and adiposity in the rat. Anat Rec 1940;78:149-72
-
(1940)
Anat Rec
, vol.78
, pp. 149-172
-
-
Hetherington, A.W.1
Ranson, S.W.2
-
23
-
-
0028139089
-
Positional cloning of the mouse Obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse Obese gene and its human homologue. Nature 1994;372:425-32
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
-
24
-
-
0031436635
-
The molecular genetics of rodent single gene obesities
-
Leibel RL, Chung WK, Chua SC. The molecular genetics of rodent single gene obesities. J Biol Chem 1997;272:31937-40
-
(1997)
J Biol Chem
, vol.272
, pp. 31937-31940
-
-
Leibel, R.L.1
Chung, W.K.2
Chua, S.C.3
-
25
-
-
0027049534
-
Molecular characterization of the mouse Agouti locus
-
Bultman SJ, Michaud EL, Woychik RP. Molecular characterization of the mouse Agouti locus. Cell 1992;71:1195-204
-
(1992)
Cell
, vol.71
, pp. 1195-1204
-
-
Bultman, S.J.1
Michaud, E.L.2
Woychik, R.P.3
-
27
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997;88:131-41
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
-
28
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
Yaswen L, Diehl N, Brennan MB, Hoggeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 1999;5:1066-70
-
(1999)
Nat Med
, vol.5
, pp. 1066-1070
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hoggeschwender, U.4
-
29
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-8
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
30
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
-
31
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson RS, Creemers JW, Ohagi S, et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997;16:303-6
-
(1997)
Nat Genet
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
-
32
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19:155-7
-
(1998)
Nat Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
-
33
-
-
0031668219
-
A frameshift in MC4R associated with dominantly inherited human obesity
-
Yeo GS, Farooqi IS, Aminian S, et al. A frameshift in MC4R associated with dominantly inherited human obesity. Nat Genet 1998;20:111-12
-
(1998)
Nat Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.S.1
Farooqi, I.S.2
Aminian, S.3
-
35
-
-
0345168238
-
The role of leptin recetor signaling in feeding and neuroendocrine function
-
Bates SH, Myers MG Jr. The role of leptin recetor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 2003;14:447- 52
-
(2003)
Trends Endocrinol Metab
, vol.14
, pp. 447-452
-
-
Bates, S.H.1
Myers Jr., M.G.2
-
36
-
-
0032177037
-
Unraveling the CNS pathways underlying responses to leptin
-
Elmquist JK. Unraveling the CNS pathways underlying responses to leptin. Nat Neurosci 1998;1:445-50
-
(1998)
Nat Neurosci
, vol.1
, pp. 445-450
-
-
Elmquist, J.K.1
-
37
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seely RJ, Baskin DG. Central nervous system control of food intake. Nature 2000;404:661-71
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr, D.3
Seely, R.J.4
Baskin, D.G.5
-
38
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004;116:337-50
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
39
-
-
13344279395
-
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
-
Qu D, Ludwig DS, Gammeltoft S. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996;380:243-7
-
(1996)
Nature
, vol.380
, pp. 243-247
-
-
Qu, D.1
Ludwig, D.S.2
Gammeltoft, S.3
-
40
-
-
0021248888
-
Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats
-
Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats. Endocrinology 1984;115:427-9
-
(1984)
Endocrinology
, vol.115
, pp. 427-429
-
-
Clark, J.T.1
Kalra, P.S.2
Crowley, W.R.3
Kalra, S.P.4
-
41
-
-
0029804743
-
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
-
Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996;274:1704-7
-
(1996)
Science
, vol.274
, pp. 1704-1707
-
-
Erickson, J.C.1
Hollopeter, G.2
Palmiter, R.D.3
-
42
-
-
0032772960
-
The central melanocortin system and energy homeostasis
-
Cone RD. The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 1999;10:211-16
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 211-216
