Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs

Domestic Animal Endocrinology

Volumn 37, Issue 4, 2009, Pages 214-226

  German, A J ^a   Hervera, M ^b   Hunter, L ^a   Holden, S L ^a   Morris, P J ^c   Biourge, V ^d   Trayhurn, P ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

^d Royal Canin Research Center   (France)

Author keywords

Acute phase protein; Adipose tissue; Diabetes mellitus; Metabolic syndrome; Obesity

Indexed keywords

ACUTE PHASE PROTEIN; ADIPOCYTOKINE; CHEMOKINE; CYTOKINE; INSULIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; DOG; DOG DISEASE; FEMALE; GLUCOSE BLOOD LEVEL; IMMUNOLOGY; INSULIN RESISTANCE; MALE; METABOLISM; NONPARAMETRIC TEST; OBESITY; PHYSIOLOGY; WEIGHT REDUCTION;

ACUTE-PHASE PROTEINS; ADIPOKINES; ADIPOSITY; ANIMALS; BLOOD GLUCOSE; CHEMOKINES; CYTOKINES; DOG DISEASES; DOGS; FEMALE; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; STATISTICS, NONPARAMETRIC; WEIGHT LOSS;

CANIS FAMILIARIS;

EID: 70349976936     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2009.07.001     Document Type: Article

References (64)

