The significance of tetramerization in promoter recruitment by Stat5

Molecular and Cellular Biology

Volumn 19, Issue 3, 1999, Pages 1910-1918

  John, Susan ^a   Vinkemeier, Uwe ^b,c   Soldaini, Elisabetta ^a,d   Darnell Jr , James E ^b   Leonard, Warren J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^d CHIRON VACCINES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; STAT5 PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; OLIGOMERIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

EID: 0033019051     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.3.1910     Document Type: Article

References (38)

1. Beadling, C., D. Guschin, B. A. Witthuhn, A. Ziemiecki, J. N. Ihle, I. M. Kerr, and D. A. Cantrell. 1994. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 13:5606-5615.
2. c chain of the IL-2 receptor. Science 266:1039-1042.
3. Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630-1635.
4. Decker, T., P. Kovarik, and A. Meinke. 1997. GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17:121-134.
5. Fujii, H., Y. Nakagawa, U. Schindler, A. Kawahara, H. Mori, F. Gouilleux, B. Groner, J. N. Ihle, Y. Minami, T. Miyazaki, and T. Taniguchi. 1995. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92:5482-5486.
6. Gaffen, S. L., S. Y. Lai, W. Xu, F. Gouilleux, B. Groner, M. A. Goldsmith, and W. C. Greene. 1995. Signaling through the interleukin 2 receptor β chain activates a STAT-5-like DNA-binding activity. Proc. Natl. Acad. Sci. USA 92:7192-7196.
7. Gilmour, K., R. Pine, and N. C. Reich. 1995. Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes. Proc. Natl. Acad. Sci. USA 92:10772-10776.
8. Horvath, C. M., Z. Wen, and J. E. Darnell, Jr. 1995. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:984-994.
9. Horvath, C. M., and J. E. Darnell, Jr. 1997. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr. Opin. Cell Biol. 9:233-239.
10. Hou, J., U. Schindler, W. J. Henzel, S. C. Wong, and S. L. McKnight. 1995. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321-329.
11. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331-334.
12. Imada, K., E. T. Bloom, H. Nakajima, J. A. Horvath-Arcidiacono, G. B. Udy, H. Davey, and W. J. Leonard. 1998. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188:2067-2074.
13. John, S., C. M. Robbins, and W. J. Leonard. 1996. An IL-2 response element in the human IL-2 receptor α chain promoter is a composite element that binds Stat5. Elf-1. HMG-I(Y) and a GATA family protein. EMBO J. 15: 5627-5635.
14. Johnston, J. A., M. Kawamura, R. A. Kirken, Y. Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151-153.
15. Lécine, P., M. Algarté, P. Rameil, C. Beadling, P. Bucher, M. Nabholz, and J. Imbert. 1996. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene. Mol. Cell. Biol. 16:6829-6840.
16. Leonard, W. J., and J. J. O'Shea. 1998. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:293-322.
17. Lin, J.-X., and W. J. Leonard. 1997. Signaling from the IL-2 receptor to the nucleus. Cytokine Growth Factor Rev. 8:313-332.
18. Lin, J. X., J. Mietz, W. S. Modi, S. John, and W. J. Leonard. 1996. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J. Biol. Chem. 271:10738-10744.
19. Lin, J.-X., T.-S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, and W. J. Leonard. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331-339.
20. Meyer, W. K., P. Reichenbach, U. Schindler, E. Soldaini, and M. Nabholz. 1997. Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription. J. Biol. Chem. 272:31821-31828.
21. Mikita, T., D. Campbell, P. Wu, K. Williamson, and U. Schindler. 1996. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16:5811-5820.
22. Miyazki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z.-J. Liu, I. Oishi, O. Silvennoinen, B. A. Witthuhn, J. N. Ihle, and T. Taniguchi. 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045-1047.
23. Nakajima, H., X. Liu, A. Wynshaw-Boris, L. A. Rosenthal, K. Imada, D. S. Finbloom, L. Hennighausen, and W. J. Leonard. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691-701.
24. Nakamura, Y., S. M. Russell, S. A. Mess, M. Friedmann, M. Erdos, C. Francois, Y. Jacques, S. Adelstein, and W. J. Leonard. 1994. Heterodimerization of the IL-2 receptor β-and γ-chain cytoplasmic domains is required for signalling. Nature 396:330-333.
25. Nielsen, M., A. Svejgaard, S. Skov, and N. Odum. 1994. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of Stat3 in human T lymphocytes. Eur. J. Immunol. 24:3082-3086.
26. c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042-1045.
27. Schindler, U., P. Wu, M. Rothe, M. Brasseur, and S. L. McKnight. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689-697.
28. Seidel, H. M., M. H. Lawrence, P. Lamb, J. E. Darnell, Jr., R. B. Stein, and J. Rosen. 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92:3041-3045.
29. Soldaini, E. Unpublished data.
30. Sperisen, P., S. M. Wang, E. Soldaini, M. Pla, C. Rusterholz, P. Bucher, P. Corthesy, P. Reichenbach, and M. Nabholz. 1995. Mouse interleukin-2 receptor α gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements. J. Biol. Chem. 270:10743-10753.
31. Vinkemeier, U., S. L. Cohen, I. Moarefi, B. T. Chait, J. Kuriyan, and J. E. Darnell, Jr. 1996. DNA binding of in vitro activated Stat1α, Stat1β and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 15:5616-5626.
32. Vinkemeier, U., I. Moarefi, J. E. Darnell, Jr., and J. Kuriyan. 1998. Structure of the amino-terminal protein interaction domain of Stat4. Science 279: 1048-1052.
33. Wakao, H., N. Harada, T. Kitamura, A. L. Mui, and A. Miyajima. 1995. Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J. 14:2527-2535.
34. Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lai, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157.
35. Xu, D., S. L. Lin, and R. Nussinov. 1997. Protein binding versus protein folding: the role of hydrophilic bridges in protein associations. J. Mol. Biol. 265:68-84.
36. Xu, X., Y.-L. Sun, and T. Hoey. 1996. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273:794-797.
37. Yan, R., S. Small, C. Desplan, C. R. Dearolf, and J. E. Darnell, Jr. 1996. Identification of a Stat gene that functions in Drosophila development. Cell 84:421-430.
38. Zhu, M.-H., J. A. Berry, S. M. Russell, and W. J. Leonard. 1998. Delineation of the regions of interleukin-2 (IL-2) receptor β chain important for association of Jak1 and Jak3. J. Biol. Chem. 273:10719-10725.