-
2
-
-
0028845212
-
Cytokine receptor signalling
-
Ihle, J.N. Cytokine receptor signalling. Nature 377, 591-594 (1995).
-
(1995)
Nature
, vol.377
, pp. 591-594
-
-
Ihle, J.N.1
-
3
-
-
0036233585
-
Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
-
O'Shea, J.J., Gadina, M. & Schreiber, R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 109, S121-131 (2002).
-
(2002)
Cell
, vol.109
-
-
O'Shea, J.J.1
Gadina, M.2
Schreiber, R.D.3
-
5
-
-
0036595049
-
Suppressors of cytokine signalling (SOCS) in the immune system
-
Alexander, W.S. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2, 410-416 (2002).
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 410-416
-
-
Alexander, W.S.1
-
6
-
-
0036892964
-
Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease
-
Greenhalgh, C.J., Miller, M.E., Hilton, D.J. & Lund, P.K. Suppressors of cytokine signaling: relevance to gastrointestinal function and disease. Gastroenterology 123, 2064-2081 (2002).
-
(2002)
Gastroenterology
, vol.123
, pp. 2064-2081
-
-
Greenhalgh, C.J.1
Miller, M.E.2
Hilton, D.J.3
Lund, P.K.4
-
7
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka, T. et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929 (1997).
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
-
8
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr, R. et al. A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921 (1997).
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
-
9
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo, T.A. et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924 (1997).
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
-
10
-
-
0029014206
-
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
-
Yoshimura, A. et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:2816-2826 (1995).
-
(1995)
EMBO J.
, vol.14
, pp. 2816-2826
-
-
Yoshimura, A.1
-
11
-
-
0033544899
-
SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
-
Ram, P.A. & Waxman, D.J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem. 274, 35553-35561 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35553-35561
-
-
Ram, P.A.1
Waxman, D.J.2
-
12
-
-
0344655657
-
Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction
-
Favre, H., Benhamou, A., Finidori, J., Kelly, P.A. & Edery, M. Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction. FESS Lett.; 453: 63-66 (1999).
-
(1999)
FESS Lett.
, vol.453
, pp. 63-66
-
-
Favre, H.1
Benhamou, A.2
Finidori, J.3
Kelly, P.A.4
Edery, M.5
-
13
-
-
0037174816
-
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
-
Greenhalgh, C.J. et al. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J. Biol. Chem. 277, 40181-40184 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40181-40184
-
-
Greenhalgh, C.J.1
-
14
-
-
85047681536
-
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)
-
Greenhalgh, C.J. et al. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol. Endocrinol. 16, 1394-1406 (2002).
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 1394-1406
-
-
Greenhalgh, C.J.1
-
15
-
-
0034729710
-
Gigantism in mice lacking suppressor of cytokine signalling-2
-
Metcalf, D. et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405, 1069-1073 (2000).
-
(2000)
Nature
, vol.405
, pp. 1069-1073
-
-
Metcalf, D.1
-
16
-
-
0036790814
-
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
-
Seki, Y. et al. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. USA 99, 13003-13008 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13003-13008
-
-
Seki, Y.1
-
17
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa, H. et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
-
18
-
-
0037317179
-
A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1)
-
Giordanetto, F. & Kroemer, R.T. A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1). Protein Eng. 16, 115-124 (2003).
-
(2003)
Protein Eng.
, vol.16
, pp. 115-124
-
-
Giordanetto, F.1
Kroemer, R.T.2
-
19
-
-
0034703097
-
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
-
Sasaki, A. et al. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29338-29347
-
-
Sasaki, A.1
-
20
-
-
0034612271
-
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
-
Nicholson, S.E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl Acad. Sci. USA 97, 6493-6498 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6493-6498
-
-
Nicholson, S.E.1
-
21
-
-
0037414817
-
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
-
Lehmann, U. et al. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J. Biol. Chem. 278, 661-671 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 661-671
-
-
Lehmann, U.1
-
22
-
-
0036105755
-
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor
-
Hortner, M., Nielsch, U., Mayr, L.M., Heinrich, P.C. & Haan, S. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur. J. Biochem. 269, 2516-2526 (2002).
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 2516-2526
-
-
Hortner, M.1
Nielsch, U.2
Mayr, L.M.3
Heinrich, P.C.4
Haan, S.5
-
23
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjorbaek, C. et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275, 40649-40657 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
-
-
Bjorbaek, C.1
-
24
-
-
0037162397
-
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
-
De Souza, D. et al. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41, 9229-9236 (2002).
