SHP-1 Suppresses Cancer Cell Growth by Promoting Degradation of JAK Kinases

Journal of Cellular Biochemistry

Volumn 90, Issue 5, 2003, Pages 1026-1037

  Wu, Chengyu ^a   Guan, Qin ^a   Wang, Yingjian ^b   Zhao, Z Joe ^c   Zhou, G Wayne ^a,d  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Hypromatrix Inc   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

ITIM; Leukemia; Lymphoma; Protein tyrosine phosphatase; SH2 domain

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEGRADATION; ENZYME SYNTHESIS; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; CELL DIVISION; CYSTEINE PROTEINASE INHIBITORS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 1; LEUKEMIA; LEUPEPTINS; LYMPHOMA; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; SHP1 PROTEIN TYROSINE PHOSPHATASE; SRC HOMOLOGY DOMAINS; TRANSFECTION; TUMOR CELLS, CULTURED; TYK2 KINASE;

EID: 0344154466     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10727     Document Type: Article

References (43)

1. Aaronson DS, Horvath CM. 2002. A road map for those who don't know JAK-STAT. Science 296:1653-1655.
2. Bittorf T, Seiler J, Zhang Z, Jaster R, Brock J. 1999. SHP-1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells. Biol Chem 380:1201-1209.
3. Bruecher-Encke B, Griffin JD, Neel BG, Lorenz U. 2001. Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation. Leukemia 15:1424-1432.
4. Chen HE, Chang S, Trub T, Neel BG. 1996. Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol 16:3685-3697.
5. Daigle I, Yousefi S, Colonna M, Green DR, Simon HU. 2002. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med 8:61-67.
6. David M, Chen HE, Goelz S, Larner AC, Neel BG. 1995. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol 15:7050-7058.
7. Delibrias CC, Floettmann JE, Rowe M, Fearon DT. 1997. Down-regulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J Exp Med 186:1575-1583.
8. Feng GS, Hui CC, Pawson T. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607-1611.
9. Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T. 1996. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol 16:6985-6992.
10. Klingmuller U, Lorenz U, Cantley LC, Neel BG, Lodish HF. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729-738.
11. Leon F, Cespon C, Franco A, Lombardia M, Roldan E, Escribano L, Harto A, Gonzalez-Porque P, Roy G. 2002. SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: Implications in JAK3-mediated signaling. Leukemia 16:1470-1477.
12. Marengere LE, Waterhouse P, Duncan GS, Mittrucker HW, Feng GS, Mak TW. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170-1173.
13. Migone TS, Cacalano NA, Taylor N, Yi T, Waldmann TA, Johnston JA. 1998. Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Proc Natl Acad Sci USA 95:3845-3850.
14. Mok SC, Kwok TT, Berkowitz RS, Barrett AJ, Tsui FW. 1995. Overexpression of the protein tyrosine phosphatase, nonreceptor type 6 (PTPN6), in human epithelial ovarian cancer. Gynecol Oncol 57:299-303.
15. Neel BG, Tonks NK. 1997. Protein tyrosine phosphatases in signal transduction. Curr Opin Cell Biol 9:193-204.
16. Oka T, Yoshino T, Hayashi K, Ohara N, Nakanishi T, Yamaai Y, Hiraki A, Sogawa C.A, Kondo E, Teramoto N, Takahashi K, Tsuchiyama J, Akagi T. 2001. Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias: Combination analysis with cDNA expression array and tissue microarray. Am J Pathol 159:1495-1505.
17. Oka T, Ouchida M, Koyama M, Ogama Y, Takada S, Nakatani Y, Tanaka T, Yoshino T, Hayashi K, Ohara N, Kondo E, Takahashi K, Tsuchiyama J, Tanimoto M, Shimizu K, Akagi T. 2002. Gene silencing of the tyrosine phosphatase SHP-1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res 62:6390-6394.
18. Pani G, Fischer KD, Mlinaric-Rascan I, Siminovitch KA. 1996. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med 184:839-852.
19. Pei D, Neel BG, Walsh CT. 1993. Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein tyrosine phosphatase. Proc Natl Acad Sci USA 90:1092-1096.
