STAT proteins and transcriptional responses to extracellular signals

Trends in Biochemical Sciences

Volumn 25, Issue 10, 2000, Pages 496-502

  Horvath, Curt M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERLEUKIN 12; JANUS KINASE; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT5B PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMAL; DNA-BINDING PROTEINS; EXTRACELLULAR MATRIX; HUMAN; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

HEXAPODA; JANUS; MYXOGASTRIA;

EID: 0034306290     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01624-8     Document Type: Review

References (56)

1. STATs and gene regulation
2. Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes
3. Cytoplasmic STAT proteins associate prior to activation
4. STAT SH2 groups contribute to specific interferon signalling by the Jak-STAT pathway
5. The significance of tetramerization in promoter recruitment by Stat5
6. DNA binding of in vitro activated Stat1α, Stat1β, and truncated Stat1: Interaction between NH2 terminal domains stabilizes binding of two dimers to tandem DNA sites
7. Structure of the amino-terminal protein interaction domain of STAT-4
8. Three-dimensional structure of the Stat3beta homodimer bound to DNA
9. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
10. Functionally distinct isoforms of STAT5 are generated by protein processing
11. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
12. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling
13. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFN-gamma-mediated signaling
14. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation
15. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes
16. Transcriptional activation by BRCA1
17. Evidence for a transcriptional activation function of BRCA1 C-terminal region
18. Interactions between STAT and non-STAT proteins in the Interferon stimulated gene factor 3 transcription complex
19. Stat1 depends on transcriptional synergy with Sp1
20. The linker domain of Stat1 is required for gamma interferon-driven transcription
21. Defective tumor necrosis factor-α induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
22. Regulation of c-myc expression by IFN-gamma through Stat1-dependent and-independent pathways
23. Function of Stat2 protein in transcriptional activation by IFN-α
24. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
25. Murine Stat2 is uncharacteristically divergent
26. Cooperation of Stat2 and p300/CBP in signalling induced by interferon α
27. Complementation of a mutant cell line: Central role of the 91-kDa polypeptide of ISGF3 in the interferon-α and-γ signal transduction pathway
28. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
29. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
30. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
31. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
32. Stat3 as an oncogene
33. Rapid activation of the Stat3 transcription complex in liver regeneration
34. Constitutive activation of Stat proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
35. Constitutive activation of STAT3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
36. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L galpha(o) protein
37. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
38. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
39. Interleukin 12 activates Stat3 and Stat4 by tyrosine phosphorylation in T cells
40. Requirement for Stat4 in IL-12 mediated responses of natural killer and T-cells
41. Impaired IL12 responses and enhanced development of Th2 cells in Stat4 deficient mice
42. Cooperative DNA binding and sequence selective recognition conferred by the Stat amino terminal domain
43. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
44. Distribution of the mammalian STAT gene family in mouse chromosomes
45. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
46. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption
47. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction
48. Functional interactions between Stat5 and the glucocorticoid receptor
49. Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription
50. A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated stat5
51. An interleukin-4-induced transcription factor: Il-4 Stat
52. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
53. Essential role of Stat6 in IL-4 signalling
54. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells
55. Requirements for Interleukin-4 induced gene expression and functional characterization of Stat6
56. Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta