Expression of Oct4 in HCC and modulation to wnt/β-catenin and TGF-β signal pathways

Molecular and Cellular Biochemistry

Volumn 343, Issue 1-2, 2010, Pages 155-162

  Yuan, Fangjun ^a   Zhou, Wenbo ^a   Zou, Can ^a   Zhang, Zhiyun ^a   Hu, Hongsheng ^a   Dai, Zongqing ^a   Zhang, Youshun ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

HCC; Oct4; Regulation; Stem cell related gene; TGF ; Wnt catenin

Indexed keywords

BETA CATENIN; OCTAMER TRANSCRIPTION FACTOR 4; SMAD3 PROTEIN; SMAD4 PROTEIN; STAT3 PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEPG2; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

BASE SEQUENCE; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA PRIMERS; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIVER NEOPLASMS; OCTAMER TRANSCRIPTION FACTOR-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS;

EID: 77957599212     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0509-3     Document Type: Article

References (33)

1. MB Thomas AX Zhu 2005 Hepatocellular carcinoma: the need for progress J clinic Oncol 23 2892 2899 10.1200/JCO.2005.03.196 (Pubitemid 46224106)
2. FJ Yuan WB Zhou JF Zhang ZY Zhang C Zou L Huang YS Zhang ZQ Dai 2008 Anti-cancer drugs are synergistic with freezing in induction of apoptosis in HCC cells Cryobiology 57 60 65 1:CAS:528:DC%2BD1cXpsVCkuro%3D 10.1016/j.cryobiol. 2008.06.001 18586021
3. T Chiba K Kita YW Zheng O Yokosuka H Saisho A Iwama H Nakauchi H Taniguchi 2006 Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties Hepatology 44 240 251 1:CAS:528:DC%2BD28XnsFWjur0%3D 10.1002/hep.21227 16799977 (Pubitemid 44049156)
4. MF Clarke M Fuller 2006 Stem cells and cancer: two faces of eve Cell 124 1111 1115 1:CAS:528:DC%2BD28Xjt1Kiu7s%3D 10.1016/j.cell.2006.03.011 16564000
5. CT Freberg JA Dahl S Timoskainen P Collas 2007 Epigenetic reprogramming of oct4 and nanog regulatory regions by embryonal carcinoma cell extract Mol Biol Cell 18 1543 1553 1:CAS:528:DC%2BD2sXlt1Orsr8%3D 10.1091/mbc.E07-01-0029 17314394 (Pubitemid 46717539)
6. Y Babaie R Herwig B Greber TC Brink W Wruck D Groth H Lehrach T Burdon J Adjaye 2007 Analysis of oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells Stem Cell 25 500 510 1:CAS:528:DC%2BD2sXivVOltL8%3D 10.1634/stemcells.2006-0426 (Pubitemid 46232806)
7. DC Hay L Sutherland J Clark T Burdon 2004 Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells Stem Cell 22 225 235 1:CAS:528:DC%2BD2cXis1Sgsbc%3D 10.1634/stemcells.22-2-225
8. LA Boyer TI Lee MF Cole SE Johnstone SS Levine JP Zucker MG Guenther RM Kumar HL Murray RG Jenner DK Gifford DA Melton R Jaenisch RA Young 2005 Core transcriptional regulatory circuitry in human embryonic stem cells Cell 122 947 956 1:CAS:528:DC%2BD2MXhtVOrurbJ 10.1016/j.cell.2005.08.020 16153702 (Pubitemid 41345211)
9. UI Ezeh PJ Turek RA Reijo AT Clark 2005 Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma Cancer 104 2255 2265 1:CAS:528:DC%2BD2MXht1Cksr7M 10.1002/cncr.21432 16228988 (Pubitemid 41579973)
10. G Gu J Yuan M Wills S Kasper 2007 Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo Cancer Res 67 4807 4815 1:CAS:528:DC%2BD2sXltl2gsL8%3D 10.1158/0008-5472.CAN-06-4608 17510410 (Pubitemid 46910189)
11. YC Chen HS Hsu YW Chen TH Tsai CK How CY Wang SC Hung YL Chang ML Tsai YY Lee HH Ku SH Chiou 2008 Oct-4 expression maintained cancer stem-like properties in lung cancer-derived cd133-positive cells PLoS ONE 3 1 14
12. J Wang A Wynshaw-Boris 2004 The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation Curr Opin Genet Dev 14 533 539 1:CAS:528:DC%2BD2cXnslGms70%3D 10.1016/j.gde.2004.07.013 15380245 (Pubitemid 39360301)
13. MD Thompson SP Monga 2007 WNT/β-catenin signaling in liver health and disease Hepatology 45 1298 1305 1:CAS:528:DC%2BD2sXlslOisr8%3D 10.1002/hep.21651 17464972 (Pubitemid 46775794)
