The N-terminal domain of Janus kinase 2 is required for golgi processing and cell surface expression of erythropoietin receptor

Molecular Cell

Volumn 8, Issue 6, 2001, Pages 1327-1338

  Huang, Lily Jun shen ^a   Constantinescu, Stefan N ^a   Lodish, Harvey F ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE RECEPTOR; ERYTHROPOIETIN RECEPTOR; JANUS KINASE; PROTEIN SUBUNIT;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SUBUNIT; GOLGI COMPLEX; LIGAND BINDING; MOUSE; MUTAGENESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALIA; JANUS;

EID: 0035694582     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00401-4     Document Type: Article

References (48)

1. Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains
2. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection
3. Mutational analysis of muscle nicotinic acetylcholine receptor subunit assembly
4. Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts
5. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain
6. The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane
7. The erythropoietin receptor: Structure, activation and intracellular signal transduction
8. Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domain
9. The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif
10. Erythropoietin receptor. Subunit structure and activation
11. Erythropoietin receptor and interleukin-2 receptor beta chain: A new receptor family
12. STATs and gene regulation
13. A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum
14. Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells
15. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
16. Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression
17. The N-termini of FAK and JAKs contain divergent band 4.1 domains
18. Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
19. Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization
20. JAK2, a third member of the JAK family of protein tyrosine kinases
21. Inhibition of the erythropoietin-induced erythroid differentiation by granulocyte-macrophage colony-stimulating factor in the human UT-7 cell line is not due to a negative regulation of the erythropoietin receptor
22. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor
23. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor
24. Stats: Signal transducers and activators of transcription
25. Signaling through the hematopoietic cytokine receptors
26. A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses
27. Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro
28. Generation of mammalian cells stably expressing multiple genes at predetermined levels
29. B receptor heterodimerization
30. Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo
31. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
32. Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes
33. Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms
34. Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo
35. Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells
36. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
37. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway
38. Assembly, sorting, and exit of oligomeric proteins from the endoplasmic reticulum
39. Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1
40. A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation
41. Failure to synthesize the T cell CD3-zeta chain: Structure and function of a partial T cell receptor complex
42. The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
43. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
44. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
45. The Janus kinase family of protein tyrosine kinases and their role in signaling
46. Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism
47. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels
48. Critical cytoplasmic domains of human interleukin-9 receptor alpha chain in interleukin-9-mediated cell proliferation and signal transduction