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Volumn 37, Issue 1-2, 2000, Pages 1-11

The Jak-STAT pathway

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; JANUS KINASE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR;

EID: 0034023759     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(00)00018-3     Document Type: Review
Times cited : (498)

References (127)
  • 1
    • 0031758022 scopus 로고    scopus 로고
    • Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes
    • Akaishi H., Takeda K., Kaisho T., Shineha R., Satomi S., Takeda J., Akira S. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int. Immunol. 10:1998;1747-1751.
    • (1998) Int. Immunol. , vol.10 , pp. 1747-1751
    • Akaishi, H.1    Takeda, K.2    Kaisho, T.3    Shineha, R.4    Satomi, S.5    Takeda, J.6    Akira, S.7
  • 2
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    • Akimoto T., Numata F., Tamura M., Takata Y., Higashida N., Takashi T., Takeda K., Akira S. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187:1998;1537-1542.
    • (1998) J. Exp. Med. , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6    Takeda, K.7    Akira, S.8
  • 6
    • 0030793345 scopus 로고    scopus 로고
    • Functionally distinct isoforms of STAT5 are generated by protein processing
    • Azam M., Lee C., Strehlow I., Schindler C. Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity. 6:1997;691-701.
    • (1997) Immunity , vol.6 , pp. 691-701
    • Azam, M.1    Lee, C.2    Strehlow, I.3    Schindler, C.4
  • 11
    • 0031899361 scopus 로고    scopus 로고
    • Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocorticoid receptor in mammary cells
    • Cella N., Groner B., Hynes N.E. Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocorticoid receptor in mammary cells. Mol. Cell Biol. 18:1998;1783-1792.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 1783-1792
    • Cella, N.1    Groner, B.2    Hynes, N.E.3
  • 12
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
    • Chai S.K., Nichols G.L., Rothman P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J. Immunol. 159:1997;4720-4728.
    • (1997) J. Immunol. , vol.159 , pp. 4720-4728
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 13
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 278:1997;1803-1805.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6    Shuai, K.7
  • 15
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-abl oncogene
    • Danial N.N., Pernis A., Rothman P.B. Jak-STAT signaling induced by the v-abl oncogene. Science. 269:1995;1875-1877.
    • (1995) Science , vol.269 , pp. 1875-1877
    • Danial, N.N.1    Pernis, A.2    Rothman, P.B.3
  • 16
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell J.E. Jr, Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1994;1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell J.E., Jr.1    Kerr, I.M.2    Stark, G.R.3
  • 17
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell J.E. Jr. STATs and gene regulation. Science. 277:1997;1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell J.E., Jr.1
  • 18
    • 0029133702 scopus 로고
    • Requirement for MAP kinase (ERK2) activity in interferon alpha- And interferon beta-stimulated gene expression through STAT proteins
    • David M., Petricoin E. III, Benjamin C., Pine R., Weber M.J., Larner A.C. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science. 269:1995;1721-1723.
    • (1995) Science , vol.269 , pp. 1721-1723
    • David, M.1    Petricoin E. III2    Benjamin, C.3    Pine, R.4    Weber, M.J.5    Larner, A.C.6
  • 20
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin J.E., Hackenmiller R., Simon M.C., Levy D.E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 84:1996;443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 22
    • 0030930196 scopus 로고    scopus 로고
    • STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
    • Feldman G.M., Rosenthal L.A., Liu X., Hayes M.P., Wynshaw-Boris A., Leonard W.J., Hennighausen L., Finbloom D.S. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood. 90:1997;1768-1776.
    • (1997) Blood , vol.90 , pp. 1768-1776
    • Feldman, G.M.1    Rosenthal, L.A.2    Liu, X.3    Hayes, M.P.4    Wynshaw-Boris, A.5    Leonard, W.J.6    Hennighausen, L.7    Finbloom, D.S.8
  • 23
    • 0028097219 scopus 로고
    • Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase
    • Frank S.J., Gilliland G., Kraft A.S., Arnold C.S. Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase. Endocrinology. 135:1994;2228-2239.
