메뉴 건너뛰기




Volumn 4, Issue 8, 2011, Pages 1296-1305

Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; DOXORUBICIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE 2; SORAFENIB; STAT3 PROTEIN;

EID: 80051490683     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0317     Document Type: Article
Times cited : (60)

References (48)
  • 3
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology, risk factors, and screening
    • DOI 10.1055/s-2005-871194
    • Sherman M. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin Liver Dis 2005;25:143-54. (Pubitemid 40781067)
    • (2005) Seminars in Liver Disease , vol.25 , Issue.2 , pp. 143-154
    • Sherman, M.1
  • 4
    • 20544454121 scopus 로고    scopus 로고
    • Liver cancer on the rise
    • Wilson JF. Liver cancer on the rise. Ann Intern Med 2005;142:1029-32. (Pubitemid 40840324)
    • (2005) Annals of Internal Medicine , vol.142 , Issue.12 I , pp. 1029-1032
    • Wilson, J.F.1
  • 6
    • 65649111667 scopus 로고    scopus 로고
    • High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
    • Wong VW, Yu J, Cheng AS, Wong GL, Chan HY, Chu ES, et al. High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer 2009;124:2766-70.
    • (2009) Int J Cancer , vol.124 , pp. 2766-2770
    • Wong, V.W.1    Yu, J.2    Cheng, A.S.3    Wong, G.L.4    Chan, H.Y.5    Chu, E.S.6
  • 9
  • 11
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 2002;8:945-54. (Pubitemid 35177340)
    • (2002) Clinical Cancer Research , vol.8 , Issue.4 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 14
    • 0037206950 scopus 로고    scopus 로고
    • Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
    • DOI 10.1038/sj.onc.1206004
    • Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 2002;21:7611-8. (Pubitemid 35398808)
    • (2002) Oncogene , vol.21 , Issue.50 , pp. 7611-7618
    • Real, P.J.1    Sierra, A.2    De Juan, A.3    Segovia, J.C.4    Lopez-Vega, J.M.5    Fernandez-Luna, J.L.6
  • 16
    • 1042302005 scopus 로고    scopus 로고
    • The stats of cancer - New molecular targets come of age
    • Yu H, Jove R. The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 2004;4:97-105. (Pubitemid 38198738)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 17
    • 25444513779 scopus 로고    scopus 로고
    • A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
    • DOI 10.1074/jbc.M502694200
    • Turkson J, Zhang S, Mora LB, Burns A, Sebti S, Jove R. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J Biol Chem 2005;280:32979-88. (Pubitemid 41368347)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.38 , pp. 32979-32988
    • Turkson, J.1    Zhang, S.2    Mora, L.B.3    Burns, A.4    Sebti, S.5    Jove, R.6
  • 19
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • DOI 10.1038/sj.onc.1206047
    • Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 2002;21:8404-13. (Pubitemid 36054883)
    • (2002) Oncogene , vol.21 , Issue.55 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 20
    • 76649098901 scopus 로고    scopus 로고
    • STAT3 blockade with shRNA enhances radiosensitivity in Hep-2 human laryngeal squamous carcinoma cells
    • Li X, Wang H, Lu X, Di B. STAT3 blockade with shRNA enhances radiosensitivity in Hep-2 human laryngeal squamous carcinoma cells. Oncol Rep 2010;23:345-53.
    • (2010) Oncol Rep , vol.23 , pp. 345-353
    • Li, X.1    Wang, H.2    Lu, X.3    Di, B.4
  • 21
    • 77956238512 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells
    • Liu Y, Li PK, Li C, Lin J. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. J Biol Chem 2010;285:27429-39.
    • (2010) J Biol Chem , vol.285 , pp. 27429-27439
    • Liu, Y.1    Li, P.K.2    Li, C.3    Lin, J.4
  • 22
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009;15:91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    Von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 23
    • 34548549283 scopus 로고    scopus 로고
    • Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    • Berishaj M, Gao SP, Ahmed S, Leslie K, Al-Ahmadie H, Gerald WL, et al. Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Breast Cancer Res 2007;9:R32.
    • (2007) Breast Cancer Res , vol.9
    • Berishaj, M.1    Gao, S.P.2    Ahmed, S.3    Leslie, K.4    Al-Ahmadie, H.5    Gerald, W.L.6
  • 24
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • DOI 10.1038/nri1995, PII NRI1995
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51. (Pubitemid 46020826)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.1 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 25
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 26
    • 60549108333 scopus 로고    scopus 로고
    • The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling
    • Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 2009;28:961-72.
    • (2009) Oncogene , vol.28 , pp. 961-972
    • Lin, L.1    Amin, R.2    Gallicano, G.I.3    Glasgow, E.4    Jogunoori, W.5    Jessup, J.M.6
  • 27
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009;457:200-4.
    • (2009) Nature , vol.457 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3    Poussin, K.4    Imbeaud, S.5    Pilati, C.6
  • 28
    • 0037123348 scopus 로고    scopus 로고
    • Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells
    • Syed V, Ulinski G, Mok SC, Ho SM. Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells. J Natl Cancer Inst 2002;94:617-29. (Pubitemid 34498649)
    • (2002) Journal of the National Cancer Institute , vol.94 , Issue.8 , pp. 617-629
    • Syed, V.1    Ulinski, G.2    Mok, S.C.3    Ho, S.-M.4
  • 29
    • 34247600538 scopus 로고    scopus 로고
    • STAT3 as a central mediator of neoplastic cellular transformation
