Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis

Journal of Biological Chemistry

Volumn 277, Issue 33, 2002, Pages 29424-29430

  Atkinson, Laura L ^a   Fischer, Melanie A ^a   Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CARDIOLOGY; FATTY ACIDS; GLYCEROL; METABOLISM; MUSCLE; OXIDATION;

LEPTIN; OXYGEN CONSUMPTION; PHOSPHORYLATION; TRIACYLGLYCEROL (TG);

ENZYMES;

ACETYL COENZYME A CARBOXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; MALONYL COENZYME A; TRIACYLGLYCEROL; ADENYLATE KINASE; FATTY ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HEART FUNCTION; LIPID STORAGE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; ANIMAL; HEART MUSCLE; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACETYL-COA CARBOXYLASE; ADENYLATE KINASE; ANIMALS; FATTY ACIDS; LEPTIN; MALE; MALONYL COENZYME A; MYOCARDIUM; OXIDATION-REDUCTION; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037119410     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203813200     Document Type: Article

References (46)

1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994) Nature 372, 425-432
2. Baile, C. A., Della-Fera, M. A., and Martin, R. J. (2000) Annu. Rev. Nutr. 20, 105-127
3. Hynes, G. R., and Jones, P. J. H. (2001) Curr. Opin. Lipidol. 12, 321-327
4. Shimabukuro, M., Koyama, K., Chen, G., Wang, M. Y., Trieu, F., Lee, Y., Newgard, C. B., and Unger, R. H. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4637-4641
5. Muoio, D. M., Dohm, G. L., Fiedorek, F. T., Jr., Tapscott, E. B., and Coleman, R. A. (1997) Diabetes 46, 1360-1363
6. Muoio, D. M., Dohm, G. L., Tapscott, E. B., and Coleman, R. A. (1999) Am. J. Physiol. 276, E913-E921
7. Steinberg, G. R., and Dyck, D. J. (2000) Am. J. Physiol. 279, E1374-E1382
8. Minokoshi, Y., Kim, Y. B., Peroni, O. D., Fryer, L. G., Muller, C., Carling, D., and Kahn, B. B. (2001) Nature 415, 339-343
9. Hardie, D. G., and Carling, D. (1997) Eur. J. Biochem. 246, 259-273
10. Saddik, M., Gamble, J., Witters, L. A., and Lopaschuk, G. D. (1993) J. Biol. Chem. 268, 25836-25845
11. McGarry, J. D., Stark, M. J., and Foster, D. W. (1978) J. Biol. Chem. 253, 8291-8293
12. Kudo, N., Gillespie, J. G., Kung, L., Witters, L. A., Schulz, R., Clanachan, A. S., and Lopaschuk, G. D. (1996) Biochim. Biophys. Acta 1301, 67-75
13. Kudo, N., Barr, A. J., Barr, R. L., Desai, S., and Lopaschuk, G. D. (1995) J. Biol. Chem. 270, 17513-17520
14. Muoio, D. M., Seefeld, K, Witters, L. A., and Coleman, R. A. (1999) Biochem. J. 338, 783-791
15. Tartaglia, L. A. (1997) J. Biol. Chem. 272, 6093-6096
16. Neely, J. R., and Morgan, H. E. (1974) Annu. Rev. Physiol. 36, 415-439
17. Carvalheira, J. B. C., Siloto, R. M. P., Ignacchitti, I., Brenelli, S. L., Carbalho, C. R. O., Leite, A., Velloso, L. A., Gontijo, J. A. R., and Saad, M. J. A. (2000) FEBS Lett. 500, 119-124
18. Szanto, I., and Kahn, C. R. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2355-2360
