-
1
-
-
0030840464
-
STATs and gene regulation
-
Damell, J.E., Jr. 1997. STATs and gene regulation. Science. 277:1630-1635.
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Damell Jr., J.E.1
-
2
-
-
0034176912
-
Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components
-
Schuringa, J.J., Jonk, L.J., Dokter, W.H., Vellenga, E., and Kruijer W. 2000. Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components. Biochem. J. 347:89-96.
-
(2000)
Biochem. J.
, vol.347
, pp. 89-96
-
-
Schuringa, J.J.1
Jonk, L.J.2
Dokter, W.H.3
Vellenga, E.4
Kruijer, W.5
-
3
-
-
0035159293
-
Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury
-
Leu, J.I., Crissey, M.A., Leu, J.P., Ciliberto, G., and Taub, R. 2001. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol. Cell. Biol. 21:414-424.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 414-424
-
-
Leu, J.I.1
Crissey, M.A.2
Leu, J.P.3
Ciliberto, G.4
Taub, R.5
-
4
-
-
0036343321
-
LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells
-
Schuringa, J.J., van der Schaaf, S., Vellenga, E., Eggen, B.J., and Kruijer, W. 2002. LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells. Exp. Cell Res. 274:119-129.
-
(2002)
Exp. Cell Res.
, vol.274
, pp. 119-129
-
-
Schuringa, J.J.1
Van Der Schaaf, S.2
Vellenga, E.3
Eggen, B.J.4
Kruijer, W.5
-
5
-
-
0036256644
-
What does Stat3 do?
-
doi:10.1172/JCI200215650
-
Levy, D.E., and Lee, C.K. 2002. What does Stat3 do? J. Clin. Invest. 109:1143-1148. doi:10.1172/JCI200215650.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1143-1148
-
-
Levy, D.E.1
Lee, C.K.2
-
6
-
-
0028349735
-
Stat3: A STAT family, member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong, Z., Wen, Z., and Darnell, J.E. 1994. Stat3: a STAT family, member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 264:95-98.
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell, J.E.3
-
7
-
-
0028296179
-
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
-
Lutticken, C., et al. 1994. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science. 263:89-92.
-
(1994)
Science
, vol.263
, pp. 89-92
-
-
Lutticken, C.1
-
8
-
-
0034658541
-
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
-
Hirano, T., Ishihara, K., and Hibi, M. 2000. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene. 19:2548-2556.
-
(2000)
Oncogene
, vol.19
, pp. 2548-2556
-
-
Hirano, T.1
Ishihara, K.2
Hibi, M.3
-
9
-
-
0034658698
-
STATs in oncogenesis
-
Bowman, T., Garcia, R., Turkson, J., and Jove, R. 2000. STATs in oncogenesis. Oncogene. 19:2474-2488.
-
(2000)
Oncogene
, vol.19
, pp. 2474-2488
-
-
Bowman, T.1
Garcia, R.2
Turkson, J.3
Jove, R.4
-
10
-
-
0030935260
-
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
-
Takeda, K., et al. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. U. S. A. 94:3801-3804.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 3801-3804
-
-
Takeda, K.1
-
11
-
-
0037047360
-
STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
-
Li, W., Liang, X., Kellendonk, C., Poli, V., and Taub, R. 2002. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J. Biol. Chem. 277:28411-28417.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28411-28417
-
-
Li, W.1
Liang, X.2
Kellendonk, C.3
Poli, V.4
Taub, R.5
-
12
-
-
0035747119
-
Activation of interleukin-6/STAT3 and liver regeneration following transplantation
-
Debonera, F., et al. 2001. Activation of interleukin-6/STAT3 and liver regeneration following transplantation. J. Surg. Res. 96:289-295.
-
(2001)
J. Surg. Res.
, vol.96
, pp. 289-295
-
-
Debonera, F.1
-
13
-
-
0035852765
-
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Srat1
-
Shen, Y., Devgan, G., Darnell, J.E., and Bromberg, J.F. 2001. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Srat1. Proc. Natl. Acad. Sci. U. S. A. 98:1543-1548.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 1543-1548
-
-
Shen, Y.1
Devgan, G.2
Darnell, J.E.3
Bromberg, J.F.4
-
14
-
-
12944272024
-
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
-
Grandis, J.R., et al. 2000. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. U. S. A. 97:4227-4232.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 4227-4232
-
-
Grandis, J.R.1
-
15
-
-
0032213273
-
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
-
Takeda, K., et al. 1998. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:4652-4660.
-
(1998)
J. Immunol.
, vol.161
, pp. 4652-4660
-
-
Takeda, K.1
-
16
-
-
0033396491
-
Fas ligand-induced apoptosis
-
Nagata, S. 1999. Fas ligand-induced apoptosis. Annu. Rev. Genet. 33:29-55.
-
(1999)
Annu. Rev. Genet.
