메뉴 건너뛰기




Volumn 150, Issue 8, 2009, Pages 3584-3593

Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5′-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; PROTEIN KINASE B; SERINE; SMALL INTERFERING RNA;

EID: 67651162132     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0921     Document Type: Article
Times cited : (61)

References (51)
  • 1
    • 2942554887 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002
    • Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM 2004 Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 291:2847-2850
    • (2004) JAMA , vol.291 , pp. 2847-2850
    • Hedley, A.A.1    Ogden, C.L.2    Johnson, C.L.3    Carroll, M.D.4    Curtin, L.R.5    Flegal, K.M.6
  • 2
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world: A growing challenge
    • Hossain P, Kawar B, El Nahas M 2007 Obesity and diabetes in the developing world: a growing challenge. N Engl J Med 356:213-215
    • (2007) N Engl J Med , vol.356 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El Nahas, M.3
  • 3
    • 0032474427 scopus 로고    scopus 로고
    • American Heart Association call to action: Obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee
    • Eckel RH, Krauss RM 1998 American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 97:2099-2100
    • (1998) Circulation , vol.97 , pp. 2099-2100
    • Eckel, R.H.1    Krauss, R.M.2
  • 4
    • 0037048167 scopus 로고    scopus 로고
    • Overweight and obesity as determinants of cardiovascular risk: The Framingham experience
    • Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB 2002 Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 162:1867-1872
    • (2002) Arch Intern Med , vol.162 , pp. 1867-1872
    • Wilson, P.W.1    D'Agostino, R.B.2    Sullivan, L.3    Parise, H.4    Kannel, W.B.5
  • 5
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL 1998 Leptin and the regulation of body weight in mammals. Nature 395:763-770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 8
    • 33646518527 scopus 로고    scopus 로고
    • Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats
    • Bełtowski J, Wójcicka G, Jamroz-Wiœniewska A 2006 Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats. Life Sci 79:63-71
    • (2006) Life Sci , vol.79 , pp. 63-71
    • Bełtowski, J.1    Wójcicka, G.2    Jamroz-Wiœniewska, A.3
  • 9
    • 0037907471 scopus 로고    scopus 로고
    • Pivotal role of nitric oxide in the control of blood pressure after leptin administration
    • Frühbeck G 1999 Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 48:903-908
    • (1999) Diabetes , vol.48 , pp. 903-908
    • Frühbeck, G.1
  • 12
    • 0040671717 scopus 로고    scopus 로고
    • Human leptin stimulates systemic nitric oxide production in the rat
    • Beltowski J, Wójcicka G, Borkowska E 2002 Human leptin stimulates systemic nitric oxide production in the rat. Obes Res 10:939-946
    • (2002) Obes Res , vol.10 , pp. 939-946
    • Beltowski, J.1    Wójcicka, G.2    Borkowska, E.3
  • 15
    • 0033542414 scopus 로고    scopus 로고
    • Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC 1999 Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601
    • Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC 1999 Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601
  • 16
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM 1999 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 18
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway: New players upstream and downstream
    • Hardie DG 2004 The AMP-activated protein kinase pathway: new players upstream and downstream. J Cell Sci 117:5479-5487
    • (2004) J Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 19
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade: A unifying system for energy control
    • Carling D 2004 The AMP-activated protein kinase cascade: a unifying system for energy control. Trends Biochem Sci 29:18-24
    • (2004) Trends Biochem Sci , vol.29 , pp. 18-24
    • Carling, D.1
  • 20
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill GF, Kurth EJ, Hardie DG, Winder WW 1997 AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 273:E1107-E1112
    • (1997) Am J Physiol , vol.273
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 21
    • 0032765396 scopus 로고    scopus 로고
    • 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle
    • Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, Winder WW 1999 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48:1667-1671
    • (1999) Diabetes , vol.48 , pp. 1667-1671
    • Kurth-Kraczek, E.J.1    Hirshman, M.F.2    Goodyear, L.J.3    Winder, W.W.4
  • 23
    • 0029978799 scopus 로고    scopus 로고
    • Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
    • Winder WW, Hardie DG 1996 Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 270:E299-E304
    • (1996) Am J Physiol , vol.270
    • Winder, W.W.1    Hardie, D.G.2
  • 25
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • Davis BJ, Xie Z, Viollet B, Zou MH 2006 Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 55:496-505
    • (2006) Diabetes , vol.55 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.H.4
  • 26
    • 0242581695 scopus 로고    scopus 로고
    • Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    • Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ 2003 Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278:45021-45026
    • (2003) J Biol Chem , vol.278 , pp. 45021-45026
