Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS Pathway

International Journal of Obesity

Volumn 34, Issue 1, 2010, Pages 165-171

  Deng, G ^a   Long, Y ^a   Yu, Y R ^a   Li, M R ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Adiponectin; Endothelial dysfunction

Indexed keywords

ADENYLATE KINASE; ADIPONECTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; SERINE; SUPEROXIDE; THREONINE; FAT INTAKE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL INJURY; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRAABDOMINAL FAT; LIPID DIET; MALE; MOLECULAR MECHANICS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SPRAGUE DAWLEY RAT; VASODILATATION; ANIMAL; DRUG EFFECTS; FAT INTAKE; METABOLISM; MUSCLE RELAXATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADIPONECTIN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA; DIETARY FATS; ENDOTHELIUM, VASCULAR; MALE; MUSCLE RELAXATION; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

RATTUS;

EID: 74249096153     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.205     Document Type: Article

References (30)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-809.
2. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunctionF A marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003; 23: 168-175.
3. Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FJ, Donato AJ et al. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 2008; 52: 72-79.
4. Burke GL, Bertoni AG, Shea S, Tracy R, Watson KE, Blumenthal RS et al. The impact of obesity on cardiovascular disease risk factors and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arch Intern Med 2008; 168: 928-935.
5. Al Suwaidi J, Higano ST, Holmes Jr DR, Lennon R, Lerman A. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am Coll Cardiol 2001; 37: 1523-2152
6. Kawashima S, Yokoyama M. Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24: 998-1005.
7. Lavi S, Yang EH, Prasad A, Mathew V, Barsness GW, Rihal CS et al. The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans. Hypertension 2008; 51: 127-133.
8. Touyz RM, Schiffrin EL. Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 2004; 122: 339-352.
9. Okui H, Hamasaki S, Ishida S, Kataoka T, Orihara K, Fukudome T et al. Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunor-eactive insulin, or triglycerides. Int J Cardiol 2008; 126: 53-61.
10. Shimabukuro M, Higa N, Asahi T, Oshiro Y, Takasu N, Tagawa T et al. Hypoadiponectinemia is closely linked to endothe-lial dysfunction in man. J Clin Endocrinol Metab 2003; 88: 3236-3240.
11. Chow WS, Cheung BMY, Tso AWK, Xu AM, Wat NMS, Fong CHY et al. Hypoadiponectinemia as a predictor for the development of hypertensionFA 5-year prospective study. Hypertension 2007; 49: 1455-1461.
12. Koenig W, Khuseyinova N, Baumert J, Meisinger C, Lowel H. Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany. J Am Coll Cardiol 2006; 48: 1369-1377.
13. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003; 23: 85-89.
14. Everett SA, Dennis MF, Tozer GM, Prise VE, Wardman P, Stratford MRL. Nitric-oxide in biological-fluidsFanalysis of nitrite and nitrate by high-performance ion chromatography. In: Heftmann E (ed). 7th International Ion Chromatography Symposium (IICS 94). Elsevier Science BV: Turin, Italy, 1994. pp 437-442.
15. Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 2001; 22: 36-52.
16. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003; 42: 231-234.
17. Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, Hough K et al. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 2007; 117: 1718-1726.
18. Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A et al. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 2006; 47: 1108-1116.
19. Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003; 278: 45021-45026.
20. Hattori Y, Suzuki M, Hattori S, Kasai K. Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 2003; 46: 1543-1549.
21. Xi W, Satoh H, Kase H, Suzuki K, Hattori Y. Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: vasorelaxation in response to globular adiponectin. Biochem Biophys Res Commun 2005; 332: 200-205.
22. Motoshima H, Wu X, Mahadev K, Goldstein BJ. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 2004; 315: 264-271.
23. Ouedraogo R, Wu X, Xu SQ, Fuchsel L, Motoshima H, Mahadev K et al. Adiponectin suppression of high glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 2006; 55: 1840-1846.
24. Cao Y, Tao L, Yuan Y, Jiao X, Lau WB, Wang Y et al. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol 2009; 46: 413-419.
25. Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 2006; 55: 496-505.
26. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004; 279: 1304-1309. (Pubitemid 38082655)
27. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001; 88: 1264-1269.
28. Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 2003; 278: 2461-2468.
29. Montagnani M, Chen H, Barr VA, Quon MJ. Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem 2001; 276: 30392-30398.
30. Wu XD, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 2003; 52: 1355-1363.