    • (1994) Endocrinology , vol.135 , pp. 2228-2239
    • Frank, S.J.1    Gilliland, G.2    Kraft, A.S.3    Arnold, C.S.4
  • 25
    • 0033168958 scopus 로고    scopus 로고
    • P300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
    • Gingras S., Simard J., Groner B., Pfitzner E. p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. Nucleic Acids Res. 27:1999;2722-2729.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2722-2729
    • Gingras, S.1    Simard, J.2    Groner, B.3    Pfitzner, E.4
  • 26
    • 0033569905 scopus 로고    scopus 로고
    • P38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
    • Goh K.C., Haque S.J., Williams B.R. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J. 18:1999;5601-5608.
    • (1999) EMBO J. , vol.18 , pp. 5601-5608
    • Goh, K.C.1    Haque, S.J.2    Williams, B.R.3
  • 29
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath C.M., Wen Z., Darnell J.E. Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:1995;984-994.
    • (1995) Genes Dev. , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell J.E., Jr.3
  • 30
    • 0030962017 scopus 로고    scopus 로고
    • The state of the STATs: Recent developments in the study of signal transduction to the nucleus
    • Horvath C.M., Darnell J.E. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr. Opin. Cell Biol. 9:1997;233-239.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 233-239
    • Horvath, C.M.1    Darnell, J.E.2
  • 31
    • 0030040691 scopus 로고    scopus 로고
    • Marelle acts downstream of the Drosophila HOP/Jak kinase and encodes a protein similar to the mammalian STATs
    • Hou X.S., Melnick M.B., Perrimon N. Marelle acts downstream of the Drosophila HOP/Jak kinase and encodes a protein similar to the mammalian STATs. Cell. 84:1996;411-419.
    • (1996) Cell , vol.84 , pp. 411-419
    • Hou, X.S.1    Melnick, M.B.2    Perrimon, N.3
  • 32
    • 0028845212 scopus 로고
    • Cytokine receptor signaling
    • Ihle J.N. Cytokine receptor signaling. Nature. 377:1995;591-594.
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 33
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle J.N. STATs: signal transducers and activators of transcription. Cell. 84:1996;331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 35
    • 0029853971 scopus 로고    scopus 로고
    • An IL-2 response element in the human IL-2 receptor α chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein
    • John S., Robbins C.M., Leonard W.J. An IL-2 response element in the human IL-2 receptor α chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein. EMBO J. 15:1996;5627-5635.
    • (1996) EMBO J. , vol.15 , pp. 5627-5635
    • John, S.1    Robbins, C.M.2    Leonard, W.J.3
  • 38
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan M.H., Sun Y.L., Hoey T., Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 382:1996;174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 39
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan M.H., Schindler U., Smiley S.T., Grusby M.J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 4:1996;313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 41
    • 0000413462 scopus 로고    scopus 로고
    • Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway
    • Kim T.K., Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science. 273:1996;1717-1719.
    • (1996) Science , vol.273 , pp. 1717-1719
    • Kim, T.K.1    Maniatis, T.2
  • 42
    • 0028956353 scopus 로고
    • Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    • Klingmuller U., Lorenz U., Cantley L.C., Neel B.G., Lodish H.F. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 80:1995;729-738.
    • (1995) Cell , vol.80 , pp. 729-738
    • Klingmuller, U.1    Lorenz, U.2    Cantley, L.C.3    Neel, B.G.4    Lodish, H.F.5
  • 44
  • 45
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman D., Schofield B., Wills-Karp M., Grusby M.J. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187:1998;939-948.
