-
1
-
-
0033257375
-
The effects of vasodilating drugs on pH in tumors. [Research Support, Non-U.S. Gov't]
-
Adachi E., Tannock I.F. The effects of vasodilating drugs on pH in tumors. [Research Support, Non-U.S. Gov't]. Oncology Research 1999, 11(4):179-185.
-
(1999)
Oncology Research
, vol.11
, Issue.4
, pp. 179-185
-
-
Adachi, E.1
Tannock, I.F.2
-
3
-
-
84862335729
-
Block copolymer micelles for controlled delivery of glycolytic enzyme inhibitors
-
Akter S., Clem B.F., Lee H.J., Chesney J., Bae Y. Block copolymer micelles for controlled delivery of glycolytic enzyme inhibitors. Pharmaceutical Research 2012, 29(3):847-855.
-
(2012)
Pharmaceutical Research
, vol.29
, Issue.3
, pp. 847-855
-
-
Akter, S.1
Clem, B.F.2
Lee, H.J.3
Chesney, J.4
Bae, Y.5
-
4
-
-
7944226627
-
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Research Support, Non-U.S. Gov't
-
Altenberg B., Greulich K.O. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Research Support, Non-U.S. Gov't. Genomics 2004, 84(6):1014-1020.
-
(2004)
Genomics
, vol.84
, Issue.6
, pp. 1014-1020
-
-
Altenberg, B.1
Greulich, K.O.2
-
5
-
-
0037460188
-
Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction
-
Anderson R.F., Shinde S.S., Hay M.P., Gamage S.A., Denny W.A. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction. Journal of the American Chemical Society 2003, 125(3):748-756.
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.3
, pp. 748-756
-
-
Anderson, R.F.1
Shinde, S.S.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
6
-
-
0037905747
-
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. [Research Support, Non-U.S. Gov't]
-
Asada K., Miyamoto K., Fukutomi T., Tsuda H., Yagi Y., Wakazono K., et al. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. [Research Support, Non-U.S. Gov't]. Oncology 2003, 64(4):380-388.
-
(2003)
Oncology
, vol.64
, Issue.4
, pp. 380-388
-
-
Asada, K.1
Miyamoto, K.2
Fukutomi, T.3
Tsuda, H.4
Yagi, Y.5
Wakazono, K.6
-
7
-
-
0037108709
-
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
-
Atsumi T., Chesney J., Metz C., Leng L., Donnelly S., Makita Z., et al. High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Research 2002, 62(20):5881-5887.
-
(2002)
Cancer Research
, vol.62
, Issue.20
, pp. 5881-5887
-
-
Atsumi, T.1
Chesney, J.2
Metz, C.3
Leng, L.4
Donnelly, S.5
Makita, Z.6
-
8
-
-
0024414165
-
Acute effects of single doses of recombinant interferon-gamma on blood cell counts and lymphocyte subsets in patients with advanced renal cell cancer
-
Aulitzky W.E., Aulitzky W., Gastl G., Lanske B., Reitter J., Frick J., et al. Acute effects of single doses of recombinant interferon-gamma on blood cell counts and lymphocyte subsets in patients with advanced renal cell cancer. Journal of Interferon Cytokine Research 1989, 9(4):425-433.
-
(1989)
Journal of Interferon Cytokine Research
, vol.9
, Issue.4
, pp. 425-433
-
-
Aulitzky, W.E.1
Aulitzky, W.2
Gastl, G.3
Lanske, B.4
Reitter, J.5
Frick, J.6
-
9
-
-
77951800160
-
GLUT1 and GLUT3 as potential prognostic markers for oral squamous cell carcinoma. [Research Support, Non-U.S. Gov't]
-
Ayala F.R., Rocha R.M., Carvalho K.C., Carvalho A.L., da Cunha I.W., Lourenco S.V., et al. GLUT1 and GLUT3 as potential prognostic markers for oral squamous cell carcinoma. [Research Support, Non-U.S. Gov't]. Molecules 2010, 15(4):2374-2387.
-
(2010)
Molecules
, vol.15
, Issue.4
, pp. 2374-2387
-
-
Ayala, F.R.1
Rocha, R.M.2
Carvalho, K.C.3
Carvalho, A.L.4
da Cunha, I.W.5
Lourenco, S.V.6
-
10
-
-
74849124330
-
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates
-
Ayral-Kaloustian S., Gu J., Lucas J., Cinque M., Gaydos C., Zask A., et al. Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates. Journal of Medicinal Chemistry 2010, 53(1):452-459.
-
(2010)
Journal of Medicinal Chemistry
, vol.53
, Issue.1
, pp. 452-459
-
-
Ayral-Kaloustian, S.1
Gu, J.2
Lucas, J.3
Cinque, M.4
Gaydos, C.5
Zask, A.6
-
11
-
-
33745820796
-
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. [Research Support, N.I.H., Extramural]
-
Back S.H., Lee K., Vink E., Kaufman R.J. Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. [Research Support, N.I.H., Extramural]. Journal of Biological Chemistry 2006, 281(27):18691-18706.
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.27
, pp. 18691-18706
-
-
Back, S.H.1
Lee, K.2
Vink, E.3
Kaufman, R.J.4
-
12
-
-
0023689603
-
Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity
-
Baker M.A., Zeman E.M., Hirst V.K., Brown J.M. Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Research 1988, 48(21):5947-5952.
-
(1988)
Cancer Research
, vol.48
, Issue.21
, pp. 5947-5952
-
-
Baker, M.A.1
Zeman, E.M.2
Hirst, V.K.3
Brown, J.M.4
-
13
-
-
0028291964
-
Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. [Comparative Study Research Support, U.S. Gov't, P.H.S.]
-
Belfi C.A., Paul C.R., Shan S., Ngo F.Q. Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. [Comparative Study Research Support, U.S. Gov't, P.H.S.]. International Journal of Radiation Oncology, Biology, Physics 1994, 29(3):473-479.
-
(1994)
International Journal of Radiation Oncology, Biology, Physics
, vol.29
, Issue.3
, pp. 473-479
-
-
Belfi, C.A.1
Paul, C.R.2
Shan, S.3
Ngo, F.Q.4
-
14
-
-
77950191479
-
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
-
Ben Sahra I., Laurent K., Giuliano S., Larbret F., Ponzio G., Gounon P., et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Research 2010, 70(6):2465-2475.
-
(2010)
Cancer Research
, vol.70
, Issue.6
, pp. 2465-2475
-
-
Ben Sahra, I.1
Laurent, K.2
Giuliano, S.3
Larbret, F.4
Ponzio, G.5
Gounon, P.6
-
15
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Ben Sahra I., Laurent K., Loubat A., Giorgetti-Peraldi S., Colosetti P., Auberger P., et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008, 27(25):3576-3586.
-
(2008)
Oncogene
, vol.27
, Issue.25
, pp. 3576-3586
-
-
Ben Sahra, I.1
Laurent, K.2
Loubat, A.3
Giorgetti-Peraldi, S.4
Colosetti, P.5
Auberger, P.6
-
16
-
-
0036895572
-
Orally administered pimonidazole to label hypoxic tumor cells
-
Bennewith K.L., Raleigh J.A., Durand R.E. Orally administered pimonidazole to label hypoxic tumor cells. Cancer Research 2002, 62(23):6827-6830.
-
(2002)
Cancer Research
, vol.62
, Issue.23
, pp. 6827-6830
-
-
Bennewith, K.L.1
Raleigh, J.A.2
Durand, R.E.3
-
17
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. [Research Support, Non-U.S. Gov't]
-
Bensaad K., Tsuruta A., Selak M.A., Vidal M.N., Nakano K., Bartrons R., et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. [Research Support, Non-U.S. Gov't]. Cell 2006, 126(1):107-120.
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
-
18
-
-
33747488399
-
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. [Research Support, N.I.H., Extramural]
-
Bernardi R., Guernah I., Jin D., Grisendi S., Alimonti A., Teruya-Feldstein J., et al. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. [Research Support, N.I.H., Extramural]. Nature 2006, 442(7104):779-785.
-
(2006)
Nature
, vol.442
, Issue.7104
, pp. 779-785
-
-
Bernardi, R.1
Guernah, I.2
Jin, D.3
Grisendi, S.4
Alimonti, A.5
Teruya-Feldstein, J.6
-
19
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. [Comparative Study Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.]
-
Bi M., Naczki C., Koritzinsky M., Fels D., Blais J., Hu N., et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. [Comparative Study Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.]. EMBO Journal 2005, 24(19):3470-3481.
-
(2005)
EMBO Journal
, vol.24
, Issue.19
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
Fels, D.4
Blais, J.5
Hu, N.6
-
20
-
-
0023132221
-
Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription
-
Birnbaum M.J., Haspel H.C., Rosen O.M. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 1987, 235(4795):1495-1498.
-
(1987)
Science
, vol.235
, Issue.4795
, pp. 1495-1498
-
-
Birnbaum, M.J.1
Haspel, H.C.2
Rosen, O.M.3
-
21
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Research 2000, 60(17):4693-4696.
-
(2000)
Cancer Research
, vol.60
, Issue.17
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
22
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S., Archer S.L., Allalunis-Turner J., Haromy A., Beaulieu C., Thompson R., et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007, 11(1):37-51.
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
-
23
-
-
0037443587
-
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R., van der Groep P., Greijer A.E., Shvarts A., Meijer S., Pinedo H.M., et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003, 97(6):1573-1581.
-
(2003)
Cancer
, vol.97
, Issue.6
, pp. 1573-1581
-
-
Bos, R.1
van der Groep, P.2
Greijer, A.E.3
Shvarts, A.4
Meijer, S.5
Pinedo, H.M.6
-
24
-
-
0037080449
-
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. [Research Support, Non-U.S. Gov't]
-
Bos R., van Der Hoeven J.J., van Der Wall E., van Der Groep P., van Diest P.J., Comans E.F., et al. Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. [Research Support, Non-U.S. Gov't]. Journal of Clinical Oncology 2002, 20(2):379-387.
