메뉴 건너뛰기




Volumn 1835, Issue 1, 2013, Pages 46-60

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma

Author keywords

Apoptosis; Hepatocellular carcinoma; Invasion; JAKs; Proliferation; STAT3

Indexed keywords

17 HYDROXY JOLKINOLIDE B; 2 (1 CHLOROPROPENYL) 4,5 DIHYDROXY CYCLOPENT 2 ENOME; 2 METHOXYESTRA 1,3,5(10),16 TETRAENE 3 CARBOXAMIDE; 4 [[(4 METHYLPHENYL)SULFONYLOXY]ACETAMIDO]SALICYLIC ACID; ANTIPRIMOD; ANTISENSE OLIGONUCLEOTIDE; BETA ESCIN; BUTEIN; CELECOXIB; DIOSGENIN; GALIELLALACTONE; GAMMA TOCOTRIENOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; JANUS KINASE; LIFICIGUAT; LUTEOLIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PARTHENOLIDE; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE; SD 1029; SORAFENIB; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STATTIC; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 84868693885     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2012.10.002     Document Type: Review
Times cited : (267)

References (283)
  • 2
    • 46049111422 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: current management and recent advances
    • Lau W.Y., Lai E.C. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat. Dis. Int. 2008, 7:237-257.
    • (2008) Hepatobiliary Pancreat. Dis. Int. , vol.7 , pp. 237-257
    • Lau, W.Y.1    Lai, E.C.2
  • 3
    • 0346786563 scopus 로고    scopus 로고
    • Clinical significance of combination study of apoptotic factors and proliferating cell nuclear antigen in estimating the prognosis of hepatocellular carcinoma
    • Osada S., Saji S., Kuno T. Clinical significance of combination study of apoptotic factors and proliferating cell nuclear antigen in estimating the prognosis of hepatocellular carcinoma. J. Surg. Oncol. 2004, 85:48-54.
    • (2004) J. Surg. Oncol. , vol.85 , pp. 48-54
    • Osada, S.1    Saji, S.2    Kuno, T.3
  • 5
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block T.M., Mehta A.S., Fimmel C.J., Jordan R. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003, 22:5093-5107.
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 7
    • 31144437639 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: therapy and prevention
    • Blum H.E. Hepatocellular carcinoma: therapy and prevention. World J. Gastroenterol. 2005, 11:7391-7400.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 7391-7400
    • Blum, H.E.1
  • 9
    • 0035490269 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: from bedside to proteomics
    • Seow T.K., Liang R.C., Leow C.K., Chung M.C. Hepatocellular carcinoma: from bedside to proteomics. Proteomics 2001, 1:1249-1263.
    • (2001) Proteomics , vol.1 , pp. 1249-1263
    • Seow, T.K.1    Liang, R.C.2    Leow, C.K.3    Chung, M.C.4
  • 10
    • 20544454121 scopus 로고    scopus 로고
    • Liver cancer on the rise
    • Wilson J.F. Liver cancer on the rise. Ann. Intern. Med. 2005, 142:1029-1032.
    • (2005) Ann. Intern. Med. , vol.142 , pp. 1029-1032
    • Wilson, J.F.1
  • 11
    • 0141626825 scopus 로고    scopus 로고
    • Mechanisms of viral hepatitis induced liver injury
    • Nakamoto Y., Kaneko S. Mechanisms of viral hepatitis induced liver injury. Curr. Mol. Med. 2003, 3:537-544.
    • (2003) Curr. Mol. Med. , vol.3 , pp. 537-544
    • Nakamoto, Y.1    Kaneko, S.2
  • 12
    • 33947236184 scopus 로고    scopus 로고
    • Hepatitis viruses: live and let die
    • Herzer K., Sprinzl M.F., Galle P.R. Hepatitis viruses: live and let die. Liver Int. 2007, 27:293-301.
    • (2007) Liver Int. , vol.27 , pp. 293-301
    • Herzer, K.1    Sprinzl, M.F.2    Galle, P.R.3
  • 13
    • 0028998145 scopus 로고
    • Clinical outcomes after transfusion-associated hepatitis C
    • Tong M.J., el-Farra N.S., Reikes A.R., Co R.L. Clinical outcomes after transfusion-associated hepatitis C. N. Engl. J. Med. 1995, 332:1463-1466.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1463-1466
    • Tong, M.J.1    el-Farra, N.S.2    Reikes, A.R.3    Co, R.L.4
  • 14
    • 0036859903 scopus 로고    scopus 로고
    • Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma
    • Hino O., Kajino K., Umeda T., Arakawa Y. Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma. J. Gastroenterol. 2002, 37:883-887.
    • (2002) J. Gastroenterol. , vol.37 , pp. 883-887
    • Hino, O.1    Kajino, K.2    Umeda, T.3    Arakawa, Y.4
  • 15
    • 17244367083 scopus 로고    scopus 로고
    • Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis
    • Feitelson M.A., Reis H.M., Liu J., Lian Z., Pan J. Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis. Front. Biosci. 2005, 10:1558-1572.
    • (2005) Front. Biosci. , vol.10 , pp. 1558-1572
    • Feitelson, M.A.1    Reis, H.M.2    Liu, J.3    Lian, Z.4    Pan, J.5
  • 16
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • Bouchard M.J., Schneider R.J. The enigmatic X gene of hepatitis B virus. J. Virol. 2004, 78:12725-12734.
    • (2004) J. Virol. , vol.78 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 17
    • 0027409855 scopus 로고
    • Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway
    • Kekule A.S., Lauer U., Weiss L., Luber B., Hofschneider P.H. Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 1993, 361:742-745.
    • (1993) Nature , vol.361 , pp. 742-745
    • Kekule, A.S.1    Lauer, U.2    Weiss, L.3    Luber, B.4    Hofschneider, P.H.5
  • 18
    • 0034597514 scopus 로고    scopus 로고
    • Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma
    • Yeh C.T., Shen C.H., Tai D.I., Chu C.M., Liaw Y.F. Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma. Oncogene 2000, 19:5213-5220.
    • (2000) Oncogene , vol.19 , pp. 5213-5220
    • Yeh, C.T.1    Shen, C.H.2    Tai, D.I.3    Chu, C.M.4    Liaw, Y.F.5
  • 19
    • 0029813585 scopus 로고    scopus 로고
    • Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinoma
    • Hsia C.C., Yuwen H., Tabor E. Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinoma. Lancet 1996, 348:625-626.
    • (1996) Lancet , vol.348 , pp. 625-626
    • Hsia, C.C.1    Yuwen, H.2    Tabor, E.3
  • 20
    • 0032499801 scopus 로고    scopus 로고
    • Three-dimensional structure of the Stat3beta homodimer bound to DNA
    • Becker S., Groner B., Muller C.W. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998, 394:145-151.
    • (1998) Nature , vol.394 , pp. 145-151
    • Becker, S.1    Groner, B.2    Muller, C.W.3
  • 21
    • 0031879557 scopus 로고    scopus 로고
    • In situ detection of hepatitis B, C, and G virus nucleic acids in human hepatocellular carcinoma tissues from different geographic regions
    • Abe K., Edamoto Y., Park Y.N., Nomura A.M., Taltavull T.C., Tani M., Thung S.N. In situ detection of hepatitis B, C, and G virus nucleic acids in human hepatocellular carcinoma tissues from different geographic regions. Hepatology 1998, 28:568-572.
    • (1998) Hepatology , vol.28 , pp. 568-572
    • Abe, K.1    Edamoto, Y.2    Park, Y.N.3    Nomura, A.M.4    Taltavull, T.C.5    Tani, M.6    Thung, S.N.7
  • 22
    • 84870308518 scopus 로고
    • Hepatitis B virus
    • R.J. Fortner JC (Ed.) Accomplishment in Cancer Research 1987, JP Lippincot, 1988, Philadelphia
    • R. Beasley, Hepatitis B virus. The major etiology of hepatocelluar carcinoma, in: R.J. Fortner JC (Ed.) Accomplishment in Cancer Research 1987, JP Lippincot, 1988, Philadelphia, 1987.
    • (1987) The major etiology of hepatocelluar carcinoma
    • Beasley, R.1
  • 23
    • 0036848564 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus proteins with host cell membranes and lipids
    • Dubuisson J., Penin F., Moradpour D. Interaction of hepatitis C virus proteins with host cell membranes and lipids. Trends Cell Biol. 2002, 12:517-523.
