Adiponectin, an unlocking adipocytokine: REVIEW

Cardiovascular Therapeutics

Volumn 27, Issue 1, 2009, Pages 59-75

  Sun, Yiyi ^a   Xun, Keli ^b   Wang, Changguang ^c   Zhao, Haiyu ^c   Bi, Huichang ^c   Chen, Xiuping ^c,d   Wang, Yitao ^c  

^a CHENGDU MEDICAL COLLEGE   (China)

^b People's Hospital of Binzhou   (China)

^c University of Macau   (Macao)

^d NONE   (China)

Author keywords

Adiponecitn; Biomarker; Drug target; Exercise; Gender difference; Inflammation

Indexed keywords

ADENYLATE KINASE; ADIPOCYTOKINE; ADIPONECTIN; ADIPONECTIN RECEPTOR; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CADHERIN; COMPLEMENT COMPONENT C1Q AND TUMOR NECROSIS FACTOR ALPHA RELATED PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; SIRTUIN 1; T CADHERIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; BRAIN ISCHEMIA; BRAIN PROTECTION; CHOLESTEROL TRANSPORT; DIABETES MELLITUS; DRUG TARGETING; ENDOCRINE GLAND; ENDOTHELIAL DYSFUNCTION; EXERCISE; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SYSTOLIC DYSFUNCTION;

EID: 60349110068     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2008.00069.x     Document Type: Review

References (162)

1. Ahima RS. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 2006 14 (Suppl. 5 242S 249S.
2. Calabro P, Yeh ET. Obesity, inflammation, and vascular disease: The role of the adipose tissue as an endocrine organ. Subcell Biochem 2007 42 : 63 91.
3. Scherer PE. Adipose tissue: From lipid storage compartment to endocrine organ. Diabetes 2006 55 : 1537 1545.
4. Mao X, Hong JY, Dong LQ. The adiponectin signaling pathway as a novel pharmacological target. Mini Rev Med Chem 2006a 6 : 1331 1340.
5. Beltowski J, Jamroz-Wisniewska A, Widomska S. Adiponectin and its role in cardiovascular diseases. Cardiovasc Hematol Disord Drug Targets 2008 8 : 7 46.
6. Karbowska J, Kochan Z. Role of adiponectin in the regulation of carbohydrate and lipid metabolism. J Physiol Pharmacol 2006 57 (Suppl 6 103 113.
7. Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: A systematic review. Br J Cancer 2006 94 : 1221 1225.
8. Nishida M, Funahashi T, Shimomura I. Pathophysiological significance of adiponectin. Med Mol Morphol 2007 40 : 55 67.
9. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995 270 : 26746 26749.
10. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996 221 : 286 289.
11. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996 271 : 10697 10703.
12. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem 1996 120 : 803 812.
13. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999 257 : 79 83.
14. Matsunaga H, Hokari R, Kurihara C, Okada Y, Takebayashi K, Okudaira K, Watanabe C, Komoto S, Nakamura M, Tsuzuki Y, et al. Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflamm Bowel Dis 2008 Ahead of print G, Qin Q, He N, Francis-David SC, Hou J, Liu J, Ricks E, Yang Q. Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma. J Mol Cell Cardiol 2007 43 : 73 84.
15. Pineiro R, Iglesias MJ, Gallego R, Raghay K, Eiras S, Rubio J, Dieguez C, Gualillo O, Gonzalez-Juanatey JR, Lago F. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 2005 579 : 5163 5169.
16. Shibata R, Sato K, Kumada M, Izumiya Y, Sonoda M, Kihara S, Ouchi N, Walsh K. Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Cardiovasc Res 2007 74 : 471 479.
17. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004 24 : 29 33.
18. Giannessi D, Maltinti M, Del Ry S. Adiponectin circulating levels: A new emerging biomarker of cardiovascular risk. Pharmacol Res 2007 56 : 459 467.
19. Garaulet M, Hernandez-Morante JJ, de Heredia FP, Tebar FJ. Adiponectin, the controversial hormone. Public Health Nutr 2007 10 : 1145 1150.
20. Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, Hada Y, Uchida S, Tsuchida A, Takekawa S, Kadowaki T. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 2005 146 : 790 796.
21. Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998 8 : 335 338.
22. Richards AA, Stephens T, Charlton HK, Jones A, Macdonald GA, Prins JB, Whitehead JP. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: Evidence for regulation of multimerization by alterations in posttranslational modifications. Mol Endocrinol 2006 20 : 1673 1687.
23. Ouchi N, Shibata R, Walsh K. Cardioprotection by adiponectin. Trends Cardiovasc Med 2006 16 : 141 146.
24. Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 2002 277 : 19521 19529.
25. Ebinuma H, Miyazaki O, Yago H, Hara K, Yamauchi T, Kadowaki T. A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta 2006 372 : 47 53.
26. Peake PW, Kriketos AD, Campbell LV, Shen Y, Charlesworth JA. The metabolism of isoforms of human adiponectin: Studies in human subjects and in experimental animals. Eur J Endocrinol 2005 153 : 409 417.
27. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 2003 278 : 9073 9085.
28. Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 2004 101 : 10308 10313.
29. Takeuchi T, Adachi Y, Ohtsuki Y, Furihata M. Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease. Med Mol Morphol 2007 40 : 115 120.
30. Ishikawa M, Kitayama J, Yamauchi T, Kadowaki T, Maki T, Miyato H, Yamashita H, Nagawa H. Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer Sci 2007 98 : 1120 1127.
31. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, Walsh K. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 2007 117 : 375 386.