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.2
, pp. 379-387
-
-
Bos, R.1
van Der Hoeven, J.J.2
van Der Wall, E.3
van Der Groep, P.4
van Diest, P.J.5
Comans, E.F.6
-
25
-
-
0022519497
-
Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses
-
Bosca L., Mojena M., Ghysdael J., Rousseau G.G., Hue L. Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses. Biochemical Journal 1986, 236(2):595-599.
-
(1986)
Biochemical Journal
, vol.236
, Issue.2
, pp. 595-599
-
-
Bosca, L.1
Mojena, M.2
Ghysdael, J.3
Rousseau, G.G.4
Hue, L.5
-
26
-
-
0031972736
-
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
-
Bowker-Kinley M.M., Davis W.I., Wu P., Harris R.A., Popov K.M. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochemical Journal 1998, 329(Pt 1):191-196.
-
(1998)
Biochemical Journal
, vol.329
, Issue.PART 1
, pp. 191-196
-
-
Bowker-Kinley, M.M.1
Davis, W.I.2
Wu, P.3
Harris, R.A.4
Popov, K.M.5
-
27
-
-
33645766204
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
-
Bowker S.L., Majumdar S.R., Veugelers P., Johnson J.A. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006, 29(2):254-258.
-
(2006)
Diabetes Care
, vol.29
, Issue.2
, pp. 254-258
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
28
-
-
33645124651
-
Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders
-
Brawer M.K. Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Reviews in Urology 2005, 7(Suppl. 7):S21-S26.
-
(2005)
Reviews in Urology
, vol.7
, Issue.SUPPL. 7
-
-
Brawer, M.K.1
-
29
-
-
36248932713
-
The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. [Research Support, Non-U.S. Gov't]
-
Bueno V., Binet I., Steger U., Bundick R., Ferguson D., Murray C., et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. [Research Support, Non-U.S. Gov't]. Transplantation 2007, 84(9):1204-1207.
-
(2007)
Transplantation
, vol.84
, Issue.9
, pp. 1204-1207
-
-
Bueno, V.1
Binet, I.2
Steger, U.3
Bundick, R.4
Ferguson, D.5
Murray, C.6
-
30
-
-
0026447087
-
Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins. [Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]
-
Burant C.F., Bell G.I. Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins. [Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Biochemistry 1992, 31(42):10414-10420.
-
(1992)
Biochemistry
, vol.31
, Issue.42
, pp. 10414-10420
-
-
Burant, C.F.1
Bell, G.I.2
-
31
-
-
0035446816
-
GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy
-
Cantuaria G., Fagotti A., Ferrandina G., Magalhaes A., Nadji M., Angioli R., et al. GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy. Cancer 2001, 92(5):1144-1150.
-
(2001)
Cancer
, vol.92
, Issue.5
, pp. 1144-1150
-
-
Cantuaria, G.1
Fagotti, A.2
Ferrandina, G.3
Magalhaes, A.4
Nadji, M.5
Angioli, R.6
-
32
-
-
48749093935
-
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
-
Cao W., Yacoub S., Shiverick K.T., Namiki K., Sakai Y., Porvasnik S., et al. Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate 2008, 68(11):1223-1231.
-
(2008)
Prostate
, vol.68
, Issue.11
, pp. 1223-1231
-
-
Cao, W.1
Yacoub, S.2
Shiverick, K.T.3
Namiki, K.4
Sakai, Y.5
Porvasnik, S.6
-
33
-
-
79961215490
-
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
-
Chan D.A., Sutphin P.D., Nguyen P., Turcotte S., Lai E.W., Banh A., et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine 2011, 3(94):94ra70.
-
(2011)
Science Translational Medicine
, vol.3
, Issue.94
-
-
Chan, D.A.1
Sutphin, P.D.2
Nguyen, P.3
Turcotte, S.4
Lai, E.W.5
Banh, A.6
-
34
-
-
83355163333
-
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models
-
Cheong J.H., Park E.S., Liang J., Dennison J.B., Tsavachidou D., Nguyen-Charles C., et al. Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models. Molecular Cancer Therapeutics 2011, 10(12):2350-2362.
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, Issue.12
, pp. 2350-2362
-
-
Cheong, J.H.1
Park, E.S.2
Liang, J.3
Dennison, J.B.4
Tsavachidou, D.5
Nguyen-Charles, C.6
-
35
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452(7184):230-233.
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
-
36
-
-
77953988924
-
Targeting the tumour vasculature: insights from physiological angiogenesis
-
Chung A.S., Lee J., Ferrara N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nature Reviews Cancer 2010, 10(7):505-514.
-
(2010)
Nature Reviews Cancer
, vol.10
, Issue.7
, pp. 505-514
-
-
Chung, A.S.1
Lee, J.2
Ferrara, N.3
-
37
-
-
77950788603
-
Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma
-
Cirstea D., Hideshima T., Rodig S., Santo L., Pozzi S., Vallet S., et al. Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma. Molecular Cancer Therapeutics 2010, 9(4):963-975.
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, Issue.4
, pp. 963-975
-
-
Cirstea, D.1
Hideshima, T.2
Rodig, S.3
Santo, L.4
Pozzi, S.5
Vallet, S.6
-
38
-
-
38349183620
-
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
-
Clem B., Telang S., Clem A., Yalcin A., Meier J., Simmons A., et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Molecular Cancer Therapeutics 2008, 7(1):110-120.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.1
, pp. 110-120
-
-
Clem, B.1
Telang, S.2
Clem, A.3
Yalcin, A.4
Meier, J.5
Simmons, A.6
-
39
-
-
38149063508
-
2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer
-
Coleman M.C., Asbury C.R., Daniels D., Du J., Aykin-Burns N., Smith B.J., et al. 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radicical Biology and Medicine 2008, 44(3):322-331.
-
(2008)
Free Radicical Biology and Medicine
, vol.44
, Issue.3
, pp. 322-331
-
-
Coleman, M.C.1
Asbury, C.R.2
Daniels, D.3
Du, J.4
Aykin-Burns, N.5
Smith, B.J.6
-
40
-
-
33646550165
-
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. [Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]
-
Connolly E., Braunstein S., Formenti S., Schneider R.J. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. [Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Molecular and Cellular Biology 2006, 26(10):3955-3965.
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.10
, pp. 3955-3965
-
-
Connolly, E.1
Braunstein, S.2
Formenti, S.3
Schneider, R.J.4
-
41
-
-
33845914327
-
Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression
-
Dachs G.U., Steele A.J., Coralli C., Kanthou C., Brooks A.C., Gunningham S.P., et al. Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression. BMC Cancer 2006, 6:280.
-
(2006)
BMC Cancer
, vol.6
, pp. 280
-
-
Dachs, G.U.1
Steele, A.J.2
Coralli, C.3
Kanthou, C.4
Brooks, A.C.5
Gunningham, S.P.6
-
42
-
-
82555166000
-
MTOR signaling in disease. [Research Support, Non-U.S. Gov't Review]
-
Dazert E., Hall M.N. mTOR signaling in disease. [Research Support, Non-U.S. Gov't Review]. Current Opinion in Cell Biology 2011, 23(6):744-755.
-
(2011)
Current Opinion in Cell Biology
, vol.23
, Issue.6
, pp. 744-755
-
-
Dazert, E.1
Hall, M.N.2
-
43
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst M.W., Cao Y., Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature Reviews Cancer 2008, 8(6):425-437.
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 425-437
-
-
Dewhirst, M.W.1
Cao, Y.2
Moeller, B.3
-
44
-
-
33645130721
-
Clinical evidence supporting the role of lonidamine for the treatment of BPH
-
Ditonno P., Battaglia M., Selvaggio O., Garofalo L., Lorusso V., Selvaggi F.P. Clinical evidence supporting the role of lonidamine for the treatment of BPH. Reviews in Urology 2005, 7(Suppl. 7):S27-S33.
-
(2005)
Reviews in Urology
, vol.7
, Issue.SUPPL. 7
-
-
Ditonno, P.1
Battaglia, M.2
Selvaggio, O.3
Garofalo, L.4
Lorusso, V.5
Selvaggi, F.P.6
-
45
-
-
0035028045
-
Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. [Comparative Study Research Support, U.S. Gov't, P.H.S.]
-
Dong B., Niwa M., Walter P., Silverman R.H. Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. [Comparative Study Research Support, U.S. Gov't, P.H.S.]. RNA 2001, 7(3):361-373.
-
(2001)
RNA
, vol.7
, Issue.3
, pp. 361-373
-
-
Dong, B.1
Niwa, M.2
Walter, P.3
Silverman, R.H.4
-
46
-
-
36348950449
-
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
-
Dowling R.J., Zakikhani M., Fantus I.G., Pollak M., Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research 2007, 67(22):10804-10812.
-
(2007)
Cancer Research
, vol.67
, Issue.22
, pp. 10804-10812
-
-
Dowling, R.J.1
Zakikhani, M.2
Fantus, I.G.3
Pollak, M.4
Sonenberg, N.5
-
47
-
-
43049083694
-
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs
-
Duan J.X., Jiao H., Kaizerman J., Stanton T., Evans J.W., Lan L., et al. Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. Journal of Medicinal Chemistry 2008, 51(8):2412-2420.
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.8
, pp. 2412-2420
-
-
Duan, J.X.1
Jiao, H.2
Kaizerman, J.3
Stanton, T.4
Evans, J.W.5
Lan, L.6
-
48
-
-
37448999132
-
Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse
-
Elekes K., Helyes Z., Kereskai L., Sandor K., Pinter E., Pozsgai G., et al. Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. European Journal of Pharmacology 2008, 578(2-3):313-322.
-
(2008)
European Journal of Pharmacology
, vol.578
, Issue.2-3
, pp. 313-322
-
-
Elekes, K.1
Helyes, Z.2
Kereskai, L.3
Sandor, K.4
Pinter, E.5
Pozsgai, G.6
-
49
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans J.M., Donnelly L.A., Emslie-Smith A.M., Alessi D.R., Morris A.D. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005, 330(7503):1304-1305.
-
(2005)
BMJ
, vol.330
, Issue.7503
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
50
-
-
39149094633
-
Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells
-
Evans J.W., Chernikova S.B., Kachnic L.A., Banath J.P., Sordet O., Delahoussaye Y.M., et al. Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells. Cancer Research 2008, 68(1):257-265.
