Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 41, 2007, Pages 16158-16163

  Zhou, Jiangbing ^a   Wulfkuhle, Julia ^c   Zhang, Hao ^a   Gu, Peihua ^a   Yang, Yanqin ^b   Deng, Jianghong ^c   Margolick, Joseph B ^a   Liotta, Lance A ^c   Petricoin III, Emanuel ^a   Zhang, Ying ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGE MASON UNIVERSITY   (United States)

Author keywords

cDNA microarray; Reverse phase protein array; Side population cells; Signaling pathway

Indexed keywords

ABC TRANSPORTER; COMPLEMENTARY DNA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CARCINOGENICITY; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DNA MICROARRAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASES; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

MAMMALIA;

EID: 36048963331     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702596104     Document Type: Article

References (34)

1. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE (1994) Nature 367:645-648.
2. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Proc Natl Acad Sci USA 100:3983-3988.
3. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB (2004) Nature 432:396-401.
4. O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) Nature 445:106-110.
5. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R (2007) Nature 445:111-115.
6. Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, Weissman IL, Clarke MF, Ailles LE (2007) Proc Natl Acad Sci USA 104:973-978.
7. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone DM (2007) Cancer Res 67:1030-1037.
8. Kondo T, Setoguchi T, Taga T (2004) Proc Natl Acad Sci USA 101:781-786.
9. Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG (2005) Cancer Res 65:6207-6219.
10. Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK (2004) Proc Natl Acad Sci USA 101:14228-14233.
11. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC (1996) J Exp Med 183:1797-1806.
12. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP (2001) Nat Med 7:1028-1034.
13. Howe HL, Wingo PA, Thun MJ, Ries LA, Rosenberg HM, Feigal EG, Edwards BK (2001) J Natl Cancer Inst 93:824-842.
14. Zhang M, Rosen JM (2006) Curr Opin Genet Dev 16:60-64.
15. Jones RJ, Matsui WH, Smith BD (2004) J Natl Cancer Inst 96:583-585.
16. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Nature 414:105-111.
17. Dean M, Fojo T, Bates S (2005) Nat Rev Cancer 5:275-284.
18. Turkson J, Zhang S, Mora LB, Burns A, Sebti S, Jove R (2005) J Biol Chem 280:32979-32988.
19. Yokogami K, Wakisaka S, Avruch J, Reeves SA (2000) Curr Biol 10:47-50.
20. Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, et al. (2006) Nature 441:518-522.
21. Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ (2006) Nature 441:475-482.
22. Furumoto Y, Brooks S, Olivera A, Takagi Y, Miyagishi M, Taira K, Casellas R, BeavenMA, Gilfillan AM, Rivera J (2006) J Immunol 176:5167-5171.
23. Abounader R, Reznik T, Colantuoni C, Martinez-Murillo F, Rosen EM, Laterra J (2004) Oncogene 23:9173-9182.
24. Chiba T, Kita K, Zheng YW, Yokosuka O, Saisho H, Iwama A, Nakauchi H, Taniguchi H (2006) Hepatology 44:240-251.
25. Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, Clarke MF (2007) N Engl J Med 356:217-226.
26. Paweletz CP, Charboneau L, Bichsel VE, Simone NL, Chen T, Gillespie JW, Emmert-Buck MR, Roth MJ, Petricoin IE, Liotta LA (2001) Oncogene 20:1981-1989.
27. Nishizuka S (2006) Eur J Cancer 42:1273-1282.
28. Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M (2003) Blood 102:972-980.
29. Ling X, Arlinghaus RB (2005) Cancer Res 65:2532-2536.
30. Leong PL, Andrews GA, Johnson DE, Dyer KF, Xi S, Mai JC, Robbins PD, Gadiparthi S, Burke NA, Watkins SF, Grandis JR (2003) Proc Natl Acad Sci USA 100:4138-4143.
31. Cheney IW, Johnson DE, Vaillancourt MT, Avanzini J, Morimoto A, Demers GW, Wills KN, Shabram PW, Bolen JB, Tavtigian SV, Bookstein R (1998) Cancer Res 58:2331-2334.
32. Jordan CT, Guzman ML (2004) Oncogene 23:7178-7187.
33. Wulfkuhle JD, Aquino JA, Calvert VS, Fishman DA, Coukos G, Liotta LA, Petricoin EF, III (2003) Proteomics 3:2085-2090.
34. Bowerman B, O'Connell R (2003) in Business Statistics in Practice (McGraw-Hill, New York), pp 728-730.