32. Ogunwobi OO, Beales IL. Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation. Mol Cell Endocrinol 2008 285 : 43 50.
33. Coope A, Milanski M, Araujo EP, Tambascia M, Saad MJ, Geloneze B, Velloso LA. AdipoR1 mediates the anorexigenic and insulin/ leptin-like actions of adiponectin in the hypothalamus. FEBS Lett 2008 582 : 1471 1476.
34. Fantuzzi G. Adiponectin and inflammation: Consensus and controversy. J Allergy Clin Immunol 2008 121 : 326 330.
35. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY, Chuang LM. Plasma adiponectin levels in overweight and obese Asians. Obes Res 2002 10 : 1104 1110.
36. Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002 147 : 173 180.
37. Leiter EH, Reifsnyder PC, Xiao Q, Mistry J. Adipokine and insulin profiles distinguish diabetogenic and non-diabetogenic obesities in mice. Obesity (Silver Spring) 2007 15 : 1961 1968.
38. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001 50 : 1126 1133.
39. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000 20 : 1595 1599.
40. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY, Chuang LM. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001 86 : 3815 3819.
41. Faraj M, Havel PJ, Phelis S, Blank D, Sniderman AD, Cianflone K. Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 2003 88 : 1594 1602.
42. Coughlin CC, Finck BN, Eagon JC, Halpin VJ, Magkos F, Mohammed BS, Klein S. Effect of marked weight loss on adiponectin gene expression and plasma concentrations. Obesity (Silver Spring) 2007 15 : 640 645.
43. Mousavinasab F, Tahtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinanen-Kiukaanniemi S. Lack of increase of serum adiponectin concentrations with a moderate weight loss during six months on a high-caloric diet in military service among a young male Finnish population. Endocrine 2005 26 : 65 69.
44. Vozarova B, Stefan N, Lindsay RS, Krakoff J, Knowler WC, Funahashi T, Matsuzawa Y, Stumvoll M, Weyer C, Tataranni PA. Low plasma adiponectin concentrations do not predict weight gain in humans. Diabetes 2002 51 : 2964 2967.
45. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, Sinha MK, Pories WJ, MacDonald KG, Dohm GL. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab 2002 283 : E861 865.
46. Ferguson MA, White LJ, McCoy S, Kim HW, Petty T, Wilsey J. Plasma adiponectin response to acute exercise in healthy subjects. Eur J Appl Physiol 2004 91 : 324 329.
47. Jurimae J, Purge P, Jurimae T. Adiponectin is altered after maximal exercise in highly trained male rowers. Eur J Appl Physiol 2005 93 : 502 505.
48. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, Chrousos GP, Sidossis LS. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 2005 54 : 1472 1479.
49. Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, Richterova B, Kraus I, Langin D, Stich V. Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women. Metabolism 2006 55 : 1375 1381.
50. O'Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP. Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol 2006 100 : 1584 1589.
51. Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol 2005 152 : 427 436.
52. Numao S, Suzuki M, Matsuo T, Nomata Y, Nakata Y, Tanaka K. Effects of acute aerobic exercise on high-molecular-weight adiponectin. Med Sci Sports Exerc 2008 40 : 1271 1276.
53. Jurimae J, Purge P, Jurimae T. Effect of prolonged training period on plasma adiponectin in elite male rowers. Horm Metab Res 2007 39 : 519 523.
54. Bluher M, Bullen JW, Jr., Lee JH, Kralisch S, Fasshauer M, Kloting N, Niebauer J, Schon MR, Williams CJ, Mantzoros CS. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: Associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab 2006 91 : 2310 2316.
55. Balagopal P, George D, Yarandi H, Funanage V, Bayne E. Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: A controlled, randomized study in obese adolescents. J Clin Endocrinol Metab 2005 90 : 6192 6197.
56. Ring-Dimitriou S, Paulweber B, von Duvillard SP, Stadlmann M, LeMura LM, Lang J, Muller E. The effect of physical activity and physical fitness on plasma adiponectin in adults with predisposition to metabolic syndrome. Eur J Appl Physiol 2006 98 : 472 481.