-
(2008)
Cancer Research
, vol.68
, Issue.1
, pp. 257-265
-
-
Evans, J.W.1
Chernikova, S.B.2
Kachnic, L.A.3
Banath, J.P.4
Sordet, O.5
Delahoussaye, Y.M.6
-
51
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin V.R., St-Pierre J., Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9(6):425-434.
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
52
-
-
56449087512
-
Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways
-
Fels D.R., Ye J., Segan A.T., Kridel S.J., Spiotto M., Olson M., et al. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Research 2008, 68(22):9323-9330.
-
(2008)
Cancer Research
, vol.68
, Issue.22
, pp. 9323-9330
-
-
Fels, D.R.1
Ye, J.2
Segan, A.T.3
Kridel, S.J.4
Spiotto, M.5
Olson, M.6
-
53
-
-
0029101515
-
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. [Research Support, Non-U.S. Gov't]
-
Firth J.D., Ebert B.L., Ratcliffe P.J. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. [Research Support, Non-U.S. Gov't]. Journal of Biological Chemistry 1995, 270(36):21021-21027.
-
(1995)
Journal of Biological Chemistry
, vol.270
, Issue.36
, pp. 21021-21027
-
-
Firth, J.D.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
54
-
-
0023158728
-
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
-
Flier J.S., Mueckler M.M., Usher P., Lodish H.F. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 1987, 235(4795):1492-1495.
-
(1987)
Science
, vol.235
, Issue.4795
, pp. 1492-1495
-
-
Flier, J.S.1
Mueckler, M.M.2
Usher, P.3
Lodish, H.F.4
-
55
-
-
0020519825
-
Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria
-
Floridi A., Lehninger A.L. Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria. Archives of Biochemistry and Biophysics 1983, 226(1):73-83.
-
(1983)
Archives of Biochemistry and Biophysics
, vol.226
, Issue.1
, pp. 73-83
-
-
Floridi, A.1
Lehninger, A.L.2
-
56
-
-
0019457193
-
Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells
-
Floridi A., Paggi M.G., Marcante M.L., Silvestrini B., Caputo A., De Martino C. Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. Journal of National Cancer Institute 1981, 66(3):497-499.
-
(1981)
Journal of National Cancer Institute
, vol.66
, Issue.3
, pp. 497-499
-
-
Floridi, A.1
Paggi, M.G.2
Marcante, M.L.3
Silvestrini, B.4
Caputo, A.5
De Martino, C.6
-
57
-
-
77957659746
-
Everolimus: a proliferation signal inhibitor with clinical applications in organ transplantation, oncology, and cardiology
-
Gabardi S., Baroletti S.A. Everolimus: a proliferation signal inhibitor with clinical applications in organ transplantation, oncology, and cardiology. Pharmacotherapy 2010, 30(10):1044-1056.
-
(2010)
Pharmacotherapy
, vol.30
, Issue.10
, pp. 1044-1056
-
-
Gabardi, S.1
Baroletti, S.A.2
-
58
-
-
45149112158
-
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
-
Gallagher F.A., Kettunen M.I., Day S.E., Hu D.E., Ardenkjaer-Larsen J.H., Zandt R., et al. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature 2008, 453(7197):940-943.
-
(2008)
Nature
, vol.453
, Issue.7197
, pp. 940-943
-
-
Gallagher, F.A.1
Kettunen, M.I.2
Day, S.E.3
Hu, D.E.4
Ardenkjaer-Larsen, J.H.5
Zandt, R.6
-
59
-
-
0035902851
-
The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N. [Comparative Study Research Support, Non-U.S. Gov't]
-
Gallagher R., Hughes C.M., Murray M.M., Friery O.P., Patterson L.H., Hirst D.G., et al. The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N. [Comparative Study Research Support, Non-U.S. Gov't]. British Journal of Cancer 2001, 85(4):625-629.
-
(2001)
British Journal of Cancer
, vol.85
, Issue.4
, pp. 625-629
-
-
Gallagher, R.1
Hughes, C.M.2
Murray, M.M.3
Friery, O.P.4
Patterson, L.H.5
Hirst, D.G.6
-
60
-
-
79957544947
-
A phase I study of the safety and pharmacokinetics of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma
-
Ganjoo K.N., Cranmer L.D., Butrynski J.E., Rushing D., Adkins D., Okuno S.H., et al. A phase I study of the safety and pharmacokinetics of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. Oncology 2011, 80(1-2):50-56.
-
(2011)
Oncology
, vol.80
, Issue.1-2
, pp. 50-56
-
-
Ganjoo, K.N.1
Cranmer, L.D.2
Butrynski, J.E.3
Rushing, D.4
Adkins, D.5
Okuno, S.H.6
-
61
-
-
32544443295
-
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity
-
Garcia-Martin M.L., Martinez G.V., Raghunand N., Sherry A.D., Zhang S., Gillies R.J. High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magnetic Resonance in Medicine 2006, 55(2):309-315.
-
(2006)
Magnetic Resonance in Medicine
, vol.55
, Issue.2
, pp. 309-315
-
-
Garcia-Martin, M.L.1
Martinez, G.V.2
Raghunand, N.3
Sherry, A.D.4
Zhang, S.5
Gillies, R.J.6
-
62
-
-
37549013776
-
A microenvironmental model of carcinogenesis. [Review]
-
Gatenby R.A., Gillies R.J. A microenvironmental model of carcinogenesis. [Review]. Nature Reviews Cancer 2008, 8(1):56-61.
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.1
, pp. 56-61
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
63
-
-
0035860147
-
Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
-
Giatromanolaki A., Koukourakis M.I., Sivridis E., Turley H., Talks K., Pezzella F., et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. British Journal of Cancer 2001, 85(6):881-890.
-
(2001)
British Journal of Cancer
, vol.85
, Issue.6
, pp. 881-890
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Sivridis, E.3
Turley, H.4
Talks, K.5
Pezzella, F.6
-
65
-
-
46749121459
-
Causes and consequences of increased glucose metabolism of cancers
-
Gillies R.J., Robey I., Gatenby R.A. Causes and consequences of increased glucose metabolism of cancers. Journal of Nuclear Medicine 2008, 49(Suppl. 2):24S-42S.
-
(2008)
Journal of Nuclear Medicine
, vol.49
, Issue.SUPPL. 2
-
-
Gillies, R.J.1
Robey, I.2
Gatenby, R.A.3
-
66
-
-
0033170557
-
Causes and effects of heterogeneous perfusion in tumors. [Research Support, U.S. Gov't, P.H.S. Review]
-
Gillies R.J., Schornack P.A., Secomb T.W., Raghunand N. Causes and effects of heterogeneous perfusion in tumors. [Research Support, U.S. Gov't, P.H.S. Review]. Neoplasia 1999, 1(3):197-207.
-
(1999)
Neoplasia
, vol.1
, Issue.3
, pp. 197-207
-
-
Gillies, R.J.1
Schornack, P.A.2
Secomb, T.W.3
Raghunand, N.4
-
67
-
-
0038012340
-
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression
-
Goel A., Mathupala S.P., Pedersen P.L. Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression. Journal of Biological Chemistry 2003, 278(17):15333-15340.
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.17
, pp. 15333-15340
-
-
Goel, A.1
Mathupala, S.P.2
Pedersen, P.L.3
-
68
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
Goel S., Duda D.G., Xu L., Munn L.L., Boucher Y., Fukumura D., et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiological Reviews 2011, 91(3):1071-1121.
-
(2011)
Physiological Reviews
, vol.91
, Issue.3
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
Munn, L.L.4
Boucher, Y.5
Fukumura, D.6
-
69
-
-
0000384544
-
Lactic dehydrogenase in human neoplastic tissues
-
Goldman R.D., Kaplan N.O., Hall T.C. Lactic dehydrogenase in human neoplastic tissues. Cancer Research 1964, 24:389-399.
-
(1964)
Cancer Research
, vol.24
, pp. 389-399
-
-
Goldman, R.D.1
Kaplan, N.O.2
Hall, T.C.3
-
70
-
-
0025886960
-
Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms
-
Gould G.W., Thomas H.M., Jess T.J., Bell G.I. Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms. Biochemistry 1991, 30(21):5139-5145.
-
(1991)
Biochemistry
, vol.30
, Issue.21
, pp. 5139-5145
-
-
Gould, G.W.1
Thomas, H.M.2
Jess, T.J.3
Bell, G.I.4
-
71
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. [Research Support, Non-U.S. Gov't P.H.S.]
-
Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. [Research Support, Non-U.S. Gov't P.H.S.]. Nature 1996, 379(6560):88-91.
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
-
72
-
-
79952806402
-
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells
-
Granchi C., Roy S., Giacomelli C., Macchia M., Tuccinardi T., Martinelli A., et al. Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. Journal of Medicinal Chemistry 2011, 54(6):1599-1612.
-
(2011)
Journal of Medicinal Chemistry
, vol.54
, Issue.6
, pp. 1599-1612
-
-
Granchi, C.1
Roy, S.2
Giacomelli, C.3
Macchia, M.4
Tuccinardi, T.5
Martinelli, A.6
-
73
-
-
0034141649
-
The effects of somatostatin and octreotide on experimental and human acute pancreatitis
-
Greenberg R., Haddad R., Kashtan H., Kaplan O. The effects of somatostatin and octreotide on experimental and human acute pancreatitis. Journal of Laboratory and Clinical Medicine 2000, 135(2):112-121.
-
(2000)
Journal of Laboratory and Clinical Medicine
, vol.135
, Issue.2
, pp. 112-121
-
-
Greenberg, R.1
Haddad, R.2
Kashtan, H.3
Kaplan, O.4
-
74
-
-
56249131779
-
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth
-
Greenberger L.M., Horak I.D., Filpula D., Sapra P., Westergaard M., Frydenlund H.F., et al. A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth. Molecular Cancer Therapeutics 2008, 7(11):3598-3608.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.11
, pp. 3598-3608
-
-
Greenberger, L.M.1
Horak, I.D.2
Filpula, D.3
Sapra, P.4
Westergaard, M.5
Frydenlund, H.F.6
-
75
-
-
0025771650
-
Are cancer cells acidic?