-
-
Cone, R.D.1
-
43
-
-
0038141363
-
The role of melanocortin signaling in the control of body weight: Evidence from human and murine genetic models
-
Yeo GS, Farooqi IS, Challis BG, Jackson RS, O'Rahilly S. The role of melanocortin signaling in the control of body weight: evidence from human and murine genetic models. Q J Med 2000;93:7-14
-
(2000)
Q J Med
, vol.93
, pp. 7-14
-
-
Yeo, G.S.1
Farooqi, I.S.2
Challis, B.G.3
Jackson, R.S.4
O'Rahilly, S.5
-
44
-
-
0030729210
-
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
-
Thornton JE, Cheung CC, Clifton DK, Steiner RA. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 1997;138:5063-16
-
(1997)
Endocrinology
, vol.138
, pp. 5063-5116
-
-
Thornton, J.E.1
Cheung, C.C.2
Clifton, D.K.3
Steiner, R.A.4
-
45
-
-
0027939946
-
Proopiomelanocortin-derived peptides
-
Bertagna X. Proopiomelanocortin-derived peptides. Endcorinol Metab Clin North Am 1994;23:467-85
-
(1994)
Endcorinol Metab Clin North Am
, vol.23
, pp. 467-485
-
-
Bertagna, X.1
-
46
-
-
0027456619
-
Molecular cloning of a novel melanocortin receptor
-
Gantz I, Konda Y, Tashiro T, et al. Molecular cloning of a novel melanocortin receptor. J Biol Chem 1993;268:8246-50
-
(1993)
J Biol Chem
, vol.268
, pp. 8246-8250
-
-
Gantz, I.1
Konda, Y.2
Tashiro, T.3
-
47
-
-
0027227288
-
Molecular cloning, expression and gene localization of a fourth melanocortin receptor
-
Gantz I, Miwa H, Konda Y, et al. Molecular cloning, expression and gene localization of a fourth melanocortin receptor. J Biol Chem 1993;268:15174-9
-
(1993)
J Biol Chem
, vol.268
, pp. 15174-15179
-
-
Gantz, I.1
Miwa, H.2
Konda, Y.3
-
48
-
-
0036528005
-
Obesity therapy: Altering the energy intake and expenditure balance sheet
-
Crowley VEF, Yeo GS. Obesity therapy: altering the energy intake and expenditure balance sheet. Nat Drug Disc Rev 2002;1:276-86
-
(2002)
Nat Drug Disc Rev
, vol.1
, pp. 276-286
-
-
Crowley, V.E.F.1
Yeo, G.S.2
-
49
-
-
0037036419
-
Molecular determinants of human melanocortin-4-receptor responsible for SHU9119 selective activity
-
Yang Y, Chen M, Lai Y, et al. Molecular determinants of human melanocortin-4-receptor responsible for SHU9119 selective activity. J Biol Chem 2002;277:2032-5
-
(2002)
J Biol Chem
, vol.277
, pp. 2032-2035
-
-
Yang, Y.1
Chen, M.2
Lai, Y.3
-
50
-
-
0033927916
-
Melanocortin-4-receptor mutations are a frequent and heterogenous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, et al. Melanocortin-4-receptor mutations are a frequent and heterogenous cause of morbid obesity. J Clin Invest 2000;106:253-62
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
-
51
-
-
0033343736
-
Several mutations in the melanocortin-4-receptor gene including a nonsense and frameshift mutation associated with a dominantly inherited obesity in humans
-
Hinney A, Schmidt A, Nottebom K, et al. Several mutations in the melanocortin-4-receptor gene including a nonsense and frameshift mutation associated with a dominantly inherited obesity in humans. J Clin Endocrinol Metab 1999;84:1483-6
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1483-1486
-
-
Hinney, A.1
Schmidt, A.2
Nottebom, K.3
-
52
-
-
0033022224
-
Truncated human leptin (delta 133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport
-
Rau H, Reaves BJ, O'Rahilly S, Whitehead JP. Truncated human leptin (delta 133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport. Endocrinology 1999;140:1718-23
-
(1999)
Endocrinology
, vol.140
, pp. 1718-1723
-
-
Rau, H.1
Reaves, B.J.2
O'Rahilly, S.3
Whitehead, J.P.4
-
53
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Issad T, Camion L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-15
-
(1998)
Nat Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camion, L.3
Ozata, M.4
Strosberg, A.D.5
-
54
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;34:879-84
-
(1999)
N Engl J Med
, vol.34
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
-
55
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyperresponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyperresponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-103