57. Hojbjerre L, Rosenzweig M, Dela F, Bruun JM, Stallknecht B. Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. Eur J Endocrinol 2007 157 : 613 623.
58. Yatagai T, Nishida Y, Nagasaka S, Nakamura T, Tokuyama K, Shindo M, Tanaka H, Ishibashi S. Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men. Endocr J 2003 50 : 233 238.
59. Huang H, Iida KT, Sone H, Yokoo T, Yamada N, Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. J Endocrinol 2006 189 : 643 653.
60. Huang H, Iida KT, Sone H, Ajisaka R. The regulation of adiponectin receptors expression by acute exercise in mice. Exp Clin Endocrinol Diabetes 2007 115 : 417 422.
61. Kimura M, Shinozaki T, Tateishi N, Yoda E, Yamauchi H, Suzuki M, Hosoyamada M, Shibasaki T. Adiponectin is regulated differently by chronic exercise than by weight-matched food restriction in hyperphagic and obese OLETF rats. Life Sci 2006 79 : 2105 2111.
62. Gordon ME, McKeever KH, Betros CL, Manso Filho HC. Exercise-induced alterations in plasma concentrations of ghrelin, adiponectin, leptin, glucose, insulin, and cortisol in horses. Vet J 2007 173 : 532 540.
63. Simpson KA, Singh MA. Effects of exercise on adiponectin: A systematic review. Obesity (Silver Spring) 2008 16 : 241 256.
64. Vu V, Riddell MC, Sweeney G. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: Effects of exercise. Diabetes Metab Res Rev 2007 23 : 600 611.
65. Kotani Y, Yokota I, Kitamura S, Matsuda J, Naito E, Kuroda Y. Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight. Clin Endocrinol (Oxf) 2004 61 : 418 423.
66. Punthakee Z, Delvin EE, O'Loughlin J, Paradis G, Levy E, Platt RW, Lambert M. Adiponectin, adiposity, and insulin resistance in children and adolescents. J Clin Endocrinol Metab 2006 91 : 2119 2125.
67. Woo JG, Dolan LM, Daniels SR, Goodman E, Martin LJ. Adolescent sex differences in adiponectin are conditional on pubertal development and adiposity. Obes Res 2005 13 : 2095 2101.
68. Tsou PL, Jiang YD, Chang CC, Wei JN, Sung FC, Lin CC, Chiang CC, Tai TY, Chuang LM. Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care 2004 27 : 308 313.
69. Adamczak M, Rzepka E, Chudek J, Wiecek A. Ageing and plasma adiponectin concentration in apparently healthy males and females. Clin Endocrinol (Oxf) 2005 62 : 114 118.
70. Huang KC, Lue BH, Yen RF, Shen CG, Ho SR, Tai TY, Yang WS. Plasma adiponectin levels and metabolic factors in nondiabetic adolescents. Obes Res 2004 12 : 119 124.
71. Smith J, Al-Amri M, Sniderman A, Cianflone K. Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. Nutr Metab (Lond) 2006 3 : 18.
72. Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: Relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002 87 : 4652 4656.
73. Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol 2005 166 : 1655 1669.
74. Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, Matsuda M, Kondo H, Furuyama N, Kihara S, et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 2002 51 : 2734 2741.
75. Jurimae J, Jurimae T. Plasma adiponectin concentration in healthy pre- and postmenopausal women: Relationship with body composition, bone mineral, and metabolic variables. Am J Physiol Endocrinol Metab 2007b 293 : E42 47.
76. Hernandez-Morante JJ, Milagro F, Gabaldon JA, Martinez JA, Zamora S, Garaulet M. Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur J Endocrinol 2006 155 : 593 600.
77. Perez-de-Heredia F, Sanchez J, Priego T, Nicolas F, Portillo Mdel P, Palou A, Zamora S, Garaulet M. Adiponectin is involved in the protective effect of DHEA against metabolic risk in aged rats. Steroids 2008 73 : 1128 1136.
78. Yasui T, Tomita J, Miyatani Y, Yamada M, Uemura H, Irahara M, Arai M, Kojimahara N, Okabe R, Ishii Y, Tashiro S, Sato H. Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations. Clin Chim Acta 2007 386 : 69 75.
79. Shand BI, Scott RS, Elder PA, George PM. Plasma adiponectin in overweight, nondiabetic individuals with or without insulin resistance. Diabetes Obes Metab 2003 5 : 349 353.
80. Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, Shulman G, Caprio S. Low adiponectin levels in adolescent obesity: A marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab 2003 88 : 2014 2018.
81. Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, Ohnuma H, Igarashi M, Tominaga M, Kato T. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: The Funagata study. Diabetes Care 2003 26 : 2015 2020.
82. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, Noguchi S. Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 2003 9 : 5699 5704.
83. Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S, Staiger H, Maerker E, Haring H, Stumvoll M. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003 52 : 239 243.
84. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagai M, Matsuzawa Y, Funahashi T. Adiponectin as a biomarker of the metabolic syndrome. Circ J 2004 68 : 975 981.
85. Ogawa Y, Kikuchi T, Nagasaki K, Hiura M, Tanaka Y, Uchiyama M. Usefulness of serum adiponectin level as a diagnostic marker of metabolic syndrome in obese Japanese children. Hypertens Res 2005 28 : 51 57.
86. Trujillo ME, Scherer PE. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005 257 : 167 175.
87. Gannage-Yared MH, Khalife S, Semaan M, Fares F, Jambart S, Halaby G. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men. Eur J Endocrinol 2006 155 : 167 176.
88. Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, Kumar S, Invitti C. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis 2006 189 : 401 407.
89. Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 2006 29 : 1357 1362.
90. Santaniemi M, Kesaniemi YA, Ukkola O. Low plasma adiponectin concentration is an indicator of the metabolic syndrome. Eur J Endocrinol 2006 155 : 745 750.
91. Tajtakova M, Petrasova D, Petrovicova J, Pytliak M, Semanova Z. Adiponectin as a biomarker of clinical manifestation of metabolic syndrome. Endocr Regul 2006 40 : 15 19.
92. Bai YM, Chen JY, Yang WS, Chi YC, Liou YJ, Lin CC, Wang YC, Lin CY, Su TP, Chou P. Adiponectin as a potential biomarker for the metabolic syndrome in Chinese patients taking clozapine for schizophrenia. J Clin Psychiatry 2007 68 : 1834 1839.
93. Ballantyne CM, Nambi V. Markers of inflammation and their clinical significance. Atheroscler 2005 6 (Suppl 21 29.
94. Schondorf T, Maiworm A, Emmison N, Forst T, Pfutzner A. Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk. Clin Lab 2005 51 : 489 494.
95. Bersinger NA, Birkhauser MH, Wunder DM. Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles. Gynecol Endocrinol 2006 22 : 479 483.
96. Cavusoglu E, Ruwende C, Chopra V, Yanamadala S, Eng C, Clark LT, Pinsky DJ, Marmur JD. Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain. Eur Heart J 2006 27 : 2300 2309.
97. Chang MC, Chang YT, Su TC, Yang WS, Chen CL, Tien YW, Liang PC, Wei SC, Wong JM. Adiponectin as a potential differential marker to distinguish pancreatic cancer and chronic pancreatitis. Pancreas 2007 35 : 16 21.
98. Jurimae J, Jurimae T. Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women. Osteoporos Int 2007a 18 : 1253 1259.
99. Shimada M, Kawahara H, Ozaki K, Fukura M, Yano H, Tsuchishima M, Tsutsumi M, Takase S. Usefulness of a combined evaluation of the serum adiponectin level, HOMA-IR, and serum type IV collagen 7S level to predict the early stage of nonalcoholic steatohepatitis. Am J Gastroenterol 2007 102 : 1931 1938.
100. Stork S, Bots ML, Angerer P, von Schacky C, Grobbee DE, Angermann CE, Seufert J. Low levels of adiponectin predict worsening of arterial morphology and function. Atherosclerosis 2007 194 : e147 153.
101. Cavusoglu E, Chopra V, Battala V, Ruwende C, Yanamadala S, Eng C, Pinsky DJ, Marmur JD. Baseline plasma adiponectin levels as a predictor of left ventricular systolic dysfunction in patients referred for coronary angiography. Am J Cardiol 2008 101 : 1073 1078.
102. Pinthus JH, Kleinmann N, Tisdale B, Chatterjee S, Lu JP, Gillis A, Hamlet T, Singh G, Farrokhyar F, Kapoor A. Lower Plasma Adiponectin Levels Are Associated with Larger Tumor Size and Metastasis in Clear-Cell Carcinoma of the Kidney. Eur Uro 2008 in press)
103. Zografos TA, Liaskos C, Rigopoulou EI, Togousidis E, Makaritsis K, Germenis A, Dalekos GN. Adiponectin: A new independent predictor of liver steatosis and response to IFN-alpha treatment in chronic hepatitis C. Am J Gastroenterol 2008 103 : 605 614.
104. Satoh N, Naruse M, Usui T, Tagami T, Suganami T, Yamada K, Kuzuya H, Shimatsu A, Ogawa Y. Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 2004 27 : 2488 2490.
