메뉴 건너뛰기




Volumn 3, Issue 9, 2002, Pages 651-662

STATs: Transcriptional control and biological impact

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CELL SURFACE RECEPTOR; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR;

EID: 0036731485     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm909     Document Type: Review
Times cited : (2728)

References (161)
  • 6
    • 0030765924 scopus 로고    scopus 로고
    • Jaks, STATs, cytokine signal transduction, and immunoregulation: Are we there yet?
    • (1997) Immunity , vol.7 , pp. 1-11
    • O'Shea, J.J.1
  • 8
    • 0029903770 scopus 로고    scopus 로고
    • DNA binding of in vitro activated Stat1 α, Stat1 β, and truncated Stat1: Interaction between NH2 terminal domains stabilizes binding of two dimers to tandem DNA sites
    • (1996) EMBO J. , vol.15 , pp. 5616-5626
    • Vinkemeier, U.1
  • 10
    • 0028979707 scopus 로고
    • Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
    • (1995) Immunity , vol.2 , pp. 677-687
    • Greenlund, A.C.1
  • 16
    • 0035933730 scopus 로고    scopus 로고
    • The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor
    • (2001) J. Biol. Chem. , vol.276 , pp. 22948-22953
    • Usacheva, A.1
  • 18
    • 0031740670 scopus 로고    scopus 로고
    • Biomolecular interaction analysis of IFN γ-Induced signaling events in whole-cell lysates: Prevalence of latent STAT1 in high-molecular weight complexes
    • (1998) Growth Factors , vol.16 , pp. 39-51
    • Lackmann, M.1
  • 20
    • 0032577678 scopus 로고    scopus 로고
    • Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to
    • (1998) DNA Cell , vol.93 , pp. 827-839
    • Chen, X.1
  • 23
    • 0037205415 scopus 로고    scopus 로고
    • Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IRF regulatory factor-1
    • (2002) J Biol. Chem. , vol.277 , pp. 19408-19417
    • Wong, L.H.1
  • 31
    • 0345281581 scopus 로고    scopus 로고
    • Inhibition of intedeukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion
    • (1999) J. Exp. Med. , vol.190 , pp. 1263-1274
    • Lee, I.H.1    Li, W.P.2    Hisert, K.B.3    Ivashkiv, L.B.4
  • 38
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence selective recognition conferred by the Stat amino terminal domain
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Ya-Lin, S.2    Hoey, T.3
  • 41
    • 0032561211 scopus 로고    scopus 로고
    • Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation
    • (1998) J. Biol. Chem. , vol.273 , pp. 28049-28056
    • Strehlow, I.1    Schindler, C.2
  • 55
    • 0036138705 scopus 로고    scopus 로고
    • A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: Dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus
    • (2002) Mol. Endocrinol. , vol.16 , pp. 58-69
    • Aoki, N.1    Matsuda, T.2
  • 57
    • 0034671546 scopus 로고    scopus 로고
    • A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b
    • (2000) J. Biol. Chem. , vol.275 , pp. 39718-39726
    • Aoki, N.1    Matsuda, T.2
  • 62
    • 0035575765 scopus 로고    scopus 로고
    • The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation
    • (2001) J. Immunol. , vol.167 , pp. 6447-6452
    • Dong, F.1    Qiu, Y.2    Yi, T.3    Touw, I.P.4    Larner, A.C.5
  • 65
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1
  • 66
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1
  • 67
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1
  • 69
    • 0037154210 scopus 로고    scopus 로고
    • Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppresor of cytokine signaling-1 (SOCS-1)
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 943-948
    • Metcalf, D.1
  • 70
  • 71
    • 0033520389 scopus 로고    scopus 로고
    • SOCS3 is essential in the regulation of fetal liver erythropoiesis
    • (1999) Cell , vol.98 , pp. 617-627
    • Marine, J.C.1
  • 73
    • 0036275657 scopus 로고    scopus 로고
    • Socs-6 binds to insulin receptor substrate 4, and mice lacking the Socs-6 gene exhibit mild growth retardation
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4567-4578
    • Krebs, D.L.1
  • 74
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1
  • 75
    • 0034657917 scopus 로고    scopus 로고
    • Modulation of STAT signaling by STAT-interacting proteins
    • (2000) Oncogene , vol.19 , pp. 2638-2644
    • Shuai, K.1
  • 78
    • 0035576737 scopus 로고    scopus 로고
    • A new RING for SUMO wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases
    • (2001) Genes Dev. , vol.15 , pp. 3053-3058
    • Jackson, P.K.1
  • 82
  • 84
    • 0035794217 scopus 로고    scopus 로고
    • DNA binding specificity of different STAT proteins. Comparisons of in vitro specificity with natural target sites
    • (2001) J. Biol. Chem. , vol.276 , pp. 6675-6688
    • Ehret, G.B.1
  • 86
    • 0035831040 scopus 로고    scopus 로고
    • Arginine methylation of STAT1 modulates IFNα/β-induced transcription
    • (2001) Cell , vol.104 , pp. 731-741
    • Mowen, K.A.1
  • 90
    • 0035123663 scopus 로고    scopus 로고
    • Antiviral response in cells containing Stat1 with heterologous transactivation domains
    • (2001) J. Virol. , vol.75 , pp. 2627-2633
    • Shen, Y.1    Darnell, J.E.2
  • 91
    • 0032401780 scopus 로고    scopus 로고
    • Ser 727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation
    • (1998) EMBO J. , vol.17 , pp. 6963-6971
    • Zhang, J.J.1
  • 92
    • 0033520422 scopus 로고    scopus 로고
    • Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
    • (1999) J Biol. Chem. , vol.274 , pp. 25343-25349