-
(2002)
Biochemistry
, vol.41
, pp. 9229-9236
-
-
De Souza, D.1
-
25
-
-
0032535364
-
The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families
-
Kamura, T. et al. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families. Genes Dev. 12, 3872-3881 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 3872-3881
-
-
Kamura, T.1
-
26
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang, J.G. et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96, 2071-2076 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
-
27
-
-
0035918239
-
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
-
Kamizono, S. et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276, 12530-12538 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12530-12538
-
-
Kamizono, S.1
-
28
-
-
0035036625
-
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation
-
Frantsve, J., Schwaller, J., Sternberg, D.W., Kutok, J. & Gilliland, D.G. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21, 3547-3557 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3547-3557
-
-
Frantsve, J.1
Schwaller, J.2
Sternberg, D.W.3
Kutok, J.4
Gilliland, D.G.5
-
29
-
-
0035818573
-
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
-
Zhang, J.G. et al. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl. Acad. Sci. USA 98, 13261-13265 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13261-13265
-
-
Zhang, J.G.1
-
30
-
-
0042357098
-
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation
-
Haan, S. et al. Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J. Biol. Chem. 278, 31972-31979 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31972-31979
-
-
Haan, S.1
-
31
-
-
13044276245
-
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice
-
Naka, T. et al. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice. Proc. Natl. Acad. Sci. USA 95, 15577-15582 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15577-15582
-
-
Naka, T.1
-
32
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
Starr, R. et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95, 14395-14399 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
-
33
-
-
0033520467
-
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
-
Marine, J.C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616 (1999).
-
(1999)
Cell
, vol.98
, pp. 609-616
-
-
Marine, J.C.1
-
34
-
-
0033520326
-
SOCS1 is a critical inhibitor of interferon-signaling and prevents the potentially fatal neonatal actions of this cytokine
-
Alexander, W.S. et al. SOCS1 is a critical inhibitor of interferon-signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597-608 (1999).
-
(1999)
Cell
, vol.98
, pp. 597-608
-
-
Alexander, W.S.1
-
36
-
-
0037154210
-
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
-
Metcalf, D. et al. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl. Acad. Sci. USA 99, 943-948 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 943-948
-
-
Metcalf, D.1
-
37
-
-
10744223505
-
Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
-
Hanada, T. et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19, 437-450 (2003).
-
(2003)
Immunity
, vol.19
, pp. 437-450
-
-
Hanada, T.1
-
38
-
-
0035168683
-
JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
-
Sporri, B., Kovanen, P.E., Sasaki, A., Yoshimura, A. & Leonard, W.J. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood 97, 221-226 (2001).
-
(2001)
Blood
, vol.97
, pp. 221-226
-
-
Sporri, B.1
Kovanen, P.E.2
Sasaki, A.3
Yoshimura, A.4
Leonard, W.J.5
-
39
-
-
0037927824
-
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γ c-dependent cytokines in peripheral T cells
-
Cornish, A.L. et al. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γ c-dependent cytokines in peripheral T cells. J. Biol. Chem. 278, 22755-22761 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22755-22761
-
-
Cornish, A.L.1
-
40
-
-
0034502224
-
Inhibition of TH1 differentiation by IL-6 is mediated by SOCS1
-
Diehl, S. et al. Inhibition of TH1 differentiation by IL-6 is mediated by SOCS1. Immunity 13, 805-815 (2000).
-
(2000)
Immunity
, vol.13
, pp. 805-815
-
-
Diehl, S.1
-
41
-
-
0038807434
-
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
-
Eyles, J.L., Metcalf, D., Grusby, M.J., Hilton, D.J. & Starr, R. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J. Biol. Chem. 277, 43735-43740 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43735-43740
-
-
Eyles, J.L.1
Metcalf, D.2
Grusby, M.J.3
Hilton, D.J.4
Starr, R.5
-
43
-
-
0344394485
-
+ thymocytes
-
prepublished online, 7 August (doi:10.1182/blood-2003-01-0175)
-
+ thymocytes. Blood prepublished online, 7 August 2003 (doi:10.1182/blood-2003-01-0175).