105. Kotani K, Sakane N, Saiga K, Kurozawa Y. Leptin : Adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes : Relationship of the index to carotid intima-media thickness. Diabetologia 2005 48 : 2684 2686.
106. Norata GD, Raselli S, Grigore L, Garlaschelli K, Dozio E, Magni P, Catapano AL. Leptin: Adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery. Stroke 2007 38 : 2844 2846.
107. Teta D, Maillard M, Halabi G, Burnier M. The leptin/adiponectin ratio: Potential implications for peritoneal dialysis. Kidney Int Suppl 2008 108 : S112 118.
108. Diamond FB, Jr., Cuthbertson D, Hanna S, Eichler D. Correlates of adiponectin and the leptin/adiponectin ratio in obese and non-obese children. J Pediatr Endocrinol Metab 2004 17 : 1069 1075.
109. Inoue T, Kotooka N, Morooka T, Komoda H, Uchida T, Aso Y, Inukai T, Okuno T, Node K. High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. Am J Cardiol 2007 100 : 569 574.
110. Kato A, Odamaki M, Ishida J, Hishida A. Association of high-molecular-weight to total adiponectin ratio with pulse wave velocity in hemodialysis patients. Nephron Clin Pract 2008 109 : c18 24.
111. Weerakiet S, Tingthanatikul Y, Boonnag P, Wansumrith S, Rattanasiri S, Leelaphiwat S. Can adiponectin predict abnormal glucose tolerance in Thai women with polycystic ovary syndrome? J Obstet Gynaecol Res 2008 34 : 55 61.
112. Soderberg S, Stegmayr B, Stenlund H, Sjostrom LG, Agren A, Johansson L, Weinehall L, Olsson T. Leptin, but not adiponectin, predicts stroke in males. J Intern Med 2004 256 : 128 136.
113. Michaelsson K, Lind L, Frystyk J, Flyvbjerg A, Gedeborg R, Berne C, Zethelius B, Mallmin H, Soderberg S, Melhus H. Serum Adiponectin in Elderly Men Does Not Correlate with Fracture Risk. J Clin Endocrinol Metab 2008 93 : 4041 4047.
114. Matsuzawa Y. Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease. Atheroscler 2005 6 (Suppl. 7 14.
115. Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 2003 14 : 561 566.
116. Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007 380 : 24 30.
117. Tilg H, Wolf AM. Adiponectin: A key fat-derived molecule regulating inflammation. Expert Opin Ther Targets 2005 9 : 245 251.
118. Ogunwobi OO, Beales IL. Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept 2006 134 : 105 113.
119. Rovin BH, Song H. Chemokine induction by the adipocyte-derived cytokine adiponectin. Clin Immunol 2006 120 : 99 105.
120. Lee SW, Kim JH, Park MC, Park YB, Lee SK. Adiponectin mitigates the severity of arthritis in mice with collagen-induced arthritis. Scand J Rheumatol 2008 37 : 260 268.
121. Tan W, Wang F, Zhang M, Guo D, Zhang Q, He S. High Adiponectin and Adiponectin Receptor 1 Expression in Synovial Fluids and Synovial Tissues of Patients with Rheumatoid Arthritis. Semin Arthritis Rheum 2008 Ahead of Print CH, Chiu YC, Tan TW, Yang RS, Fu WM. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 2007 179 : 5483 5492.
122. Lappas M, Permezel M, Rice GE. Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase 1/2. Endocrinology 2005 146 : 3334 3342.
123. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006 65 : 1198 1201.
124. Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Scholmerich J, et al. The potential of adiponectin in driving arthritis. J Immunol 2006 176 : 4468 4478.
125. Rovin BH, Song H, Hebert LA, Nadasdy T, Nadasdy G, Birmingham DJ, Yung Yu C, Nagaraja HN. Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int 2005 68 : 1825 1833.
126. Haugen F, Drevon CA. Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Endocrinology 2007 148 : 5478 03075486.
127. Bobbert P, Antoniak S, Schultheiss HP, Rauch U. Globular adiponectin but not full-length adiponectin induces increased procoagulability in human endothelial cells. J Mol Cell Cardiol 2008 44 : 388 394.
128. Fang X, Palanivel R, Zhou X, Liu Y, Xu A, Wang Y, Sweeney G. Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts. J Mol Endocrinol 2005 35 : 465 476.
129. Thakur V, Pritchard MT, McMullen MR, Nagy LE. Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol 2006 290 : G998 1007.
