Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases

Molecular Cell

Volumn 8, Issue 5, 2001, Pages 959-969

  Zhou, Yong Jie ^a   Chen, Min ^a   Cusack, Nancy A ^c   Kimmel, Lida H ^c   Magnuson, Kelly S ^c   Boyd, James G ^c   Lin, Wen ^c   Roberts, Joseph L ^d   Lengi, Andrea ^d   Buckley, Rebecca H ^d   Geahlen, Robert L ^e   Candotti, Fabio ^b   Gadina, Massimo ^a   Changelian, Paul S ^c   O'Shea, John J ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; JANUS KINASE; JANUS KINASE 3; PHOSPHOTRANSFERASE; PSEUDOKINASE; SH2 LIKE KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ISOLATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MUTATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

JANUS;

EID: 18244393495     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00398-7     Document Type: Article

References (37)

1. Development of inhibitors for protein tyrosine kinases
2. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
3. Selected glimpses into the activation and function of src kinase
4. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain
5. The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals
6. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains
7. Affinity labeling of the nucleotide-binding site of myosin light chain kinases
8. Multiple sequence alignment with hierarchical-clustering
9. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
10. Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2
11. Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor
12. Signaling by type I and II cytokine receptors: Ten years after
13. The N-termini of FAK and JAKs contain divergent band 4.1 domains
14. Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
15. Signaling by the cytokine receptor superfamily
16. Jaks and STATs: Biological implications
17. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
18. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
19. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
20. Defective lymphoid development in mice lacking Jak3
21. Jaks and Stats as therapeutic targets
22. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
23. Signaling network of the btk family kinases
24. Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha /beta receptor component IFNAR1
25. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
26. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID
27. Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
28. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
29. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
30. FAK integrates growth-factor and integrin signals to promote cell migration
31. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
32. A conserved helix motif complements the protein kinase core
33. Three-dimensional structure of the tyrosine kinase c-Src
34. A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling
35. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
36. Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: Activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
37. Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors