β-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: Potential uses for gene therapy

Oncology Reports

Volumn 24, Issue 4, 2010, Pages 1093-1099

  Wang, Xin Hong ^a,b   Sun, Xun ^a   Meng, Xiang Wei ^a   Lv, Zhi Wu ^b   Du, Ya Ju ^b   Zhu, Yan ^a   Chen, Jing ^b   Kong, De Xia ^a   Jin, Shi Zhu ^a  

^a JILIN UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

catenin; Angiogenesis factor; Apoptosis; Smad3; Telomerase

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BETA CATENIN; CASPASE 3; GELATINASE A; GELATINASE B; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 27; MESSENGER RNA; SMAD3 PROTEIN; SMALL INTERFERING RNA; TELOMERASE REVERSE TRANSCRIPTASE; VASCULOTROPIN A; VASCULOTROPIN C; X LINKED INHIBITOR OF APOPTOSIS;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL ASSAY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

BETA CATENIN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; LIVER NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; WNT PROTEINS;

EID: 77957369041     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000960     Document Type: Article

References (38)

1. Global cancer facts and figures. American Cancer Society, Atlanta, GA, pp1-52, 2007.
2. Zhang HK, Pan K, Wang H, et al: Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma. Cancer Lett 261: 183-192, 2008.
3. Lee HC, Kim M and Wands JR: Wnt/Frizzled signaling in hepatocellular carcinoma. Front Biosci 11: 1901-1915, 2006.
4. Ogasawara N, Tsukamoto T, Mizoshita T, et al: Mutations and nuclear accumulation of beta-catenin correlate with intestinal phenotypic expression in human gastric cancer. Histopathology 49: 612-621, 2006.
5. Ozaki S, Ikeda S, Ishizaki Y, et al: Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer. Oncol Rep 14: 1437-1443, 2005.
6. Martensson A, Oberg A, Jung A, Cederquist K, Stenling R and Palmqvist R: Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep 17: 447-452, 2007.
7. Thompson MD and Monga SP: WNT/beta-catenin signaling in liver health and disease. Hepatology 45: 1298-1305, 2007.
8. Seto ES and Bellen HJ: The ins and outs of Wingless signaling. Trends Cell Biol 14: 45-53, 2004.
9. Sangkhathat S, Kusafuka T, Miao J, et al: In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors. Int J Oncol 28: 715-722, 2006.
10. Zeng G, Apte U, Cieply B, Singh S and Monga SP: SiRNA-mediated β-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia 9: 951-959, 2007.
11. Kawada M, Seno H, Uenoyama Y, et al: Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. Cancer Res 66: 2913-2917, 2006.
12. Yan S, Zhou C, Zhang W, et al: beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett 271: 85-97, 2008.
13. Zhang M, Lee CH, Luo DD, Krupa A, Fraser D and Phillips A: Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. J Biol Chem 282: 28639-28647, 2007.
14. Nakamoto K, Kuratsu J and Ozawa M: Beta-catenin cleavage in non-apoptotic cells with reduced cell adhesion activity. Int J Mol Med 15: 973-979, 2005.
15. Poma P, Notarbartolo M, Labbozzetta M, et al: Antitumor effects of the novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin on human hepatic cancer cells: analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production. Int J Oncol 28: 923-930, 2006.
16. Calviello G, Resci F, Serini S, et al: Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis 28: 1202-1209, 2007.
17. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811, 1998. (Pubitemid 28099681)
18. Gumireddy K, Li A, Gimotty PA, et al: KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol 11: 1297-1304, 2009.
19. Gailhouste L, Ezan F, Bessard A, et al: RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo. Int J Cancer 126: 1367-1377, 2009.
20. Li Y, Ye X, Tan C, et al: Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene 28: 3442-3455, 2009.
21. Cai MJ, Xie RF, Han L, et al: Effect of RNAi-mediated LRIG3 gene silencing on proliferation of glioma GL15 cells and expression of PCNA and Ki-67. Chin J Cancer 28: 1-4, 2009.
22. Dudich E, Semenkova L, Dudich I, Denesyuk A, Tatulov E and Korpela T: Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP-caspase interaction. FEBS J 273: 3837-3849, 2006.
23. Varfolomeev E, Alicke B, Elliott JM, et al: X chromosome- linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. J Biol Chem 284: 34553-34560, 2009.
24. Shi YH, Ding WX, Zhou J, et al: Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology 48: 497-507, 2008.
25. Sakemi R, Yano H, Ogasawara S, et al: X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues. Oncol Rep 18: 65-70, 2007.
26. Jaffer S, Orta L, Sunkara S, Sabo E and Burstein DE: Immunohistochemical detection of antiapoptotic protein X-linked inhibitor of apoptosis in mammary carcinoma. Hum Pathol 38: 864-870, 2007.
27. Matsuyama M, Chijiwa T, Inoue Y, et al: Alternative splicing variant of vascular endothelial growth factor-A is a critical prognostic factor in non-small cell lung cancer. Oncol Rep 22: 1407-1413, 2009.
28. Surazynski A, Donald SP, Cooper SK, et al: Extracellular matrix and HIF-1 signaling: the role of prolidase. Int J Cancer 122: 1435-1440, 2008.
29. Gao ZL, Zhang C, Du GY and Lu ZJ: Clinical significance of changes in tumor markers, extracellular matrix, MMP-9 and VEGF in patients with gastric carcinoma. Hepatogastroenterology 54: 1591-1595, 2007.
30. Carmeliet P: VEGF as a key mediator of angiogenesis in cancer. Oncology 69: 4-10, 2005.
31. Kong D, Li Y, Wang Z, Banerjee S and Sarkar FH: Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res 67: 3310-3319, 2007.
32. Yang J, Wang J, Zhao J, Zuo D, Li X and Wang L: Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin. Oncol Rep 21: 949-955, 2009.
33. Wu B, Crampton SP and Hughes CC: Wnt signaling induces MMP expression and regulates T cell transmigration. Immunity 26: 227-239, 2007.
34. Chen CL, Loy A, Cen L, et al: Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. BMC Cancer 7: 111, 2007.
35. Hao J, Li TG, Qi X, Zhao DF and Zhao GQ: WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol 290: 81-91, 2006.
36. Kim SG, Kim HA, Jong HS, et al: The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3. Mol Biol Cell 16: 4672-4683, 2005.
37. Janknecht R: On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett 564: 9-13, 2004.
38. Li H, Xu D, Li J, Berndt MC and Liu JP: Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene. J Biol Chem 281: 25588-25600, 2006.