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Volumn 457, Issue 7226, 2009, Pages 200-204

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLYCOPROTEIN GP 130; INTERLEUKIN 6; STAT3 PROTEIN;

EID: 58149326854     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature07475     Document Type: Article
Times cited : (414)

References (34)
  • 1
    • 34250763945 scopus 로고    scopus 로고
    • Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
    • Bioulac-Sage, P. et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 46, 740-748 (2007).
    • (2007) Hepatology , vol.46 , pp. 740-748
    • Bioulac-Sage, P.1
  • 2
    • 33645223878 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC
    • Zucman-Rossi, J. et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 43, 515-524 (2006).
    • (2006) Hepatology , vol.43 , pp. 515-524
    • Zucman-Rossi, J.1
  • 3
    • 37349098725 scopus 로고    scopus 로고
    • Autocrine IL-6 signaling: A key event in tumourigenesis?
    • Grivennikov, S. & Karin, M. Autocrine IL-6 signaling: a key event in tumourigenesis? Cancer Cell 13, 7-9 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 7-9
    • Grivennikov, S.1    Karin, M.2
  • 4
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira, S. et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77, 63-71 (1994).
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1
  • 5
    • 0027441586 scopus 로고
    • Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
    • Wegenka, U. M., Buschmann, J., Lutticken, C., Heinrich, P. C. & Horn, F. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 13, 276-288 (1993).
    • (1993) Mol. Cell. Biol , vol.13 , pp. 276-288
    • Wegenka, U.M.1    Buschmann, J.2    Lutticken, C.3    Heinrich, P.C.4    Horn, F.5
  • 6
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • Hibi, M. et al. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157 (1990).
    • (1990) Cell , vol.63 , pp. 1149-1157
    • Hibi, M.1
  • 7
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6α-receptor/gp130 complex
    • Boulanger, M. J., Chow, D. C., Brevnova, E. E. & Garcia, K. C. Hexameric structure and assembly of the interleukin-6/IL-6α-receptor/gp130 complex. Science 300, 2101-2104 (2003).
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 8
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130
    • Ward, L. D. et al. High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol. Chem. 269, 23286-23289 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 23286-23289
    • Ward, L.D.1
  • 9
    • 0028296179 scopus 로고
    • Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
    • Lutticken, C. et al. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263, 89-92 (1994).
    • (1994) Science , vol.263 , pp. 89-92
    • Lutticken, C.1
  • 10
    • 0027199126 scopus 로고
    • IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
    • Murakami, M. et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260, 1808-1810 (1993).
    • (1993) Science , vol.260 , pp. 1808-1810
    • Murakami, M.1
  • 11
    • 0028281794 scopus 로고
    • Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6β receptor components
    • Stahl, N. et al. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6β receptor components. Science 263, 92-95 (1994).
    • (1994) Science , vol.263 , pp. 92-95
    • Stahl, N.1
  • 12
    • 25844505836 scopus 로고    scopus 로고
    • Genome-wide response of the human Hep3B hepatoma cell to proinflammatory cytokines, from transcription to translation
    • Coulouarn, C. et al. Genome-wide response of the human Hep3B hepatoma cell to proinflammatory cytokines, from transcription to translation. Hepatology 42, 946-955 (2005).
    • (2005) Hepatology , vol.42 , pp. 946-955
    • Coulouarn, C.1
  • 13
    • 0029084805 scopus 로고
    • Interleukin-6 family of cytokines and gp130
    • Kishimoto, T., Akira, S., Narazaki, M. & Taga, T. Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254 (1995).
    • (1995) Blood , vol.86 , pp. 1243-1254
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 14
    • 0035896394 scopus 로고    scopus 로고
    • Structure of an extracellular gp130 cytokine receptor signaling complex
    • Chow, D., He, X., Snow, A. L., Rose-John, S. & Garcia, K. C. Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291, 2150-2155 (2001).
    • (2001) Science , vol.291 , pp. 2150-2155
    • Chow, D.1    He, X.2    Snow, A.L.3    Rose-John, S.4    Garcia, K.C.5
  • 15
    • 22444442637 scopus 로고    scopus 로고
    • Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
    • Skiniotis, G., Boulanger, M. J., Garcia, K. C. & Walz, T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nature Struct. Mol. Biol. 12, 545-551 (2005).
    • (2005) Nature Struct. Mol. Biol , vol.12 , pp. 545-551
    • Skiniotis, G.1    Boulanger, M.J.2    Garcia, K.C.3    Walz, T.4
  • 16
    • 0036091823 scopus 로고    scopus 로고
    • Identification of amino acid residues of gp130 signal transducer and gp80α receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6
    • Li, H. & Nicholas, J. Identification of amino acid residues of gp130 signal transducer and gp80α receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6. J. Virol. 76, 5627-5636 (2002).
