Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity

Thrombosis and Haemostasis

Volumn 100, Issue 6, 2008, Pages 1123-1129

  Dellas, Claudia ^a   Schäfer, Katrin ^a   Rohm, Ilonka ^a   Lankeit, Mareike ^a   Ellrott, Thomas ^a   Faustin, Vivien ^a   Riggert, Joachim ^a   Hasenfuss, Gerd ^a   Konstantinides, Stavros ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Aggregation; Leptin; Obesity; Platelets; Resistance

Indexed keywords

ADENOSINE DIPHOSPHATE; JANUS KINASE 2; LEPTIN; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME PHOSPHORYLATION; FEMALE; HORMONE BLOOD LEVEL; HORMONE RESISTANCE; HUMAN; LEAN BODY WEIGHT; LEPTIN RESISTANCE; MALE; MORBID OBESITY; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOSIS; WESTERN BLOTTING;

ADENOSINE DIPHOSPHATE; ADULT; BLOOD PLATELETS; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; HUMANS; JANUS KINASE 2; LEPTIN; MALE; OBESITY, MORBID; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RISK ASSESSMENT; RISK FACTORS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; THROMBOSIS; UP-REGULATION;

EID: 57349151521     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-05-0314     Document Type: Article

References (28)

1. Caro JF, Sinha MK, Kolaczynski JW, et al. Leptin: the tale of an obesity gene. Diabetes 1996; 45: 1455-1462.
2. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770.
3. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295.
4. Munzberg H, Bjornholm M, Bates SH, et al. Leptin receptor action and mechanisms of leptin resistance. Cell Mol Life Sci 2005; 62: 642-652.
5. Huang W, Dedousis N, Bhatt BA, et al. Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem 2004; 279: 21695-21700.
6. Rahmouni K, Morgan DA, Morgan GM, et al. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 2005; 54: 2012-2018.
7. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 2001; 104: 3052-3056.
8. Wolk R, Berger P, Lennon RJ, et al. Plasma leptin and prognosis in patients with established coronary atherosclerosis. J Am Coll Cardiol 2004; 44: 1819-1824.
9. Konstantinides S, Schäfer K, Koschnick S, et al. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001; 108: 1533-1540.
10. Bodary PF, Westrick RJ, Wickenheiser KJ, et al. Effect of leptin on arterial thrombosis following vascular injury in mice. J Am Med Assoc 2002; 287: 1706-1709.
11. Corsonello A, Perticone F, Malara A, et al. Leptin-dependent platelet aggregation in healthy, overweight and obese subjects. Int J Obes Relat Metab Disord 2003; 27: 566-573.
12. Nakata M, Yada T, Soejima N, et al. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 1999; 48: 426-429.
13. Wallaschofski H, Kobsar A, Sokolova O, et al. Differences in platelet activation by prolactin and leptin. Horm Metab Res 2004; 36: 453-457.
14. Giandomenico G, Dellas C, Czekay RP, et al. The leptin receptor system of human platelets. J Thromb Haemost 2005; 3: 1042-1049.
15. Sugiyama C, Ishizawa M, Kajita K, et al. Platelet aggregation in obese and diabetic subjects: association with leptin level. Platelets 2007; 18: 128-134.
16. Elbatarny HS, Maurice DH. Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex. Am J Physiol Endocrinol Metab 2005; 289: E695-E702.
17. Corica F, Corsonello A, Lucchetti M, et al. Relationship between metabolic syndrome and platelet responsiveness to leptin in overweight and obese patients. Int J Obes (Lond) 2007; 31: 842-849.
18. Jancinova V, Nosal R, Petrikova M. Dose-response aggregometry- contribution to the precise platelet function evaluation. Thromb Res 1992; 65: 1-11.
19. Dellas C, Schafer K, Rohm IK, et al. Leptin signalling and leptin-mediated activation of human platelets: Importance of JAK2 and the phospholipases Cgamma2 and A(2). Thromb Haemost 2007; 98: 1063-1071.
20. Gomez-Ambrosi J, Salvador J, Silva C, et al. Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin. Thromb Haemost 2006; 95: 991-996.
21. Bjorbaek C, El Haschimi K, Frantz JD, et al. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 1999; 274: 30059-30065.
22. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, et al. PTP1B regulates leptin signal transduction in vivo. Dev Cell 2002; 2: 489-495.
23. Juhan I, Gabrielli M, Jouve R, et al. [A study of platelet abnormalities in obese subjects (author's transl)]. Diabete Metab 1980; 6: 17-24.
24. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000; 62: 413-437.
25. Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004; 59: 305-331.
26. Bates SH, Stearns WH, Dundon TA, et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003; 421: 856-859.
27. Elchebly M, Payette P, Michaliszyn E, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999; 283: 1544-1548.
28. Lam NT, Covey SD, Lewis JT, et al. Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. J Mol Endocrinol 2006; 36: 163-174