, vol.33
, pp. 29-55
-
-
Nagata, S.1
-
17
-
-
0034638827
-
Necrotic death pathway in Fas receptor signaling
-
Matsumura, H., et al. 2000. Necrotic death pathway in Fas receptor signaling. J. Cell Biol. 151:1247-1256.
-
(2000)
J. Cell Biol.
, vol.151
, pp. 1247-1256
-
-
Matsumura, H.1
-
18
-
-
0035979998
-
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway
-
Siegmund, D., et al. 2001. Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway. J. Biol. Chem. 276:32585-32590.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32585-32590
-
-
Siegmund, D.1
-
19
-
-
0035854780
-
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL
-
Kovalovich, K., et al. 2001. Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J. Biol. Chem. 276:26605-26613.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26605-26613
-
-
Kovalovich, K.1
-
20
-
-
0036179645
-
Death receptors couple to both cell proliferation and apoptosis
-
doi:10.1172/JCI200215077
-
Budd, R.C. 2002. Death receptors couple to both cell proliferation and apoptosis. J. Clin. Invest. 109:437-442. doi:10.1172/JCI200215077.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 437-442
-
-
Budd, R.C.1
-
21
-
-
0034062699
-
Fas and Fas ligand in gut and liver
-
Pinkoski, M.J., Brunner, T., Green, D.R., and Lin, T. 2000. Fas and Fas ligand in gut and liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278:G354-G366.
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.278
-
-
Pinkoski, M.J.1
Brunner, T.2
Green, D.R.3
Lin, T.4
-
22
-
-
0028783367
-
Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage
-
Galle, P.R., et al. 1995. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med. 182:1223-1230.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1223-1230
-
-
Galle, P.R.1
-
24
-
-
0032919402
-
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
-
Faubion, W.A., et al. 1999. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J. Clin. Invest. 103:137-145.
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 137-145
-
-
Faubion, W.A.1
-
25
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg, J., and Darnell, J.E. 2000. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 19:2468-2473.
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell, J.E.2
-
26
-
-
0036618347
-
Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase
-
Ozaki, M., Suzuki, S., and Irani, K. 2002. Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase. FASEB J. 16:889-890.
-
(2002)
FASEB J.
, vol.16
, pp. 889-890
-
-
Ozaki, M.1
Suzuki, S.2
Irani, K.3
-
27
-
-
0034106862
-
Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation
-
Yamakawa, Y., et al. 2000. Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. Ann. Surg. 231:387-398.
-
(2000)
Ann. Surg.
, vol.231
, pp. 387-398
-
-
Yamakawa, Y.1
-
28
-
-
0032743421
-
Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
-
Daemen, M.A.R.C., et al. 1999. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J. Clin. Invest. 104:541-549.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 541-549
-
-
Daemen, M.A.R.C.1
-
29
-
-
0033594893
-
Normal growth and development in the absence of hepatic insulin-like growth factor 1
-
Yakar, S., et al. 1999. Normal growth and development in the absence of hepatic insulin-like growth factor 1. Proc. Natl. Acad. Sci. U. S. A. 96:7324-7329.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 7324-7329
-
-
Yakar, S.1
-
30
-
-
0033960425
-
Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo
-
Ozaki, M., et al. 2000. Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. FASEB J. 14:418-429.
-
(2000)
FASEB J.
, vol.14
, pp. 418-429
-
-
Ozaki, M.1
-
31
-
-
0032188756
-
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation
-
Grosch, S., Fritz, G., and Kaina, B. 1998. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Res. 58:4410-4416.
-
(1998)
Cancer Res.
, vol.58
, pp. 4410-4416
-
-
Grosch, S.1
Fritz, G.2
Kaina, B.3
-
32
-
-
0344980129
-
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB
-
Grosch, S., and Kaina, B. 1999. Transcriptional activation of apurinic/ apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB. Biochem. Biophys. Res. Commun. 261:859-863.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.261
, pp. 859-863
-
-
Grosch, S.1
Kaina, B.2
-
33
-
-
0033810515
-
Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury
-
Galun, E., Zeira, E., Pappo, O., Peters, M., and Rose-John, S. 2000. Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury. FASEB J 14:1979-1987.
-
(2000)
FASEB J.
, vol.14
, pp. 1979-1987
-
-
Galun, E.1
Zeira, E.2
Pappo, O.3
Peters, M.4
Rose-John, S.5
-
34
-
-
0034464010
-
Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration
-
Peters, M., et al. 2000. Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Gastroenterology. 119:1663-1671.
-
(2000)
Gastroenterology
, vol.119
, pp. 1663-1671
-
-
Peters, M.1
-
35
-
-
0034985726
-
Hyper-IL-6 gene therapy reverses fulminant hepatic failure
-
Hecht, N., et al. 2001. Hyper-IL-6 gene therapy reverses fulminant hepatic failure. Mol. Ther. 3:683-687.