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
-
56
-
-
0033304576
-
Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
-
Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999;84:3686-95
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 3686-3695
-
-
Ozata, M.1
Ozdemir, I.C.2
Licinio, J.3
-
57
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
Halaas JL, Boozer C, Blair-West J, et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997;94:8878-83
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8878-8883
-
-
Halaas, J.L.1
Boozer, C.2
Blair-West, J.3
-
58
-
-
0035172040
-
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
-
Harris M, Aschkenasai C, Elias CF, et al. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 2001;107:111-20
-
(2001)
J Clin Invest
, vol.107
, pp. 111-120
-
-
Harris, M.1
Aschkenasai, C.2
Elias, C.F.3
-
59
-
-
33846409122
-
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
-
Farooqi IS, Wangensteen T, Collins S, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 2007;356:237-47
-
(2007)
N Engl J Med
, vol.356
, pp. 237-247
-
-
Farooqi, I.S.1
Wangensteen, T.2
Collins, S.3
-
60
-
-
33645048441
-
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
-
Lee YS, Challis BG, Thompson DA, et al. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab 2006;3:135-40
-
(2006)
Cell Metab
, vol.3
, pp. 135-140
-
-
Lee, Y.S.1
Challis, B.G.2
Thompson, D.A.3
-
61
-
-
0346096721
-
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
-
Jackson RS, Creemers JW, Farooqi IS, et al. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest 2003;112:1550-60
-
(2003)
J Clin Invest
, vol.112
, pp. 1550-1560
-
-
Jackson, R.S.1
Creemers, J.W.2
Farooqi, I.S.3
-
62
-
-
18644363563
-
Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: The Swedish Obese Subjects, the HERITAGE Family Study and a Memphis cohort
-
Jacobson P, Ukkola O, Rankinen T, et al. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study and a Memphis cohort. J Clin Endocrinol Metab 2002;87:4442-6
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4442-4446
-
-
Jacobson, P.1
Ukkola, O.2
Rankinen, T.3
-
63
-
-
6344260502
-
Large quantitative effect on melanocortin-4 receptor gene mutations on body mass index
-
Dempfle A, Hinney A, Heinzel-Gutenbrunner M, et al. Large quantitative effect on melanocortin-4 receptor gene mutations on body mass index. J Med Genet 2005;41:795-800
-
(2005)
J Med Genet
, vol.41
, pp. 795-800
-
-
Dempfle, A.1
Hinney, A.2
Heinzel-Gutenbrunner, M.3
-
64
-
-
33847186636
-
Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE
-
Alharbi KK, Spanakis E, Tan K, et al. Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum Mutat 2007;28:294- 302
-
(2007)
Hum Mutat
, vol.28
, pp. 294-302
-
-
Alharbi, K.K.1
Spanakis, E.2
Tan, K.3
-
65
-
-
0037456768
-
Clinical spectrum of obesity mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GS, et al. Clinical spectrum of obesity mutations in the melanocortin 4 receptor gene. N Engl J Med 2003;348:1085-95
-
(2003)
N Engl J Med
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.3
-
66
-
-
0030160429
-
-
Cosnidine RV, Caro JF. Leptin in humans: current progress and future directions. Clin Chem 1996;42:843-4
-
Cosnidine RV, Caro JF. Leptin in humans: current progress and future directions. Clin Chem 1996;42:843-4
-
-
-
-
67
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
-
Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999;282:1568-75
-
(1999)
JAMA
, vol.282
, pp. 1568-1575
-
-
Heymsfield, S.B.1
Greenberg, A.S.2
Fujioka, K.3
-
68
-
-
33746537247
-
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC expressing cells
-
Kievit P, Howard JK, Badman MK, et al. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC expressing cells. Cell Metab 2006;4:123-32
-
(2006)
Cell Metab
, vol.4
, pp. 123-132
-
-
Kievit, P.1
Howard, J.K.2
Badman, M.K.3
-
69
-
-
0034179734
-
Neuroendocrine mechanisms regulating food intake and body weight
-
McMinn JE, Baskin DG, Schwartz MW. Neuroendocrine mechanisms regulating food intake and body weight. Obes Rev 2000;1:37-46