14. T Reya H Clevers 2005 Wnt signalling in stem cells and cancer Nature 434 843 850 1:CAS:528:DC%2BD2MXjtFOmsrw%3D 10.1038/nature03319 15829953 (Pubitemid 40558990)
15. E Glasgow L Mishra 2008 Transforming growth factor-b signaling and ubiquitinators in cancer Endocr Relat Cancer 15 59 72 1:CAS:528: DC%2BD1cXkslKntbc%3D 10.1677/ERC-07-0168 18310276 (Pubitemid 351449728)
16. R Amin L Mishra 2008 Liver stem cells and TGF-β in hepatic carcinogenesis Gastrointest Cancer Res 2 4 Suppl S27 S30 19343145
17. L Mishra T Banker J Murray S Byers A Thenappan AR He K Shetty L Johnson EP Reddy 2009 Liver stem cells and hepatocellular carcinoma Hepatology 49 318 329 10.1002/hep.22704 19111019
18. L Ouyang LY Shen T Li J Liu 2006 Inhibition effedt of Oncostatin M on metastatic homan lumg cancer cells 95-D in vitro and on mutine melanoma cells B16BL6 in vitro Biomed Res 27 197 202 1:CAS:528:DC%2BD28XpsFKnsrY%3D 10.2220/biomedres.27.197 16971773 (Pubitemid 44420488)
19. KJ Hamill L Langbein JR Jones W McLean 2009 Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization JBC 284 35588 35596 1:CAS:528:DC%2BD1MXhsFCqurbP 10.1074/jbc.M109.052811
20. K Takahashi S Yamanaka 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 663 676 1:CAS:528:DC%2BD28Xpt1aktbs%3D 10.1016/j.cell.2006.07.024 16904174 (Pubitemid 44233629)
21. K Takahashi K Tanabe M Ohnuki 2007 Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 861 872 1:CAS:528:DC%2BD2sXhsVCntbbK 10.1016/j.cell.2007.11.019 18035408 (Pubitemid 350138099)
22. M Wernig A Meissner R Foreman T Brambrink M Ku K Hochedlinger BE Bernstein R Jaenisch 2007 In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 448 318 324 1:CAS:528:DC%2BD2sXnvVeqsLg%3D 10.1038/nature05944 17554336 (Pubitemid 47080337)
23. MW Lensch JA West 2008 Looking into the future of cell-based therapy South Med J 101 79 82 18176297
24. J Gil A Stembalska KA Pesz MM Sasiadek 2008 Cancer stem cells: the theory and perspectives in cancer therapy J App Genet 49 193 199
25. CC Chang GS Shieh P Wu CC Lin AL Shiau CL Wu 2008 Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells Cancer Res 68 6281 6291 1:CAS:528:DC%2BD1cXpt1WjsLw%3D 10.1158/0008-5472.CAN-08-0094 18676852
26. Y Tang K Kitisin W Jogunoori SC Mueller HW Ressom A Rashid AR He JS Mendelson JM Jessup K Shetty M Zasloff B Mishra EP Reddy L Johnson L Mishra 2008 Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling Proc Natl Acad Sci USA 105 2445 2450 1:CAS:528: DC%2BD1cXis1Khtbc%3D 10.1073/pnas.0705395105 18263735 (Pubitemid 351520533)
27. I Palma RY Pen A Contreras G Ceballos-Reyes N Coyote L Eran S Kofman-Alfaro G Queipo 2008 Participation of OCT3/4 and b-catenin during dysgenetic gonadal malignant transformation Cancer Lett 263 204 211 1:CAS:528:DC%2BD1cXks12ns7k%3D 10.1016/j.canlet.2008.01.019 18295396
28. MF Cole SE Johnstone JJ Newman MH Kagey RA Young 2008 Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells Genes Dev 22 746 755 1:CAS:528:DC%2BD1cXjvFeqsrc%3D 10.1101/gad.1642408 18347094 (Pubitemid 351439106)
29. WL Tam CY Lim JY Han JQ Zhang YS Ang HH Ng H Yang B Lim 2008 T-Cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways Stem Cells 26 2019 2031 1:CAS:528:DC%2BD1cXhtVKmt7zL 10.1634/stemcells.2007-1115 18467660
30. F Yi L Pereira BJ Merrill 2008 Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal Stem Cell 26 1951 1960 1:CAS:528:DC%2BD1cXhtVKmt7%2FJ 10.1634/stemcells.2008-0229
31. WC Hahn K Polyak 2005 Roots and stems: stem cells in cancer Nat Med 11 296 300
32. C Millet YE Zhang 2007 Roles of smad3 in TGF-β signaling during carcinogenesis Crit Rev Eukaryot Gene Expr 17 281 293 1:CAS:528: DC%2BD2sXhtVWgtLjF 17725494
33. NA Shackel GW McCaughan FJ Warner 2008 Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling Hepatology 47 2134 2136 10.1002/hep.22369 18508299 (Pubitemid 351945578)