In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 1, 2008, Pages

  Sheikh, Ahmad Y ^a   Chun, Hyung J ^a   Glassford, Alexander J ^a   Kundu, Ramendera K ^a   Kutschka, Ingo ^a   Ardigo, Diego ^a   Hendry, Stephen L ^a   Wagner, Roger A ^a   Chen, Mary M ^a   Ali, Ziad A ^a   Yue, Patrick ^a   Huynh, Diem T ^a   Connolly, Andrew J ^a   Pelletier, Marc P ^a   Tsao, Philip S ^a   Robbins, Robert C ^a   Quertermous, Thomas ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Congestive heart failure; Endothelium; Gene expression

Indexed keywords

APELIN; BETA GALACTOSIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HEART FAILURE; HEART MUSCLE INJURY; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION;

ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARRIER PROTEINS; CELL HYPOXIA; CELLS, CULTURED; CORONARY VESSELS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION PROFILING; GENES, REPORTER; HEART FAILURE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LAC OPERON; LIGATION; LUNG; MICE; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROMOTER REGIONS (GENETICS); QUADRICEPS MUSCLE; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 38149051165     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00935.2007     Document Type: Article

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