    • DOI 10.1016/j.canlet.2006.10.017, PII S0304383506005763
    • Frank DA. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 2007;251:199-210. (Pubitemid 46680370)
    • (2007) Cancer Letters , vol.251 , Issue.2 , pp. 199-210
    • Frank, D.A.1
  • 30
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
    • Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 2009;1171:59-76.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Gupta, S.R.4    Tharakan, S.T.5    Koca, C.6
  • 31
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 2002;62:3351-5.
    • (2002) Cancer Res , vol.62 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3    Nakashima, T.4    Kuratomi, Y.5    Azuma, K.6
  • 33
    • 0033451992 scopus 로고    scopus 로고
    • Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
    • Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 1999;11:709-19. (Pubitemid 30030710)
    • (1999) Immunity , vol.11 , Issue.6 , pp. 709-719
    • Shirogane, T.1    Fukada, T.2    Muller, J.M.M.3    Shima, D.T.4    Hibi, M.5    Hirano, T.6
  • 36
    • 33644526633 scopus 로고    scopus 로고
    • Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells
    • Itoh M, Murata T, Suzuki T, Shindoh M, Nakajima K, Imai K, et al. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene 2006;25:1195-204.
    • (2006) Oncogene , vol.25 , pp. 1195-1204
    • Itoh, M.1    Murata, T.2    Suzuki, T.3    Shindoh, M.4    Nakajima, K.5    Imai, K.6
  • 37
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • DOI 10.1038/sj.onc.1207383
    • Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004;23:3550-60. (Pubitemid 38658421)
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3550-3560
    • Xie, T.-X.1    Wei, D.2    Liu, M.3    Gao, A.C.4    Ali-Osman, F.5    Sawaya, R.6    Huang, S.7
  • 38
    • 47249161129 scopus 로고    scopus 로고
    • Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function
    • Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola D, Mansour M, et al. Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem 2008;283:14665-73.
    • (2008) J Biol Chem , vol.283 , pp. 14665-14673
    • Cheng, G.Z.1    Zhang, W.Z.2    Sun, M.3    Wang, Q.4    Coppola, D.5    Mansour, M.6
  • 39
    • 44749084859 scopus 로고    scopus 로고
    • Role of Stat3 in suppressing anti-tumor immunity
    • Kortylewski M, Yu H. Role of Stat3 in suppressing anti-tumor immunity. Curr Opin Immunol 2008;20:228-33.
    • (2008) Curr Opin Immunol , vol.20 , pp. 228-233
    • Kortylewski, M.1    Yu, H.2
  • 41
    • 85047689502 scopus 로고    scopus 로고
    • Hepatoprotection via the IL-6/Stat3 pathway
    • DOI 10.1172/JCI200319974
    • Taub R. Hepatoprotection via the IL-6/Stat3 pathway. J Clin Invest 2003;112:978-80. (Pubitemid 38056310)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.7 , pp. 978-980
    • Taub, R.1
  • 42
    • 0033970969 scopus 로고    scopus 로고
    • Increased toxin-induced liver injury and fibrosis in interleukin-6- deficient mice
    • Kovalovich K, DeAngelis RA, Li W, Furth EE, Ciliberto G, Taub R. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology 2000;31:149-59. (Pubitemid 30033701)
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 149-159
    • Kovalovich, K.1    Deangelis, R.A.2    Li, W.3    Furth, E.E.4    Ciliberto, G.5    Taub, R.6
  • 43
    • 0033810515 scopus 로고    scopus 로고
    • Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury
    • Galun E, Zeira E, Pappo O, Peters M, Rose-John S. Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury. FASEB J 2000;14:1979-87.
    • (2000) FASEB J , vol.14 , pp. 1979-1987
    • Galun, E.1    Zeira, E.2    Pappo, O.3    Peters, M.4    Rose-John, S.5
  • 44
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • DOI 10.1126/science.1140485
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121-4. (Pubitemid 47056470)
    • (2007) Science , vol.317 , Issue.5834 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 45
    • 84876017972 scopus 로고    scopus 로고
    • Effects of inflammatory cytokines on the recurrence of liver cancer after an apparently curative operation
    • DOI 10.1111/j.1443-9573.2007.00292.x
    • Bai L, Mao GP, Cao CP. Effects of inflammatory cytokines on the recurrence of liver cancer after an apparently curative operation. J Dig Dis 2007;8:154-9. (Pubitemid 47161789)
    • (2007) Multiphase Pumping and Technologies Conference and Exhibition 2007 , vol.8 , Issue.3 , pp. 154-159
    • Bai, L.1    Mao, G.P.2    Cao, C.P.3
  • 46
    • 0037032482 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells
    • DOI 10.1016/S0014-5793(02)03535-4, PII S0014579302035354
    • Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells. FEBS Lett 2002;531:278-84. (Pubitemid 35341208)
    • (2002) FEBS Letters , vol.531 , Issue.2 , pp. 278-284
    • Yamazaki, R.1    Kusunoki, N.2    Matsuzaki, T.3    Hashimoto, S.4    Kawai, S.5
  • 47
    • 77649195951 scopus 로고    scopus 로고
    • Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence
    • Zheng X, Cui XX, Gao Z, Zhao Y, Lin Y, Shih WJ, et al. Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence. Cancer Prev Res 2010;3:114-24.
    • (2010) Cancer Prev Res , vol.3 , pp. 114-124
    • Zheng, X.1    Cui, X.X.2    Gao, Z.3    Zhao, Y.4    Lin, Y.5    Shih, W.J.6
  • 48
    • 0036468287 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    • Leahy KM, Ornberg RL, Wang Y, Zweifel BS, Koki AT, Masferrer JL. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res 2002;62:625-31. (Pubitemid 34126930)
    • (2002) Cancer Research , vol.62 , Issue.3 , pp. 625-631
    • Leahy, K.M.1    Ornberg, R.L.2    Wang, Y.3    Zweifel, B.S.4    Koki, A.T.5    Masferrer, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.