    • (1998) J. Exp. Med. , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 46
    • 0029909493 scopus 로고    scopus 로고
    • Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene
    • Lecine P., Algarte M., Rameil P., Beadling C., Bucher P., Nabholz M., Imbert J. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene. Mol. Cell. Biol. 16:1996;6829-6840.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6829-6840
    • Lecine, P.1    Algarte, M.2    Rameil, P.3    Beadling, C.4    Bucher, P.5    Nabholz, M.6    Imbert, J.7
  • 47
    • 0029924265 scopus 로고    scopus 로고
    • The Molecular Basis of X-linked Combined Immunodeficiency: Defective Cytokine Receptor Signaling
    • Leonard W.J. The Molecular Basis of X-linked Combined Immunodeficiency: Defective Cytokine Receptor Signaling. Annu. Rev. Med. 47:1996;229-239.
    • (1996) Annu. Rev. Med. , vol.47 , pp. 229-239
    • Leonard, W.J.1
  • 48
    • 0029793368 scopus 로고    scopus 로고
    • Stats and cytokine specificity
    • Leonard W.J. Stats and cytokine specificity. Nature Med. 2:1996;968-969.
    • (1996) Nature Med. , vol.2 , pp. 968-969
    • Leonard, W.J.1
  • 49
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard W.J., O'Shea J.J. Jaks and STATs: Biological implications. Annu. Rev. Immunol. 16:1998;293-322.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 50
    • 0002028093 scopus 로고    scopus 로고
    • Type I cytokines and interferons and their receptors
    • W.E. Paul. Philadelphia PA: Lippincott Raven Publishers
    • Leonard W.J. Type I cytokines and interferons and their receptors. Paul W.E. Fundamental Immunology. 4th ed. 1999;741-774 Lippincott Raven Publishers, Philadelphia PA.
    • (1999) Fundamental Immunology 4th Ed. , pp. 741-774
    • Leonard, W.J.1
  • 51
    • 0026069531 scopus 로고
    • Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons
    • Lew D.J., Decker T., Strehlow I., Darnell J.E. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol. Cell. Biol. 11:1991;182-191.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 182-191
    • Lew, D.J.1    Decker, T.2    Strehlow, I.3    Darnell, J.E.4
  • 52
    • 15844386904 scopus 로고    scopus 로고
    • Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells
    • Lin J.-X., Mietz J., Modi W.S., John S., Leonard W.J. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J. Biol. Chem. 271:1996;10738-10744.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10738-10744
    • Lin, J.-X.1    Mietz, J.2    Modi, W.S.3    John, S.4    Leonard, W.J.5
  • 56
    • 0027946007 scopus 로고
    • A null mutation in the perforin gene impairs cytolytic T lymphocyte- And natural killer cell-mediated cytotoxicity
    • Lowin B., Beermann F., Schmidt A., Tschopp J. A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA. 91:1994;11571-11575.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11571-11575
    • Lowin, B.1    Beermann, F.2    Schmidt, A.3    Tschopp, J.4
  • 61
    • 0030956715 scopus 로고    scopus 로고
    • CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
    • Matsumoto A., Masuhara M., Mitsui K., Yokouchi M., Ohtsubo M., Misawa H., Miyajima A., Yoshimura A. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood. 89:1997;3148-3154.
    • (1997) Blood , vol.89 , pp. 3148-3154
    • Matsumoto, A.1    Masuhara, M.2    Mitsui, K.3    Yokouchi, M.4    Ohtsubo, M.5    Misawa, H.6    Miyajima, A.7    Yoshimura, A.8
  • 63
    • 0033106168 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
    • Matsumura I., Kitamura T., Wakao H., Tanaka H., Hashimoto K., Albanese C., Downward J., Pestell R.G., Kanakura Y. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J. 18:1999;1367-1377.
    • (1999) EMBO J. , vol.18 , pp. 1367-1377
    • Matsumura, I.1    Kitamura, T.2    Wakao, H.3    Tanaka, H.4    Hashimoto, K.5    Albanese, C.6    Downward, J.7    Pestell, R.G.8    Kanakura, Y.9
  • 64
    • 0032797730 scopus 로고    scopus 로고
    • Cooperation of the transcriptional coactivators CBP and p300 with Stat6
    • McDonald C., Reich N.C. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. 19:1999;711-722.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 711-722
    • McDonald, C.1    Reich, N.C.2
  • 67
    • 0032504232 scopus 로고    scopus 로고
    • Mutational analysis of the STAT6 SH2 domain
    • Mikita T., Daniel C., Wu P., Schindler U. Mutational analysis of the STAT6 SH2 domain. J. Biol. Chem. 273:1998;17634-17642.
