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Volumn 4, Issue 12, 2003, Pages 1169-1176

Suppressors of cytokine signaling and immunity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 6; REGULATOR PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; UNCLASSIFIED DRUG;

EID: 0346121599     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1012     Document Type: Review
Times cited : (554)

References (81)
  • 2
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • Ihle, J.N. Cytokine receptor signalling. Nature 377, 591-594 (1995).
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 3
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea, J.J., Gadina, M. & Schreiber, R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 109, S121-131 (2002).
    • (2002) Cell , vol.109
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 4
    • 0034082217 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling pathways
    • Yasukawa, H., Sasaki A. & Yoshimura A. Negative regulation of cytokine signaling pathways. Annu. Rev. Immunol. 18, 143-164 (2000).
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 143-164
    • Yasukawa, H.1    Sasaki, A.2    Yoshimura, A.3
  • 5
    • 0036595049 scopus 로고    scopus 로고
    • Suppressors of cytokine signalling (SOCS) in the immune system
    • Alexander, W.S. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2, 410-416 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 410-416
    • Alexander, W.S.1
  • 6
    • 0036892964 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease
    • Greenhalgh, C.J., Miller, M.E., Hilton, D.J. & Lund, P.K. Suppressors of cytokine signaling: relevance to gastrointestinal function and disease. Gastroenterology 123, 2064-2081 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 2064-2081
    • Greenhalgh, C.J.1    Miller, M.E.2    Hilton, D.J.3    Lund, P.K.4
  • 7
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • Naka, T. et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929 (1997).
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1
  • 8
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • Starr, R. et al. A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921 (1997).
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1
  • 9
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • Endo, T.A. et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924 (1997).
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1
  • 10
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • Yoshimura, A. et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:2816-2826 (1995).
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1
  • 11
    • 0033544899 scopus 로고    scopus 로고
    • SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
    • Ram, P.A. & Waxman, D.J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem. 274, 35553-35561 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 35553-35561
    • Ram, P.A.1    Waxman, D.J.2
  • 12
    • 0344655657 scopus 로고    scopus 로고
    • Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction
    • Favre, H., Benhamou, A., Finidori, J., Kelly, P.A. & Edery, M. Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction. FESS Lett.; 453: 63-66 (1999).
    • (1999) FESS Lett. , vol.453 , pp. 63-66
    • Favre, H.1    Benhamou, A.2    Finidori, J.3    Kelly, P.A.4    Edery, M.5
  • 13
    • 0037174816 scopus 로고    scopus 로고
    • Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
    • Greenhalgh, C.J. et al. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J. Biol. Chem. 277, 40181-40184 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 40181-40184
    • Greenhalgh, C.J.1
  • 14
    • 85047681536 scopus 로고    scopus 로고
    • Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)
    • Greenhalgh, C.J. et al. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol. Endocrinol. 16, 1394-1406 (2002).
    • (2002) Mol. Endocrinol. , vol.16 , pp. 1394-1406
    • Greenhalgh, C.J.1
  • 15
    • 0034729710 scopus 로고    scopus 로고
    • Gigantism in mice lacking suppressor of cytokine signalling-2
    • Metcalf, D. et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405, 1069-1073 (2000).
    • (2000) Nature , vol.405 , pp. 1069-1073
    • Metcalf, D.1
  • 16
    • 0036790814 scopus 로고    scopus 로고
    • Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
    • Seki, Y. et al. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. USA 99, 13003-13008 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13003-13008
    • Seki, Y.1
  • 17
    • 20244389693 scopus 로고    scopus 로고
    • The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
    • Yasukawa, H. et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320 (1999).
    • (1999) EMBO J. , vol.18 , pp. 1309-1320
    • Yasukawa, H.1
  • 18
    • 0037317179 scopus 로고    scopus 로고
    • A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1)
    • Giordanetto, F. & Kroemer, R.T. A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1). Protein Eng. 16, 115-124 (2003).