-
Griffiths J.R. Are cancer cells acidic?. British Journal of Cancer 1991, 64(3):425-427.
-
(1991)
British Journal of Cancer
, vol.64
, Issue.3
, pp. 425-427
-
-
Griffiths, J.R.1
-
76
-
-
0024529464
-
Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. [Research Support, Non-U.S. Gov't Review]
-
Grinstein S., Rotin D., Mason M.J. Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. [Research Support, Non-U.S. Gov't Review]. Biochimica et Biophysica Acta 1989, 988(1):73-97.
-
(1989)
Biochimica et Biophysica Acta
, vol.988
, Issue.1
, pp. 73-97
-
-
Grinstein, S.1
Rotin, D.2
Mason, M.J.3
-
77
-
-
68049110633
-
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. [Research support, N.I.H., extramural research support, Non-U.S. Gov't]
-
Han D., Lerner A.G., Vande Walle L., Upton J.P., Xu W., Hagen A., et al. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. [Research support, N.I.H., extramural research support, Non-U.S. Gov't]. Cell 2009, 138(3):562-575.
-
(2009)
Cell
, vol.138
, Issue.3
, pp. 562-575
-
-
Han, D.1
Lerner, A.G.2
Vande Walle, L.3
Upton, J.P.4
Xu, W.5
Hagen, A.6
-
78
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674.
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
79
-
-
79960825218
-
Imaging pH and metastasis. [Review]
-
Hashim A.I., Zhang X., Wojtkowiak J.W., Martinez G.V., Gillies R.J. Imaging pH and metastasis. [Review]. NMR in Biomedicine 2011, 24(6):582-591.
-
(2011)
NMR in Biomedicine
, vol.24
, Issue.6
, pp. 582-591
-
-
Hashim, A.I.1
Zhang, X.2
Wojtkowiak, J.W.3
Martinez, G.V.4
Gillies, R.J.5
-
80
-
-
0016374648
-
Transport of sugars in tumor cell membranes
-
Hatanaka M. Transport of sugars in tumor cell membranes. Biochimica et Biophysica Acta 1974, 355(1):77-104.
-
(1974)
Biochimica et Biophysica Acta
, vol.355
, Issue.1
, pp. 77-104
-
-
Hatanaka, M.1
-
81
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991, 253(5022):905-909.
-
(1991)
Science
, vol.253
, Issue.5022
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
82
-
-
67349237061
-
Two-year follow-up of the phase II marker lesion study of intravesical apaziquone for patients with non-muscle invasive bladder cancer
-
Hendricksen K., van der Heijden A.G., Cornel E.B., Vergunst H., de Reijke T.M., van Boven E., et al. Two-year follow-up of the phase II marker lesion study of intravesical apaziquone for patients with non-muscle invasive bladder cancer. World Journal of Urology 2009, 27(3):337-342.
-
(2009)
World Journal of Urology
, vol.27
, Issue.3
, pp. 337-342
-
-
Hendricksen, K.1
van der Heijden, A.G.2
Cornel, E.B.3
Vergunst, H.4
de Reijke, T.M.5
van Boven, E.6
-
83
-
-
68949102180
-
Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
-
Hess G., Herbrecht R., Romaguera J., Verhoef G., Crump M., Gisselbrecht C., et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. Journal of Clinical Oncology 2009, 27(23):3822-3829.
-
(2009)
Journal of Clinical Oncology
, vol.27
, Issue.23
, pp. 3822-3829
-
-
Hess, G.1
Herbrecht, R.2
Romaguera, J.3
Verhoef, G.4
Crump, M.5
Gisselbrecht, C.6
-
84
-
-
0031785201
-
Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model
-
Hicks K.O., Fleming Y., Siim B.G., Koch C.J., Wilson W.R. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. International Journal of Radiation Oncology, Biology, Physics 1998, 42(3):641-649.
-
(1998)
International Journal of Radiation Oncology, Biology, Physics
, vol.42
, Issue.3
, pp. 641-649
-
-
Hicks, K.O.1
Fleming, Y.2
Siim, B.G.3
Koch, C.J.4
Wilson, W.R.5
-
85
-
-
77958060317
-
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
-
Hicks K.O., Siim B.G., Jaiswal J.K., Pruijn F.B., Fraser A.M., Patel R., et al. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clinical Cancer Research 2010, 16(20):4946-4957.
-
(2010)
Clinical Cancer Research
, vol.16
, Issue.20
, pp. 4946-4957
-
-
Hicks, K.O.1
Siim, B.G.2
Jaiswal, J.K.3
Pruijn, F.B.4
Fraser, A.M.5
Patel, R.6
-
86
-
-
0035925098
-
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. [Research support, Non-U.S. Gov't Review]
-
Hockel M., Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. [Research support, Non-U.S. Gov't Review]. Journal of National Cancer Institute 2001, 93(4):266-276.
-
(2001)
Journal of National Cancer Institute
, vol.93
, Issue.4
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
87
-
-
0346158376
-
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. [Research Support, Non-U.S. Gov't Review]
-
Holness M.J., Sugden M.C. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. [Research Support, Non-U.S. Gov't Review]. Biochemical Society Transactions 2003, 31(Pt 6):1143-1151.
-
(2003)
Biochemical Society Transactions
, vol.31
, Issue.PART 6
, pp. 1143-1151
-
-
Holness, M.J.1
Sugden, M.C.2
-
88
-
-
0026600356
-
Relationship between the hydralazine-induced changes in murine tumor blood supply and mouse blood pressure. [Research support, Non-U.S. Gov't]
-
Horsman M.R., Christensen K.L., Overgaard J. Relationship between the hydralazine-induced changes in murine tumor blood supply and mouse blood pressure. [Research support, Non-U.S. Gov't]. International Journal of Radiation Oncology, Biology, Physics 1992, 22(3):455-458.
-
(1992)
International Journal of Radiation Oncology, Biology, Physics
, vol.22
, Issue.3
, pp. 455-458
-
-
Horsman, M.R.1
Christensen, K.L.2
Overgaard, J.3
-
89
-
-
0020523643
-
Human brain tumor xenografts in nude mice as a chemotherapy model
-
Houchens D.P., Ovejera A.A., Riblet S.M., Slagel D.E. Human brain tumor xenografts in nude mice as a chemotherapy model. European Journal of Cancer & Clinical Oncology 1983, 19(6):799-805.
-
(1983)
European Journal of Cancer & Clinical Oncology
, vol.19
, Issue.6
, pp. 799-805
-
-
Houchens, D.P.1
Ovejera, A.A.2
Riblet, S.M.3
Slagel, D.E.4
-
90
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. [Research support, U.S. Gov't, P.H.S.]
-
Hsiang Y.H., Hertzberg R., Hecht S., Liu L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. [Research support, U.S. Gov't, P.H.S.]. Journal of Biological Chemistry 1985, 260(27):14873-14878.
-
(1985)
Journal of Biological Chemistry
, vol.260
, Issue.27
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.F.4
-
91
-
-
77956585456
-
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug
-
Hu J., Handisides D.R., Van Valckenborgh E., De Raeve H., Menu E., Vande Broek I., et al. Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood 2010, 116(9):1524-1527.
-
(2010)
Blood
, vol.116
, Issue.9
, pp. 1524-1527
-
-
Hu, J.1
Handisides, D.R.2
Van Valckenborgh, E.3
De Raeve, H.4
Menu, E.5
Vande Broek, I.6
-
92
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G., Carducci M., Tomczak P., Dutcher J., Figlin R., Kapoor A., et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. New England Journal of Medicine 2007, 356(22):2271-2281.
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
-
93
-
-
0033673203
-
Mechanism by which metformin reduces glucose production in type 2 diabetes
-
Hundal R.S., Krssak M., Dufour S., Laurent D., Lebon V., Chandramouli V., et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 2000, 49(12):2063-2069.
-
(2000)
Diabetes
, vol.49
, Issue.12
, pp. 2063-2069
-
-
Hundal, R.S.1
Krssak, M.2
Dufour, S.3
Laurent, D.4
Lebon, V.5
Chandramouli, V.6
-
94
-
-
82355173293
-
Reduction of metastasis using a non-volatile buffer
-
Ibrahim Hashim A., Cornnell H.H., Coelho Ribeiro Mde L., Abrahams D., Cunningham J., Lloyd M., et al. Reduction of metastasis using a non-volatile buffer. Clinical and Experimental Metastasis 2011, 28(8):841-849.
-
(2011)
Clinical and Experimental Metastasis
, vol.28
, Issue.8
, pp. 841-849
-
-
Ibrahim Hashim, A.1
Cornnell, H.H.2
Coelho Ribeiro Mde, L.3
Abrahams, D.4
Cunningham, J.5
Lloyd, M.6
-
95
-
-
34147124095
-
Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells
-
Ikezoe T., Nishioka C., Bandobashi K., Yang Y., Kuwayama Y., Adachi Y., et al. Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells. Leukemia Research 2007, 31(5):673-682.
-
(2007)
Leukemia Research
, vol.31
, Issue.5
, pp. 673-682
-
-
Ikezoe, T.1
Nishioka, C.2
Bandobashi, K.3
Yang, Y.4
Kuwayama, Y.5
Adachi, Y.6
-
96
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115(5):577-590.
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
97
-
-
0002548343
-
Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of DNA
-
Iyer V.N., Szybalski W. Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of DNA. Science 1964, 145(3627):55-58.
-
(1964)
Science
, vol.145
, Issue.3627
, pp. 55-58
-
-
Iyer, V.N.1
Szybalski, W.2
-
98
-
-
84864774480
-
Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model
-
Ibrahim-Hashim A., Wojtkowiak J.W., de Lourdes Coelho Ribeiro M., Estrella V., Bailey K.M., et al. Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model. Journal of Cancer Science and Therapy S1 2011.
-
(2011)
Journal of Cancer Science and Therapy S1
-
-
Ibrahim-Hashim, A.1
Wojtkowiak, J.W.2
de Lourdes Coelho Ribeiro, M.3
Estrella, V.4
Bailey, K.M.5
-
99
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. [Research Support, Non-U.S. Gov't]
-
Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. [Research Support, Non-U.S. Gov't]. Science 2001, 292(5516):468-472.