    • (1998) J. Biol. Chem. , vol.273 , pp. 17634-17642
    • Mikita, T.1    Daniel, C.2    Wu, P.3    Schindler, U.4
  • 69
    • 0028963550 scopus 로고
    • Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two Stat5 homologs
    • Mui A.L., Wakao H., O'Farrell A.M., Harada N., Miyajima A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two Stat5 homologs. EMBO J. 14:1995;1166-1175.
    • (1995) EMBO J. , vol.14 , pp. 1166-1175
    • Mui, A.L.1    Wakao, H.2    O'Farrell, A.M.3    Harada, N.4    Miyajima, A.5
  • 73
    • 0031433362 scopus 로고    scopus 로고
    • An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction
    • Nakajima H., Liu X.W., Wynshaw-Boris A., Rosenthal L.A., Imada K., Finbloom D.S., Hennighausen L., Leonard W.J. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity. 7:1997;691-701.
    • (1997) Immunity , vol.7 , pp. 691-701
    • Nakajima, H.1    Liu, X.W.2    Wynshaw-Boris, A.3    Rosenthal, L.A.4    Imada, K.5    Finbloom, D.S.6    Hennighausen, L.7    Leonard, W.J.8
  • 74
    • 18244432009 scopus 로고    scopus 로고
    • Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
    • Neubauer H., Cumano A., Müller M., Wu H., Huffstadt U., Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 93:1998;397-409.
    • (1998) Cell , vol.93 , pp. 397-409
    • Neubauer, H.1    Cumano, A.2    Müller, M.3    Wu, H.4    Huffstadt, U.5    Pfeffer, K.6
  • 75
    • 0030882317 scopus 로고    scopus 로고
    • STAT3 is a serine kinase target in T lymphocytes
    • Ng J., Cantrell D. STAT3 is a serine kinase target in T lymphocytes. J. Biol. Chem. 272:1997;24542-24549.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24542-24549
    • Ng, J.1    Cantrell, D.2
  • 80
    • 0030765924 scopus 로고    scopus 로고
    • Jaks, STATs, cytokine signaling and immunoregulation: Are we there yet?
    • O'Shea J.J. Jaks, STATs, cytokine signaling and immunoregulation: Are we there yet? Immunity. 7:1997;1-11.
    • (1997) Immunity , vol.7 , pp. 1-11
    • O'Shea, J.J.1
  • 83
    • 0032230282 scopus 로고    scopus 로고
    • P300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transaction domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response
    • Pfitzner E., Jahne R., Wissler M., Stoecklin E., Groner B. P300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transaction domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol. Endocrinol. 12:1998;1582-1593.
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1582-1593
    • Pfitzner, E.1    Jahne, R.2    Wissler, M.3    Stoecklin, E.4    Groner, B.5
  • 84
    • 0033330660 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
    • Pircher T.J., Petersen H., Gustafsson J.A., Haldosen L.A. Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a. Mol. Endocrinol. 13:1999;555-565.