    • (2003) Protein Eng. , vol.16 , pp. 115-124
    • Giordanetto, F.1    Kroemer, R.T.2
  • 19
    • 0034703097 scopus 로고    scopus 로고
    • CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    • Sasaki, A. et al. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 29338-29347
    • Sasaki, A.1
  • 20
    • 0034612271 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
    • Nicholson, S.E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl Acad. Sci. USA 97, 6493-6498 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6493-6498
    • Nicholson, S.E.1
  • 21
    • 0037414817 scopus 로고    scopus 로고
    • SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
    • Lehmann, U. et al. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J. Biol. Chem. 278, 661-671 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 661-671
    • Lehmann, U.1
  • 22
    • 0036105755 scopus 로고    scopus 로고
    • A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor
    • Hortner, M., Nielsch, U., Mayr, L.M., Heinrich, P.C. & Haan, S. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur. J. Biochem. 269, 2516-2526 (2002).
    • (2002) Eur. J. Biochem. , vol.269 , pp. 2516-2526
    • Hortner, M.1    Nielsch, U.2    Mayr, L.M.3    Heinrich, P.C.4    Haan, S.5
  • 23
    • 0001421697 scopus 로고    scopus 로고
    • SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
    • Bjorbaek, C. et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275, 40649-40657 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40649-40657
    • Bjorbaek, C.1
  • 24
    • 0037162397 scopus 로고    scopus 로고
    • SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
    • De Souza, D. et al. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41, 9229-9236 (2002).
    • (2002) Biochemistry , vol.41 , pp. 9229-9236
    • De Souza, D.1
  • 25
    • 0032535364 scopus 로고    scopus 로고
    • The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families
    • Kamura, T. et al. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families. Genes Dev. 12, 3872-3881 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 3872-3881
    • Kamura, T.1
  • 26
    • 13044263097 scopus 로고    scopus 로고
    • The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
    • Zhang, J.G. et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96, 2071-2076 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2071-2076
    • Zhang, J.G.1
  • 27
    • 0035918239 scopus 로고    scopus 로고
    • The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
    • Kamizono, S. et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276, 12530-12538 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 12530-12538
    • Kamizono, S.1
  • 28
    • 0035036625 scopus 로고    scopus 로고
    • Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation
    • Frantsve, J., Schwaller, J., Sternberg, D.W., Kutok, J. & Gilliland, D.G. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21, 3547-3557 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3547-3557
    • Frantsve, J.1    Schwaller, J.2    Sternberg, D.W.3    Kutok, J.4    Gilliland, D.G.5
  • 29
    • 0035818573 scopus 로고    scopus 로고
    • The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
    • Zhang, J.G. et al. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl. Acad. Sci. USA 98, 13261-13265 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13261-13265
    • Zhang, J.G.1
  • 30
    • 0042357098 scopus 로고    scopus 로고
    • Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation
    • Haan, S. et al. Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J. Biol. Chem. 278, 31972-31979 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 31972-31979
    • Haan, S.1
  • 31
    • 13044276245 scopus 로고    scopus 로고
    • Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice
    • Naka, T. et al. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice. Proc. Natl. Acad. Sci. USA 95, 15577-15582 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15577-15582
    • Naka, T.1
  • 32
    • 0032564463 scopus 로고    scopus 로고
    • Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
    • Starr, R. et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95, 14395-14399 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14395-14399
    • Starr, R.1
  • 33
    • 0033520467 scopus 로고    scopus 로고
    • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
    • Marine, J.C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616 (1999).
    • (1999) Cell , vol.98 , pp. 609-616
    • Marine, J.C.1
  • 34
    • 0033520326 scopus 로고    scopus 로고
    • SOCS1 is a critical inhibitor of interferon-signaling and prevents the potentially fatal neonatal actions of this cytokine
    • Alexander, W.S. et al. SOCS1 is a critical inhibitor of interferon-signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597-608 (1999).
    • (1999) Cell , vol.98 , pp. 597-608
    • Alexander, W.S.1
  • 36
    • 0037154210 scopus 로고    scopus 로고
    • Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
    • Metcalf, D. et al. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl. Acad. Sci. USA 99, 943-948 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 943-948
    • Metcalf, D.1
  • 37
    • 10744223505 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    • Hanada, T. et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19, 437-450 (2003).
    • (2003) Immunity , vol.19 , pp. 437-450
    • Hanada, T.1
  • 38
    • 0035168683 scopus 로고    scopus 로고
    • JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
    • Sporri, B., Kovanen, P.E., Sasaki, A., Yoshimura, A. & Leonard, W.J. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood 97, 221-226 (2001).
    • (2001) Blood , vol.97 , pp. 221-226
    • Sporri, B.1    Kovanen, P.E.2    Sasaki, A.3    Yoshimura, A.4    Leonard, W.J.5
  • 39
    • 0037927824 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γ c-dependent cytokines in peripheral T cells
    • Cornish, A.L. et al. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γ c-dependent cytokines in peripheral T cells. J. Biol. Chem. 278, 22755-22761 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 22755-22761
    • Cornish, A.L.1
  • 40
    • 0034502224 scopus 로고    scopus 로고
    • Inhibition of TH1 differentiation by IL-6 is mediated by SOCS1
    • Diehl, S. et al. Inhibition of TH1 differentiation by IL-6 is mediated by SOCS1. Immunity 13, 805-815 (2000).
    • (2000) Immunity , vol.13 , pp. 805-815
    • Diehl, S.1
  • 41
    • 0038807434 scopus 로고    scopus 로고
    • Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
    • Eyles, J.L., Metcalf, D., Grusby, M.J., Hilton, D.J. & Starr, R. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J. Biol. Chem. 277, 43735-43740 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 43735-43740
    • Eyles, J.L.1    Metcalf, D.2    Grusby, M.J.3    Hilton, D.J.4    Starr, R.5
  • 43
    • 0344394485 scopus 로고    scopus 로고
    • + thymocytes
    • prepublished online, 7 August (doi:10.1182/blood-2003-01-0175)
    • + thymocytes. Blood prepublished online, 7 August 2003 (doi:10.1182/blood-2003-01-0175).
    • (2003) Blood
    • Ilangumaran, S.1
  • 44
    • 0034624986 scopus 로고    scopus 로고
    • Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor - Induced cell death in fibroblasts
    • Morita, Y. et al. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor - induced cell death in fibroblasts. Proc. Natl. Acad. Sci. USA 97, 5405-5410 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5405-5410
    • Morita, Y.1
  • 45
    • 0036850946 scopus 로고    scopus 로고
    • SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    • Kinjyo, I. et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17, 583-591 (2002).
    • (2002) Immunity , vol.17 , pp. 583-591
    • Kinjyo, I.1
  • 46
    • 18744371050 scopus 로고    scopus 로고
    • SOCS-1 participates in negative regulation of LPS responses
    • Nakagawa, R. et al. SOCS-1 participates in negative regulation of LPS responses. Immunity 17, 677-687 (2002).
    • (2002) Immunity , vol.17 , pp. 677-687
    • Nakagawa, R.1
  • 47
    • 0035862334 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
    • Kawazoe, Y. et al. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J. Exp. Med. 193, 263-269 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 263-269
    • Kawazoe, Y.1
  • 48
    • 0033558088 scopus 로고    scopus 로고
    • Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
    • De Sepulveda, P. et al. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 18, 904-915 (1999).
    • (1999) EMBO J. , vol.18 , pp. 904-915
    • De Sepulveda, P.1
  • 49
    • 0035008978 scopus 로고    scopus 로고
    • SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN- and IL-4 signaling in vivo
    • Naka, T. et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN- and IL-4 signaling in vivo. Immunity 14, 535-545 (2001).