-
(2003)
Blood
-
-
Ilangumaran, S.1
-
44
-
-
0034624986
-
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor - Induced cell death in fibroblasts
-
Morita, Y. et al. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor - induced cell death in fibroblasts. Proc. Natl. Acad. Sci. USA 97, 5405-5410 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5405-5410
-
-
Morita, Y.1
-
45
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo, I. et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17, 583-591 (2002).
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
-
46
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa, R. et al. SOCS-1 participates in negative regulation of LPS responses. Immunity 17, 677-687 (2002).
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
-
47
-
-
0035862334
-
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
-
Kawazoe, Y. et al. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J. Exp. Med. 193, 263-269 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 263-269
-
-
Kawazoe, Y.1
-
48
-
-
0033558088
-
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
-
De Sepulveda, P. et al. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 18, 904-915 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 904-915
-
-
De Sepulveda, P.1
-
49
-
-
0035008978
-
SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN- and IL-4 signaling in vivo
-
Naka, T. et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN- and IL-4 signaling in vivo. Immunity 14, 535-545 (2001).
-
(2001)
Immunity
, vol.14
, pp. 535-545
-
-
Naka, T.1
-
51
-
-
0037396793
-
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
-
Chong, M.M. et al. Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18, 475-487 (2003).
-
(2003)
Immunity
, vol.18
, pp. 475-487
-
-
Chong, M.M.1
-
52
-
-
0037438475
-
Suppressor of cytokine signaling-1 has IFN-independent actions in T cell homeostasis
-
Cornish, A.L. et al. Suppressor of cytokine signaling-1 has IFN-independent actions in T cell homeostasis J. Immunol. 170, 878-886 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 878-886
-
-
Cornish, A.L.1
-
53
-
-
0026074762
-
Interleukin 4 expressed in situ selectively alters thymocyte development
-
Lewis, D.B. et al. Interleukin 4 expressed in situ selectively alters thymocyte development. J. Exp. Med. 173, 89-100 (1991).
-
(1991)
J. Exp. Med.
, vol.173
, pp. 89-100
-
-
Lewis, D.B.1
-
54
-
-
0036195161
-
+ immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
-
+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16, 311-323 (2002).
-
(2002)
Immunity
, vol.16
, pp. 311-323
-
-
McHugh, R.S.1
-
55
-
-
0347144518
-
Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
-
(in the press)
-
Naka, T. et al. Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int. Immunol. (in the press).
-
Int. Immunol.
-
-
Naka, T.1
-
56
-
-
0037436119
-
+ T cell-mediated suppression by dendritic cells
-
+ T cell-mediated suppression by dendritic cells. Science 299, 1033-1036 (2003).
-
(2003)
Science
, vol.299
, pp. 1033-1036
-
-
Pasare, C.1
Medzhitov, R.2
-
57
-
-
0036849109
-
h polarization in vivo
-
h polarization in vivo. Int. Immunol. 14, 1343-1350 (2002).
-
(2002)
Int. Immunol.
, vol.14
, pp. 1343-1350
-
-
Fujimoto, M.1
-
58
-
-
85047687240
-
Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
-
Egan, P.J., Lawlor, K.E., Alexander, W.S. & Wicks, I.P. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J. Clin. Invest. 111, 915-924 (2003).
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 915-924
-
-
Egan, P.J.1
Lawlor, K.E.2
Alexander, W.S.3
Wicks, I.P.4
-
59
-
-
0036533474
-
Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: Implications for Th cell lineage commitment and maintenance
-
Egwuagu, C.E. et al. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168, 3181-3187 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 3181-3187
-
-
Egwuagu, C.E.1
-
60
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
Roberts, A.W. et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. USA 98, 9324-9329 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9324-9329
-
-
Roberts, A.W.1
-
61
-
-
0037415694
-
SOCS3: An essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
-
Takahashi, Y. et al. SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J. 22, 372-384 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 372-384
-
-
Takahashi, Y.1
-
62
-
-
0042967672
-
SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
-
Seki, Y. et al. SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses Nat. Med. 9, 1047-1054 (2003).
-
(2003)
Nat. Med.
, vol.9
, pp. 1047-1054
-
-
Seki, Y.1
-
63
-
-
0033037268
-
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
-
Cohney, S.J. et al. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell Biol. 19, 4980-4988 (1999).
