Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: The receptor is crucial for kinase activation

Biochemical Journal

Volumn 361, Issue 1, 2002, Pages 105-111

  Haan, Claude ^a   Heinrich, Peter C ^a   Behrmann, Iris ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Box1 box2 region; Cytokine; Jak association; Jak STAT; Tyrosine kinase

Indexed keywords

AMINO ACIDS; CELLS; DIMERIZATION;

RECEPTOR CHAINS;

BIOCHEMISTRY;

ALANINE; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 5 RECEPTOR; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 1; PHENYLALANINE; PROLINE; RECEPTOR SUBUNIT; STAT PROTEIN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CHIMERA; CYTOKINE PRODUCTION; CYTOPLASM; DIMERIZATION; ENZYME ACTIVATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; HOMEOBOX; LIGAND BINDING; MONKEY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; BASE SEQUENCE; COS CELLS; CYTOKINE RECEPTOR GP130; DIMERIZATION; ENZYME ACTIVATION; INTERLEUKIN-6; JANUS KINASE 1; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, QUATERNARY; PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA; JANUS;

EID: 0036176428     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3610105     Document Type: Article

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