    • (1999) Mol. Endocrinol. , vol.13 , pp. 555-565
    • Pircher, T.J.1    Petersen, H.2    Gustafsson, J.A.3    Haldosen, L.A.4
  • 89
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
    • Shaefer T.S., Sanders L.K., Nathans D. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA. 92:1995;9097-9101.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9097-9101
    • Shaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 91
    • 0033988447 scopus 로고    scopus 로고
    • DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites
    • Soldaini, E., John, S., Moro, S., Bollenbacher, J., Schindler, U., Leonard, W.J., 2000. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. Mol. Cell. Biol., 20, 389-401.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 389-401
    • Soldaini, E.1    John, S.2    Moro, S.3    Bollenbacher, J.4    Schindler, U.5    Leonard, W.J.6
  • 92
    • 0028958849 scopus 로고
    • Mouse interleukin-2 receptor α gene expression: Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements
    • Sperisen P., Wang S.M., Soldaini E., Pla M., Rusterholz C., Bucher P., Corthesy P., Reichenbach P., Nabholz M. Mouse interleukin-2 receptor α gene expression: Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements. J. Biol. Chem. 270:1995;10743-10753.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10743-10753
    • Sperisen, P.1    Wang, S.M.2    Soldaini, E.3    Pla, M.4    Rusterholz, C.5    Bucher, P.6    Corthesy, P.7    Reichenbach, P.8    Nabholz, M.9
  • 95
    • 0029851231 scopus 로고    scopus 로고
    • Functional interactions between Stat5 and the glucocorticoid receptor
    • Stocklin E., Wissler M., Gouilleux F., Groner B. Functional interactions between Stat5 and the glucocorticoid receptor. Nature. 383:1996;726-728.
    • (1996) Nature , vol.383 , pp. 726-728
    • Stocklin, E.1    Wissler, M.2    Gouilleux, F.3    Groner, B.4
  • 99
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T-cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • Takeda K., Kaisho T., Yoshida N., Takeda J., Kishimoto T., Akira S. Stat3 activation is responsible for IL-6-dependent T-cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:1998;4652-4660.
    • (1998) J. Immunol. , vol.161 , pp. 4652-4660
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 100
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K., Clausen B.E., Kaisho T., Tsujimura T., Terada N., Forster I., Akira S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 10:1999;39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 104
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis D.C., Gurniak C.B., Tivol E., Sharpe A.H., Berg L.J. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 270:1995;794-797.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 107
    • 0032007351 scopus 로고    scopus 로고
    • IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    • Urban J.F. Jr, Noben-Trauth N., Donaldson D.D., Madden K.B., Morris S.C., Collins M., Finkelman F.D. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity. 8:1998;255-264.
    • (1998) Immunity , vol.8 , pp. 255-264
    • Urban J.F., Jr.1    Noben-Trauth, N.2    Donaldson, D.D.3    Madden, K.B.4    Morris, S.C.5    Collins, M.6    Finkelman, F.D.7
  • 108
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the interferon α/β signaling pathway
    • Velazquez L., Fellous M., Stark G.R., Pellegrini S. A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 70:1992;313-322.
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellous, M.2    Stark, G.R.3    Pellegrini, S.4
  • 109
    • 0028835347 scopus 로고
    • Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction
    • Velazquez L., Mogensen K.E., Barbieri G., Fellous M., Uze G., Pellegrini S. Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction. J. Biol. Chem. 270:1995;3327-3334.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3327-3334
    • Velazquez, L.1    Mogensen, K.E.2    Barbieri, G.3    Fellous, M.4    Uze, G.5    Pellegrini, S.6
  • 110
    • 0029903770 scopus 로고    scopus 로고
    • DNA binding of in vitro activated Stat1a, Stat1b and truncated Stat1: Interaction between NH2- terminal domains stabilizes binding of two dimers to tandem DNA sites
    • Vinkemeier U., Cohen S.L., Moarefi I., Chait B.T., Kuriyan J., Darnell J.E. Jr. DNA binding of in vitro activated Stat1a, Stat1b and truncated Stat1: interaction between NH2- terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 15:1996;5616-5626.
    • (1996) EMBO J. , vol.15 , pp. 5616-5626
    • Vinkemeier, U.1    Cohen, S.L.2    Moarefi, I.3    Chait, B.T.4    Kuriyan, J.5    Darnell J.E., Jr.6
  • 111
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • Vinkemeier U., Moarefi I., Darnell J.E. Jr, Kuriyan J. Structure of the amino-terminal protein interaction domain of STAT-4. Science. 279:1998;1048-1052.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell J.E., Jr.3    Kuriyan, J.4
  • 112
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • Wakao H., Gouilleux F., Groner B. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13:1994;2182-2191.