19. Kim, Y.-B., Uotani, S., Pierroz, D. D., Flier, J. S., and Kahn, B. B. (2000) Endocrinology 141, 2328-2339
20. Witters, L. A., and Kemp, B. E. (1992) J. Biol. Chem. 267, 284-2867
21. Gamble, J., and Lopaschuk, G. D. (1997) Metabolism 46, 1270-1274
22. Beauloye, C., Marsin, A. S., Bertrand, L., Krause, U., Hardie, D. G., Vanoverschelde, J. L., and Hue, L. (2001) FEBS Lett. 505, 348-352
23. Lopaschuk, G. D., and Barr, R. L. (1997) Mol. Cell. Biochem. 172, 137-147
24. Folch, J., Lees, M., and Stanley, G. H. S. (1957) J. Biol. Chem. 226, 497-509
25. Danno, H., Jincho, Y., Budiyanto, S., Furukawa, Y., and Kimura, S. (1992) J. Nutr. Sci. Vitaminol. 38, 517-521
26. Saddik, M., and Lopaschuk, G. D. (1991) J. Biol. Chem. 266, 8162-8170
27. Saddik, M., and Lopaschuk, G. D. (1992) J. Biol. Chem. 267, 3825-3831
28. King, M. T., and Reiss, P. D. (1985) Anal. Biochem. 146, 173-179
29. Davies, S. P., Hawley, S. A., Woods, A., Carling, D., Haystead, T. A. J., and Hardie, D. G. (1994) Eur. J. Biochem. 223, 251-357
30. Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., and Hardie, D. G. (1996) J. Biol. Chem. 271, 27879-27887
31. Moore, F., Weekes, J., and Hardie, D. G. (1991) Eur. J. Biochem. 199, 691-697
32. Ponticos, M., Lu, Q. L., Morgan, J. E., Hardie, D. G., Partridge, T. A., and Carling, D. (1998) EMBO J. 17, 1688-1699
33. Woods, A., Cheung, P. C. F., Smith, F. C., Davison, M. D., Scott, J., Beri, R. K, and Carling, D. (1996) J. Biol. Chem. 271, 10282-10290
34. Cheung, P. C. F., Salt, I. P., Davies, S. P., Hardie, D. G., and Carling, D. (2000) Biochem. J. 346, 659-669
35. Steinberg, G. R., Bonen, A., and Dyck, D. J. (2002) Am. J. Physiol. 282, E593-E600
36. Leyva, F., Godsland, I. F., Ghatei, M., Proudler, A. J., Aldis, S., Walton, C., Bloom, S., and Stevenson, J. C. (1998) Arterioscler. Thromb. Vasc. Biol. 18, 928-933
37. Liu, Q., Docherty, J. C., Rendell, J. C., Clanachan, A. S., and Lopaschuk, G. D. (2002) J. Am. Coll. Cardiol. 39, 718-725
38. Unger, R. H. (2002) Annu. Rev. Med. 53, 319-336
39. Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., and Unger, R. H. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1784-1789
40. Chiu, H.-C., Kovacs, A., Ford, D. A., Hsu, F.-F., Garcia, R., Herrero, P., Saffitz, J. E., and Schaffer, J. E. (2001) J. Clin. Invest. 107, 813-822
41. Corr, P. B., Creer, M. H., Yamada, K. A., Saffitz, J. E., and Sobel, B. E. (1989) J. Clin. Invest. 83, 927-936
42. Regan, T. J., and Weisse, A. B. (1992) J. Am. Coll. Cardiol. 19, 1165-1166
43. Zoneraich, S., and Mollura, J. L. (1993) Can. J. Cardiol. 9, 293-299
44. Fiordaliso, F., Latini, R., Li, B., Malhotra, A., and Kajstura, J. (1999) Circulation 100, Suppl. 1, 759
45. Yamagishi, S.-I., Edelstein, D., Du, X.-L., Kaneda, Y., Guzman, M., and Brownlee, M. (2001) J. Biol. Chem. 276, 25096-25100
46. Zhang, C. Y., Hagen, T., Mootha, V. K., Slieker, L. J., and Lowell, B. B. (1999) FEBS Lett. 449, 129-134