    • (2002) Trends Cell Biol. , vol.12 , pp. 517-523
    • Dubuisson, J.1    Penin, F.2    Moradpour, D.3
  • 24
    • 0035933837 scopus 로고    scopus 로고
    • Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase
    • Bureau C., Bernad J., Chaouche N., Orfila C., Beraud M., Gonindard C., Alric L., Vinel J.P., Pipy B. Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase. J. Biol. Chem. 2001, 276:23077-23083.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23077-23083
    • Bureau, C.1    Bernad, J.2    Chaouche, N.3    Orfila, C.4    Beraud, M.5    Gonindard, C.6    Alric, L.7    Vinel, J.P.8    Pipy, B.9
  • 25
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G., Waris G., Tanveer R., Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:9599-9604.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 26
    • 20344366296 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: molecular pathways and new therapeutic targets
    • Roberts L.R., Gores G.J. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin. Liver Dis. 2005, 25:212-225.
    • (2005) Semin. Liver Dis. , vol.25 , pp. 212-225
    • Roberts, L.R.1    Gores, G.J.2
  • 28
    • 33644759114 scopus 로고    scopus 로고
    • The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence
    • El-Serag H.B., Hampel H., Javadi F. The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin. Gastroenterol. Hepatol. 2006, 4:369-380.
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 369-380
    • El-Serag, H.B.1    Hampel, H.2    Javadi, F.3
  • 29
    • 24044536090 scopus 로고    scopus 로고
    • Recent concepts in non-alcoholic fatty liver disease
    • Adams L.A., Angulo P. Recent concepts in non-alcoholic fatty liver disease. Diabet. Med. 2005, 22:1129-1133.
    • (2005) Diabet. Med. , vol.22 , pp. 1129-1133
    • Adams, L.A.1    Angulo, P.2
  • 30
    • 76549084356 scopus 로고    scopus 로고
    • Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link
    • Toffanin S., Friedman S.L., Llovet J.M. Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link. Cancer Cell 2010, 17:115-117.
    • (2010) Cancer Cell , vol.17 , pp. 115-117
    • Toffanin, S.1    Friedman, S.L.2    Llovet, J.M.3
  • 31
    • 0035127525 scopus 로고    scopus 로고
    • Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease
    • Fracanzani A.L., Conte D., Fraquelli M., Taioli E., Mattioli M., Losco A., Fargion S. Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology 2001, 33:647-651.
    • (2001) Hepatology , vol.33 , pp. 647-651
    • Fracanzani, A.L.1    Conte, D.2    Fraquelli, M.3    Taioli, E.4    Mattioli, M.5    Losco, A.6    Fargion, S.7
  • 35
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas S.M., Brugge J.S. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 1997, 13:513-609.
    • (1997) Annu. Rev. Cell Dev. Biol. , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 36
    • 0002651574 scopus 로고
    • Exagenous Steroid Hormones and Hepatocellular Carcinoma
    • Gulf Publishing Company, Houston, A.D.B.E. Tabor, R.H. Purcell (Eds.)
    • Thomas D. Exagenous Steroid Hormones and Hepatocellular Carcinoma. Etiology, Pathology and Treatment of Hepatocellular Carcinoma in North America 1991, Gulf Publishing Company, Houston. A.D.B.E. Tabor, R.H. Purcell (Eds.).
    • (1991) Etiology, Pathology and Treatment of Hepatocellular Carcinoma in North America
    • Thomas, D.1
  • 37
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
    • Shuai K., Stark G.R., Kerr I.M., Darnell J.E. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 1993, 261:1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell, J.E.4
  • 38
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell J.E., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 39
    • 0031105579 scopus 로고    scopus 로고
    • The JAK-STAT pathway in Drosophila
    • Hou X.S., Perrimon N. The JAK-STAT pathway in Drosophila. Trends Genet. 1997, 13:105-110.
    • (1997) Trends Genet. , vol.13 , pp. 105-110
    • Hou, X.S.1    Perrimon, N.2
  • 40
    • 0001514956 scopus 로고    scopus 로고
    • Identification of a Stat gene that functions in Drosophila development
    • Yan R., Small S., Desplan C., Dearolf C.R., Darnell J.E. Identification of a Stat gene that functions in Drosophila development. Cell 1996, 84:421-430.
    • (1996) Cell , vol.84 , pp. 421-430
    • Yan, R.1    Small, S.2    Desplan, C.3    Dearolf, C.R.4    Darnell, J.E.5
  • 41
    • 0030935791 scopus 로고    scopus 로고
    • Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling
    • Ueno H., Sasaki K., Miyagawa K., Honda H., Mitani K., Yazaki Y., Hirai H. Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling. J. Biol. Chem. 1997, 272:8739-8743.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8739-8743
    • Ueno, H.1    Sasaki, K.2    Miyagawa, K.3    Honda, H.4    Mitani, K.5    Yazaki, Y.6    Hirai, H.7
  • 42
    • 0033557744 scopus 로고    scopus 로고
    • Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection
    • Barillas-Mury C., Han Y.S., Seeley D., Kafatos F.C. Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection. EMBO J. 1999, 18:959-967.
    • (1999) EMBO J. , vol.18 , pp. 959-967
    • Barillas-Mury, C.1    Han, Y.S.2    Seeley, D.3    Kafatos, F.C.4
  • 43
    • 0032771170 scopus 로고    scopus 로고
    • Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line
    • Oates A.C., Wollberg P., Pratt S.J., Paw B.H., Johnson S.L., Ho R.K., Postlethwait J.H., Zon L.I., Wilks A.F. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev. Dyn. 1999, 215:352-370.
    • (1999) Dev. Dyn. , vol.215 , pp. 352-370
    • Oates, A.C.1    Wollberg, P.2    Pratt, S.J.3    Paw, B.H.4    Johnson, S.L.5    Ho, R.K.6    Postlethwait, J.H.7    Zon, L.I.8    Wilks, A.F.9
  • 44
    • 32144438326 scopus 로고    scopus 로고
    • Signal Transducers and Activators of Transcription (STATs): Activation and Biology
    • Kluwer Academic Publishers, The Netherlands, T. Hirano, P. Shegal (Eds.)
    • Heim M. Signal Transducers and Activators of Transcription (STATs): Activation and Biology. The Stat protein family 2003, vol. 2:11-26. Kluwer Academic Publishers, The Netherlands. T. Hirano, P. Shegal (Eds.).
    • (2003) The Stat protein family , vol.2 , pp. 11-26
    • Heim, M.1
  • 45
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg J. Stat proteins and oncogenesis. J. Clin. Invest. 2002, 109:1139-1142.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 48
    • 85047689502 scopus 로고    scopus 로고
    • Hepatoprotection via the IL-6/Stat3 pathway
    • Taub R. Hepatoprotection via the IL-6/Stat3 pathway. J. Clin. Invest. 2003, 112:978-980.
    • (2003) J. Clin. Invest. , vol.112 , pp. 978-980
    • Taub, R.1
  • 49
    • 0345017786 scopus 로고    scopus 로고
    • Transcription factors in liver development, differentiation, and regeneration
    • Costa R.H., Kalinichenko V.V., Holterman A.X., Wang X. Transcription factors in liver development, differentiation, and regeneration. Hepatology 2003, 38:1331-1347.
    • (2003) Hepatology , vol.38 , pp. 1331-1347
    • Costa, R.H.1    Kalinichenko, V.V.2    Holterman, A.X.3    Wang, X.4
  • 50
    • 0041785525 scopus 로고    scopus 로고
    • The molecular physiology of liver regeneration following partial hepatectomy
    • Mangnall D., Bird N.C., Majeed A.W. The molecular physiology of liver regeneration following partial hepatectomy. Liver Int. 2003, 23:124-138.
    • (2003) Liver Int. , vol.23 , pp. 124-138
    • Mangnall, D.1    Bird, N.C.2    Majeed, A.W.3
  • 51
    • 0027441586 scopus 로고
    • Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
    • Wegenka U.M., Buschmann J., Lutticken C., Heinrich P.C., Horn F. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 1993, 13:276-288.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 276-288
    • Wegenka, U.M.1    Buschmann, J.2    Lutticken, C.3    Heinrich, P.C.4    Horn, F.5
  • 52
    • 0028349735 scopus 로고
    • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z., Wen Z., Darnell J.E. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994, 264:95-98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 54
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S., Nishio Y., Inoue M., Wang X.J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994, 77:63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 55
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990, 63:1149-1157.
    • (1990) Cell , vol.63 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Taga, T.5    Kishimoto, T.6
  • 56
    • 0031429943 scopus 로고    scopus 로고
    • Signaling mechanisms through gp130: a model of the cytokine system
    • Hirano T., Nakajima K., Hibi M. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 1997, 8:241-252.
    • (1997) Cytokine Growth Factor Rev. , vol.8 , pp. 241-252
    • Hirano, T.1    Nakajima, K.2    Hibi, M.3
  • 57
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • Stahl N., Farruggella T.J., Boulton T.G., Zhong Z., Darnell J.E., Yancopoulos G.D. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 1995, 267:1349-1353.
