Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs

Molecular and Cellular Biology

Volumn 17, Issue 6, 1997, Pages 3295-3304

  Chaturvedi, Priya ^a   Sharma, Sunita ^a   Reddy, E Premkumar ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA TRANSFECTION; HEMATOPOIETIC CELL; IMMUNOPRECIPITATION; MOUSE; MYELOBLAST; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030992813     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.6.3295     Document Type: Article

References (44)

1. Anderson, S. M., P. M. Carroll, and F. D. Lee. 1990. Abrogation of IL-3 dependent growth requires a functional v-src gene product: evidence for an autocrine growth cycle. Oncogene 6:245-256.
2. Argetsinger, L. S., G. S. Campbell, X. Yang, B. A. Witthuhn, O. Silvennoinen, J. N. Ihle, and C. Carter-Su. 1993. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74:237-244.
3. Azam, M., H. Erdjument-Bromage, B. L. Kreider, M. Xia, F. Quelle, R. Basu, C. Saris, P. Tepst, J. N. Ihle, and C. Spindlier. 1995. Interleukin-3 signals through multiple of STAT 5. EMBO J. 14:1402-1411.
4. Cao, X., A. G. Tay, R. Guy, and Y. H. Tan. 1996. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16:1595-1603.
5. Carlesso, N., D. A. Frank, and J. D. Griffin. 1996. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in haematopoeitic cell lines transformed by Bcr/Abl. J. Exp. Med. 183:811-820.
6. Daniel, N. N., A. Pernis, P. B. Rothman. 1995. Jak-STAT signaling induced by the v-abl oncogene. Science 269:1875-1877.
7. Darnell, J. E., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:415-421.
8. Frank, D. A., M. J. Robertson, A. Bonni, J. Ritz, and M. E. Greenberg. 1995. Interleukin-2 signaling involves the phosphorylation of STAT proteins. Proc. Natl. Acad. Sci. USA 92:7779-7783.
9. Halpern, K. J., J. T. Hoeve, X. Rao, and C. J. Sawyers. 1996. Constitutive activation of STAT-5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13:247-254.
10. Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. Darnell. 1995. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267:1347-1349.
11. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein and UV-responsive protein kinase that hinds and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148.
12. Hunter, T. 1993. Signal transduction. Cytokine connections. Nature 366:114-116.
13. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331-334.
14. Ihle, J. N., B. A. Witthuhn, F. W. Quelle, K. Yamamoto, and O. Silvennoinen. 1995. Signaling through the hematopoietic cytokine receptors. Annu. Rev. Immunol. 13:369-398.
15. King, F. J., and M. D. Cole. 1990. Molecular cloning and sequencing of the murine c-fgr gene. Oncogene 5:337-344.
16. Kirchmeier, P. T., G. M. Housey, M. D. Johnson, A. S. Perkins, and I. B. Weinstein. 1988. Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences. DNA 7:219-225.
17. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell 76:253-262.
18. Kosh, C. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668-674.
19. Kruger, A., and S. M. Anderson. 1991. The v-src oncogene blocks the differentiation of a murine myeloid progenitor cell line and induces a tumorigenic phenotype. Oncogene 6:245-256.
20. Laemmli, E. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
21. Laneuville, P., N. Heisterkamp, and J. Groffen. 1991. Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene 6:275-279.
22. Lutticken, C., U. M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A. G. Harpur, A. F. Wilks, K. Yasukawa, T. Taga, T. Kishimoto, G. Barbieri, S. Pellegrini, M. Sendtner, P. C. Heinrich, and F. Horn. 1994. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89-92.
23. Meyer, D. J., G. S. Campbell, B. H. Cochran, L. S. Argetsinger, A. C. Larner, D. S. Finbloom, C. Carter-Su, and J. Schwartz. 1994. Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor. J. Biol. Chem. 269:4701-4704.
24. Mui, A., H. Wakao, A. M. O'Farrell, N. Harada, and A. Miyajima. 1995. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 14:1166-1175.
25. Naharro, G., K. C. Robbins, and E. P. Reddy. 1984. Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific kinase. Science 223:23-26.
26. Pierce, J. H. 1989. Oncogenes, growth factors and hematopoietic cell transformation. Biochim. Biophys. Acta 989:179-208.
27. Rane, S., and E. P. Reddy. Unpublished data.
28. c subunit and constitutively induce its tyrosine phosphorylation. Cancer Res. 56:3426-3430.
29. Reddy, E. P., M. J. Smith, and A. Srinivasan. 1983. Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity. Proc. Natl. Acad. Sci. USA 80:3623-3627.
30. Rovera, G., M. Valtieri, F. Mavilio, and E. P. Reddy. 1987. Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line. Oncogene 1:29-35.
31. Rui, H., R. A. Kirken, and W. L. Farrar. 1994. Activation of receptor-associated tyrosine kinase JAK2 by prolactin. J. Biol. Chem. 269:5364-5368.
32. Schindler, C., and J. E. Darnell. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621-651.
33. Schlessinger, J. 1994. SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev. 4:502-505.
34. Shreiber, E., P. Matthias, M. Muller, and W. Shaffner. 1989. Rapid detection of octamer binding protein with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
35. Silvennoinen, O., B. A. Witthuhn, F. W. Quelle, J. L. Cleveland, T. Yi, and J. N. Ihle. 1993. Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc. Natl. Acad. Sci. USA 90:8429-8933.
36. Stahl, N., and G. D. Yancopoulos. 1993. The alphas, betas, and kinasos of cytokine receptor complexes. Cell 74:587-590.
37. Taylor, S. J., and D. Shalloway. 1994. An RNA-binding protein associates with Src through its SH2 and SH3 domains in mitosis. Nature 382:867-871.
38. Valteri, M., D. J. Tweardy, D. Caracciolo, K. Johnson, F. Mavilio, S. Altman, D. Santoli, and G. Rovera. 1987. Cytokine dependent granulocyte differentiation regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 138:3829-3835.
39. Witthuhn, B. A., F. W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and J. N. Ihle. 1993. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227-236.
40. Ymer, S., W. Q. J. Tucker, C. J. Sanderson, A. J. Hapel, H. D. Campbell, and I. G. Young. 1985. Constitutive synthesis of interleukin-3 by leukemia cell line Wehi-3B due to retroviral insertion near the gene. Nature (London) 317:255-258.
41. Yon, J., and M. Freid. 1989. Precise gene fusion by PCR. Nucleic Acid Res. 17:4895.
42. Yoshimura, A., M. Ichihara, I. Moriyama, N. G. Copeland, D. J. Gilbert, N. A. Jenkin, T. Hara, and A. Miyajima. 1996. Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J. 15:1055-1063.
43. Yu, C. L., D. J. Meyer, G. S. Campbell, A. C. Larner, C. C. Su, J. Schwartz, and R. Jove. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83.
44. Zhong, Z., Z. Wen, and J. E. Darnell. 1994. Stat-3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95-98.