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
-
100
-
-
0025267314
-
Protection of cultured malignant cells from mitoxantrone cytotoxicity by low extracellular pH: a possible mechanism for chemoresistance in vivo
-
Jahde E., Glusenkamp K.H., Rajewsky M.F. Protection of cultured malignant cells from mitoxantrone cytotoxicity by low extracellular pH: a possible mechanism for chemoresistance in vivo. European Journal Cancer 1990, 26(2):101-106.
-
(1990)
European Journal Cancer
, vol.26
, Issue.2
, pp. 101-106
-
-
Jahde, E.1
Glusenkamp, K.H.2
Rajewsky, M.F.3
-
101
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
-
Jain R.K. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nature Medicine 2001, 7(9):987-989.
-
(2001)
Nature Medicine
, vol.7
, Issue.9
, pp. 987-989
-
-
Jain, R.K.1
-
102
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307(5706):58-62.
-
(2005)
Science
, vol.307
, Issue.5706
, pp. 58-62
-
-
Jain, R.K.1
-
103
-
-
20444430874
-
Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478
-
Jordan B.F., Runquist M., Raghunand N., Baker A., Williams R., Kirkpatrick L., et al. Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia 2005, 7(5):475-485.
-
(2005)
Neoplasia
, vol.7
, Issue.5
, pp. 475-485
-
-
Jordan, B.F.1
Runquist, M.2
Raghunand, N.3
Baker, A.4
Williams, R.5
Kirkpatrick, L.6
-
104
-
-
77950501014
-
MTOR regulation of autophagy. [Research support, N.I.H., extramural research support, Non-U.S. Gov't Review]
-
Jung C.H., Ro S.H., Cao J., Otto N.M., Kim D.H. mTOR regulation of autophagy. [Research support, N.I.H., extramural research support, Non-U.S. Gov't Review]. FEBS Letters 2010, 584(7):1287-1295.
-
(2010)
FEBS Letters
, vol.584
, Issue.7
, pp. 1287-1295
-
-
Jung, C.H.1
Ro, S.H.2
Cao, J.3
Otto, N.M.4
Kim, D.H.5
-
105
-
-
32944456143
-
Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]
-
Kaper F., Dornhoefer N., Giaccia A.J. Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Cancer Research 2006, 66(3):1561-1569.
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1561-1569
-
-
Kaper, F.1
Dornhoefer, N.2
Giaccia, A.J.3
-
106
-
-
0017688926
-
Reconstitution and purification of the D-glucose transporter from human erythrocytes
-
Kasahara M., Hinkle P.C. Reconstitution and purification of the D-glucose transporter from human erythrocytes. Journal of Biological Chemistry 1977, 252(20):7384-7390.
-
(1977)
Journal of Biological Chemistry
, vol.252
, Issue.20
, pp. 7384-7390
-
-
Kasahara, M.1
Hinkle, P.C.2
-
107
-
-
0022476828
-
Synaptosomal bioenergetics. The role of glycolysis, pyruvate oxidation and responses to hypoglycaemia. [In Vitro Research Support, Non-U.S. Gov't]
-
Kauppinen R.A., Nicholls D.G. Synaptosomal bioenergetics. The role of glycolysis, pyruvate oxidation and responses to hypoglycaemia. [In Vitro Research Support, Non-U.S. Gov't]. European Journal of Biochemistry 1986, 158(1):159-165.
-
(1986)
European Journal of Biochemistry
, vol.158
, Issue.1
, pp. 159-165
-
-
Kauppinen, R.A.1
Nicholls, D.G.2
-
108
-
-
20244376908
-
Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development
-
Kelloff G.J., Hoffman J.M., Johnson B., Scher H.I., Siegel B.A., Cheng E.Y., et al. Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development. Clinical Cancer Research 2005, 11(8):2785-2808.
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.8
, pp. 2785-2808
-
-
Kelloff, G.J.1
Hoffman, J.M.2
Johnson, B.3
Scher, H.I.4
Siegel, B.A.5
Cheng, E.Y.6
-
109
-
-
68349133231
-
Hypoxic tumor microenvironment and cancer cell differentiation
-
Kim Y., Lin Q., Glazer P.M., Yun Z. Hypoxic tumor microenvironment and cancer cell differentiation. Current Molecular Medicine 2009, 9(4):425-434.
-
(2009)
Current Molecular Medicine
, vol.9
, Issue.4
, pp. 425-434
-
-
Kim, Y.1
Lin, Q.2
Glazer, P.M.3
Yun, Z.4
-
110
-
-
30744469862
-
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
-
Knoechel T.R., Tucker A.D., Robinson C.M., Phillips C., Taylor W., Bungay P.J., et al. Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. Biochemistry 2006, 45(2):402-415.
-
(2006)
Biochemistry
, vol.45
, Issue.2
, pp. 402-415
-
-
Knoechel, T.R.1
Tucker, A.D.2
Robinson, C.M.3
Phillips, C.4
Taylor, W.5
Bungay, P.J.6
-
111
-
-
0035829074
-
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase
-
Ko Y.H., Pedersen P.L., Geschwind J.F. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Letters 2001, 173(1):83-91.
-
(2001)
Cancer Letters
, vol.173
, Issue.1
, pp. 83-91
-
-
Ko, Y.H.1
Pedersen, P.L.2
Geschwind, J.F.3
-
112
-
-
38349092288
-
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha
-
Koh M.Y., Spivak-Kroizman T., Venturini S., Welsh S., Williams R.R., Kirkpatrick D.L., et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Molecular Cancer Therapeutics 2008, 7(1):90-100.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.1
, pp. 90-100
-
-
Koh, M.Y.1
Spivak-Kroizman, T.2
Venturini, S.3
Welsh, S.4
Williams, R.R.5
Kirkpatrick, D.L.6
-
113
-
-
0025854920
-
Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts
-
Kole H.K., Resnick R.J., Van Doren M., Racker E. Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts. Archives of Biochemistry and Biophysics 1991, 286(2):586-590.
-
(1991)
Archives of Biochemistry and Biophysics
, vol.286
, Issue.2
, pp. 586-590
-
-
Kole, H.K.1
Resnick, R.J.2
Van Doren, M.3
Racker, E.4
-
114
-
-
59649111087
-
The unfolded protein response signals through high-order assembly of Ire1. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't]
-
Korennykh A.V., Egea P.F., Korostelev A.A., Finer-Moore J., Zhang C., Shokat K.M., et al. The unfolded protein response signals through high-order assembly of Ire1. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't]. Nature 2009, 457(7230):687-693.
-
(2009)
Nature
, vol.457
, Issue.7230
, pp. 687-693
-
-
Korennykh, A.V.1
Egea, P.F.2
Korostelev, A.A.3
Finer-Moore, J.4
Zhang, C.5
Shokat, K.M.6
-
115
-
-
0036837864
-
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]
-
Koumenis C., Naczki C., Koritzinsky M., Rastani S., Diehl A., Sonenberg N., et al. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Molecular and Cellular Biology 2002, 22(21):7405-7416.
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.21
, pp. 7405-7416
-
-
Koumenis, C.1
Naczki, C.2
Koritzinsky, M.3
Rastani, S.4
Diehl, A.5
Sonenberg, N.6
-
116
-
-
44449147036
-
Tumor cell metabolism: cancer's Achilles' heel
-
Kroemer G., Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 2008, 13(6):472-482.
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
117
-
-
79960989122
-
Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors. [Clinical Trial, Phase I research support, N.I.H., Extramural]
-
Kummar S., Raffeld M., Juwara L., Horneffer Y., Strassberger A., Allen D., et al. Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors. [Clinical Trial, Phase I research support, N.I.H., Extramural]. Clinical Cancer Research 2011, 17(15):5123-5131.
-
(2011)
Clinical Cancer Research
, vol.17
, Issue.15
, pp. 5123-5131
-
-
Kummar, S.1
Raffeld, M.2
Juwara, L.3
Horneffer, Y.4
Strassberger, A.5
Allen, D.6
-
118
-
-
34547902505
-
Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells
-
Kurtoglu M., Maher J.C., Lampidis T.J. Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells. Antioxidants & Redox Signaling 2007, 9(9):1383-1390.
-
(2007)
Antioxidants & Redox Signaling
, vol.9
, Issue.9
, pp. 1383-1390
-
-
Kurtoglu, M.1
Maher, J.C.2
Lampidis, T.J.3
-
119
-
-
0032917763
-
Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model
-
Kyle A.H., Minchinton A.I. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model. Cancer Chemotherapy and Pharmacology 1999, 43(3):213-220.
-
(1999)
Cancer Chemotherapy and Pharmacology
, vol.43
, Issue.3
, pp. 213-220
-
-
Kyle, A.H.1
Minchinton, A.I.2
-
120
-
-
33748473375
-
Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells"
-
Lampidis T.J., Kurtoglu M., Maher J.C., Liu H., Krishan A., Sheft V., et al. Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells". Cancer Chemotherapy and Pharmacology 2006, 58(6):725-734.
-
(2006)
Cancer Chemotherapy and Pharmacology
, vol.58
, Issue.6
, pp. 725-734
-
-
Lampidis, T.J.1
Kurtoglu, M.2
Maher, J.C.3
Liu, H.4
Krishan, A.5
Sheft, V.6
-
121
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. [Research support, N.I.H., Extramural Research Support, Non-U.S. Gov't]
-
Le A., Cooper C.R., Gouw A.M., Dinavahi R., Maitra A., Deck L.M., et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. [Research support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Proceedings of the National Academy of Sciences U S A 2010, 107(5):2037-2042.
-
(2010)
Proceedings of the National Academy of Sciences U S A
, vol.107
, Issue.5
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
-
122
-
-
4143091521
-
Phase I study of tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy in limited-stage small cell lung cancer (S0004): a Southwest Oncology Group study
-
Le Q.T., McCoy J., Williamson S., Ryu J., Gaspar L.E., Edelman M.J., et al. Phase I study of tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy in limited-stage small cell lung cancer (S0004): a Southwest Oncology Group study. Clinical Cancer Research 2004, 10(16):5418-5424.