-
(2000)
Obes Rev
, vol.1
, pp. 37-46
-
-
McMinn, J.E.1
Baskin, D.G.2
Schwartz, M.W.3
-
70
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-5
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
-
71
-
-
7044262828
-
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
-
Yeo GS, Connie Hung CC, Rochford J, et al. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004;7:1187-9
-
(2004)
Nat Neurosci
, vol.7
, pp. 1187-1189
-
-
Yeo, G.S.1
Connie Hung, C.C.2
Rochford, J.3
-
75
-
-
0028823717
-
Cholecystokinin is a satiety hormone in humans at physiological post-prandial plasma concentrations
-
Ballinger A, McLoughlin L, Medbak S, Clark M. Cholecystokinin is a satiety hormone in humans at physiological post-prandial plasma concentrations. Clin Sci (Lond) 1995;89:375-81
-
(1995)
Clin Sci (Lond)
, vol.89
, pp. 375-381
-
-
Ballinger, A.1
McLoughlin, L.2
Medbak, S.3
Clark, M.4
-
77
-
-
0033781032
-
Cholecystokinin and satiety: Current perspectives
-
Moran TH. Cholecystokinin and satiety: current perspectives. Nutrition 2000;16:858-65
-
(2000)
Nutrition
, vol.16
, pp. 858-865
-
-
Moran, T.H.1
-
78
-
-
0030901415
-
Enteroglucagon
-
Holst JJ. Enteroglucagon. Annu Rev Physiol 1997;59:257-71
-
(1997)
Annu Rev Physiol
, vol.59
, pp. 257-271
-
-
Holst, J.J.1
-
79
-
-
13344282056
-
A role for glucagon-like peptide-1 in the regulation of feeding
-
Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the regulation of feeding. Nature 1996;379:66-72
-
(1996)
Nature
, vol.379
, pp. 66-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
-
80
-
-
0033811433
-
Afferent signals regulating food intake
-
Bray GA. Afferent signals regulating food intake. Proc Nutr Soc 2000;59:373-84
-
(2000)
Proc Nutr Soc
, vol.59
, pp. 373-384
-
-
Bray, G.A.1
-
81
-
-
33745771673
-
Biologic actions and therapeutic potential of the proglucagon-derived peptides
-
Drucker DJ. Biologic actions and therapeutic potential of the proglucagon-derived peptides. Nat Clin Pract Endcrinol Metab 2005;1:22-31
-
(2005)
Nat Clin Pract Endcrinol Metab
, vol.1
, pp. 22-31
-
-
Drucker, D.J.1
-
82
-
-
0029826237
-
Influence of meal composition on postprandial peripheral concentrations of vasoactive peptides in man
-
Pedersen-Bjergaard U, Host U, Kelbaek H, et al. Influence of meal composition on postprandial peripheral concentrations of vasoactive peptides in man. Scand J Clin Lab Invest 1996;56:497-503
-
(1996)
Scand J Clin Lab Invest
, vol.56
, pp. 497-503
-
-
Pedersen-Bjergaard, U.1
Host, U.2
Kelbaek, H.3
-
83
-
-
0037043704
-
Gut hormone PYY(3-36) physiologically inhibits food intake
-
Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-4
-
(2002)
Nature
, vol.418
, pp. 650-654
-
-
Batterham, R.L.1
Cowley, M.A.2
Small, C.J.3
-
84
-
-
0242437949
-
Acute effects of PYY(3-36) on food intake and hypothalamic neuropeptide expression in the mouse
-
Challis BG, Pinnock SB, Coll AP, et al. Acute effects of PYY(3-36) on food intake and hypothalamic neuropeptide expression in the mouse. Biochem Biophys Res Comm 2003;311:915-19
-
(2003)
Biochem Biophys Res Comm
, vol.311
, pp. 915-919
-
-
Challis, B.G.1
Pinnock, S.B.2
Coll, A.P.3
-
85
-
-
9244224088
-
Effects of peptide YY(3-36) on short-term food intake in mice are not affected by prevailing plasma ghrelin levels
-
Adams SH, Won WB, Schonhoff SE, Leiter AB, Patreniti JR. Effects of peptide YY(3-36) on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology 2004;145:4967-75
-
(2004)
Endocrinology
, vol.145
, pp. 4967-4975
-
-
Adams, S.H.1
Won, W.B.2
Schonhoff, S.E.3
Leiter, A.B.4
Patreniti, J.R.5
-
86
-
-
0041859261
-
Inhibition of food intake in obese subjects by peptide YY3-36
-
Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003;349:941-8
-
(2003)
N Engl J Med
, vol.349
, pp. 941-948
-
-
Batterham, R.L.1
Cohen, M.A.2
Ellis, S.M.3
-
87
-
-
33845595901
-
Gut peptides in the regulation of food intake and energy homeostasis
-
Murphy KG, Dhillo WS, Bloom SR. Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 2006;27:719-27
-
(2006)
Endocr Rev
, vol.27