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell, J.E.5    Yancopoulos, G.D.6
  • 59
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence
    • Trikha M., Corringham R., Klein B., Rossi J.F. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin. Cancer Res. 2003, 9:4653-4665.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 60
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler W.E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A.M., Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007, 317:121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 61
    • 0033970969 scopus 로고    scopus 로고
    • Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
    • Kovalovich K., DeAngelis R.A., Li W., Furth E.E., Ciliberto G., Taub R. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology 2000, 31:149-159.
    • (2000) Hepatology , vol.31 , pp. 149-159
    • Kovalovich, K.1    DeAngelis, R.A.2    Li, W.3    Furth, E.E.4    Ciliberto, G.5    Taub, R.6
  • 65
    • 77956238512 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells
    • Liu Y., Li P.K., Li C., Lin J. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. J. Biol. Chem. 2010, 285:27429-27439.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27429-27439
    • Liu, Y.1    Li, P.K.2    Li, C.3    Lin, J.4
  • 66
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver
    • Alonzi T., Maritano D., Gorgoni B., Rizzuto G., Libert C., Poli V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol. Cell. Biol. 2001, 21:1621-1632.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1621-1632
    • Alonzi, T.1    Maritano, D.2    Gorgoni, B.3    Rizzuto, G.4    Libert, C.5    Poli, V.6
  • 67
    • 0034730141 scopus 로고    scopus 로고
    • Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor
    • Dumoutier L., Van Roost E., Colau D., Renauld J.C. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:10144-10149.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 10144-10149
    • Dumoutier, L.1    Van Roost, E.2    Colau, D.3    Renauld, J.C.4
  • 68
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S., Sun R., Pan H.N., Hong F., Gao B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 2004, 39:1332-1342.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 69
    • 0029966664 scopus 로고    scopus 로고
    • Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins
    • Vignais M.L., Sadowski H.B., Watling D., Rogers N.C., Gilman M. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. 1996, 16:1759-1769.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1759-1769
    • Vignais, M.L.1    Sadowski, H.B.2    Watling, D.3    Rogers, N.C.4    Gilman, M.5
  • 70
    • 0028826595 scopus 로고
    • Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts
    • Novak U., Harpur A.G., Paradiso L., Kanagasundaram V., Jaworowski A., Wilks A.F., Hamilton J.A. Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. Blood 1995, 86:2948-2956.
    • (1995) Blood , vol.86 , pp. 2948-2956
    • Novak, U.1    Harpur, A.G.2    Paradiso, L.3    Kanagasundaram, V.4    Jaworowski, A.5    Wilks, A.F.6    Hamilton, J.A.7
  • 72
    • 0030902977 scopus 로고    scopus 로고
    • Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway
    • Guillet-Deniau I., Burnol A.F., Girard J. Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway. J. Biol. Chem. 1997, 272:14825-14829.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14825-14829
    • Guillet-Deniau, I.1    Burnol, A.F.2    Girard, J.3
  • 74
    • 0031278431 scopus 로고    scopus 로고
    • Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement
    • Karras J.G., Wang Z., Huo L., Frank D.A., Rothstein T.L. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement. J. Immunol. 1997, 159:4350-4355.
    • (1997) J. Immunol. , vol.159 , pp. 4350-4355
    • Karras, J.G.1    Wang, Z.2    Huo, L.3    Frank, D.A.4    Rothstein, T.L.5
  • 75
    • 0033578049 scopus 로고    scopus 로고
    • STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation
    • Sachsenmaier C., Sadowski H.B., Cooper J.A. STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation. Oncogene 1999, 18:3583-3592.
    • (1999) Oncogene , vol.18 , pp. 3583-3592
    • Sachsenmaier, C.1    Sadowski, H.B.2    Cooper, J.A.3
  • 76
    • 0034690026 scopus 로고    scopus 로고
    • Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity
    • Wang Y.Z., Wharton W., Garcia R., Kraker A., Jove R., Pledger W.J. Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity. Oncogene 2000, 19:2075-2085.
    • (2000) Oncogene , vol.19 , pp. 2075-2085
    • Wang, Y.Z.1    Wharton, W.2    Garcia, R.3    Kraker, A.4    Jove, R.5    Pledger, W.J.6
  • 77
    • 0036731485 scopus 로고    scopus 로고
    • Stats: transcriptional control and biological impact
    • Levy D.E., Darnell J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 2002, 3:651-662.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.2
  • 78
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson S.S., Grisham J.W. Molecular pathogenesis of human hepatocellular carcinoma. Nat. Genet. 2002, 31:339-346.
    • (2002) Nat. Genet. , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 79
    • 14544292426 scopus 로고    scopus 로고
    • Preneoplastic lesions in human hepatocarcinogenesis
    • Libbrecht L., Desmet V., Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int. 2005, 25:16-27.
    • (2005) Liver Int. , vol.25 , pp. 16-27
    • Libbrecht, L.1    Desmet, V.2    Roskams, T.3
  • 80
    • 0032566516 scopus 로고    scopus 로고
    • HBx protein of hepatitis B virus activates Jak1-STAT signaling
    • Lee Y.H., Yun Y. HBx protein of hepatitis B virus activates Jak1-STAT signaling. J. Biol. Chem. 1998, 273:25510-25515.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25510-25515
    • Lee, Y.H.1    Yun, Y.2
  • 81
    • 35348893870 scopus 로고    scopus 로고
    • Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy
    • Germain D., Frank D.A. Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin. Cancer Res. 2007, 13:5665-5669.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 5665-5669
    • Germain, D.1    Frank, D.A.2
  • 82
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • Vinkemeier U., Moarefi I., Darnell J.E., Kuriyan J. Structure of the amino-terminal protein interaction domain of STAT-4. Science 1998, 279:1048-1052.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell, J.E.3    Kuriyan, J.4
  • 86
    • 0037124037 scopus 로고    scopus 로고
    • Interdomain interaction of Stat3 regulates its Src homology 2 domain-mediated receptor binding activity
    • Zhang T., Seow K.T., Ong C.T., Cao X. Interdomain interaction of Stat3 regulates its Src homology 2 domain-mediated receptor binding activity. J. Biol. Chem. 2002, 277:17556-17563.
    • (2002) J. Biol. Chem. , vol.277 , pp. 17556-17563
    • Zhang, T.1    Seow, K.T.2    Ong, C.T.3    Cao, X.4
  • 87
    • 0034306290 scopus 로고    scopus 로고
    • STAT proteins and transcriptional responses to extracellular signals
    • Horvath C.M. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem. Sci. 2000, 25:496-502.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 496-502
    • Horvath, C.M.1
  • 88
    • 33646365075 scopus 로고    scopus 로고
    • Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements
    • Ma J., Cao X. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. Cell. Signal. 2006, 18:1117-1126.
    • (2006) Cell. Signal. , vol.18 , pp. 1117-1126
    • Ma, J.1    Cao, X.2
  • 89
    • 0032921172 scopus 로고    scopus 로고
    • The STAT family of proteins in cytokine signaling
    • Shuai K. The STAT family of proteins in cytokine signaling. Prog. Biophys. Mol. Biol. 1999, 71:405-422.
    • (1999) Prog. Biophys. Mol. Biol. , vol.71 , pp. 405-422
    • Shuai, K.1
  • 90
    • 0030953448 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases in signal transduction
    • Neel B.G., Tonks N.K. Protein tyrosine phosphatases in signal transduction. Curr. Opin. Cell Biol. 1997, 9:193-204.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 193-204
    • Neel, B.G.1    Tonks, N.K.2
  • 92
    • 0037071409 scopus 로고    scopus 로고
    • JAKs, STATs and Src kinases in hematopoiesis
    • Rane S.G., Reddy E.P. JAKs, STATs and Src kinases in hematopoiesis. Oncogene 2002, 21:3334-3358.
    • (2002) Oncogene , vol.21 , pp. 3334-3358
    • Rane, S.G.1    Reddy, E.P.2
  • 93
    • 0030804219 scopus 로고    scopus 로고
    • The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
    • Pellegrini S., Dusanter-Fourt I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur. J. Biochem. 1997, 248:615-633.
    • (1997) Eur. J. Biochem. , vol.248 , pp. 615-633
    • Pellegrini, S.1    Dusanter-Fourt, I.2
  • 94
  • 97
    • 0034638632 scopus 로고    scopus 로고
    • Computational and functional analysis of the putative SH2 domain in Janus Kinases
    • Kampa D., Burnside J. Computational and functional analysis of the putative SH2 domain in Janus Kinases. Biochem. Biophys. Res. Commun. 2000, 278:175-182.
