Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial

JAMA

Volumn 289, Issue 14, 2003, Pages 1799-1804

  Esposito, Katherine ^a,b   Pontillo, Alessandro ^a   Di Palo, Carmen ^a   Giugliano, Giovanni ^a   Masella, Mariangela ^a   Marfella, Raffaele ^a   Giugliano, Dario ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Policlinico Universitario   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; INTERLEUKIN 18; INTERLEUKIN 6; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; SATURATED FATTY ACID; BIOLOGICAL MARKER; PROTEIN; SIGNAL PEPTIDE;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CALORIC INTAKE; CARBOHYDRATE INTAKE; CARDIOVASCULAR DISEASE; CHOLESTEROL INTAKE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; DIETARY FIBER; FAT INTAKE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE INTAKE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIFESTYLE; LOW CALORY DIET; MAJOR CLINICAL STUDY; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SINGLE BLIND PROCEDURE; WEIGHT REDUCTION; BLOOD; EXERCISE; METABOLISM; PHYSIOLOGY; PREMENOPAUSE; RISK REDUCTION;

ADIPONECTIN; ADULT; BIOLOGICAL MARKERS; BODY MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; DIET, REDUCING; EXERCISE; FEMALE; HUMANS; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-18; INTERLEUKIN-6; LIFE STYLE; OBESITY; PREMENOPAUSE; PROTEINS; RISK FACTORS; RISK REDUCTION BEHAVIOR; SINGLE-BLIND METHOD; WEIGHT LOSS;

EID: 0037840403     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.289.14.1799     Document Type: Article

References (30)

1. Serdula MK, Mokdad AH, Williamson DF, et al. Prevalence of attempting weight loss and strategies for controlling weight. JAMA. 1999;282:1353-1358.
2. National Task Force on the Prevention and Treatment of Obesity. Overweight, obesity, and health risk. Arch Intern Med. 2000;160:898-904.
3. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002;288:1723-1727.
4. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA. 2002;288:1728-1732.
5. Kopelman PG. Obesity as a medical problem. Nature. 2000;404:635-643.
6. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose tissue expression of tumor necrosis factor-α. Science. 1993;259:87-91.
7. Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab. 1997;82:4196-4200.
8. Maeda K, Okubo K, Shimomuro I, et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1. Biochem Biophys Res Commun. 1996;221:286-289.
9. Bastard JP, Jardel C, Bruckert E, et al. Elevated levels of interleukin-6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab. 2000;85:3338-3342.
10. Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation. 2002;105:804-809.
11. Esposito K, Pontillo A, Ciotola M, et al. Weight loss reduces interleukin-18 levels in obese women. J Clin Endocrinol Metab. 2002;87:3864-3866.
12. Yudkin JS, Stehouwer CD, Emeis JJ, et al. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction. Arterioscler Thromb Vasc Biol. 1999;19:972-978.
13. Ridker PM, Hennekens CH, Buring JE, Rifal N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836-843.
14. Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106:506-512.
15. Blankenberg S, Tiret L, Bickel C, et al. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation. 2002;106:24-30.
16. Stefan N, Stumvoll M. Adiponectin - its role in metabolism and beyond. Horm Metab Res. 2002;34:469-474.
17. Robertson RM, Smaha L. Can a Mediterranean style diet reduce heart disease? Circulation. 2001;103:1821-1822.
18. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
19. Corbi GM, Carbone S, Ziccardi P, et al. FFAs and QT intervals in obese women with visceral adiposity. J Clin Endocrinol Metab. 2002;87:2080-2083.
20. Freedman MR, King J, Kennedy E. Popular diets: a scientific review. Obes Res. 2001;9(suppl 1):1S-40S.
21. Stouthard JM, Romjin JA, Van Der Poll T, et al. Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol. 1995;268:ES13-ES19.
22. Yang W-S, Lee WJ, Funahashi T, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab. 2001;86:3815-3819.
23. Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of a 30 Kd adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A. 2001;98:2005-2010.
24. Egger G, Swinburn B. An ecological approach to the obesity pandemic. BMJ. 1997;315:477-480.
25. de Lorgeril M, Salen P, Martin I, et al. Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Circulation. 1999;99:779-785.
26. Singh RB, Dubnov G, Niaz MA, et al. Effect of Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study). Lancet. 2002;360:1455-1461.
27. Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. Circ Res. 2001;89:763-771.
28. Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003;23:85-89.
29. Heilbronn LK, Noakes M, Clifton MP. Energy restriction and weight loss on very-low-fat diet reduces C-reactive protein concentrations in obese, healthy women, Arterioscler Thromb Vasc Biol. 2001;21:968-970.
30. Tchernof A, Nolan A, Sites CK, Ades PA, Poehlman ET. Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation. 2002;105:564-569.