1. Kopelman P.G. Obesity as a medical problem. Nature 404 (2000) 635-643
2. Lund E.M., Armstrong P.J., Kirk C.A., and Klausner J.S. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Int J Appl Res Vet Med. 4 (2000) 177-186
3. German A.J. The growing problem of obesity in dogs and cats. J Nutr. 136 (2006) 1940S-1946S
4. Bach J.F., Rozanski E.A., Bedenice D., et al. Association of expratory airway dysfunction with marked obesity in healthy adult dogs. Am J Vet Res. 68 (2007) 670-675
5. Weeth L.P., Fascetti A.J., Kass P.H., Suter S.E., Santos A.M., and Delaney S.J. Prevalence of obese dogs in a population of dogs with cancer. Am J Vet Res. 68 (2007) 389-398
6. Reisin E., and Alpert M.A. Definition of the metabolic syndrome: current proposals and controversies. Am J Med Sci. 330 (2005) 269-272
7. Diabetes U.K. Type 2 Diabetes & Obesity. A Heavy Burden (2005)
8. Marmor M., Willeberg P., Glickman L.T., Priester W.A., Cypress R.H., and Hurvitz A.I. Epizootiologic patterns of diabetes mellitus in dogs. Am J Vet Res. 43 (1982) 465-470
9. Davison L.J., Herrtage M.E., and Catchpole B. Study of 253 dogs in the United Kingdom with diabetes mellitus. Vet Rec. 156 (2005) 467-471
10. Fall T., Hamlin H.H., Hedhammar A., Kämpe O., and Egenvall A. Diabetes mellitus in a population of 180,000 insured dogs: incidence, survival, and breed distribution. J Vet Int Med. 21 (2007) 1209-1216
11. Hoenig M. Comparative aspects of diabetes mellitus in dogs and cats. Mol Cell Endocrinol. 2002; 197; (2002) 221-229
12. Rand J.S., Fleeman L.M., Harrow H.A., Appleton D.J., and Lederer R. Canine and feline diabetes mellitus: nature or nuture?. J Nutr. 134 (2004) 2072S-2080S
13. Catchpole B., Ristic J.M., Fleeman L.M., and Davison L.J. Canine diabetes mellitus: can old dogs teach us new tricks? Diabetologia. 48 (2005) 1948-1956
14. Bailhache E., Nguyen P., Krempf M., Siliart B., Magot T., and Ouquerram K. Lipoproteins abnormalities in obese insulin-resistant dogs. Metabolism. 52 (2003) 559-564
15. Gayet C., Bailhache E., Dumon H., Martin L., Siliart B., and Nguyen P. Insulin resistance and changes in plasma concentration of TNFα, IGF1, and NEFA in dogs during weight gain and obesity. J Anim Physiol Anim Nutr. 88 (2004) 157-165
16. Gayet C., Leray V., Saito M., Siliart B., and Nguyen P. The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor γ target genes in dogs. Brit J Nutr. 98 (2007) 497-503
17. Respondek F., Swanson K.S., Belsito K.R., et al. Short-chain fructooligosaccharides influence insulin sensitivity and gene expression of fat tissue in obese dogs. J Nutr. 138 (2008) 1712-1718
18. Larson B.T., Lawler D.F., Spitznagel Jr. E.L., and Kealy R.D. Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs. J Nutr. 133 (2003) 2887-2892
19. Mattheeuws D., Rottiers R., Baeyens D., and Vermeulen A. Glucose tolerance and insulin response in obese dogs. J Am Anim Hosp Assoc. 20 (1984) 287-293
20. Trayhurn P., and Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 60 (2001) 329-339
21. Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand. 84 (2005) 285-293
22. Yudkin J.S., Stehouwer C.D., Emeis J.J., and Coppack S.W. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol 19 (1999) 972-978
23. Trayhurn P., and Wood I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Brit J Nutr. 92 (2004) 347-355
24. Das U.N. Is obesity an inflammatory condition?. Nutr. 17 (2001) 953-966
25. Trayhurn P. Adipose tissue in obesity-an inflammatory issue. Endocrinology. 146 (2005) 1003-1005
26. Phelan S., Wadden T.A., Berkowitz R.I., et al. Impact of weight loss on the metabolic syndrome. Int J Obes (Lond). 31 (2007) 1442-1448
27. Manco M., Fernandez-Real J.M., Equitani F., et al. Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. J Clin Endocrinol Metab. 92 (2007) 483-490
28. Eisele I., Wood I.S., German A.J., Hunter L., and Trayhurn P. Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary culture. Hormone Metab Res. 37 (2005) 474-481
29. Ryan V.H., German A.J., Wood I.S., Hunter L., Morris P., and Trayhurn P. NGF Gene expression and secretion by canine adipocytes in primary culture: upregulation by the infl{ligature}ammatory mediators LPS and TNF-α. Hormone Metab Res. 40 (2008) 861-868
30. German A.J., Holden S.L., Bissot T., Hackett R.M., and Biourge V. Dietary energy restriction and successful weight loss in obese client-owned dogs. J Vet Intern Med. 21 (2007) 1174-1180
31. Laflamme D. Development and validation of a body condition score system for dogs. Canine Pract. 22 (1997) 10-15
32. Raffan E., Holden S.L., Cullingham F., Hackett R.M., Rawlings J.M., and German A.J. Standardized positioning is essential for precise determination of body composition using dual-energy x-ray absorptiometry in dogs. J Nutr. 136 (2006) 1976S-1978S
