Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis

Journal of Hepatology

Volumn 47, Issue 4, 2007, Pages 546-555

  Kusaba, Mariko ^a   Nakao, Kazuhiko ^a   Goto, Takashi ^a   Nishimura, Daisuke ^a   Kawashimo, Hiroshi ^a   Shibata, Hidetaka ^a   Motoyoshi, Yasuhide ^a   Taura, Naota ^a   Ichikawa, Tatsuki ^a   Hamasaki, Keisuke ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

AG490; Hepatoma; STAT3; TRAIL

Indexed keywords

CYCLIN D1; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BCL XL; STAT3 PROTEIN; SURVIVIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYCLIN D1; HUMANS; JANUS KINASE 2; LIVER NEOPLASMS; MICE; MICE, NUDE; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TYRPHOSTINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34548260509     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.04.017     Document Type: Article

References (44)

1. Aaronson D.S., and Horvath C.M. A road map for those who don't know JAK-STAT. Science 296 (2002) 1653-1655
2. Bowman T., Garcia R., Turkson J., and Jove R. STATs in oncogenesis. Oncogene 19 (2000) 2474-2488
3. Buettner R., Mora L.B., and Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8 (2002) 945-954
4. Wei D., Le X., Zheng L., Wang L., Frey J.A., Gao A.C., et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22 (2003) 319-329
5. Kanda N., Seno H., Konda Y., Marusawa H., Kanai M., Nakajima T., et al. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 23 (2004) 4921-4929
6. Clevenger C.V. Roles and regulation of stat family transcription factors in human breast cancer. Am J Pathol 165 (2004) 1449-1460
7. Kusaba T., Nakayama T., Yamazumi K., Yakata Y., Yoshizaki A., Nagayasu T., et al. Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol 58 (2005) 833-838
8. Hirano T., Ishihara K., and Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19 (2000) 2548-2556
9. Burke W.M., Jin X., Lin H.J., Huang M., Liu R., Reynolds R.K., et al. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 20 (2001) 7925-7934
10. Rahaman S.O., Harbor P.C., Chernova O., Barnett G.H., Vogelbaum M.A., and Haque S.J. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21 (2002) 8404-8413
11. Aoki Y., Feldman G.M., and Tosato G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 101 (2003) 1535-1542
12. Scholz A., Heinze S., Detjen K.M., Peters M., Welzel M., Hauff P., et al. Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 125 (2003) 891-905
13. Turkson J., Ryan D., Kim J.S., Zhang Y., Chen Z., Haura E., et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 276 (2001) 45443-45455
14. Leong P.L., Andrews G.A., Johnson D.E., Dyer K.F., Xi S., Mai J.C., et al. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci USA 100 (2003) 4138-4143
15. Mora L.B., Buettner R., Seigne J., Diaz J., Ahmad N., Garcia R., et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 62 (2002) 6659-6666
16. Chan K.S., Sano S., Kiguchi K., Anders J., Komazawa N., Takeda J., et al. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest 114 (2004) 720-728
17. Tiollais P., Pourcel C., and Dejean A. The hepatitis B virus. Nature 317 (1985) 489-495
18. Kiyosawa K., Sodeyama T., Tanaka E., Gibo Y., Yoshizawa K., Nakano Y., et al. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12 (1990) 671-675
19. Yoshikawa H., Matsubara K., Qian G.S., Jackson P., Groopman J.D., Manning J.E., et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28 (2001) 29-35
20. Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., et al. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene 24 (2005) 6406-6417
21. Feng D.Y., Zheng H., Tan Y., and Cheng R.X. Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance. World J Gastroenterol 7 (2001) 33-36
22. Liu P., Kimmoun E., Legrand A., Sauvanet A., Degott C., Lardeux B., et al. Activation of NF-kappa B, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas. J Hepatol 37 (2002) 63-71
23. Waris G., Turkson J., Hassanein T., and Siddiqui A. Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J Virol 79 (2005) 1569-1580
24. Yoshida T., Hanada T., Tokuhisa T., Kosai K., Sata M., Kohara M., et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 196 (2002) 641-653
25. Walczak H., Miller R.E., Ariail K., Gliniak B., Griffith T.S., Kubin M., et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5 (1999) 157-163
26. Ashkenazi A., Pai R.C., Fong S., Leung S., Lawrence D.A., Marsters S.A., et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104 (1999) 155-162
27. Yamanaka T., Shiraki K., Sugimoto K., Ito T., Fujikawa K., Ito M., et al. Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines. Hepatology 32 (2000) 482-490
28. Lacour S., Hammann A., Wotawa A., Corcos L., Solary E., and Dimanche-Boitrel M.T. Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. Cancer Res 61 (2001) 1645-1651
29. Chinnaiyan A.M., Prasad U., Shankar S., Hamstra D.A., Shanaiah M., Chenevert T.L., et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci USA 97 (2000) 1754-1759
30. Nakabayashi H., Taketa K., Yamane T., Miyazaki M., Miyano K., and Sato J. Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium. Gann 75 (1984) 151-158
31. Osawa Y., Banno Y., Nagaki M., Brenner D.A., Naiki T., Nozawa Y., et al. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol 167 (2001) 173-180
32. Takehara T., Liu X., Fujimoto J., Friedman S.L., and Takahashi H. Expression and role of Bcl-xL in human hepatocellular carcinomas. Hepatology 34 (2001) 55-61
33. Notarbartolo M., Cervello M., Giannitrapani L., Meli M., Poma P., Dusonchet L., et al. Expression of IAPs and alternative splice variants in hepatocellular carcinoma tissues and cells. Ann N Y Acad Sci 1028 (2004) 289-293
34. Niu G., Bowman T., Huang M., Shivers S., Reintgen D., Daud A., et al. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene 21 (2002) 7001-7010
35. Xi S., Zhang Q., Dyer K.F., Lerner E.C., Smithgall T.E., Gooding W.E., et al. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem 278 (2003) 31574-31583
36. Laird A.D., Li G., Moss K.G., Blake R.A., Broome M.A., Cherrington J.M., et al. Src family kinase activity is required for signal transducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells. Mol Cancer Ther 2 (2003) 461-469
37. Song L., Turkson J., Karras J.G., Jove R., and Haura E.B. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene 22 (2003) 4150-4165
38. Silva C.M. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 23 (2004) 8017-8023
39. Real P.J., Sierra A., De Juan A., Segovia J.C., Lopez-Vega J.M., and Fernandez-Luna J.L. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 21 (2002) 7611-7618
40. Alas S., and Bonavida B. Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clin Cancer Res 9 (2003) 316-326
41. Burdelya L., Catlett-Falcone R., Levitzki A., Cheng F., Mora L.B., Sotomayor E., et al. Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone. Mol Cancer Ther 1 (2002) 893-899
42. Sano S., Chan K.S., Kira M., Kataoka K., Takagi S., Tarutani M., et al. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res 65 (2005) 5720-5729
43. Shigeno M., Nakao K., Ichikawa T., Suzuki K., Kawakami A., Abiru S., et al. Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation. Oncogene 22 (2003) 1653-1662
44. Alvarez J.V., Febbo P.G., Ramaswamy S., Loda M., Richardson A., and Frank D.A. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 65 (2005) 5054-5062