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 175-182
    • Kampa, D.1    Burnside, J.2
  • 98
    • 33750522675 scopus 로고    scopus 로고
    • Jaks and cytokine receptors-an intimate relationship
    • Haan C., Kreis S., Margue C., Behrmann I. Jaks and cytokine receptors-an intimate relationship. Biochem. Pharmacol. 2006, 72:1538-1546.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1538-1546
    • Haan, C.1    Kreis, S.2    Margue, C.3    Behrmann, I.4
  • 99
    • 0032544656 scopus 로고    scopus 로고
    • Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1
    • Richter M.F., Dumenil G., Uze G., Fellous M., Pellegrini S. Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J. Biol. Chem. 1998, 273:24723-24729.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24723-24729
    • Richter, M.F.1    Dumenil, G.2    Uze, G.3    Fellous, M.4    Pellegrini, S.5
  • 100
    • 0036176428 scopus 로고    scopus 로고
    • Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation
    • Haan C., Heinrich P.C., Behrmann I. Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation. Biochem. J. 2002, 361:105-111.
    • (2002) Biochem. J. , vol.361 , pp. 105-111
    • Haan, C.1    Heinrich, P.C.2    Behrmann, I.3
  • 101
    • 0030665789 scopus 로고    scopus 로고
    • The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor
    • Gauzzi M.C., Barbieri G., Richter M.F., Uze G., Ling L., Fellous M., Pellegrini S. The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:11839-11844.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 11839-11844
    • Gauzzi, M.C.1    Barbieri, G.2    Richter, M.F.3    Uze, G.4    Ling, L.5    Fellous, M.6    Pellegrini, S.7
  • 102
  • 103
    • 0035694582 scopus 로고    scopus 로고
    • The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    • Huang L.J., Constantinescu S.N., Lodish H.F. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol. Cell 2001, 8:1327-1338.
    • (2001) Mol. Cell , vol.8 , pp. 1327-1338
    • Huang, L.J.1    Constantinescu, S.N.2    Lodish, H.F.3
  • 106
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis D.C., Gurniak C.B., Tivol E., Sharpe A.H., Berg L.J. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995, 270:794-797.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 107
    • 0029896163 scopus 로고    scopus 로고
    • Regulation, substrates and functions of src
    • Brown M.T., Cooper J.A. Regulation, substrates and functions of src. Biochim. Biophys. Acta 1996, 1287:121-149.
    • (1996) Biochim. Biophys. Acta , vol.1287 , pp. 121-149
    • Brown, M.T.1    Cooper, J.A.2
  • 108
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • Turkson J., Bowman T., Garcia R., Caldenhoven E., De Groot R.P., Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell. Biol. 1998, 18:2545-2552.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2545-2552
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    De Groot, R.P.5    Jove, R.6
  • 111
    • 0029024880 scopus 로고
    • The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck
    • Briggs S.D., Bryant S.S., Jove R., Sanderson S.D., Smithgall T.E. The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck. J. Biol. Chem. 1995, 270:14718-14724.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14718-14724
    • Briggs, S.D.1    Bryant, S.S.2    Jove, R.3    Sanderson, S.D.4    Smithgall, T.E.5
  • 112
    • 0027182279 scopus 로고
    • Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src
    • Superti-Furga G., Fumagalli S., Koegl M., Courtneidge S.A., Draetta G. Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J. 1993, 12:2625-2634.
    • (1993) EMBO J. , vol.12 , pp. 2625-2634
    • Superti-Furga, G.1    Fumagalli, S.2    Koegl, M.3    Courtneidge, S.A.4    Draetta, G.5
  • 113
    • 0027261372 scopus 로고
    • Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae
    • Murphy S.M., Bergman M., Morgan D.O. Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae. Mol. Cell. Biol. 1993, 13:5290-5300.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5290-5300
    • Murphy, S.M.1    Bergman, M.2    Morgan, D.O.3
  • 114
    • 0027219338 scopus 로고
    • Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine
    • Okada M., Howell B.W., Broome M.A., Cooper J.A. Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine. J. Biol. Chem. 1993, 268:18070-18075.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18070-18075
    • Okada, M.1    Howell, B.W.2    Broome, M.A.3    Cooper, J.A.4
  • 115
    • 0030950608 scopus 로고    scopus 로고
    • Modular peptide recognition domains in eukaryotic signaling
    • Kuriyan J., Cowburn D. Modular peptide recognition domains in eukaryotic signaling. Annu. Rev. Biophys. Biomol. Struct. 1997, 26:259-288.
    • (1997) Annu. Rev. Biophys. Biomol. Struct. , vol.26 , pp. 259-288
    • Kuriyan, J.1    Cowburn, D.2
  • 116
    • 0027409064 scopus 로고
    • Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms
    • Waksman G., Shoelson S.E., Pant N., Cowburn D., Kuriyan J. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell 1993, 72:779-790.
    • (1993) Cell , vol.72 , pp. 779-790
    • Waksman, G.1    Shoelson, S.E.2    Pant, N.3    Cowburn, D.4    Kuriyan, J.5
  • 117
    • 0027986678 scopus 로고
    • Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif
    • Koegl M., Zlatkine P., Ley S.C., Courtneidge S.A., Magee A.I. Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem. J. 1994, 303(Pt 3):749-753.
    • (1994) Biochem. J. , vol.303 , Issue.PART 3 , pp. 749-753
    • Koegl, M.1    Zlatkine, P.2    Ley, S.C.3    Courtneidge, S.A.4    Magee, A.I.5
  • 118
    • 0032875098 scopus 로고    scopus 로고
    • Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins
    • Resh M.D. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim. Biophys. Acta 1999, 1451:1-16.
    • (1999) Biochim. Biophys. Acta , vol.1451 , pp. 1-16
    • Resh, M.D.1
  • 119
    • 0037483090 scopus 로고    scopus 로고
    • The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src
    • Summy J.M., Qian Y., Jiang B.H., Guappone-Koay A., Gatesman A., Shi X., Flynn D.C. The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src. J. Cell Sci. 2003, 116:2585-2598.
    • (2003) J. Cell Sci. , vol.116 , pp. 2585-2598
    • Summy, J.M.1    Qian, Y.2    Jiang, B.H.3    Guappone-Koay, A.4    Gatesman, A.5    Shi, X.6    Flynn, D.C.7
  • 121
    • 33746570647 scopus 로고    scopus 로고
    • Tracking STAT nuclear traffic
    • Reich N.C., Liu L. Tracking STAT nuclear traffic. Nat. Rev. Immunol. 2006, 6:602-612.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 602-612
    • Reich, N.C.1    Liu, L.2
  • 122
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • Ihle J.N. Cytokine receptor signalling. Nature 1995, 377:591-594.
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 123
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: the JAK-STAT pathway
    • Schindler C., Darnell J.E. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 1995, 64:621-651.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell, J.E.2
  • 124
    • 0034657415 scopus 로고    scopus 로고
    • The roles of the Drosophila JAK/STAT pathway
    • Zeidler M.P., Bach E.A., Perrimon N. The roles of the Drosophila JAK/STAT pathway. Oncogene 2000, 19:2598-2606.
    • (2000) Oncogene , vol.19 , pp. 2598-2606
    • Zeidler, M.P.1    Bach, E.A.2    Perrimon, N.3
  • 125
    • 0034658541 scopus 로고    scopus 로고
    • Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
    • Hirano T., Ishihara K., Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000, 19:2548-2556.
    • (2000) Oncogene , vol.19 , pp. 2548-2556
    • Hirano, T.1    Ishihara, K.2    Hibi, M.3
  • 127
    • 0032877019 scopus 로고    scopus 로고
    • The role of STATs in proliferation, differentiation, and apoptosis
    • Mui A.L. The role of STATs in proliferation, differentiation, and apoptosis. Cell. Mol. Life Sci. 1999, 55:1547-1558.
    • (1999) Cell. Mol. Life Sci. , vol.55 , pp. 1547-1558
    • Mui, A.L.1
  • 130
    • 20444446371 scopus 로고    scopus 로고
    • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
    • Alvarez J.V., Febbo P.G., Ramaswamy S., Loda M., Richardson A., Frank D.A. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 2005, 65:5054-5062.
    • (2005) Cancer Res. , vol.65 , pp. 5054-5062
    • Alvarez, J.V.1    Febbo, P.G.2    Ramaswamy, S.3    Loda, M.4    Richardson, A.5    Frank, D.A.6
  • 131
    • 28244475975 scopus 로고    scopus 로고
    • Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    • Nilsson M.B., Langley R.R., Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res. 2005, 65:10794-10800.