    • Chen, H.1    Montagnani, M.2    Funahashi, T.3    Shimomura, I.4    Quon, M.J.5
  • 27
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K 2004 Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 279:1304-1309
    • (2004) J Biol Chem , vol.279 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3    Kumada, M.4    Sato, K.5    Inoue, T.6    Funahashi, T.7    Walsh, K.8
  • 28
    • 4344628605 scopus 로고    scopus 로고
    • Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt
    • Thors B, Halldórsson H, Thorgeirsson G 2004 Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt. FEBS Lett 573:175-180
    • (2004) FEBS Lett , vol.573 , pp. 175-180
    • Thors, B.1    Halldórsson, H.2    Thorgeirsson, G.3
  • 29
    • 34547124878 scopus 로고    scopus 로고
    • Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK→Rac→Akt→endothelial nitric-oxide synthase pathway
    • Levine YC, Li GK, Michel T 2007 Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK→Rac→Akt→endothelial nitric-oxide synthase pathway. J Biol Chem 282:20351-20364
    • (2007) J Biol Chem , vol.282 , pp. 20351-20364
    • Levine, Y.C.1    Li, G.K.2    Michel, T.3
  • 30
    • 0042733154 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    • Nagata D, Mogi M, Walsh K 2003 AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem 278:31000-31006
    • (2003) J Biol Chem , vol.278 , pp. 31000-31006
    • Nagata, D.1    Mogi, M.2    Walsh, K.3
  • 31
    • 0041355355 scopus 로고    scopus 로고
    • Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells
    • Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP 2003 Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem 278:31629-31639
    • (2003) J Biol Chem , vol.278 , pp. 31629-31639
    • Morrow, V.A.1    Foufelle, F.2    Connell, J.M.3    Petrie, J.R.4    Gould, G.W.5    Salt, I.P.6
  • 33
    • 33846083468 scopus 로고    scopus 로고
    • Farooqi IS, O'Rahilly S 2007 Is leptin an important physiological regulator of CRP? Nat Med 13:16-17; author reply 19-21
    • Farooqi IS, O'Rahilly S 2007 Is leptin an important physiological regulator of CRP? Nat Med 13:16-17; author reply 19-21
  • 34
    • 33846087071 scopus 로고    scopus 로고
    • Hutchinson WL, Coll AP, Gallimore JR, Tennent GA, Pepys MB 2007 Is leptin an important physiological regulator of CRP? Nat Med 13:17-18; author reply 19-21
    • Hutchinson WL, Coll AP, Gallimore JR, Tennent GA, Pepys MB 2007 Is leptin an important physiological regulator of CRP? Nat Med 13:17-18; author reply 19-21
  • 35
    • 33846107585 scopus 로고    scopus 로고
    • Gertler A, Niv-Spector L, Reicher S 2007 Is leptin an important physiological regulator of CRP? Nat Med 13:18-19; author reply 19-21
    • Gertler A, Niv-Spector L, Reicher S 2007 Is leptin an important physiological regulator of CRP? Nat Med 13:18-19; author reply 19-21
  • 37
    • 0033537013 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels in overweight and obese adults
    • Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB 1999 Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131-2135
    • (1999) JAMA , vol.282 , pp. 2131-2135
    • Visser, M.1    Bouter, L.M.2    McQuillan, G.M.3    Wener, M.H.4    Harris, T.B.5
  • 38
    • 0030956673 scopus 로고    scopus 로고
    • Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
    • Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH 1997 Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336:973-979
    • (1997) N Engl J Med , vol.336 , pp. 973-979
    • Ridker, P.M.1    Cushman, M.2    Stampfer, M.J.3    Tracy, R.P.4    Hennekens, C.H.5
  • 40
    • 33847616879 scopus 로고    scopus 로고
    • C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport
    • D'Alessandris C, Lauro R, Presta I, Sesti G 2007 C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport. Diabetologia 50:840-849
    • (2007) Diabetologia , vol.50 , pp. 840-849
    • D'Alessandris, C.1    Lauro, R.2    Presta, I.3    Sesti, G.4
  • 45
    • 33846617797 scopus 로고    scopus 로고
    • C-reactive protein suppresses insulin signaling in endothelial cells: Role of spleen tyrosine kinase
    • Xu JW, Morita I, Ikeda K, Miki T, Yamori Y 2007 C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 21:564-573
    • (2007) Mol Endocrinol , vol.21 , pp. 564-573
    • Xu, J.W.1    Morita, I.2    Ikeda, K.3    Miki, T.4    Yamori, Y.5
  • 47
  • 48
    • 0141925771 scopus 로고    scopus 로고
    • Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    • Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JRB 2003 Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278:39422-39427
    • (2003) J Biol Chem , vol.278 , pp. 39422-39427
    • Kovacic, S.1    Soltys, C.L.2    Barr, A.J.3    Shiojima, I.4    Walsh, K.5    Dyck, J.R.B.6
  • 49
    • 0034604248 scopus 로고    scopus 로고
    • Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS)
    • Festa A, D'Agostino Jr R, Howard G, Mykkänen L, Tracey RP, Haffner SM 2000 Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-47
    • (2000) Circulation , vol.102 , pp. 42-47
    • Festa, A.1    D'Agostino Jr, R.2    Howard, G.3    Mykkänen, L.4    Tracey, R.P.5    Haffner, S.M.6
  • 50
    • 0033366583 scopus 로고    scopus 로고
    • Body mass index, diabetes, and C-reactive protein among US adults
    • Ford ES 1999 Body mass index, diabetes, and C-reactive protein among US adults. Diabetes Care 22:1971-1977
    • (1999) Diabetes Care , vol.22 , pp. 1971-1977
    • Ford, E.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.