20. Pei D, Lorenz U, Klingmuller U, Neel BG, Walsh CT. 1994. Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: A new function for Src homology 2 domains. Biochemistry 33:15483-15493.
21. Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, Aruffo AA, Kanner SB. 1999. CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: Involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol 19:2903-2912.
22. Plas DR, Johnson R, Pingel JT, Matthews RJ, Dalton M, Roy G, Chan AC, Thomas ML. 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272:1173-1176.
23. Plutzky J, Neel BG, Rosenberg RD, Eddy RL, Byers MG, Jani-Sait S, Shows TB. 1992. Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6). Genomics 13:869-872.
24. Rane SG, Reddy EP. 2002. JAKs, STATs, and Src kinases in hematopoiesis. Oncogene 21:3334-3358.
25. Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN. 2003. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 4:248-254.
26. Tamir I, Dal Porto JM, Cambier JC. 2000. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: Regulators of B cell signal transduction. Curr Opin Immunol 12:307-315.
27. Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE. 1994. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem 269:25206-25211.
28. Tauchi T, Feng GS, Shen R, Hoatlin M, Bagby GC, Jr., Kabat D, Lu L, Broxmeyer HE. 1995. Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem 270:5631-5635.
29. Townley R, Shen SH, Banville D, Ramachandran C. 1993. Inhibition of the activity of protein tyrosine phosphate 1C by its SH2 domains. Biochemistry 32:13414-13418.
30. Uesugi Y, Fuse I, Toba K, Kishi K, Furukawa T, Koike T, Aizawa Y. 1999. Involvement of SHP-1, a phosphotyrosine phosphatase, during myeloid cell differentiation in acute promyelocytic leukemia cell lines. Eur J Haematol 62:239-245.
31. Unkeless JC, Jin J. 1997. Inhibitory receptors, ITIM sequences, and phosphatases. Curr Opin Immunol 9:338-343.
32. Vambutas V, Kaplan DR, Sells MA, Chernoff J. 1995. Nerve growth factor stimulates tyrosine phosphorylation and activation of Src homology-containing protein-tyrosine phosphatase 1 in PC12 cells. J Biol Chem 270:25629-25633.
33. Wu C, Sun M, Liu L, Zhou GW. 2003. The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene 306:1-12.
34. Yang J, Liu L, He D, Song X, Liang X, Zhao ZJ, Zhou GW. 2003. Crystal structure of human protein-tyrosine phosphatase SHP-1. J Biol Chem 278:6516-6520.
35. Yi T, Ihle JN. 1993. Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit Ligand. Mol Cell Biol 13:3350-3358.
36. Yi T, Mui AL, Krystal G, Ihle JN. 1993. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol 13:7577-7586.
37. Yi T, Zhang J, Miura O, Ihle JN. 1995. Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: Identification of potential binding sites. Blood 85:87-95.
38. Yip SS, Crew AJ, Gee JM, Hui R, Blamey RW, Robertson JF, Nicholson RI, Sutherland RL, Daly RJ. 2000. Upregulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation with GRB2 expression. Int J Cancer 88:363-368.
39. You M, Zhao Z. 1997. Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells. J Biol Chem 272:23376-23381.
40. Zapata PD, Ropero RM, Valencia AM, Buscail L, Lopez JI, Martin-Orozco RM, Prieto JC, Angulo J, Susini C, Lopez-Ruiz P, Colas B. 2002. Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1. J Clin Endocrinol Metab 87:915-926.
41. Zhang J, Somani AK, Siminovitch KA. 2000a. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signaling. Semin Immunol 12:361-378.
42. Zhang Q, Raghunath PN, Vonderheid E, Odum N, Wasik MA. 2000b. Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. Am J Pathol 157:1137-1146.
43. Zhao Z, Bouchard P, Diltz CD, Shen SH, Fischer EH. 1993. Purification and characterization of a protein tyrosine phosphatase containing SH2 domains. J Biol Chem 268:2816-2820.