    • (2001) Immunity , vol.14 , pp. 535-545
    • Naka, T.1
  • 51
    • 0037396793 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
    • Chong, M.M. et al. Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18, 475-487 (2003).
    • (2003) Immunity , vol.18 , pp. 475-487
    • Chong, M.M.1
  • 52
    • 0037438475 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 has IFN-independent actions in T cell homeostasis
    • Cornish, A.L. et al. Suppressor of cytokine signaling-1 has IFN-independent actions in T cell homeostasis J. Immunol. 170, 878-886 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 878-886
    • Cornish, A.L.1
  • 53
    • 0026074762 scopus 로고
    • Interleukin 4 expressed in situ selectively alters thymocyte development
    • Lewis, D.B. et al. Interleukin 4 expressed in situ selectively alters thymocyte development. J. Exp. Med. 173, 89-100 (1991).
    • (1991) J. Exp. Med. , vol.173 , pp. 89-100
    • Lewis, D.B.1
  • 54
    • 0036195161 scopus 로고    scopus 로고
    • + immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16, 311-323 (2002).
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1
  • 55
    • 0347144518 scopus 로고    scopus 로고
    • Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
    • (in the press)
    • Naka, T. et al. Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int. Immunol. (in the press).
    • Int. Immunol.
    • Naka, T.1
  • 56
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 299, 1033-1036 (2003).
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 57
    • 0036849109 scopus 로고    scopus 로고
    • h polarization in vivo
    • h polarization in vivo. Int. Immunol. 14, 1343-1350 (2002).
    • (2002) Int. Immunol. , vol.14 , pp. 1343-1350
    • Fujimoto, M.1
  • 58
    • 85047687240 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
    • Egan, P.J., Lawlor, K.E., Alexander, W.S. & Wicks, I.P. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J. Clin. Invest. 111, 915-924 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 915-924
    • Egan, P.J.1    Lawlor, K.E.2    Alexander, W.S.3    Wicks, I.P.4
  • 59
    • 0036533474 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: Implications for Th cell lineage commitment and maintenance
    • Egwuagu, C.E. et al. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168, 3181-3187 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3181-3187
    • Egwuagu, C.E.1
  • 60
    • 0035979275 scopus 로고    scopus 로고
    • Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
    • Roberts, A.W. et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. USA 98, 9324-9329 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9324-9329
    • Roberts, A.W.1
  • 61
    • 0037415694 scopus 로고    scopus 로고
    • SOCS3: An essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
    • Takahashi, Y. et al. SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J. 22, 372-384 (2003).
    • (2003) EMBO J. , vol.22 , pp. 372-384
    • Takahashi, Y.1
  • 62
    • 0042967672 scopus 로고    scopus 로고
    • SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
    • Seki, Y. et al. SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses Nat. Med. 9, 1047-1054 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 1047-1054
    • Seki, Y.1
  • 63
    • 0033037268 scopus 로고    scopus 로고
    • SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
    • Cohney, S.J. et al. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell Biol. 19, 4980-4988 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 4980-4988
    • Cohney, S.J.1
  • 64
    • 0036569393 scopus 로고    scopus 로고
    • Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp
    • Banerjee, A., Banks, A.S., Nawijn, M.C., Chen, X.P. & Rothman, P.B. Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp. J. Immunol. 168, 4277-4281 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 4277-4281
    • Banerjee, A.1    Banks, A.S.2    Nawijn, M.C.3    Chen, X.P.4    Rothman, P.B.5
  • 65
    • 0037450813 scopus 로고    scopus 로고
    • A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production
    • Matsumoto, A. et al. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J. Exp. Med. 197, 425-436 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 425-436
    • Matsumoto, A.1
  • 66
    • 0034234797 scopus 로고    scopus 로고
    • Indirect induction of suppressor of cytokine signaling-1 in macrophages stimulated with bacterial lipopolysaccharide: Partial role of autocrine/paracrine interferon-α/β
    • Crepso, A., Filla, M.B., Russell, S.W. & Murphy, W.J. Indirect induction of suppressor of cytokine signaling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-α/β. Biochem. J. 349, 99-104 (2000).