    • (1994) EMBO J. , vol.13 , pp. 2182-2191
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 115
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt R.M., Egen C., Wehinger J., Ludwig W., Gouilleux-Gruart V., Mertelsmann R., Finke J. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood. 88:1996;809-816.
    • (1996) Blood , vol.88 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3    Ludwig, W.4    Gouilleux-Gruart, V.5    Mertelsmann, R.6    Finke, J.7
  • 116
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z., Zhong Z., Darnell J.E. Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82:1995;241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell J.E., Jr.3
  • 117
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn B.A., Quellee F.W., Silvennoinen O., Yi T., Tang B., Miura O., Ihle J.N. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 74:1993;227-236.
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1    Quellee, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6    Ihle, J.N.7
  • 118
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino terminal domain
    • Xu X., Sun Y.-L., Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino terminal domain. Science. 273:1996;794-797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.-L.2    Hoey, T.3
  • 119
    • 0001514956 scopus 로고    scopus 로고
    • Identiication of a STAT gene that functions in Drosophila development
    • Yan R., Small S., Desplan C., Dearolf C.R., Darnell J.E. Jr. Identiication of a STAT gene that functions in Drosophila development. Cell. 84:1996;421-430.
    • (1996) Cell , vol.84 , pp. 421-430
    • Yan, R.1    Small, S.2    Desplan, C.3    Dearolf, C.R.4    Darnell J.E., Jr.5
  • 120
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • Yoshimura A., Ohkubo T., Kiguchi T., Jenkins N.A., Gilbert D.J., Copeland N.G., Hara T., Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:1995;2816-2826.
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1    Ohkubo, T.2    Kiguchi, T.3    Jenkins, N.A.4    Gilbert, D.J.5    Copeland, N.G.6    Hara, T.7    Miyajima, A.8
  • 121
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu C.L., Meyer D.J., Campbell G.S., Larner A.C., Carter-Su C., Schwartz J., Jove R. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 269:1995;81-83.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6    Jove, R.7
  • 124
    • 0032401780 scopus 로고    scopus 로고
    • Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation
    • Zhang J.J., Zhao Y., Chait B.T., Lathem W.W., Ritzi M., Knippers R., Darnell J.E. Jr. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. 17:1998;6963-6971.
    • (1998) EMBO J. , vol.17 , pp. 6963-6971
    • Zhang, J.J.1    Zhao, Y.2    Chait, B.T.3    Lathem, W.W.4    Ritzi, M.5    Knippers, R.6    Darnell J.E., Jr.7
  • 125
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STA-promoter complexes
    • Zhang X., Blenis J., Li H.C., Schidler C., Chen-Kiang S. Requirement of serine phosphorylation for formation of STA-promoter complexes. Science. 267:1995;1990-1994.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schidler, C.4    Chen-Kiang, S.5
  • 126
    • 0030667790 scopus 로고    scopus 로고
    • STAT3 acts as a co-activator of glucocorticoid receptor signaling
    • Zhang Z., Jones S., Hagood J.S., Fuentes N.L., Fuller G.M. STAT3 acts as a co-activator of glucocorticoid receptor signaling. J. Biol. Chem. 272:1997;30607-30610.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30607-30610
    • Zhang, Z.1    Jones, S.2    Hagood, J.S.3    Fuentes, N.L.4    Fuller, G.M.5
  • 127
    • 0033534562 scopus 로고    scopus 로고
    • Functional association of Nmi with Stat5 and Stat1 in IL-2- And IFNgamma-mediated signaling
    • Zhu M., John S., Berg M., Leonard W.J. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell. 96:1999;121-130.
    • (1999) Cell , vol.96 , pp. 121-130
    • Zhu, M.1    John, S.2    Berg, M.3    Leonard, W.J.4


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