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.16
, pp. 5418-5424
-
-
Le, Q.T.1
McCoy, J.2
Williamson, S.3
Ryu, J.4
Gaspar, L.E.5
Edelman, M.J.6
-
123
-
-
0043193876
-
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]
-
Lee A.H., Iwakoshi N.N., Anderson K.C., Glimcher L.H. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]. Proceedings of the National Academy of Sciences U S A 2003, 100(17):9946-9951.
-
(2003)
Proceedings of the National Academy of Sciences U S A
, vol.100
, Issue.17
, pp. 9946-9951
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Anderson, K.C.3
Glimcher, L.H.4
-
124
-
-
23844461100
-
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. [Research support, Non-U.S. Gov't]
-
Li L., Lin X., Staver M., Shoemaker A., Semizarov D., Fesik S.W., et al. Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. [Research support, Non-U.S. Gov't]. Cancer Research 2005, 65(16):7249-7258.
-
(2005)
Cancer Research
, vol.65
, Issue.16
, pp. 7249-7258
-
-
Li, L.1
Lin, X.2
Staver, M.3
Shoemaker, A.4
Semizarov, D.5
Fesik, S.W.6
-
125
-
-
37248999267
-
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. [Research support, N.I.H., Extramural research support, U.S. Gov't, Non-P.H.S.]
-
Li Y., Wang Y., Kim E., Beemiller P., Wang C.Y., Swanson J., et al. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. [Research support, N.I.H., Extramural research support, U.S. Gov't, Non-P.H.S.]. Journal of Biological Chemistry 2007, 282(49):35803-35813.
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.49
, pp. 35803-35813
-
-
Li, Y.1
Wang, Y.2
Kim, E.3
Beemiller, P.4
Wang, C.Y.5
Swanson, J.6
-
126
-
-
0037174915
-
Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells
-
Li Y.C., Fung K.P., Kwok T.T., Lee C.Y., Suen Y.K., Kong S.K. Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells. Life Science 2002, 71(23):2729-2740.
-
(2002)
Life Science
, vol.71
, Issue.23
, pp. 2729-2740
-
-
Li, Y.C.1
Fung, K.P.2
Kwok, T.T.3
Lee, C.Y.4
Suen, Y.K.5
Kong, S.K.6
-
127
-
-
0038407274
-
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism
-
Lin X., Zhang F., Bradbury C.M., Kaushal A., Li L., Spitz D.R., et al. 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Research 2003, 63(12):3413-3417.
-
(2003)
Cancer Research
, vol.63
, Issue.12
, pp. 3413-3417
-
-
Lin, X.1
Zhang, F.2
Bradbury, C.M.3
Kaushal, A.4
Li, L.5
Spitz, D.R.6
-
128
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
Liu L., Cash T.P., Jones R.G., Keith B., Thompson C.B., Simon M.C. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Molecular Cell 2006, 21(4):521-531.
-
(2006)
Molecular Cell
, vol.21
, Issue.4
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
129
-
-
79955490807
-
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors
-
Lou Y., McDonald P.C., Oloumi A., Chia S., Ostlund C., Ahmadi A., et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Research 2011, 71(9):3364-3376.
-
(2011)
Cancer Research
, vol.71
, Issue.9
, pp. 3364-3376
-
-
Lou, Y.1
McDonald, P.C.2
Oloumi, A.3
Chia, S.4
Ostlund, C.5
Ahmadi, A.6
-
130
-
-
9744260934
-
Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
-
Luciani F., Spada M., De Milito A., Molinari A., Rivoltini L., Montinaro A., et al. Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. Journal of National Cancer Institute 2004, 96(22):1702-1713.
-
(2004)
Journal of National Cancer Institute
, vol.96
, Issue.22
, pp. 1702-1713
-
-
Luciani, F.1
Spada, M.2
De Milito, A.3
Molinari, A.4
Rivoltini, L.5
Montinaro, A.6
-
131
-
-
0030882879
-
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
-
Mathupala S.P., Heese C., Pedersen P.L. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. Journal of Biological Chemistry 1997, 272(36):22776-22780.
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.36
, pp. 22776-22780
-
-
Mathupala, S.P.1
Heese, C.2
Pedersen, P.L.3
-
132
-
-
80054020825
-
Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia
-
Matsumoto S., Batra S., Saito K., Yasui H., Choudhuri R., Gadisetti C., et al. Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia. Cancer Research 2011, 71(20):6350-6359.
-
(2011)
Cancer Research
, vol.71
, Issue.20
, pp. 6350-6359
-
-
Matsumoto, S.1
Batra, S.2
Saito, K.3
Yasui, H.4
Choudhuri, R.5
Gadisetti, C.6
-
133
-
-
78650387484
-
Imaging cycling tumor hypoxia
-
Matsumoto S., Yasui H., Mitchell J.B., Krishna M.C. Imaging cycling tumor hypoxia. Cancer Research 2010, 70(24):10019-10023.
-
(2010)
Cancer Research
, vol.70
, Issue.24
, pp. 10019-10023
-
-
Matsumoto, S.1
Yasui, H.2
Mitchell, J.B.3
Krishna, M.C.4
-
134
-
-
80053598625
-
A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients
-
McKeage M.J., Gu Y., Wilson W.R., Hill A., Amies K., Melink T.J., et al. A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients. BMC Cancer 2011, 11:432.
-
(2011)
BMC Cancer
, vol.11
, pp. 432
-
-
McKeage, M.J.1
Gu, Y.2
Wilson, W.R.3
Hill, A.4
Amies, K.5
Melink, T.J.6
-
135
-
-
0015501409
-
The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase. Kinetic and stereochemical studies
-
Meloche H.P., Luczak M.A., Wurster J.M. The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase. Kinetic and stereochemical studies. Journal of Biological Chemistry 1972, 247(13):4186-4191.
-
(1972)
Journal of Biological Chemistry
, vol.247
, Issue.13
, pp. 4186-4191
-
-
Meloche, H.P.1
Luczak, M.A.2
Wurster, J.M.3
-
136
-
-
84859378451
-
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302
-
Meng F., Evans J.W., Bhupathi D., Banica M., Lan L., Lorente G., et al. Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Molecular Cancer Therapeutics 2012.
-
(2012)
Molecular Cancer Therapeutics
-
-
Meng, F.1
Evans, J.W.2
Bhupathi, D.3
Banica, M.4
Lan, L.5
Lorente, G.6
-
137
-
-
77952995998
-
Metabolic modulation of glioblastoma with dichloroacetate
-
Michelakis E.D., Sutendra G., Dromparis P., Webster L., Haromy A., Niven E., et al. Metabolic modulation of glioblastoma with dichloroacetate. Science Translational Medicine 2010, 2(31):31ra34.
-
(2010)
Science Translational Medicine
, vol.2
, Issue.31
-
-
Michelakis, E.D.1
Sutendra, G.2
Dromparis, P.3
Webster, L.4
Haromy, A.5
Niven, E.6
-
138
-
-
79952955367
-
Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells
-
Milane L., Duan Z., Amiji M. Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells. Molecular Pharmacology 2011, 8(1):185-203.
-
(2011)
Molecular Pharmacology
, vol.8
, Issue.1
, pp. 185-203
-
-
Milane, L.1
Duan, Z.2
Amiji, M.3
-
139
-
-
80052552395
-
Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer
-
Milane L., Duan Z., Amiji M. Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer. PLoS One 2011, 6(9):e24075.
-
(2011)
PLoS One
, vol.6
, Issue.9
-
-
Milane, L.1
Duan, Z.2
Amiji, M.3
-
140
-
-
78651336357
-
Anti-angiogenic therapy: adapting strategies to overcome resistant tumors. [Review]
-
Mitchell D.C., Bryan B.A. Anti-angiogenic therapy: adapting strategies to overcome resistant tumors. [Review]. Journal of Cellular Biochemistry 2010, 111(3):543-553.
-
(2010)
Journal of Cellular Biochemistry
, vol.111
, Issue.3
, pp. 543-553
-
-
Mitchell, D.C.1
Bryan, B.A.2
-
141
-
-
44449089860
-
Acid treatment of melanoma cells selects for invasive phenotypes
-
Moellering R.E., Black K.C., Krishnamurty C., Baggett B.K., Stafford P., Rain M., et al. Acid treatment of melanoma cells selects for invasive phenotypes. Clinical and Experimental Metastasis 2008, 25(4):411-425.
-
(2008)
Clinical and Experimental Metastasis
, vol.25
, Issue.4
, pp. 411-425
-
-
Moellering, R.E.1
Black, K.C.2
Krishnamurty, C.3
Baggett, B.K.4
Stafford, P.5
Rain, M.6
-
142
-
-
0030009250
-
Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas
-
Mohanti B.K., Rath G.K., Anantha N., Kannan V., Das B.S., Chandramouli B.A., et al. Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas. International Journal of Radiation Oncology, Biology, Physics 1996, 35(1):103-111.
-
(1996)
International Journal of Radiation Oncology, Biology, Physics
, vol.35
, Issue.1
, pp. 103-111
-
-
Mohanti, B.K.1
Rath, G.K.2
Anantha, N.3
Kannan, V.4
Das, B.S.5
Chandramouli, B.A.6
-
143
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
-
Motzer R.J., Escudier B., Oudard S., Hutson T.E., Porta C., Bracarda S., et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372(9637):449-456.
-
(2008)
Lancet
, vol.372
, Issue.9637
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
-
144
-
-
80355146252
-
Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells
-
Nakano A., Tsuji D., Miki H., Cui Q., El Sayed S.M., Ikegame A., et al. Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. PLoS One 2011, 6(11):e27222.
-
(2011)
PLoS One
, vol.6
, Issue.11
-
-
Nakano, A.1
Tsuji, D.2
Miki, H.3
Cui, Q.4
El Sayed, S.M.5
Ikegame, A.6
-
145
-
-
29244470510
-
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't]
-
Nawrocki S.T., Carew J.S., Dunner K., Boise L.H., Chiao P.J., Huang P., et al. Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't]. Cancer Research 2005, 65(24):11510-11519.