    • (2005) Cancer Res. , vol.65 , pp. 10794-10800
    • Nilsson, M.B.1    Langley, R.R.2    Fidler, I.J.3
  • 134
    • 34249902824 scopus 로고    scopus 로고
    • RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells
    • Qiu Z., Huang C., Sun J., Qiu W., Zhang J., Li H., Jiang T., Huang K., Cao J. RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci. 2007, 98:1099-1106.
    • (2007) Cancer Sci. , vol.98 , pp. 1099-1106
    • Qiu, Z.1    Huang, C.2    Sun, J.3    Qiu, W.4    Zhang, J.5    Li, H.6    Jiang, T.7    Huang, K.8    Cao, J.9
  • 135
    • 0034624986 scopus 로고    scopus 로고
    • Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts
    • Morita Y., Naka T., Kawazoe Y., Fujimoto M., Narazaki M., Nakagawa R., Fukuyama H., Nagata S., Kishimoto T. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:5405-5410.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 5405-5410
    • Morita, Y.1    Naka, T.2    Kawazoe, Y.3    Fujimoto, M.4    Narazaki, M.5    Nakagawa, R.6    Fukuyama, H.7    Nagata, S.8    Kishimoto, T.9
  • 136
    • 1442285917 scopus 로고    scopus 로고
    • Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?
    • Gamero A.M., Young H.A., Wiltrout R.H. Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?. Cancer Cell 2004, 5:111-112.
    • (2004) Cancer Cell , vol.5 , pp. 111-112
    • Gamero, A.M.1    Young, H.A.2    Wiltrout, R.H.3
  • 137
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: how successful are we?
    • Yue P., Turkson J. Targeting STAT3 in cancer: how successful are we?. Expert Opin. Investig. Drugs 2009, 18:45-56.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 45-56
    • Yue, P.1    Turkson, J.2
  • 138
    • 0030046753 scopus 로고    scopus 로고
    • STATs: signal transducers and activators of transcription
    • Ihle J.N. STATs: signal transducers and activators of transcription. Cell 1996, 84:331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 139
    • 0029991793 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation
    • Hemmann U., Gerhartz C., Heesel B., Sasse J., Kurapkat G., Grotzinger J., Wollmer A., Zhong Z., Darnell J.E., Graeve L., Heinrich P.C., Horn F. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation. J. Biol. Chem. 1996, 271:12999-13007.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12999-13007
    • Hemmann, U.1    Gerhartz, C.2    Heesel, B.3    Sasse, J.4    Kurapkat, G.5    Grotzinger, J.6    Wollmer, A.7    Zhong, Z.8    Darnell, J.E.9    Graeve, L.10    Heinrich, P.C.11    Horn, F.12
  • 140
    • 0035794217 scopus 로고    scopus 로고
    • DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites
    • Ehret G.B., Reichenbach P., Schindler U., Horvath C.M., Fritz S., Nabholz M., Bucher P. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J. Biol. Chem. 2001, 276:6675-6688.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6675-6688
    • Ehret, G.B.1    Reichenbach, P.2    Schindler, U.3    Horvath, C.M.4    Fritz, S.5    Nabholz, M.6    Bucher, P.7
  • 141
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • Wen Z., Darnell J.E. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 1997, 25:2062-2067.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2062-2067
    • Wen, Z.1    Darnell, J.E.2
  • 142
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H., Pardoll D., Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 2009, 9:798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 148
    • 0033517123 scopus 로고    scopus 로고
    • STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
    • Matsuda T., Nakamura T., Nakao K., Arai T., Katsuki M., Heike T., Yokota T. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J. 1999, 18:4261-4269.
    • (1999) EMBO J. , vol.18 , pp. 4261-4269
    • Matsuda, T.1    Nakamura, T.2    Nakao, K.3    Arai, T.4    Katsuki, M.5    Heike, T.6    Yokota, T.7
  • 149
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • Akira S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 2000, 19:2607-2611.
    • (2000) Oncogene , vol.19 , pp. 2607-2611
    • Akira, S.1
  • 150
    • 0037047360 scopus 로고    scopus 로고
    • STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
    • Li W., Liang X., Kellendonk C., Poli V., Taub R. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J. Biol. Chem. 2002, 277:28411-28417.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28411-28417
    • Li, W.1    Liang, X.2    Kellendonk, C.3    Poli, V.4    Taub, R.5
  • 153
    • 0030851722 scopus 로고    scopus 로고
    • Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells
    • Shimozaki K., Nakajima K., Hirano T., Nagata S. Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J. Biol. Chem. 1997, 272:25184-25189.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25184-25189
    • Shimozaki, K.1    Nakajima, K.2    Hirano, T.3    Nagata, S.4
  • 156
    • 0033198793 scopus 로고    scopus 로고
    • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
    • Sano S., Itami S., Takeda K., Tarutani M., Yamaguchi Y., Miura H., Yoshikawa K., Akira S., Takeda J. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 1999, 18:4657-4668.
    • (1999) EMBO J. , vol.18 , pp. 4657-4668
    • Sano, S.1    Itami, S.2    Takeda, K.3    Tarutani, M.4    Yamaguchi, Y.5    Miura, H.6    Yoshikawa, K.7    Akira, S.8    Takeda, J.9
  • 158
    • 0034046605 scopus 로고    scopus 로고
    • STAT family of transcription factors in cytokine-mediated biological responses
    • Takeda K., Akira S. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 2000, 11:199-207.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 199-207
    • Takeda, K.1    Akira, S.2
  • 159
    • 0036008472 scopus 로고    scopus 로고
    • Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
    • Yoo J.Y., Huso D.L., Nathans D., Desiderio S. Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell 2002, 108:331-344.
    • (2002) Cell , vol.108 , pp. 331-344
    • Yoo, J.Y.1    Huso, D.L.2    Nathans, D.3    Desiderio, S.4
  • 161
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J., Darnell J.E. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000, 19:2468-2473.
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell, J.E.2
  • 162
    • 0346121599 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling and immunity
    • Kubo M., Hanada T., Yoshimura A. Suppressors of cytokine signaling and immunity. Nat. Immunol. 2003, 4:1169-1176.
    • (2003) Nat. Immunol. , vol.4 , pp. 1169-1176
    • Kubo, M.1    Hanada, T.2    Yoshimura, A.3
  • 163
    • 0034657917 scopus 로고    scopus 로고
    • Modulation of STAT signaling by STAT-interacting proteins
    • Shuai K. Modulation of STAT signaling by STAT-interacting proteins. Oncogene 2000, 19:2638-2644.
    • (2000) Oncogene , vol.19 , pp. 2638-2644
    • Shuai, K.1
  • 164
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • Yoshimura A., Ohkubo T., Kiguchi T., Jenkins N.A., Gilbert D.J., Copeland N.G., Hara T., Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 1995, 14:2816-2826.
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1    Ohkubo, T.2    Kiguchi, T.3    Jenkins, N.A.4    Gilbert, D.J.5    Copeland, N.G.6    Hara, T.7    Miyajima, A.8
  • 165
    • 2542478996 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response
    • Alexander W.S., Hilton D.J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 2004, 22:503-529.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 170
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1998, 1:619-625.
    • (1998) Mol. Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 171
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 1999, 274:30059-30065.
    • (1999) J. Biol. Chem. , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 172
    • 0033001325 scopus 로고    scopus 로고
    • Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues
    • Emilsson V., Arch J.R., de Groot R.P., Lister C.A., Cawthorne M.A. Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett. 1999, 455:170-174.
    • (1999) FEBS Lett. , vol.455 , pp. 170-174
    • Emilsson, V.1    Arch, J.R.2    de Groot, R.P.3    Lister, C.A.4    Cawthorne, M.A.5
  • 174
    • 0032535364 scopus 로고    scopus 로고
    • The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
    • Kamura T., Sato S., Haque D., Liu L., Kaelin W.G., Conaway R.C., Conaway J.W. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 1998, 12:3872-3881.
    • (1998) Genes Dev. , vol.12 , pp. 3872-3881
    • Kamura, T.1    Sato, S.2    Haque, D.3    Liu, L.4    Kaelin, W.G.5    Conaway, R.C.6    Conaway, J.W.7
  • 177
    • 0037462645 scopus 로고    scopus 로고
    • The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6
    • Sasaki A., Inagaki-Ohara K., Yoshida T., Yamanaka A., Sasaki M., Yasukawa H., Koromilas A.E., Yoshimura A. The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J. Biol. Chem. 2003, 278:2432-2436.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2432-2436
    • Sasaki, A.1    Inagaki-Ohara, K.2    Yoshida, T.3    Yamanaka, A.4    Sasaki, M.5    Yasukawa, H.6    Koromilas, A.E.7    Yoshimura, A.8
  • 179
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa H., Matsubara K., Qian G.S., Jackson P., Groopman J.D., Manning J.E., Harris C.C., Herman J.G. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 2001, 28:29-35.