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 4980-4988
-
-
Cohney, S.J.1
-
64
-
-
0036569393
-
Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp
-
Banerjee, A., Banks, A.S., Nawijn, M.C., Chen, X.P. & Rothman, P.B. Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp. J. Immunol. 168, 4277-4281 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 4277-4281
-
-
Banerjee, A.1
Banks, A.S.2
Nawijn, M.C.3
Chen, X.P.4
Rothman, P.B.5
-
65
-
-
0037450813
-
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production
-
Matsumoto, A. et al. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J. Exp. Med. 197, 425-436 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 425-436
-
-
Matsumoto, A.1
-
66
-
-
0034234797
-
Indirect induction of suppressor of cytokine signaling-1 in macrophages stimulated with bacterial lipopolysaccharide: Partial role of autocrine/paracrine interferon-α/β
-
Crepso, A., Filla, M.B., Russell, S.W. & Murphy, W.J. Indirect induction of suppressor of cytokine signaling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-α/β. Biochem. J. 349, 99-104 (2000).
-
(2000)
Biochem. J.
, vol.349
, pp. 99-104
-
-
Crepso, A.1
Filla, M.B.2
Russell, S.W.3
Murphy, W.J.4
-
67
-
-
0033233214
-
LPS and TNFalpha induce SOCS3 mRNA and inhibit L-6-induced activation of STAT3 in macrophages. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
-
Bode, J.G. et al. LPS and TNFalpha induce SOCS3 mRNA and inhibit L-6-induced activation of STAT3 in macrophages. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Lett. 463, 365-370 (1999).
-
(1999)
FEBS Lett.
, vol.463
, pp. 365-370
-
-
Bode, J.G.1
-
68
-
-
0035877256
-
Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
-
Dalpke, A.H., Opper, S., Zimmermann, S. & Heeg, K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166, 7082-7089 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 7082-7089
-
-
Dalpke, A.H.1
Opper, S.2
Zimmermann, S.3
Heeg, K.4
-
69
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49 (1999).
-
(1999)
Immunity
, vol.10
, pp. 39-49
-
-
Takeda, K.1
-
70
-
-
0037600741
-
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
-
Yasukawa, H. et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4, 551-556 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 551-556
-
-
Yasukawa, H.1
-
71
-
-
0141790820
-
A critical role for Stat3 signaling in immune tolerance
-
Cheng, F. et al. A critical role for Stat3 signaling in immune tolerance. Immunity 19, 425-436 (2003).
-
(2003)
Immunity
, vol.19
, pp. 425-436
-
-
Cheng, F.1
-
72
-
-
0038614944
-
SOCS3 regulates the plasticity of gp130 signaling
-
Lang, R. et al. SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol. 4, 546-550 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 546-550
-
-
Lang, R.1
-
73
-
-
0037938816
-
SOCS3 negatively regulates IL-6 signaling in vivo
-
Croker, B.A. et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4, 540-555 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 540-555
-
-
Croker, B.A.1
-
74
-
-
0036975241
-
Ingested type I interferon: A potential treatment for autoimmunity
-
Brod, S.A. Ingested type I interferon: a potential treatment for autoimmunity. J. Interferon Cytokine Res. 22, 1153-11566 (2002).
-
(2002)
J. Interferon Cytokine Res.
, vol.22
, pp. 1153-11566
-
-
Brod, S.A.1
-
75
-
-
0037037586
-
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
-
Atsumi, T. et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp. Med. 196, 979-990 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 979-990
-
-
Atsumi, T.1
-
76
-
-
0036796060
-
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
-
Tebbutt, N.C. et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8, 1089-1097 (2002).
-
(2002)
Nat. Med.
, vol.8
, pp. 1089-1097
-
-
Tebbutt, N.C.1
-
77
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki, A. et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193, 471-481 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
-
78
-
-
0035667907
-
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
-
Shouda, T. et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108, 1781-1788 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1781-1788
-
-
Shouda, T.1
-
79
-
-
0032772125
-
Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
-
Matsumoto, A. et al. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell Biol. 19, 6396-6407 (1999).
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 6396-6407
-
-
Matsumoto, A.1
-
80
-
-
0034689007
-
Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells
-
Li, S. et al. Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells. J. Exp. Med. 191, 985-994 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 985-994
-
-
Li, S.1
-
81
-
-
0036275657
-
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
-
Krebs, D.L. et al. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol. Cell Biol. 22, 4567-4578 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 4567-4578
-
-
Krebs, D.L.1
|