A reduction in the amount and anti-contractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats

Hypertension Research

Volumn 31, Issue 7, 2008, Pages 1415-1423

  Gálvez Prieto, Beatriz ^a   Dubrovska, Galyna ^b   Cano, M Victoria ^c   Delgado, Mercedes ^a   Aranguez, Isabel ^a   Gonzalez, M Carmen ^d   Ruiz Gayo, Mariano ^c   Gollasch, Maik ^b   Fernández Alfonso, Maria S ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Dpto Q Inorg Mat   (Spain)

^d AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

Author keywords

Adipocyte derived relaxing factor; Mesenteric arteries; Periadventitial adipose tissue; Prehypertension; Spontaneously hypertensive rat

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; SEROTONIN;

ADIPOSE TISSUE BLOOD FLOW; ADVENTITIA; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY BLOOD FLOW; ARTICLE; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE COURSE; HYPERTENSION; INTRAABDOMINAL FAT; MALE; MESENTERIC ARTERY; NONHUMAN; PATHOPHYSIOLOGY; RAT; SMOOTH MUSCLE CONTRACTION; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

4-AMINOPYRIDINE; ADIPOSE TISSUE; ANIMALS; HYPERTENSION; MALE; MESENTERIC ARTERIES; NITRIC OXIDE; NOREPINEPHRINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SPLANCHNIC CIRCULATION; VASOCONSTRICTION;

EID: 55449093720     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.31.1415     Document Type: Article

References (26)

1. Soltis EE, Cassis LA: Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens 1991; 275: 681-692.
2. Löhm M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM: Periadventitial fat releases a vascular relaxing factor. FASEB J 2002; 16: 1057-1063.
3. Gao YJ, Lu C, Su LY, Sharma AM, Lee RM: Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol 2007; 151: 323-331.
4. Verlohren S, Dubrovska G, Tsang SY, et al: Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 2004; 44: 271-276.
5. Gálvez B, de Castro J, Herold D, et al: Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 2006; 26: 1297-1302.
6. Gao YJ, Zeng ZH, Teoh K, et al: Perivascular adipose tissue modulates vascular function in the human internal thoracic artery. J Thorac Cardiovasc Surg 2005; 130: 1130-1136.
7. DiGirolamo M, Fine JB, Tagra KR: Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. Am J Phsyiol 1998; 274: 1460-1467.
8. Lee RMKW: Vascular changes at the prehypertensive phase in the mesenteric arteries from spontaneously hypertensive rats. Blood Vessels 1985; 22: 105-126.
9. Tsuji T, Su C, Lee FJF: Enhanced presynaptic beta-2-adrenoceptor mediated facilitation of the pressor responses in the prehypertensive SHR. J Cardiovasc Pharmacol 1989; 14: 737-746.
10. Rioux F, Berkowitz BA: Role of the thyroid gland in the development and maintenance of spontaneous hypertension in rats. Circ Res 1977; 40: 306-312.
11. Dickhout JG, Lee RM: Blood pressure and heart rate development in young spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 1998; 274: 794-800.
12. Dickhout JG, Lee RM: Structural and functional analysis of small arteries from young spontaneously hypertensive rats. Hypertension 1997; 29: 781-789.
13. McGregor DD: The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat. J Physiol 1965; 177: 21-30.
14. Mulvany MJ, Halpern W: Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977; 41: 19-26.
15. Frohlich ED, Pfeffer MA: Adrenergic mechanisms in human hypertension and in spontaneously hypertensive rats. Clin Sci Mol Med 1975; 2: 225-238.
16. Cabassi A, Vinci S, Cantoni AM, et al: Sympathetic activation in adipose tissue and skeletal muscle of hypertensive rats. Hypertension 2002; 36: 656-661.
17. Youngstrom TG, Bartness TJU: White adipose tissue sympathetic nervous system denervation increases fat pad mass and fat cell number. Am J Physiol 1998; 275: R1488-R1493.
18. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ: The biology of white adipocyte proliferation. Obesity Rev 2002; 2: 239-254.
19. Hwa JJ, Ghibaudi L, Williams P, Chatterjee M: Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed. Am J Physiol 1994; 266: 952-958.
20. G-nitro-L-arginine in rats. J Physiol Heart Circ Physiol 1992; 263: 1090-1094.
21. Shimokawa H, Yasutake H, Fujii K, et al: The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J Cardiovasc Pharmacol 1996; 28: 703-711.
22. Tomioka H, Hattori Y, Fukao M, et al: Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: importance of processes mediating precontractions. J Vasc Res 1999; 36: 311-320.
23. Schwartz MW, Peskind E, Raskin M, Boyko EJ, Porte D Jr: Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2: 589-593.
24. Kong JQ, Taylor DA, Fleming WW: Mesenteric vascular responses of young spontaneously hypertensive rats. J Pharmacol Exp Ther 1991; 258: 13-17.
25. Rizzoni D, Castellano M, Porteri E, Bettoni G, Muiesan ML, Agabiti-Rosei E: Vascular structural and functional alterations before and after the development of hypertension in SHR. Am J Hypertens 1994; 7: 193-200.
26. Gao YJ, Holloway AC, Zeng ZH, et al: Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function. Obes Res 2005; 13: 687-692.