    • (2001) Nat. Genet. , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3    Jackson, P.4    Groopman, J.D.5    Manning, J.E.6    Harris, C.C.7    Herman, J.G.8
  • 180
    • 27144433826 scopus 로고    scopus 로고
    • Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
    • Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., Yamamoto J., Kubo T., Yoshikawa H. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene 2005, 24:6406-6417.
    • (2005) Oncogene , vol.24 , pp. 6406-6417
    • Niwa, Y.1    Kanda, H.2    Shikauchi, Y.3    Saiura, A.4    Matsubara, K.5    Kitagawa, T.6    Yamamoto, J.7    Kubo, T.8    Yoshikawa, H.9
  • 182
    • 54049142069 scopus 로고    scopus 로고
    • Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats
    • Bagnyukova T.V., Tryndyak V.P., Muskhelishvili L., Ross S.A., Beland F.A., Pogribny I.P. Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. Cell Cycle 2008, 7:3202-3210.
    • (2008) Cell Cycle , vol.7 , pp. 3202-3210
    • Bagnyukova, T.V.1    Tryndyak, V.P.2    Muskhelishvili, L.3    Ross, S.A.4    Beland, F.A.5    Pogribny, I.P.6
  • 183
    • 0035576737 scopus 로고    scopus 로고
    • A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases
    • Jackson P.K. A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Genes Dev. 2001, 15:3053-3058.
    • (2001) Genes Dev. , vol.15 , pp. 3053-3058
    • Jackson, P.K.1
  • 184
    • 23444461182 scopus 로고    scopus 로고
    • Regulation of gene-activation pathways by PIAS proteins in the immune system
    • Shuai K., Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol. 2005, 5:593-605.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 593-605
    • Shuai, K.1    Liu, B.2
  • 185
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997, 278:1803-1805.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6    Shuai, K.7
  • 186
    • 0242468041 scopus 로고    scopus 로고
    • Regulation of JAK-STAT signalling in the immune system
    • Shuai K., Liu B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 2003, 3:900-911.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 900-911
    • Shuai, K.1    Liu, B.2
  • 188
    • 0344154466 scopus 로고    scopus 로고
    • SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases
    • Wu C., Guan Q., Wang Y., Zhao Z.J., Zhou G.W. SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases. J. Cell. Biochem. 2003, 90:1026-1037.
    • (2003) J. Cell. Biochem. , vol.90 , pp. 1026-1037
    • Wu, C.1    Guan, Q.2    Wang, Y.3    Zhao, Z.J.4    Zhou, G.W.5
  • 189
    • 38849199799 scopus 로고    scopus 로고
    • STAT3 as a target for inducing apoptosis in solid and hematological tumors
    • Al Zaid Siddiquee K., Turkson J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 2008, 18:254-267.
    • (2008) Cell Res. , vol.18 , pp. 254-267
    • Al Zaid Siddiquee, K.1    Turkson, J.2
  • 190
    • 0029916933 scopus 로고    scopus 로고
    • Activation and association of Stat3 with Src in v-Src-transformed cell lines
    • Cao X., Tay A., Guy G.R., Tan Y.H. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 1996, 16:1595-1603.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1595-1603
    • Cao, X.1    Tay, A.2    Guy, G.R.3    Tan, Y.H.4
  • 191
    • 0030992813 scopus 로고    scopus 로고
    • Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs
    • Chaturvedi P., Sharma S., Reddy E.P. Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol. Cell. Biol. 1997, 17:3295-3304.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3295-3304
    • Chaturvedi, P.1    Sharma, S.2    Reddy, E.P.3
  • 193
    • 0034658499 scopus 로고    scopus 로고
    • STAT signaling in head and neck cancer
    • Song J.I., Grandis J.R. STAT signaling in head and neck cancer. Oncogene 2000, 19:2489-2495.
    • (2000) Oncogene , vol.19 , pp. 2489-2495
    • Song, J.I.1    Grandis, J.R.2
  • 194
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro
    • Grandis J.R., Drenning S.D., Chakraborty A., Zhou M.Y., Zeng Q., Pitt A.S., Tweardy D.J. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J. Clin. Invest. 1998, 102:1385-1392.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6    Tweardy, D.J.7
  • 195
    • 33845771270 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
    • Li W.C., Ye S.L., Sun R.X., Liu Y.K., Tang Z.Y., Kim Y., Karras J.G., Zhang H. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin. Cancer Res. 2006, 12:7140-7148.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 7140-7148
    • Li, W.C.1    Ye, S.L.2    Sun, R.X.3    Liu, Y.K.4    Tang, Z.Y.5    Kim, Y.6    Karras, J.G.7    Zhang, H.8
  • 197
    • 0035113393 scopus 로고    scopus 로고
    • Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance
    • Feng D.Y., Zheng H., Tan Y., Cheng R.X. Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance. World J. Gastroenterol. 2001, 7:33-36.
    • (2001) World J. Gastroenterol. , vol.7 , pp. 33-36
    • Feng, D.Y.1    Zheng, H.2    Tan, Y.3    Cheng, R.X.4
  • 198
    • 0142089813 scopus 로고    scopus 로고
    • STAT-3 activity in chemically-induced hepatocellular carcinoma
    • Sanchez A., Nagy P., Thorgeirsson S.S. STAT-3 activity in chemically-induced hepatocellular carcinoma. Eur. J. Cancer 2003, 39:2093-2098.
    • (2003) Eur. J. Cancer , vol.39 , pp. 2093-2098
    • Sanchez, A.1    Nagy, P.2    Thorgeirsson, S.S.3
  • 201
    • 34250858888 scopus 로고    scopus 로고
    • Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma
    • Yang S.F., Wang S.N., Wu C.F., Yeh Y.T., Chai C.Y., Chunag S.C., Sheen M.C., Lee K.T. Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma. J. Clin. Pathol. 2007, 60:642-648.
    • (2007) J. Clin. Pathol. , vol.60 , pp. 642-648
    • Yang, S.F.1    Wang, S.N.2    Wu, C.F.3    Yeh, Y.T.4    Chai, C.Y.5    Chunag, S.C.6    Sheen, M.C.7    Lee, K.T.8
  • 206
    • 78650859531 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 - key players in liver inflammation and cancer
    • He G., Karin M. NF-kappaB and STAT3 - key players in liver inflammation and cancer. Cell Res. 2011, 21:159-168.
    • (2011) Cell Res. , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 207
    • 4444281108 scopus 로고    scopus 로고
    • The role of STATs in inflammation and inflammatory diseases
    • Pfitzner E., Kliem S., Baus D., Litterst C.M. The role of STATs in inflammation and inflammatory diseases. Curr. Pharm. Des. 2004, 10:2839-2850.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 2839-2850
    • Pfitzner, E.1    Kliem, S.2    Baus, D.3    Litterst, C.M.4
  • 210
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
    • Grivennikov S.I., Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010, 21:11-19.
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 211
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S., Kamata H., Luo J.L., Leffert H., Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005, 121:977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 213
    • 77957369041 scopus 로고    scopus 로고
    • Beta-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy
    • Wang X.H., Sun X., Meng X.W., Lv Z.W., Du Y.J., Zhu Y., Chen J., Kong D.X., Jin S.Z. beta-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy. Oncol. Rep. 2010, 24:1093-1099.
    • (2010) Oncol. Rep. , vol.24 , pp. 1093-1099
    • Wang, X.H.1    Sun, X.2    Meng, X.W.3    Lv, Z.W.4    Du, Y.J.5    Zhu, Y.6    Chen, J.7    Kong, D.X.8    Jin, S.Z.9
  • 214
    • 84864465226 scopus 로고    scopus 로고
    • Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    • Ji J., Wang X.W. Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin. Oncol. 2012, 39:461-472.
    • (2012) Semin. Oncol. , vol.39 , pp. 461-472
    • Ji, J.1    Wang, X.W.2
  • 215
    • 77957599212 scopus 로고    scopus 로고
    • Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways
    • Yuan F., Zhou W., Zou C., Zhang Z., Hu H., Dai Z., Zhang Y. Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways. Mol. Cell. Biochem. 2010, 343:155-162.
    • (2010) Mol. Cell. Biochem. , vol.343 , pp. 155-162
    • Yuan, F.1    Zhou, W.2    Zou, C.3    Zhang, Z.4    Hu, H.5    Dai, Z.6    Zhang, Y.7
  • 221
    • 20844444135 scopus 로고    scopus 로고
    • Targeting Stat3 in cancer therapy
    • Jing N., Tweardy D.J. Targeting Stat3 in cancer therapy. Anticancer Drugs 2005, 16:601-607.