    • (2002) J. Virol , vol.76 , pp. 5627-5636
    • Li, H.1    Nicholas, J.2
  • 17
    • 43049096401 scopus 로고    scopus 로고
    • STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumourigenesis in gp130 receptor mutant mice
    • Ernst, M. et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumourigenesis in gp130 receptor mutant mice. J. Clin. Invest. 118, 1727-1738 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 1727-1738
    • Ernst, M.1
  • 18
    • 0032190524 scopus 로고    scopus 로고
    • Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver
    • Maione, D. et al. Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J. 17, 5588-5597 (1998).
    • (1998) EMBO J , vol.17 , pp. 5588-5597
    • Maione, D.1
  • 19
    • 9144249648 scopus 로고    scopus 로고
    • Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130
    • Judd, L. M. et al. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology 126, 196-207 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 196-207
    • Judd, L.M.1
  • 20
    • 33749328700 scopus 로고    scopus 로고
    • STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumourigenesis
    • Judd, L. M. et al. STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumourigenesis. Gastroenterology 131, 1073-1085 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1073-1085
    • Judd, L.M.1
  • 21
    • 0036796060 scopus 로고    scopus 로고
    • Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
    • Tebbutt, N. C. et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nature Med. 8, 1089-1097 (2002).
    • (2002) Nature Med , vol.8 , pp. 1089-1097
    • Tebbutt, N.C.1
  • 22
    • 0028279791 scopus 로고
    • Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    • Boulton, T. G., Stahl, N. & Yancopoulos, G. D. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269, 11648-11655 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 11648-11655
    • Boulton, T.G.1    Stahl, N.2    Yancopoulos, G.D.3
  • 23
    • 0037938816 scopus 로고    scopus 로고
    • SOCS3 negatively regulates IL-6 signaling in vivo
    • Croker, B. A. et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nature Immunol. 4, 540-545 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 540-545
    • Croker, B.A.1
  • 24
    • 21044446925 scopus 로고    scopus 로고
    • Clinical, morphologic, and molecular features defining socalled telangiectatic focal nodular hyperplasias of the liver
    • Bioulac-Sage, P. et al. Clinical, morphologic, and molecular features defining socalled telangiectatic focal nodular hyperplasias of the liver. Gastroenterology 128, 1211-1218 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 1211-1218
    • Bioulac-Sage, P.1
  • 26
    • 18644363653 scopus 로고    scopus 로고
    • Bi-allelic inactivation of TCF1 in hepatic adenomas
    • Bluteau, O. et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nature Genet. 32, 312-315 (2002).
    • (2002) Nature Genet , vol.32 , pp. 312-315
    • Bluteau, O.1
  • 27
    • 84984537259 scopus 로고    scopus 로고
    • Chen, Y. W., Jeng, Y. M., Yeh, S. H. & Chen, P. J. P53 gene and Wnt signaling in benign neoplasms: β-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology 36, 927-935 (2002).
    • Chen, Y. W., Jeng, Y. M., Yeh, S. H. & Chen, P. J. P53 gene and Wnt signaling in benign neoplasms: β-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology 36, 927-935 (2002).
  • 28
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault, S. et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 45, 42-52 (2007).
    • (2007) Hepatology , vol.45 , pp. 42-52
    • Boyault, S.1
  • 29
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler, W. E. et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007).
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1
  • 30
    • 34347204495 scopus 로고    scopus 로고
    • HNF1α inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation
    • Rebouissou, S. et al. HNF1α inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation. J. Biol. Chem. 282, 14437-14446 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 14437-14446
    • Rebouissou, S.1
  • 31
    • 1342288026 scopus 로고    scopus 로고
    • Affy-analysis of Affymetrix GeneChip data at the probe level
    • Gautier, L., Cope, L., Bolstad, B. M. & Irizarry, R. A. Affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307-315 (2004).
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 32
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1
  • 33
    • 17744413236 scopus 로고    scopus 로고
    • Model-based analysis of oligonucleotide arrays: Model validation, design issues and standard error application
    • Research0032
    • Li, C. & Hung Wong, W. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol. 2, Research0032 (2001).
    • (2001) Genome Biol , vol.2
    • Li, C.1    Hung Wong, W.2
  • 34
    • 12344280017 scopus 로고    scopus 로고
    • Summaries of Affymetrix GeneChip probe level data
    • Irizarry, R. A. et al. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31, e15 (2003).
    • (2003) Nucleic Acids Res , vol.31
    • Irizarry, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.