33. Martinez-Subiela S., Tecles F., and Ceron J.J. Critical differences of acute phase proteins in canine serum samples. Vet J. 166 (2003) 233-237
34. Martinez-Subiela S., Tecles F., and Ceron J.J. Evaluation of acute phase protein indexes in dogs with leishmaniasis at diagnosis, during and after short-term treatment. Vet Med (Praha). 50 (2005) 39-46
35. Bergman R.N., Ider Y.Z., Bowden C.R., and Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol. 236 (1979) E667-E677
36. DeFronzo R.A., Soman V., Sherwin R.S., Hendler R., and Felig P. Insulin binding to monocytes and insulin action in human obesity starvation and refeeding. J Clin Invest. 62 (1978) 204-213
37. Appleton D.J., Rand J.S., and Sunvold G.D. Basal plasma insulin and homeostasis model assessment (HOMA) are indicators of insulin sensitivity in cats. J Fel Med Surg. 7 (2005) 183-193
38. Burkholder W.J. Precision and practicality of methods assessing body composition of dogs and cats. Comp Cont Edu Pract Vet. 23 (2001) 1-10
39. Jeusette I.C., Detilleux J., Shibata H., et al. Effect of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dog. Res Vet Sci. 79 (2005) 169-175
40. Diez M., Michaux C., Jeusette I., Baldwin P., Istasse L., and Biourge V. Evolution of blood parameters in experimental obese beagle dogs. J Anim Physiol Anim Nutr. 88 (2004) 166-171
41. Hanusch-Enserer U., Cauza E., Spak M., et al. Improvement of Insulin Resistance and Early Atherosclerosis in Patients after Gastric Banding. Obes Res. 12 (2004) 284-291
42. Chikamune T., Katamoto H., Nomura K., and Ohashi F. Serum lipid and lipoprotein concentrations in obese dogs. J Am Vet Med Assoc. 57 (1998) 595-598
43. Bailhache E., Ouguerram K., Gayet C., et al. An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique. J Anim Physiol Anim Nutr. 87 (2003) 86-95
44. LeMay D.R., LeMay L.G., Kluger M.J., and D'Alecy L.G. Plasma profiles of IL-6 and TNF with fever-inducing doses of lipopolysaccharide in dogs. Am J Physiol. 259 (1990) R126-R132
45. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 259 (1993) 87-91
46. Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., and Spiegelman B.M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 95 (1995) 2409-2415
47. Mohamed-Ali V., Pinkney J.H., and Coppack S.W. Adipose tissue as an endocrine and paracrine organ. Int J Obes Rel Metab Dis. 22 (1998) 1145-1158
48. Mohamed-Ali V., Flower L., Sethi J., et al. beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab. 86 (2001) 5864-5869
49. Senn J.J., Klover P.J., Nowak I.A., and Mooney R.A. Interleukin-6 induces insulin resistance in hepatocytes. Diabetes. 51 (2002) 3391-3399
50. Rau S., Kohn B., Richter C., et al. Plasma interleukin-6 response is predictive for severity and mortality in canine systemic inflammatory response syndrome and sepsis. Vet Clin Pathol. 36 (2007) 253-260
51. Fain J.N., Madan A.K., Hiler M.L., Cheema P., and Bahouth S.W. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145 (2004) 2273-2282
52. Cook D.G., Mendall M.A., Whincup P.H., et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 149 (2000) 139-150
53. Putz D.M., Goldner W.S., Bar R.S., Haynes W.G., Sivitz W.I., and Adiponectin. C-reactive protein in obesity, type 2 diabetes, and monodrug therapy. Metabolism 53 (2004) 1454-1461
54. Yudkin J.S., Stehouwer C.D., Emeis J.J., and Coppack S.W. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol. 19 (1999) 972-978
55. Chiellini C., Bertacca A., Novelli S.E., et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol 190 (2002) 251-258
56. do Nascimento C.O., Hunter L., and Trayhurn P. Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma. Biochem Biophys res Comm 313 (2004) 702-708
57. McLaughlin T., Abbasi F., Lamendola C., et al. Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation 106 (2002) 2908-2912
58. Gerhardt C.C., Romero I.A., Cancello R., Camoin L., and Strosberg A.D. Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol. 175 (2001) 81-92
59. Kim C.S., Park H.S., Kawada T., et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond). 30 (2006) 1347-1355
60. Abbasi F., Chu J.W., Lamendola C., et al. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 53 (2004) 585-590
61. Ishioka K., Omachi A., Sagawa M., et al. Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Res Vet Sci. 80 (2006) 127-132
62. Brunson B.L., Zhong Q., Clarke K.J., et al. Serum concentrations of adiponectin and characterization of adiponectin protein complexes in dogs. Am J Vet Res. 68 (2007) 57-62
63. Diez J.J., and Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endorcrinol. 148 (2003) 293-300
64. Ishioka K., Hosoya K., Kitagawa H., et al. Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breed. Res Vet Sci. 82 (2007) 11-15