    • (2005) Anticancer Drugs , vol.16 , pp. 601-607
    • Jing, N.1    Tweardy, D.J.2
  • 226
    • 0042334830 scopus 로고    scopus 로고
    • Loss of p16 contributes to p27 sequestration by cyclin D(1)-cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular carcinoma
    • Matsuda Y., Ichida T., Genda T., Yamagiwa S., Aoyagi Y., Asakura H. Loss of p16 contributes to p27 sequestration by cyclin D(1)-cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular carcinoma. Clin. Cancer Res. 2003, 9:3389-3396.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 3389-3396
    • Matsuda, Y.1    Ichida, T.2    Genda, T.3    Yamagiwa, S.4    Aoyagi, Y.5    Asakura, H.6
  • 227
    • 33845735124 scopus 로고    scopus 로고
    • P16 and p27 are functionally correlated during the progress of hepatocarcinogenesis
    • Matsuda Y., Ichida T. p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis. Med. Mol. Morphol. 2006, 39:169-175.
    • (2006) Med. Mol. Morphol. , vol.39 , pp. 169-175
    • Matsuda, Y.1    Ichida, T.2
  • 228
    • 0030484797 scopus 로고    scopus 로고
    • Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenesis progression' hypothesis
    • Rak J., Filmus J., Kerbel R.S. Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenesis progression' hypothesis. Eur. J. Cancer 1996, 32A:2438-2450.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2438-2450
    • Rak, J.1    Filmus, J.2    Kerbel, R.S.3
  • 229
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 1990, 82:4-6.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 4-6
    • Folkman, J.1
  • 230
  • 231
    • 0034650802 scopus 로고    scopus 로고
    • Regulation of angiogenesis via vascular endothelial growth factor receptors
    • Veikkola T., Karkkainen M., Claesson-Welsh L., Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res. 2000, 60:203-212.
    • (2000) Cancer Res. , vol.60 , pp. 203-212
    • Veikkola, T.1    Karkkainen, M.2    Claesson-Welsh, L.3    Alitalo, K.4
  • 232
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 233
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I., Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2:489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 234
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Millauer B., Shawver L.K., Plate K.H., Risau W., Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 1994, 367:576-579.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 235
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein J., Roberts W.G., Mathieu-Costello O., Hanahan D., Johnson R.S. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res. 1999, 59:1592-1598.
    • (1999) Cancer Res. , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 236
    • 0034802560 scopus 로고    scopus 로고
    • Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma
    • Poon R.T., Ng I.O., Lau C., Yu W.C., Fan S.T., Wong J. Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma. Am. J. Surg. 2001, 182:298-304.
    • (2001) Am. J. Surg. , vol.182 , pp. 298-304
    • Poon, R.T.1    Ng, I.O.2    Lau, C.3    Yu, W.C.4    Fan, S.T.5    Wong, J.6
  • 237
    • 0031690845 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma
    • Torimura T., Sata M., Ueno T., Kin M., Tsuji R., Suzaku K., Hashimoto O., Sugawara H., Tanikawa K. Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum. Pathol. 1998, 29:986-991.
    • (1998) Hum. Pathol. , vol.29 , pp. 986-991
    • Torimura, T.1    Sata, M.2    Ueno, T.3    Kin, M.4    Tsuji, R.5    Suzaku, K.6    Hashimoto, O.7    Sugawara, H.8    Tanikawa, K.9
  • 239
    • 0031778206 scopus 로고    scopus 로고
    • Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver
    • El-Assal O.N., Yamanoi A., Soda Y., Yamaguchi M., Igarashi M., Yamamoto A., Nabika T., Nagasue N. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 1998, 27:1554-1562.
    • (1998) Hepatology , vol.27 , pp. 1554-1562
    • El-Assal, O.N.1    Yamanoi, A.2    Soda, Y.3    Yamaguchi, M.4    Igarashi, M.5    Yamamoto, A.6    Nabika, T.7    Nagasue, N.8
  • 240
    • 70350541138 scopus 로고    scopus 로고
    • STAT3 as a central regulator of tumor metastases
    • Devarajan E., Huang S. STAT3 as a central regulator of tumor metastases. Curr. Mol. Med. 2009, 9:626-633.
    • (2009) Curr. Mol. Med. , vol.9 , pp. 626-633
    • Devarajan, E.1    Huang, S.2
  • 242
    • 34249028607 scopus 로고    scopus 로고
    • PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression
    • Fischer A.N., Fuchs E., Mikula M., Huber H., Beug H., Mikulits W. PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 2007, 26:3395-3405.
    • (2007) Oncogene , vol.26 , pp. 3395-3405
    • Fischer, A.N.1    Fuchs, E.2    Mikula, M.3    Huber, H.4    Beug, H.5    Mikulits, W.6
  • 246
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134:1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 247
    • 20444453281 scopus 로고    scopus 로고
    • A role of STAT3 in Rho GTPase-regulated cell migration and proliferation
    • Debidda M., Wang L., Zang H., Poli V., Zheng Y. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. J. Biol. Chem. 2005, 280:17275-17285.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17275-17285
    • Debidda, M.1    Wang, L.2    Zang, H.3    Poli, V.4    Zheng, Y.5
  • 249
    • 0037313015 scopus 로고    scopus 로고
    • Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors
    • Pelletier S., Duhamel F., Coulombe P., Popoff M.R., Meloche S. Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol. Cell. Biol. 2003, 23:1316-1333.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1316-1333
    • Pelletier, S.1    Duhamel, F.2    Coulombe, P.3    Popoff, M.R.4    Meloche, S.5
  • 250
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 1998, 279:509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 252
    • 33746603930 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer
    • Dien J., Amin H.M., Chiu N., Wong W., Frantz C., Chiu B., Mackey J.R., Lai R. Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. Am. J. Pathol. 2006, 169:633-642.
    • (2006) Am. J. Pathol. , vol.169 , pp. 633-642
    • Dien, J.1    Amin, H.M.2    Chiu, N.3    Wong, W.4    Frantz, C.5    Chiu, B.6    Mackey, J.R.7    Lai, R.8
  • 253
    • 0035794196 scopus 로고    scopus 로고
    • A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells
    • Gaemers I.C., Vos H.L., Volders H.H., van der Valk S.W., Hilkens J. A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells. J. Biol. Chem. 2001, 276:6191-6199.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6191-6199
    • Gaemers, I.C.1    Vos, H.L.2    Volders, H.H.3    van der Valk, S.W.4    Hilkens, J.5
  • 254
    • 80051490683 scopus 로고    scopus 로고
    • Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells
    • Liu Y., Liu A., Li H., Li C., Lin J. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer Prev. Res. (Phila.) 2011, 4:1296-1305.
    • (2011) Cancer Prev. Res. (Phila.) , vol.4 , pp. 1296-1305
    • Liu, Y.1    Liu, A.2    Li, H.3    Li, C.4    Lin, J.5
  • 255
    • 79955839265 scopus 로고    scopus 로고
    • XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells
    • Liu Y., Liu A., Xu Z., Yu W., Wang H., Li C., Lin J. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis 2011, 16:502-510.
    • (2011) Apoptosis , vol.16 , pp. 502-510
    • Liu, Y.1    Liu, A.2    Xu, Z.3    Yu, W.4    Wang, H.5    Li, C.6    Lin, J.7
  • 256
    • 77956409919 scopus 로고    scopus 로고
    • IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells
    • Liu Y., Fuchs J., Li C., Lin J. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. Cell Cycle 2010, 9:3423-3427.
    • (2010) Cell Cycle , vol.9 , pp. 3423-3427
    • Liu, Y.1    Fuchs, J.2    Li, C.3    Lin, J.4
  • 257
    • 48949087080 scopus 로고    scopus 로고
    • ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
    • Moser C., Lang S.A., Mori A., Hellerbrand C., Schlitt H.J., Geissler E.K., Fogler W.E., Stoeltzing O. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer 2008, 8:206.
    • (2008) BMC Cancer , vol.8 , pp. 206
    • Moser, C.1    Lang, S.A.2    Mori, A.3    Hellerbrand, C.4    Schlitt, H.J.5    Geissler, E.K.6    Fogler, W.E.7    Stoeltzing, O.8
  • 258
    • 54349127051 scopus 로고    scopus 로고
    • Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein
    • Fletcher S., Turkson J., Gunning P.T. Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein. ChemMedChem 2008, 3:1159-1168.
    • (2008) ChemMedChem , vol.3 , pp. 1159-1168
    • Fletcher, S.1    Turkson, J.2    Gunning, P.T.3
  • 259
    • 77951908366 scopus 로고    scopus 로고
    • Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
    • Li F., Fernandez P.P., Rajendran P., Hui K.M., Sethi G. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010, 292:197-207.
