Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

Science

Volumn 317, Issue 5834, 2007, Pages 121-124

  Naugler, Willscott E ^a,b   Sakurai, Toshiharu ^a   Kim, Sunhwa ^a   Maeda, Shin ^c   Kim, KyoungHyun ^a   Elsharkawy, Ahmed M ^a,d   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c INSTITUTE FOR ADULT DISEASES   (Japan)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLNITROSAMINE; ESTROGEN; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88;

CANCER; CARCINOGEN; CHEMICAL COMPOUND; ESTROGENIC COMPOUND; GENDER DISPARITY; HEALTH RISK; INHIBITION; RODENT; SEX-RELATED DIFFERENCE; SEXUAL DIMORPHISM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CANCER RISK; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENDER; KUPFFER CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RISK REDUCTION; SEX DIFFERENCE;

ANIMALS; CARBON TETRACHLORIDE; DIETHYLNITROSAMINE; ESTRADIOL; FEMALE; HEPATOCYTES; INTERLEUKIN-6; KUPFFER CELLS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NECROSIS; OVARIECTOMY; RNA, MESSENGER; SEX CHARACTERISTICS;

MUS;

EID: 34447327216     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140485     Document Type: Article

References (30)

1. G. Fattovich, T. Stroffolini, I. Zagni, F. Donato, Gastroenterology 127, 535 (2004).
2. M. Sherman, Semin. Liver Dis. 25, 143 (2005).
3. F. X. Bosch, J. Ribes, M. Diaz, R. Cleries, Gastroenterology 127, 55 (2004).
4. N. Ghebranious, S. Sell, Hepatology 27, 383 (1998).
5. S. Maeda, H. Kamata, J. L. Luo, H. Leffert, M. Karin, Cell 121, 977 (2005).
6. T. Nakatani, G. Roy, N. Fujimoto, T. Asahara, A. Ito, Jpn. J. Cancer Res. 92, 249 (2001).
7. F. Balkwill, A. Mantovani, Lancet 357, 539 (2001).
8. M. Karin, F. R. Greten, Nat. Rev. Immunol. 5, 749 (2005).
9. E. Pikarsky et al., Nature 431, 461 (2004).
10. T. Sakurai, S. Maeda, L. Chang, M. Karin, Proc. Natl. Acad. Sci. U.S.A. 103, 10544 (2006).
11. J. S. Lee et al., Nat. Genet. 36, 1306 (2004).
12. S. Abiru et al., Liver Int. 26, 39 (2006).
13. M. Soresi et al., World J. Gastroenterol. 12, 2563 (2006).
14. D. E. Cressman et al., Science 274, 1379 (1996).
15. Materials and methods are available as supporting material on Science Online.
16. I. Kovalszky et al., Carcinogenesis 13, 773 (1992).
17. L. W. Weber, Boll, A. Stampfl, Crit. Rev. Toxicol. 33, 105 (2003).
18. L. Verna, J. Whysner, G. M. Williams, Pharmacol. Ther. 71, 57 (1996).
19. M. Erikoglu, M. Sahin, S. Ozer, M. C. Avunduk, Surg. Today 35, 467 (2005).
20. T. Suzuki et al., J. Appl. Physiol. 102, 163 (2007).
21. R. Taub, Nat. Rev. Mol. Cell Biol. 5, 836 (2004).
22. B. Stein, M. X. Yang, Mol. Cell. Biol. 15, 4971 (1995).
23. R. Zheng et al., Mol. Med. 12, 65 (2006).
24. A. Velayudham et al., J. Hepatol. 45, 813 (2006).
25. Y. Yamada, I. Kirillova, J. J. Peschon, N. Fausto, Proc. Natl. Acad. Sci. U.S.A. 94, 1441 (1997).
26. S. Akira, S. Uematsu, O. Takeuchi, Cell 124, 783 (2006).
27. -/- mice resulted in as much IL-6 induction as seen in WT mice.
28. M. Karin, T. Lawrence, V. Nizet, Cell 124, 823 (2006).
29. M. T. Lotze, K. J. Tracey, Nat. Rev. Immunol. 5, 331 (2005).
30. We thank J. Feramisco for help with image capture and analysis and E. Karin for help with the surgical models. Supported by National Institute of Diabetes and Digestive and Kidney Diseases grant DK007202 (W.E.N.); Japan Society for the Promotion of Science (T.S.); Human Frontier Science Program (S.K.); and NIH grants ES004151 and ES006376, CA118165, and the Superfund Basic Research Program (M.K.). M.K. is an American Cancer Society Professor.