-
(2001)
Mol. Ther.
, vol.3
, pp. 683-687
-
-
Hecht, N.1
-
36
-
-
0035210750
-
The superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouse
-
Malassagne, B., et al. 2001. The superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouse. Gastroenterology. 121:1451-1459.
-
(2001)
Gastroenterology
, vol.121
, pp. 1451-1459
-
-
Malassagne, B.1
-
37
-
-
0032571565
-
Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis
-
Suzuki, Y., Ono, Y., and Hirabayashi, Y. 1998. Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis. FEBS Lett. 425:209-212.
-
(1998)
FEBS Lett.
, vol.425
, pp. 209-212
-
-
Suzuki, Y.1
Ono, Y.2
Hirabayashi, Y.3
-
38
-
-
0032955276
-
NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: The role of reactive oxygen species
-
Giardina, C., Boulares, H., and Inan, M.S. 1999. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. Biochem. Biophys. Acta. 1448:425-438.
-
(1999)
Biochem. Biophys. Acta
, vol.1448
, pp. 425-438
-
-
Giardina, C.1
Boulares, H.2
Inan, M.S.3
-
39
-
-
0032862023
-
Dual mechanism of Fas-induced cell death in neuroglioma cells: A role for reactive oxygen species
-
Jayanthi, S., Ordonez, S., McCoy, M.T., and Cadet, J.L. 1999. Dual mechanism of Fas-induced cell death in neuroglioma cells: a role for reactive oxygen species. Brain Res. Mol. Brain Res. 72:158-165.
-
(1999)
Brain Res. Mol. Brain Res.
, vol.72
, pp. 158-165
-
-
Jayanthi, S.1
Ordonez, S.2
McCoy, M.T.3
Cadet, J.L.4
-
40
-
-
0029826849
-
Fas-induced programmed cell death is mediated by a Ras-regulated O2-synthesis
-
Gulbins, E., et al. 1996. Fas-induced programmed cell death is mediated by a Ras-regulated O2-synthesis. Immunology. 89:205-212.
-
(1996)
Immunology
, vol.89
, pp. 205-212
-
-
Gulbins, E.1
-
41
-
-
0026323008
-
Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of family of DNA repair enzymes
-
Demple, B., Herman, T., and Chen, D. 1991. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of family of DNA repair enzymes. Proc. Natl. Acad. Sci. U. S. A. 88:11450-11454.
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 11450-11454
-
-
Demple, B.1
Herman, T.2
Chen, D.3
-
42
-
-
0027963233
-
Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro
-
Miromo, K., et al. 1994. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro. Gene. 145:197-203.
-
(1994)
Gene
, vol.145
, pp. 197-203
-
-
Miromo, K.1
-
43
-
-
0030900605
-
Identification of redox/repair protein Ref-1 as a potent activator of p53
-
Jayaraman, L., et al. 1997. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev. 11:558-570.
-
(1997)
Genes Dev.
, vol.11
, pp. 558-570
-
-
Jayaraman, L.1
-
44
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
Huang, L.E., Arany, Z., Livingston, D.M., and Bunn, H.F. 1996. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J. Biol. Chem. 271:32253-32259.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
45
-
-
0030936987
-
Redox regulation of cellular activation
-
Nakamura, H., Nakamura, K., and Yodoi, J. 1997. Redox regulation of cellular activation. Annu. Rev. Immunol. 15:351-369.
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 351-369
-
-
Nakamura, H.1
Nakamura, K.2
Yodoi, J.3
-
46
-
-
0035964305
-
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase
-
Negoro, S., et al. 2001. Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. Circulation. 104:979-981.
-
(2001)
Circulation
, vol.104
, pp. 979-981
-
-
Negoro, S.1
-
47
-
-
0035092841
-
Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells
-
Nakagami, H., et al. 2001. Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension. 37:581-586.
-
(2001)
Hypertension
, vol.37
, pp. 581-586
-
-
Nakagami, H.1
-
48
-
-
0038146887
-
Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated anti-apoptotic signaling: Role of PI3-K and Akt kinase upon rac1
-
Ozaki, M., Haga, S., Zhang, H., Irani, K., and Suzuki, S. 2003. Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated anti-apoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell Death Differ. 10:508-515.
-
(2003)
Cell Death Differ.
, vol.10
, pp. 508-515
-
-
Ozaki, M.1
Haga, S.2
Zhang, H.3
Irani, K.4
Suzuki, S.5
-
49
-
-
0036177969
-
Formation of protein kinase Cε-Lck signaling modules confers cardioprotection
-
JCI200213200
-
Ping, P., et al. 2002. Formation of protein kinase Cε-Lck signaling modules confers cardioprotection. J. Clin. Invest. 109:499-507. JCI200213200.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 499-507
-
-
Ping, P.1
|