    • (2010) Cancer Lett. , vol.292 , pp. 197-207
    • Li, F.1    Fernandez, P.P.2    Rajendran, P.3    Hui, K.M.4    Sethi, G.5
  • 260
    • 77953753016 scopus 로고    scopus 로고
    • Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells
    • Tan S.M., Li F., Rajendran P., Kumar A.P., Hui K.M., Sethi G. Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. J. Pharmacol. Exp. Ther. 2010, 334:285-293.
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 285-293
    • Tan, S.M.1    Li, F.2    Rajendran, P.3    Kumar, A.P.4    Hui, K.M.5    Sethi, G.6
  • 262
    • 79954459349 scopus 로고    scopus 로고
    • Gamma-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
    • Rajendran P., Li F., Manu K.A., Shanmugam M.K., Loo S.Y., Kumar A.P., Sethi G. gamma-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. Br. J. Pharmacol. 2011, 163:283-298.
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 283-298
    • Rajendran, P.1    Li, F.2    Manu, K.A.3    Shanmugam, M.K.4    Loo, S.Y.5    Kumar, A.P.6    Sethi, G.7
  • 263
    • 84862907992 scopus 로고    scopus 로고
    • Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
    • Rajendran P., Li F., Shanmugam M.K., Vali S., Abbasi T., Kapoor S., Ahn K.S., Kumar A.P., Sethi G. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1. J. Cell. Physiol. 2012, 227:2184-2195.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 2184-2195
    • Rajendran, P.1    Li, F.2    Shanmugam, M.K.3    Vali, S.4    Abbasi, T.5    Kapoor, S.6    Ahn, K.S.7    Kumar, A.P.8    Sethi, G.9
  • 265
    • 84860331447 scopus 로고    scopus 로고
    • A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation
    • Chen K.F., Su J.C., Liu C.Y., Huang J.W., Chen K.C., Chen W.L., Tai W.T., Shiau C.W. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation. Cancer Lett. 2012, 321:27-35.
    • (2012) Cancer Lett. , vol.321 , pp. 27-35
    • Chen, K.F.1    Su, J.C.2    Liu, C.Y.3    Huang, J.W.4    Chen, K.C.5    Chen, W.L.6    Tai, W.T.7    Shiau, C.W.8
  • 267
    • 84984586832 scopus 로고    scopus 로고
    • Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3
    • Tai W.T., Cheng A.L., Shiau C.W., Liu C.Y., Ko C.H., Lin M.W., Chen P.J., Chen K.F. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Mol. Cancer Ther. 2012, 11:452-463.
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 452-463
    • Tai, W.T.1    Cheng, A.L.2    Shiau, C.W.3    Liu, C.Y.4    Ko, C.H.5    Lin, M.W.6    Chen, P.J.7    Chen, K.F.8
  • 268
    • 78650499336 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 inhibitors: a patent review
    • Page B.D., Ball D.P., Gunning P.T. Signal transducer and activator of transcription 3 inhibitors: a patent review. Expert Opin. Ther. Pat. 2011, 21:65-83.
    • (2011) Expert Opin. Ther. Pat. , vol.21 , pp. 65-83
    • Page, B.D.1    Ball, D.P.2    Gunning, P.T.3
  • 270
    • 0034710843 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 signaling and Stat3 activation by a new class of bioactive cyclopentenone derivatives
    • Weidler M., Rether J., Anke T., Erkel G. Inhibition of interleukin-6 signaling and Stat3 activation by a new class of bioactive cyclopentenone derivatives. Biochem. Biophys. Res. Commun. 2000, 276:447-453.
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 447-453
    • Weidler, M.1    Rether, J.2    Anke, T.3    Erkel, G.4
  • 271
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
    • Schust J., Sperl B., Hollis A., Mayer T.U., Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 2006, 13:1235-1242.
    • (2006) Chem. Biol. , vol.13 , pp. 1235-1242
    • Schust, J.1    Sperl, B.2    Hollis, A.3    Mayer, T.U.4    Berg, T.5
  • 272
    • 79952711704 scopus 로고    scopus 로고
    • Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation
    • Carlisi D., D'Anneo A., Angileri L., Lauricella M., Emanuele S., Santulli A., Vento R., Tesoriere G. Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation. J. Cell. Physiol. 2011, 226:1632-1641.
    • (2011) J. Cell. Physiol. , vol.226 , pp. 1632-1641
    • Carlisi, D.1    D'Anneo, A.2    Angileri, L.3    Lauricella, M.4    Emanuele, S.5    Santulli, A.6    Vento, R.7    Tesoriere, G.8
  • 273
    • 79957940748 scopus 로고    scopus 로고
    • STAT-3 inhibitors: state of the art and new horizons for cancer treatment
    • Lavecchia A., Di Giovanni C., Novellino E. STAT-3 inhibitors: state of the art and new horizons for cancer treatment. Curr. Med. Chem. 2011, 18:2359-2375.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 2359-2375
    • Lavecchia, A.1    Di Giovanni, C.2    Novellino, E.3
  • 275
    • 84984589185 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
    • Tai W.T., Cheng A.L., Shiau C.W., Huang H.P., Huang J.W., Chen P.J., Chen K.F. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J. Hepatol. 2011, 55:1041-1048.
    • (2011) J. Hepatol. , vol.55 , pp. 1041-1048
    • Tai, W.T.1    Cheng, A.L.2    Shiau, C.W.3    Huang, H.P.4    Huang, J.W.5    Chen, P.J.6    Chen, K.F.7
  • 277
    • 77950530704 scopus 로고    scopus 로고
    • CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation
    • Won C., Lee C.S., Lee J.K., Kim T.J., Lee K.H., Yang Y.M., Kim Y.N., Ye S.K., Chung M.H. CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation. Anticancer. Res. 2010, 30:481-488.
    • (2010) Anticancer. Res. , vol.30 , pp. 481-488
    • Won, C.1    Lee, C.S.2    Lee, J.K.3    Kim, T.J.4    Lee, K.H.5    Yang, Y.M.6    Kim, Y.N.7    Ye, S.K.8    Chung, M.H.9
  • 278
    • 70349754439 scopus 로고    scopus 로고
    • 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells
    • Wang Y., Ma X., Yan S., Shen S., Zhu H., Gu Y., Wang H., Qin G., Yu Q. 17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells. Cancer Res. 2009, 69:7302-7310.
    • (2009) Cancer Res. , vol.69 , pp. 7302-7310
    • Wang, Y.1    Ma, X.2    Yan, S.3    Shen, S.4    Zhu, H.5    Gu, Y.6    Wang, H.7    Qin, G.8    Yu, Q.9
  • 279
    • 33847701356 scopus 로고    scopus 로고
    • Characterization of the interleukin (IL)-6 inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins
    • Metz S., Wiesinger M., Vogt M., Lauks H., Schmalzing G., Heinrich P.C., Muller-Newen G. Characterization of the interleukin (IL)-6 inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins. J. Biol. Chem. 2007, 282:1238-1248.
    • (2007) J. Biol. Chem. , vol.282 , pp. 1238-1248
    • Metz, S.1    Wiesinger, M.2    Vogt, M.3    Lauks, H.4    Schmalzing, G.5    Heinrich, P.C.6    Muller-Newen, G.7
  • 281
    • 33846785187 scopus 로고    scopus 로고
    • Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod
    • Choudhari S.R., Khan M.A., Harris G., Picker D., Jacob G.S., Block T., Shailubhai K. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Mol. Cancer Ther. 2007, 6:112-121.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 112-121
    • Choudhari, S.R.1    Khan, M.A.2    Harris, G.3    Picker, D.4    Jacob, G.S.5    Block, T.6    Shailubhai, K.7
  • 282
    • 33646411225 scopus 로고    scopus 로고
    • Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids
    • Selvendiran K., Koga H., Ueno T., Yoshida T., Maeyama M., Torimura T., Yano H., Kojiro M., Sata M. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Res. 2006, 66:4826-4834.
    • (2006) Cancer Res. , vol.66 , pp. 4826-4834
    • Selvendiran, K.1    Koga, H.2    Ueno, T.3    Yoshida, T.4    Maeyama, M.5    Torimura, T.6    Yano, H.7    Kojiro, M.8    Sata, M.9
  • 283
    • 20144379879 scopus 로고    scopus 로고
    • Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins
    • Arnaud C., Burger F., Steffens S., Veillard N.R., Nguyen T.H., Trono D., Mach F. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arterioscler. Thromb. Vasc. Biol. 2005, 25:1231-1236.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 1231-1236
    • Arnaud, C.1    Burger, F.2    Steffens, S.3    Veillard, N.R.4    Nguyen, T.H.5    Trono, D.6    Mach, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.