Leptin stimulates rat aortic smooth muscle cell proliferation and migration

Kobe Journal of Medical Sciences

Volumn 47, Issue 3, 2001, Pages 141-150

  Oda, A ^a   Taniguchi, T ^a   Yokoyama, M ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Leptin; MAP kinase; Migration; PI 3 kinase; Proliferation; Vascular smooth muscle cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE; WORTMANNIN;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CARDIOVASCULAR DISEASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY EXPENDITURE; ENZYME ACTIVITY; FOOD INTAKE; NONHUMAN; OBESITY; PHOSPHORYLATION; PROTEIN SECRETION; RAT; RISK FACTOR; SMOOTH MUSCLE FIBER; VASCULAR LESION; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; AORTA, THORACIC; CARRIER PROTEINS; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHROMONES; ENZYME INHIBITORS; HUMANS; LEPTIN; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PHOSPHOTYROSINE; RATS; RECEPTORS, CELL SURFACE;

EID: 0035206659     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. The pathogenesis of atherosclerosis - An update
2. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: The Manitoba study
3. Weight and thirty-year mortality of men in the Framingham study
4. Body weight and mortality among women
5. Subgroup analyses of the major clinical endpoints in the Program on the Surgical Control of the Hyperlipidemias (POSCH): Overall mortality, atherosclerotic coronary heart disease (ACHD) mortality, and ACHD mortality or myocardial infarction
6. A prospective study of obesity and risk of coronary heart disease in women
7. Positional cloning of the mouse obese gene and its human homologue
8. Identification and expression cloning of a leptin receptor, OB-R
9. Abnormal splicing of the leptin receptor in diabetic mice
10. Identification of targets of leptin action in rat hypothalamus
11. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
12. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization
13. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
14. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
15. Leptin stimulates fetal and adult erythroid and myeloid development
16. Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells
17. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells
18. Leptin induces proliferation of pancreatic β cell line MIN6 through activation of mitogen-activated protein kinase
19. Leptin, the product of Obgene, promotes angiogenesis
20. Biological action of leptin as an angiogenic factor
21. Functional angiotensin II receptors in cultured vascular smooth muscle cells
22. Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21 (waf1/cip1/sdi1) and p53
23. Effects of lipoprotein(a) and low density lipoprotein on growth of mitogen-stimulated human umbilical vein endothelial cells
24. Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells
25. Phosphatidylinositol kinase or associated protein is a substrate for the insulin receptor tyrosine kinase
26. Divergent signaling capacities of the long and short isoforms of the leptin receptor
27. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
28. Angiotensin II type 1 receptor-mediated activation of Ras in cultured rat vascular smooth muscle cells
29. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase
30. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
31. Defective STAT signaling by the leptin receptor in diabetic mice
32. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
33. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
34. Leptin receptor signal transduction: OBRa and OBRb of fa type
35. Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase
36. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
37. A short form of leptin receptor performs signal transduction
38. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
39. Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation
40. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury
41. NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses