Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells

Obesity

Volumn 15, Issue 11, 2007, Pages 2571-2582

  Moon, Hyun Seuk ^a   Chung, Chung Soo ^b   Lee, Hong Gu ^a   Kim, Tae Gyu ^c   Choi, Yun Jaie ^a   Cho, Chong Su ^a  

^a Seoul National University   (South Korea)

^b Chungbuk National University   (South Korea)

^c Agribrands Purina Korea Inc   (South Korea)

Author keywords

Adenosine; Anti obesity; Cell signaling; Obesity treatment; Peroxisome proliferator activated

Indexed keywords

AMP ACTIVATED PROTEIN KINASE KINASE; AMP-ACTIVATED PROTEIN KINASE KINASE; ANTIOXIDANT; CATECHIN; CELL RECEPTOR; DNA BINDING PROTEIN; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; LIVER X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; LIPID METABOLISM; METABOLISM; MOUSE; PATHOLOGY; TIME;

3T3-L1 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOCYTES; ANIMALS; ANTIOXIDANTS; CATECHIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; LIPID METABOLISM; MICE; PPAR GAMMA; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TIME FACTORS;

EID: 38049030825     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.309     Document Type: Article

References (50)

1. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrel MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab. 2001;280:E827-47.
2. Lee WJ, Koh EH, Won JC, Kim MS, Park JY, Lee KU. Obesity: the role of hypothalamic AMP-activated protein kinase in body weight regulation. Int J Biochem Cell Biol. 2005;37:2254-9.
3. Kelly DE, Goodpaster BH. Skeletal muscle triglyceride an aspect of regional adiposity and insulin resistance. Diabetes Care. 2001;24:933-41.
4. Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005;48:1147-53.
5. Farmer SR, Auwerx J. Adipose tissue: new therapeutic targets from molecular and genetic studies: IASO Stock Conference 2003 report. Obes Rev. 2004;5:189-96.
6. Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes. 2001;50:S118-21.
7. Naef R, Jaquier A, Velluz A, Maurer B. New constituents related to 3-methyl-2,4-nonanedione identified in green tea. J Agric Food Chem. 2006;54:9201-5.
8. Liao S, Kao YH, Hiipakka RA. Green tea: biochemical and biological basis for health benefits. Vitam Horm. 2001;62:1-94.
9. Borse BB, Kumar HV, Rao LJ. Radical scavenging conserves from unused fresh green tea leaves. J Agric Food Chem. 2007;55:1750-4.
10. Ahmad N, Mukhtar H. Green tea polyphenols and cancer: biologic mechanisms and practical implications. Nutr Rev. 1999;57:78-83.
11. Lin JK, Liang YC, Lin-Shiau SY. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem Pharmacol. 1999;58:911-5.
12. Mitscher LA, Jung M, Shankel D, Dou JH, Steele L, Pillai SP. Chemoprotection: a review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituents. Med Res Rev. 1997;17:327-65.
13. Yang CS, Wang ZY. Tea and cancer. J Natl Cancer Inst. 1993;85:1038-49.
14. Haqqi TM, Anthony DD, Gupta S, et al. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA. 1999;96:4524-9.
15. Mendel S, Youdim MB. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radic Biol Med. 2004;37:304-17.
16. Song EK, Hur H, Han MK. Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice. Arch Pharmacol Res. 2003;26:559-63.
17. Kao YH, Hiipakka RA, Liao S. Modulation of obesity by a green tea catechin. Am J Clin Nutr. 2000;72:1232-4.
18. Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999;70:1040-5.
19. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000;24:252-8.
20. Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002;277:34933-40.
21. Weinreb O, Mandel S, Youdim MBH. cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells. FASEB J. 2003;17:935-7.
22. Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?. Annu Rev Biochem. 1998;67:821-55.
23. Kemp BE, Stapleton D, Campbell DJ, et al. AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans. 2003;31:162-8.
24. Shaw RJ, Kosmatka M, Bardeesy N, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA. 2004;101:3329-35.
25. Jones RG, Plas DR, Kubek S, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell. 2005;18:283-93.
26. Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci. 2005;26:69-76.
27. Song XM, Fiedler M, Galuska D, et al. 5-Aminoimidazole-4- carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia. 2002;45:56-65.
28. Meisse D, Van de Casteele M, Beauloye C, et al. Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett. 2002;526:38-42.
29. Horman S, Browne G, Krause U, et al. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol. 2002;12:1419-23.
30. Browne GJ, Finn SG, Proud CG. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem. 2002;279:12220-31.
31. Brown JM, Boysen MS, Jensen SS, et al. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res. 2003;44:1287-300.
32. Wise LS, Green H. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J Biol Chem. 1979;254:273-5.
33. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54.
34. Suryawan A, Hu CY. Effect of serum on differentiation of porcine adipose stromal-vascular cells in primary culture. Comp Biochem Physiol Comp Physiol. 1993;105:485-92.
35. Dalei S, Lazar MA. Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein alpha, and cell cycle status regulate the commitment to adipocyte differentiation. J Biol Chem. 1997;272:21473-8.
36. Wolfram S, Wang Y, Thielecke F. Anti-obesity effects of green tea: from bedside to bench. Mol Nutr Food Res. 2006;50:176-87.
37. Hung PF, Wu BT, Chen HC, Chen YH. Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. J Physiol Cell Physiol. 2005;288:C1094-108.
38. Scavo LM, Karas M, Murray M, Leroith D. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. J Clin Endocrinol Metab. 2004;89:3543-53.
39. Wolfram S, Raederstorff D, Wang Y, Teixeira SR, Elste V, Weber P. TEAVIGO (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass. Ann Nutr Metab. 2005;49:54-63.
40. Moussalli C, Downs RW, May JM. Potentiation by glucose of lipolytic responsiveness of human adipocytes. Diabetes. 1986;35:759-63.
41. Bhathena SJ, Velasquez MT. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr. 2002;76:1191-201.
42. Kawada T, Kamei Y, Fujita A, et al. Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors. Biofactors. 2000;13:103-109.
43. Moon HS, Lee HG, Seo JH, et al. Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis. Arch Biochem Biophys. 2006;456:19-29.
44. Moon HS, Guo DD, Song HH, et al. Regulation of adipocyte differentiation by PEGylated all-trans retinoic acid: reduced cytotoxicity and attenuated lipid accumulation. J Nutr Biochem. 2007;18:322-31.
45. Chu R, Madison LD, Lin Y, et al. Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways. Proc Natl Acad Sci USA. 1995;92:11593-7.
46. Furuyashiki T, Nagayasu H, Aoki Y, et al. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. Biosci Biotechnol Biochem. 2004;68:2353-9.
47. Juvet LK, Andresen SM, Schuster G, et al. On the role of liver X receptors in lipid accumulation in adipocytes. Mol Endocrinol. 2003;17:172-82.
48. Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord. 2002;26:1459-64.
49. Ahmad F, Khalid P, Khan MM, Rastogi AK, Kidwai JR. insulin like activity in (-) epicatechin. Acta Diabetol Lat. 1989;26:291-300.
50. Hii CS, Howell SL. Effects of epicatechin on rat islets of Langerhans. Diabetes. 1984;33:291-6.