    • Paulson, M.1
  • 98
    • 0028917885 scopus 로고
    • Characterization of an intedeukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: Regulation by NF-IL-4, a C/EBP family member and NF-κB/p50
    • (1995) J. Exp. Med. , vol.181 , pp. 181-192
    • Delphin, S.1    Stavenezer, J.2
  • 101
    • 0033574767 scopus 로고    scopus 로고
    • Synergistic signaling in fetal brain by STAT3-Smad 1 complex bridged by p300
    • (1999) Science , vol.284 , pp. 479-482
    • Nakashima, K.1
  • 107
    • 0035930688 scopus 로고    scopus 로고
    • Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling
    • (2001) Science , vol.294 , pp. 2546-2549
    • Tulina, N.1    Matunis, E.2
  • 109
    • 0035966321 scopus 로고    scopus 로고
    • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
    • (2001) Cell , vol.107 , pp. 831-841
    • Silver, D.L.1    Montell, D.J.2
  • 110
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1
  • 111
    • 0031057929 scopus 로고    scopus 로고
    • Stat5a is mandatory for adult mammary gland development and lactogenesis
    • (1997) Genes Dev. , vol.11 , pp. 179-186
    • Uu, X.1
  • 113
    • 0035760889 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in Stat5a(-/-) 5b(-/-) mice due to decreased survival of early erythroblasts
    • (2001) Blood , vol.98 , pp. 3261-3273
    • Socolovsky, M.1
  • 114
    • 0033082138 scopus 로고    scopus 로고
    • Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    • (1999) Immunity , vol.10 , pp. 249-259
    • Moriggl, R.1
  • 115
    • 0037079697 scopus 로고    scopus 로고
    • Reduced Lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5
    • (2002) Blood , vol.99 , pp. 479-487
    • Bunting, K.D.1
  • 117
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • (2000) Oncogene , vol.19 , pp. 2607-2611
    • Akira, S.1
  • 120
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 122
    • 0035854542 scopus 로고    scopus 로고
    • Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation
    • (2001) Science , vol.293 , pp. 300-303
    • Dupuis, S.1
  • 123
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation in the liver
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1621-1632
    • Alonzi, T.1
  • 124
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for 11-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • (1998) J. Immunol. , vol.161 , pp. 4652-4660
    • Takeda, K.1
  • 125
    • 0033034365 scopus 로고    scopus 로고
    • H 1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1
  • 126
    • 85006273344 scopus 로고    scopus 로고
    • STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
    • Immunity
    • Lee, C.-K.1
  • 128
    • 0032473555 scopus 로고    scopus 로고
    • Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
    • (1998) J. Exp. Med. , vol.187 , pp. 675-683
    • Miller, D.M.1
  • 130
    • 0035837045 scopus 로고    scopus 로고
    • The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2
    • (2001) Virology , vol.283 , pp. 230-239
    • Parisien, J.P.1
  • 132
    • 0034969251 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    • (2001) J. Virol. , vol.75 , pp. 6095-6106
    • Polyak, S.J.1
  • 133
    • 0033636997 scopus 로고    scopus 로고
    • Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleopodn Nup98
    • (2000) Mol. Cell. , vol.6 , pp. 1243-1252
    • Von Kobbe, C.1
  • 134
    • 0030810744 scopus 로고    scopus 로고
    • Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus
    • (1997) Science , vol.276 , pp. 1845-1848
    • Her, L.S.1    Lund, E.2    Dahlberg, J.E.3
  • 140
    • 0034292328 scopus 로고    scopus 로고
    • Distinct requirements for IFNs and STAT1 in NK cell function
    • (2000) J. Immunol. , vol.165 , pp. 3571-3577
    • Lee, C.K.1
  • 141
    • 0035953308 scopus 로고    scopus 로고
    • IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1
  • 146
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • (2001) Nature Genet. , vol.28 , pp. 29-35
    • Yoshikawa, H.1
  • 147
    • 0036134884 scopus 로고    scopus 로고
    • Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
    • (2002) J. Immunity , vol.168 , pp. 466-474
    • Zhang, Q.1
  • 149
    • 0029656001 scopus 로고    scopus 로고
    • Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth facton
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 369-375
    • Leaman, D.W.1
  • 151
    • 0034690026 scopus 로고    scopus 로고
    • Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity
    • (2000) Oncogene , vol.19 , pp. 2075-2085
    • Wang, Y.Z.1
  • 154
    • 0038496288 scopus 로고    scopus 로고
    • Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway
    • (2000) Mol. Endocrinol. , vol.14 , pp. 662-670
    • Park, E.S.1
  • 155
    • 0029069540 scopus 로고
    • Enhanced DNA-binding of a Stat3-related protein in cells transformed by the Src oncoprotein
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1
  • 157
    • 0029019246 scopus 로고
    • Direct stimulation of JAk/STAT pathway by the angiotensin II AT1 receptor
    • (1995) Nature , vol.375 , pp. 247-250
    • Marrero, M.B.1
  • 158
    • 0037155831 scopus 로고    scopus 로고
    • Stat2 binding to the interferon-α receptor 2 subunit is not required for interferon-α signaling
    • (2002) J. Biol. Chem. , vol.277 , pp. 9713-9721
    • Nguyen, V.P.1
  • 161
    • 0032577678 scopus 로고    scopus 로고
    • Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
    • (1998) Cell , vol.93 , pp. 827-839
    • Chen, X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.