, pp. 719-727
-
-
Murphy, K.G.1
Dhillo, W.S.2
Bloom, S.R.3
-
88
-
-
0034807498
-
Oxyntomodulin inhibits food intake in the rat
-
Dakin CL, Gunn I, Small CJ, et al. Oxyntomodulin inhibits food intake in the rat. Endcorinology 2001;142:4244-50
-
(2001)
Endcorinology
, vol.142
, pp. 4244-4250
-
-
Dakin, C.L.1
Gunn, I.2
Small, C.J.3
-
89
-
-
0242288734
-
Oxyntomodulin suppresses appetite and reduces food intake in humans
-
Cohen MA, Ellis SM, Le Roux CW, et al. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab 2003;88:4696-701
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4696-4701
-
-
Cohen, M.A.1
Ellis, S.M.2
Le Roux, C.W.3
-
90
-
-
0033540056
-
Ghrelin is a growth-hormone-releasing acylated peptide from the stomach
-
Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from the stomach. Nature 1999;402:656-60
-
(1999)
Nature
, vol.402
, pp. 656-660
-
-
Kojima, M.1
Hosoda, H.2
Date, Y.3
-
91
-
-
0035514596
-
Ghrelin causes hyperphagia and obesity in rats
-
Wren AM, Small CJ, Abbott CR, et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001;50:2540-7
-
(2001)
Diabetes
, vol.50
, pp. 2540-2547
-
-
Wren, A.M.1
Small, C.J.2
Abbott, C.R.3
-
92
-
-
0035216623
-
Ghrelin enhances appetite and increases food intake in humans
-
Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001;86:5992
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 5992
-
-
Wren, A.M.1
Seal, L.J.2
Cohen, M.A.3
-
93
-
-
0037387092
-
Roles for ghrelin in the regulation of appetite and body weight
-
Cummings DE, Shannon MH. Roles for ghrelin in the regulation of appetite and body weight. Arch Surg 2003;138:389-96
-
(2003)
Arch Surg
, vol.138
, pp. 389-396
-
-
Cummings, D.E.1
Shannon, M.H.2
-
94
-
-
12244288887
-
Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY and insulin
-
Korner J, Bessler M, Cirilo CJ, et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY and insulin. J Clin Endocrinol Metab 2005;90:359-65
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 359-365
-
-
Korner, J.1
Bessler, M.2
Cirilo, C.J.3
-
95
-
-
0037209172
-
The investigation and management of obesity
-
Labib M. The investigation and management of obesity. J Clin Path 2003;56:17-25
-
(2003)
J Clin Path
, vol.56
, pp. 17-25
-
-
Labib, M.1
-
97
-
-
85069416391
-
Obesity and disease: Hormones and obesity
-
Kopelman Caterson ID, Dietz WH, eds, 2nd edn. Oxford: Blackwell Publishing
-
Pinkney J. Obesity and disease: hormones and obesity. In: Kopelman PG, Caterson ID, Dietz WH, eds. Clinical Obesity in Adults and Children. 2nd edn. Oxford: Blackwell Publishing, 2005:198-212
-
(2005)
Clinical Obesity in Adults and Children
, pp. 198-212
-
-
Pinkney, J.1
-
98
-
-
33645280903
-
The severly obese patient-agentic work-up
-
Farooqi IS. The severly obese patient-agentic work-up. Nat Clin Pract Endocrinol Metab 2006;2:172-7
-
(2006)
Nat Clin Pract Endocrinol Metab
, vol.2
, pp. 172-177
-
-
Farooqi, I.S.1
-
99
-
-
33845874637
-
Drug treatments for obesity: Orlistat, sibutramine and rimonabant
-
Padwal RS, Majumdar SR. Drug treatments for obesity: orlistat, sibutramine and rimonabant. Lancet 2007;369:71-7
-
(2007)
Lancet
, vol.369
, pp. 71-77
-
-
Padwal, R.S.1
Majumdar, S.R.2
-
100
-
-
17144382751
-
Effects of cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from RIO-Europe study
-
Van Gaal LF, Rissanen AM, Scheen AJ, et al. Effects of cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from RIO-Europe study. Lancet 2005;365:1389-97
-
(2005)
Lancet
, vol.365
, pp. 1389-1397
-
-
Van Gaal, L.F.1
Rissanen, A.M.2
Scheen, A.J.3
-
101
-
-
42749107961
-
-
Curioni C, Andre C. Rimonabant for overweight or obesity Cochrane Database Syst Rev 2006, Oct 18(4):CD006162
-
Curioni C, Andre C. Rimonabant for overweight or obesity Cochrane Database Syst Rev 2006, Oct 18(4):CD006162
-
-
-
-
102
-
-
34247547424
-
Is rimonabant a safe and effective treatment for obesity?
-
Aronne LJ. Is rimonabant a safe and effective treatment for obesity? Nat Clin Pract Endocrinol Metab 2007;3:388-9
-
(2007)
Nat Clin Pract Endocrinol Metab
, vol.3
, pp. 388-389
-
-
Aronne, L.J.1
|