-
(2005)
Cancer Research
, vol.65
, Issue.24
, pp. 11510-11519
-
-
Nawrocki, S.T.1
Carew, J.S.2
Dunner, K.3
Boise, L.H.4
Chiao, P.J.5
Huang, P.6
-
146
-
-
80053563164
-
Interfering with pH regulation in tumours as a therapeutic strategy. [Research Support, Non-U.S. Gov't Review]
-
Neri D., Supuran C.T. Interfering with pH regulation in tumours as a therapeutic strategy. [Research Support, Non-U.S. Gov't Review]. Nature Reviews Drug Discovery 2011, 10(10):767-777.
-
(2011)
Nature Reviews Drug Discovery
, vol.10
, Issue.10
, pp. 767-777
-
-
Neri, D.1
Supuran, C.T.2
-
147
-
-
0034809586
-
Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire1p from Saccharomyces cerevisiae. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]
-
Nock S., Gonzalez T.N., Sidrauski C., Niwa M., Walter P. Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire1p from Saccharomyces cerevisiae. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]. Methods in Enzymology 2001, 342:3-10.
-
(2001)
Methods in Enzymology
, vol.342
, pp. 3-10
-
-
Nock, S.1
Gonzalez, T.N.2
Sidrauski, C.3
Niwa, M.4
Walter, P.5
-
148
-
-
0029922606
-
Effect of hydralazine in spontaneous tumours assessed by oxygen electrodes and 31P-magnetic resonance spectroscopy. [Research Support, Non-U.S. Gov't]
-
Nordsmark M., Maxwell R.J., Wood P.J., Stratford I.J., Adams G.E., Overgaard J., et al. Effect of hydralazine in spontaneous tumours assessed by oxygen electrodes and 31P-magnetic resonance spectroscopy. [Research Support, Non-U.S. Gov't]. British Journal of Cancer Supplement 1996, 27:S232-235.
-
(1996)
British Journal of Cancer Supplement
, vol.27
-
-
Nordsmark, M.1
Maxwell, R.J.2
Wood, P.J.3
Stratford, I.J.4
Adams, G.E.5
Overgaard, J.6
-
149
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. [Research Support, Non-U.S. Gov't]
-
Ohh M., Park C.W., Ivan M., Hoffman M.A., Kim T.Y., Huang L.E., et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. [Research Support, Non-U.S. Gov't]. Nature Cell Biology 2000, 2(7):423-427.
-
(2000)
Nature Cell Biology
, vol.2
, Issue.7
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
-
150
-
-
0023694816
-
Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]
-
Okunieff P., Kallinowski F., Vaupel P., Neuringer L.J. Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]. Journal of National Cancer Institute 1988, 80(10):745-750.
-
(1988)
Journal of National Cancer Institute
, vol.80
, Issue.10
, pp. 745-750
-
-
Okunieff, P.1
Kallinowski, F.2
Vaupel, P.3
Neuringer, L.J.4
-
151
-
-
34547838192
-
Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. [Research support, Non-U.S. Gov't]
-
Osada R., Horiuchi A., Kikuchi N., Yoshida J., Hayashi A., Ota M., et al. Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. [Research support, Non-U.S. Gov't]. Human Pathology 2007, 38(9):1310-1320.
-
(2007)
Human Pathology
, vol.38
, Issue.9
, pp. 1310-1320
-
-
Osada, R.1
Horiuchi, A.2
Kikuchi, N.3
Yoshida, J.4
Hayashi, A.5
Ota, M.6
-
152
-
-
0033598320
-
Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle
-
Owa T., Yoshino H., Okauchi T., Yoshimatsu K., Ozawa Y., Sugi N.H., et al. Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. Journal of Medicinal Chemistry 1999, 42(19):3789-3799.
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.19
, pp. 3789-3799
-
-
Owa, T.1
Yoshino, H.2
Okauchi, T.3
Yoshimatsu, K.4
Ozawa, Y.5
Sugi, N.H.6
-
153
-
-
78851471290
-
Imaging tumor hypoxia by magnetic resonance methods. [Research support, Non-U.S. Gov't review]
-
Pacheco-Torres J., Lopez-Larrubia P., Ballesteros P., Cerdan S. Imaging tumor hypoxia by magnetic resonance methods. [Research support, Non-U.S. Gov't review]. NMR in Biomedicine 2011, 24(1):1-16.
-
(2011)
NMR in Biomedicine
, vol.24
, Issue.1
, pp. 1-16
-
-
Pacheco-Torres, J.1
Lopez-Larrubia, P.2
Ballesteros, P.3
Cerdan, S.4
-
154
-
-
53449096820
-
PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells
-
Palayoor S.T., Mitchell J.B., Cerna D., Degraff W., John-Aryankalayil M., Coleman C.N. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. International Journal of Cancer 2008, 123(10):2430-2437.
-
(2008)
International Journal of Cancer
, vol.123
, Issue.10
, pp. 2430-2437
-
-
Palayoor, S.T.1
Mitchell, J.B.2
Cerna, D.3
Degraff, W.4
John-Aryankalayil, M.5
Coleman, C.N.6
-
155
-
-
58149250648
-
A phase 1 open-label, accelerated dose-escalation study of the hypoxia-activated prodrug AQ4N in patients with advanced malignancies. [Clinical Trial, Phase I Research support, Non-U.S. Gov't]
-
Papadopoulos K.P., Goel S., Beeram M., Wong A., Desai K., Haigentz M., et al. A phase 1 open-label, accelerated dose-escalation study of the hypoxia-activated prodrug AQ4N in patients with advanced malignancies. [Clinical Trial, Phase I Research support, Non-U.S. Gov't]. Clinical Cancer Research 2008, 14(21):7110-7115.
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.21
, pp. 7110-7115
-
-
Papadopoulos, K.P.1
Goel, S.2
Beeram, M.3
Wong, A.4
Desai, K.5
Haigentz, M.6
-
156
-
-
79251589342
-
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't]
-
Papandreou I., Denko N.C., Olson M., Van Melckebeke H., Lust S., Tam A., et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't]. Blood 2011, 117(4):1311-1314.
-
(2011)
Blood
, vol.117
, Issue.4
, pp. 1311-1314
-
-
Papandreou, I.1
Denko, N.C.2
Olson, M.3
Van Melckebeke, H.4
Lust, S.5
Tam, A.6
-
157
-
-
0033584157
-
2-nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the PARP inhibitor 5-bromoisoquinolinone
-
Parveen I., Naughton D.P., Whish W.J., Threadgill M.D. 2-nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the PARP inhibitor 5-bromoisoquinolinone. Bioorganic & Medicinal Chemistry Letters 1999, 9(14):2031-2036.
-
(1999)
Bioorganic & Medicinal Chemistry Letters
, vol.9
, Issue.14
, pp. 2031-2036
-
-
Parveen, I.1
Naughton, D.P.2
Whish, W.J.3
Threadgill, M.D.4
-
158
-
-
0034029002
-
Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent
-
Patterson L.H., McKeown S.R., Ruparelia K., Double J.A., Bibby M.C., Cole S., et al. Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. British Journal of Cancer 2000, 82(12):1984-1990.
-
(2000)
British Journal of Cancer
, vol.82
, Issue.12
, pp. 1984-1990
-
-
Patterson, L.H.1
McKeown, S.R.2
Ruparelia, K.3
Double, J.A.4
Bibby, M.C.5
Cole, S.6
-
159
-
-
70450284314
-
V-ATPase inhibitors and implication in cancer treatment
-
Perez-Sayans M., Somoza-Martin J.M., Barros-Angueira F., Rey J.M., Garcia-Garcia A. V-ATPase inhibitors and implication in cancer treatment. Cancer Treatment Reviews 2009, 35(8):707-713.
-
(2009)
Cancer Treatment Reviews
, vol.35
, Issue.8
, pp. 707-713
-
-
Perez-Sayans, M.1
Somoza-Martin, J.M.2
Barros-Angueira, F.3
Rey, J.M.4
Garcia-Garcia, A.5
-
160
-
-
58149192169
-
Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma. [Research Support, Non-U.S. Gov't]
-
Pinheiro C., Longatto-Filho A., Ferreira L., Pereira S.M., Etlinger D., Moreira M.A., et al. Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma. [Research Support, Non-U.S. Gov't]. International Journal of Gynecological Pathology 2008, 27(4):568-574.
-
(2008)
International Journal of Gynecological Pathology
, vol.27
, Issue.4
, pp. 568-574
-
-
Pinheiro, C.1
Longatto-Filho, A.2
Ferreira, L.3
Pereira, S.M.4
Etlinger, D.5
Moreira, M.A.6
-
161
-
-
39149130681
-
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
-
Pinheiro C., Longatto-Filho A., Scapulatempo C., Ferreira L., Martins S., Pellerin L., et al. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. Virchows Archives 2008, 452(2):139-146.
-
(2008)
Virchows Archives
, vol.452
, Issue.2
, pp. 139-146
-
-
Pinheiro, C.1
Longatto-Filho, A.2
Scapulatempo, C.3
Ferreira, L.4
Martins, S.5
Pellerin, L.6
-
162
-
-
80053319008
-
GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. [Research Support, Non-U.S. Gov't]
-
Pinheiro C., Sousa B., Albergaria A., Paredes J., Dufloth R., Vieira D., et al. GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. [Research Support, Non-U.S. Gov't]. Histology and Histopathology 2011, 26(10):1279-1286.
-
(2011)
Histology and Histopathology
, vol.26
, Issue.10
, pp. 1279-1286
-
-
Pinheiro, C.1
Sousa, B.2
Albergaria, A.3
Paredes, J.4
Dufloth, R.5
Vieira, D.6
-
164
-
-
0037310125
-
Renal and systemic pH imaging by contrast-enhanced MRI
-
Raghunand N., Howison C., Sherry A.D., Zhang S., Gillies R.J. Renal and systemic pH imaging by contrast-enhanced MRI. Magnetic Resonance in Medicine 2003, 49(2):249-257.