130. Tsatsanis C, Zacharioudaki V, Androulidaki A, Dermitzaki E, Charalampopoulos I, Minas V, Gravanis A, Margioris AN. Adiponectin induces TNF-a and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli. Biochem Biophys Res Commun 2005 335 : 1254 1263.
131. Nawrocki AR, Scherer PE. Keynote review: The adipocyte as a drug discovery target. Drug Discov Today 2005 10 : 1219 1230.
132. Nishida M, Yamashita S. Adipocytokines: Target for treatment of metabolic syndrome. Nippon Rinsho 2006 64 (Suppl. 9 685 689.
133. Bauche IB, Ait El Mkadem S, Rezsohazy R, Funahashi T, Maeda N, Miranda LM, Brichard SM. Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. Biochem Biophys Res Commun 2006 345 : 1414 1424.
134. Lin HV, Kim JY, Pocai A, Rossetti L, Shapiro L, Scherer PE, Accili D. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes 2007 56 : 1969- 1976.
135. Mullen KL, Smith AC, Junkin KA, Dyck DJ. Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats. Am J Physiol Endocrinol Metab 2007 293 : E83 90.
136. Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 2003 278 : 50810 50817.
137. Narasimhan ML, Coca MA, Jin J, Yamauchi T, Ito Y, Kadowaki T, Kim KK, Pardo JM, Damsz B, Hasegawa PM, et al. Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Mol Cell 2005 17 : 171 180.
138. Wong GW, Wang J, Hug C, Tsao TS, Lodish HF. A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A 2004 101 : 10302 10307.
139. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005 26 : 439 451.
140. Wölfing B, Buechler C, Weigert J, Neumeier M, Aslanidis C, Schöelmerich J, Schäffler A. Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines. Obesity (Silver Spring) 2008 16 : 1481 1486.
141. Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006b 8 : 516 523.
142. Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 2007 56 : 1387 1394.
143. Chandrasekar B, Boylston WH, Venkatachalam K, Webster NJ, Prabhu SD, Valente AJ. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappa B/PTEN suppression. J Biol Chem 2008 283 : 24889 24898.
144. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007 450 : 712 716.
145. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004 429 : 771 776.
146. Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer- binding protein alpha transcriptional complex. J Biol Chem 2006 281 : 39915 39924.
147. Qiang L, Wang H, Farmer SR. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 2007 27 : 4698 4707.
148. Ahn J, Lee H, Kim S, Ha T. Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2007 364 : 972 977.
149. Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 2007 47 : 185 210.
150. Misra P. AMP activated protein kinase: A next generation target for total metabolic control. Expert Opin Ther Targets 2008 12 : 91 100.
151. Motoshima H, Goldstein BJ, Igata M, Araki E. AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol 2006 574 : 63 71.
152. Zou MH, Wu Y. AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function. Clin Exp Pharmacol Physiol 2008 35 : 535 545.
153. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002 8 : 1288 1295.
154. Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and
155. Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003 278 : 45021 45026.
156. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004 279 : 1304 1309.
157. Gonon AT, Widegren U, Bulhak A, Salehzadeh F, Persson J, Sjoquist PO, Pernow J. Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide. Cardiovasc Res 2008 78 : 116 122.
158. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 2005 11 : 1096 1103.
159. Hattori Y, Nakano Y, Hattori S, Tomizawa A, Inukai K, Kasai K. High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells. FEBS Lett 2008 582 : 1719 1724.
160. Ouedraogo R, Wu X, Xu SQ, Fuchsel L, Motoshima H, Mahadev K, Hough K, Scalia R, Goldstein BJ. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: Evidence for involvement of a cAMP signaling pathway. Diabetes 2006 55 : 1840 1846.
161. Kistorp C, Faber J, Galatius S, Gustafsson F, Frystyk J, Flyvbjerg A, Hildebrandt P. Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation 2005 112 : 1756 1762.
162. George J, Patal S, Wexler D, Sharabi Y, Peleg E, Kamari Y, Grossman E, Sheps D, Keren G, Roth A. Circulating adiponectin concentrations in patients with congestive heart failure. Heart 2006 92 : 1420 1424.