    • (2000) Biochem. J. , vol.349 , pp. 99-104
    • Crepso, A.1    Filla, M.B.2    Russell, S.W.3    Murphy, W.J.4
  • 67
    • 0033233214 scopus 로고    scopus 로고
    • LPS and TNFalpha induce SOCS3 mRNA and inhibit L-6-induced activation of STAT3 in macrophages. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
    • Bode, J.G. et al. LPS and TNFalpha induce SOCS3 mRNA and inhibit L-6-induced activation of STAT3 in macrophages. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Lett. 463, 365-370 (1999).
    • (1999) FEBS Lett. , vol.463 , pp. 365-370
    • Bode, J.G.1
  • 68
    • 0035877256 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
    • Dalpke, A.H., Opper, S., Zimmermann, S. & Heeg, K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166, 7082-7089 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 7082-7089
    • Dalpke, A.H.1    Opper, S.2    Zimmermann, S.3    Heeg, K.4
  • 69
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49 (1999).
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1
  • 70
    • 0037600741 scopus 로고    scopus 로고
    • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    • Yasukawa, H. et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4, 551-556 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 551-556
    • Yasukawa, H.1
  • 71
    • 0141790820 scopus 로고    scopus 로고
    • A critical role for Stat3 signaling in immune tolerance
    • Cheng, F. et al. A critical role for Stat3 signaling in immune tolerance. Immunity 19, 425-436 (2003).
    • (2003) Immunity , vol.19 , pp. 425-436
    • Cheng, F.1
  • 72
    • 0038614944 scopus 로고    scopus 로고
    • SOCS3 regulates the plasticity of gp130 signaling
    • Lang, R. et al. SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol. 4, 546-550 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 546-550
    • Lang, R.1
  • 73
    • 0037938816 scopus 로고    scopus 로고
    • SOCS3 negatively regulates IL-6 signaling in vivo
    • Croker, B.A. et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4, 540-555 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 540-555
    • Croker, B.A.1
  • 74
    • 0036975241 scopus 로고    scopus 로고
    • Ingested type I interferon: A potential treatment for autoimmunity
    • Brod, S.A. Ingested type I interferon: a potential treatment for autoimmunity. J. Interferon Cytokine Res. 22, 1153-11566 (2002).
    • (2002) J. Interferon Cytokine Res. , vol.22 , pp. 1153-11566
    • Brod, S.A.1
  • 75
    • 0037037586 scopus 로고    scopus 로고
    • A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
    • Atsumi, T. et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp. Med. 196, 979-990 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 979-990
    • Atsumi, T.1
  • 76
    • 0036796060 scopus 로고    scopus 로고
    • Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
    • Tebbutt, N.C. et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8, 1089-1097 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 1089-1097
    • Tebbutt, N.C.1
  • 77
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • Suzuki, A. et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193, 471-481 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 471-481
    • Suzuki, A.1
  • 78
    • 0035667907 scopus 로고    scopus 로고
    • Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
    • Shouda, T. et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108, 1781-1788 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 1781-1788
    • Shouda, T.1
  • 79
    • 0032772125 scopus 로고    scopus 로고
    • Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
    • Matsumoto, A. et al. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell Biol. 19, 6396-6407 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 6396-6407
    • Matsumoto, A.1
  • 80
    • 0034689007 scopus 로고    scopus 로고
    • Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells
    • Li, S. et al. Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells. J. Exp. Med. 191, 985-994 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 985-994
    • Li, S.1
  • 81
    • 0036275657 scopus 로고    scopus 로고
    • SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
    • Krebs, D.L. et al. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol. Cell Biol. 22, 4567-4578 (2002).
    • (2002) Mol. Cell Biol. , vol.22 , pp. 4567-4578
    • Krebs, D.L.1


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