Characterization of the interleukin (IL)-6 inhibitor IL-6-RFP: Fused receptor domains act as high affinity cytokine-binding proteins

Journal of Biological Chemistry

Volumn 282, Issue 2, 2007, Pages 1238-1248

  Metz, Silke ^a   Wiesinger, Monique ^a   Vogt, Michael ^a   Lauks, Heike ^a   Schmalzing, Günther ^a   Heinrich, Peter C ^a   Müller Newen, Gerhard ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE INHIBITORS; CYTOKINE TRAPS; GEL FILTRATION; LIGAND BINDING;

BIOACTIVITY; CELLS; COMPLEXATION; LIGANDS; MOLECULAR MASS; SOLUBILITY; UREA;

PROTEINS;

CYTOKINE RECEPTOR; FLUORESCENT DYE; GLYCOPROTEIN GP 130; HYBRID PROTEIN; INTERLEUKIN 6 INHIBITOR; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA; INTERLEUKIN 6 RECEPTOR FUSION PROTEIN; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M; RECOMBINANT INTERLEUKIN 6; UNCLASSIFIED DRUG; UREA; ANTINEOPLASTIC AGENT; BACTERIAL PROTEIN; INTERLEUKIN 6; LIF PROTEIN, HUMAN; PHOTOPROTEIN; STAT3 PROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING COMPETITION; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; GEL FILTRATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR WEIGHT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; ACUTE PHASE RESPONSE; ANIMAL; BACULOVIRUS; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; GENE EXPRESSION; GENETICS; IMMUNOLOGY; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ACUTE-PHASE REACTION; ANIMALS; ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; BACULOVIRIDAE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOKINE RECEPTOR GP130; DRUG DESIGN; GENE EXPRESSION; HUMANS; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LIVER NEOPLASMS; LUMINESCENT PROTEINS; ONCOSTATIN M; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; STAT3 TRANSCRIPTION FACTOR;

EID: 33847701356     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606885200     Document Type: Article

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