-
(2003)
Magnetic Resonance in Medicine
, vol.49
, Issue.2
, pp. 249-257
-
-
Raghunand, N.1
Howison, C.2
Sherry, A.D.3
Zhang, S.4
Gillies, R.J.5
-
165
-
-
0034884690
-
Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone
-
Raghunand N., Mahoney B., van Sluis R., Baggett B., Gillies R.J. Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone. Neoplasia 2001, 3(3):227-235.
-
(2001)
Neoplasia
, vol.3
, Issue.3
, pp. 227-235
-
-
Raghunand, N.1
Mahoney, B.2
van Sluis, R.3
Baggett, B.4
Gillies, R.J.5
-
166
-
-
80155126675
-
2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma
-
Ramirez-Peinado S., Alcazar-Limones F., Lagares-Tena L., El Mjiyad N., Caro-Maldonado A., Tirado O.M., et al. 2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma. Cancer Research 2011.
-
(2011)
Cancer Research
-
-
Ramirez-Peinado, S.1
Alcazar-Limones, F.2
Lagares-Tena, L.3
El Mjiyad, N.4
Caro-Maldonado, A.5
Tirado, O.M.6
-
167
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. [Research Support, U.S. Gov't, P.H.S.]
-
Rapisarda A., Uranchimeg B., Scudiero D.A., Selby M., Sausville E.A., Shoemaker R.H., et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. [Research Support, U.S. Gov't, P.H.S.]. Cancer Research 2002, 62(15):4316-4324.
-
(2002)
Cancer Research
, vol.62
, Issue.15
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
-
168
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. [Research Support, U.S. Gov't, P.H.S.]
-
Rapisarda A., Uranchimeg B., Sordet O., Pommier Y., Shoemaker R.H., Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. [Research Support, U.S. Gov't, P.H.S.]. Cancer Research 2004, 64(4):1475-1482.
-
(2004)
Cancer Research
, vol.64
, Issue.4
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
169
-
-
4944229705
-
Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. [Research support, U.S. Gov't, P.H.S.]
-
Rapisarda A., Zalek J., Hollingshead M., Braunschweig T., Uranchimeg B., Bonomi C.A., et al. Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. [Research support, U.S. Gov't, P.H.S.]. Cancer Research 2004, 64(19):6845-6848.
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 6845-6848
-
-
Rapisarda, A.1
Zalek, J.2
Hollingshead, M.3
Braunschweig, T.4
Uranchimeg, B.5
Bonomi, C.A.6
-
170
-
-
35148870732
-
Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines
-
Rastogi S., Banerjee S., Chellappan S., Simon G.R. Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Letters 2007, 257(2):244-251.
-
(2007)
Cancer Letters
, vol.257
, Issue.2
, pp. 244-251
-
-
Rastogi, S.1
Banerjee, S.2
Chellappan, S.3
Simon, G.R.4
-
171
-
-
0033594404
-
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
-
Ravagnan L., Marzo I., Costantini P., Susin S.A., Zamzami N., Petit P.X., et al. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene 1999, 18(16):2537-2546.
-
(1999)
Oncogene
, vol.18
, Issue.16
, pp. 2537-2546
-
-
Ravagnan, L.1
Marzo, I.2
Costantini, P.3
Susin, S.A.4
Zamzami, N.5
Petit, P.X.6
-
172
-
-
40949118437
-
Temsirolimus, an inhibitor of mammalian target of rapamycin
-
Rini B.I. Temsirolimus, an inhibitor of mammalian target of rapamycin. Clinical Cancer Research 2008, 14(5):1286-1290.
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.5
, pp. 1286-1290
-
-
Rini, B.I.1
-
173
-
-
16644377045
-
Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
-
Rischin D., Peters L., Fisher R., Macann A., Denham J., Poulsen M., et al. Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). Journal of Clinical Oncology 2005, 23(1):79-87.
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.1
, pp. 79-87
-
-
Rischin, D.1
Peters, L.2
Fisher, R.3
Macann, A.4
Denham, J.5
Poulsen, M.6
-
174
-
-
77954600498
-
Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group
-
Rischin D., Peters L.J., O'Sullivan B., Giralt J., Fisher R., Yuen K., et al. Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group. Journal of Clinical Oncology 2010, 28(18):2989-2995.
-
(2010)
Journal of Clinical Oncology
, vol.28
, Issue.18
, pp. 2989-2995
-
-
Rischin, D.1
Peters, L.J.2
O'Sullivan, B.3
Giralt, J.4
Fisher, R.5
Yuen, K.6
-
175
-
-
65549166946
-
Bicarbonate increases tumor pH and inhibits spontaneous metastases
-
Robey I.F., Baggett B.K., Kirkpatrick N.D., Roe D.J., Dosescu J., Sloane B.F., et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Research 2009, 69(6):2260-2268.
-
(2009)
Cancer Research
, vol.69
, Issue.6
, pp. 2260-2268
-
-
Robey, I.F.1
Baggett, B.K.2
Kirkpatrick, N.D.3
Roe, D.J.4
Dosescu, J.5
Sloane, B.F.6
-
177
-
-
33746149756
-
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. [Research support, Non-U.S. Gov't]
-
Rofstad E.K., Mathiesen B., Kindem K., Galappathi K. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. [Research support, Non-U.S. Gov't]. Cancer Research 2006, 66(13):6699-6707.
-
(2006)
Cancer Research
, vol.66
, Issue.13
, pp. 6699-6707
-
-
Rofstad, E.K.1
Mathiesen, B.2
Kindem, K.3
Galappathi, K.4
-
178
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. [Research support, Non-U.S. Gov't Research support, U.S. Gov't, P.H.S.]
-
Romero-Ramirez L., Cao H., Nelson D., Hammond E., Lee A.H., Yoshida H., et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. [Research support, Non-U.S. Gov't Research support, U.S. Gov't, P.H.S.]. Cancer Research 2004, 64(17):5943-5947.
-
(2004)
Cancer Research
, vol.64
, Issue.17
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
Hammond, E.4
Lee, A.H.5
Yoshida, H.6
-
179
-
-
74949118681
-
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. [Research support, Non-U.S. Gov't]
-
Rouschop K.M., van den Beucken T., Dubois L., Niessen H., Bussink J., Savelkouls K., et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. [Research support, Non-U.S. Gov't]. Journal of Clinical Investigation 2010, 120(1):127-141.
-
(2010)
Journal of Clinical Investigation
, vol.120
, Issue.1
, pp. 127-141
-
-
Rouschop, K.M.1
van den Beucken, T.2
Dubois, L.3
Niessen, H.4
Bussink, J.5
Savelkouls, K.6
-
180
-
-
84857370393
-
Transient decrease in tumor oxygenation after intravenous administration of pyruvate
-
Saito K., Matsumoto S., Devasahayam N., Subramanian S., Munasinghe J.P., Morris H.D., et al. Transient decrease in tumor oxygenation after intravenous administration of pyruvate. Magnetic Resonance in Medicine 2011.
-
(2011)
Magnetic Resonance in Medicine
-
-
Saito, K.1
Matsumoto, S.2
Devasahayam, N.3
Subramanian, S.4
Munasinghe, J.P.5
Morris, H.D.6
-
181
-
-
66249092010
-
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. [Research Support, Non-U.S. Gov't]
-
Saito S., Furuno A., Sakurai J., Sakamoto A., Park H.R., Shin-Ya K., et al. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. [Research Support, Non-U.S. Gov't]. Cancer Research 2009, 69(10):4225-4234.
-
(2009)
Cancer Research
, vol.69
, Issue.10
, pp. 4225-4234
-
-
Saito, S.1
Furuno, A.2
Sakurai, J.3
Sakamoto, A.4
Park, H.R.5
Shin-Ya, K.6
-
182
-
-
84858640254
-
Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
-
Santo L., Hideshima T., Kung A.L., Tseng J.C., Tamang D., Yang M., et al. Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood 2012.
-
(2012)
Blood
-
-
Santo, L.1
Hideshima, T.2
Kung, A.L.3
Tseng, J.C.4
Tamang, D.5
Yang, M.6
-
183
-
-
33644539489
-
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors
-
Schimmer A.D., Thomas M.P., Hurren R., Gronda M., Pellecchia M., Pond G.R., et al. Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer Research 2006, 66(4):2367-2375.
-
(2006)
Cancer Research
, vol.66
, Issue.4
, pp. 2367-2375
-
-
Schimmer, A.D.1
Thomas, M.P.2
Hurren, R.3
Gronda, M.4
Pellecchia, M.5
Pond, G.R.6
-
184
-
-
0025771024
-
Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. [Research support, Non-U.S. Gov't]
-
Schlappack O.K., Zimmermann A., Hill R.P. Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. [Research support, Non-U.S. Gov't]. British Journal of Cancer 1991, 64(4):663-670.
-
(1991)
British Journal of Cancer
, vol.64
, Issue.4
, pp. 663-670
-
-
Schlappack, O.K.1
Zimmermann, A.2
Hill, R.P.3
-
185
-
-
66449118481
-
The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
-
Schwartz D.L., Powis G., Thitai-Kumar A., He Y., Bankson J., Williams R., et al. The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Molecular Cancer Therapeutics 2009, 8(4):947-958.
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, Issue.4
, pp. 947-958
-
-
Schwartz, D.L.1
Powis, G.2
Thitai-Kumar, A.3
He, Y.4
Bankson, J.5
Williams, R.6
-
186
-
-
0000653106
-
Mitomycin C: chemical and biological studies on alkylation
-
Schwartz H.S., Sodergren J.E., Philips F.S. Mitomycin C: chemical and biological studies on alkylation. Science 1963, 142(3596):1181-1183.
-
(1963)
Science
, vol.142
, Issue.3596
, pp. 1181-1183
-
-
Schwartz, H.S.1
Sodergren, J.E.2
Philips, F.S.3
-
187
-
-
0142166332
-
Targeting HIF-1 for cancer therapy. [Review]
-
Semenza G.L. Targeting HIF-1 for cancer therapy. [Review]. Nature Reviews Cancer 2003, 3(10):721-732.
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
188
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]
-
Semenza G.L., Jiang B.H., Leung S.W., Passantino R., Concordet J.P., Maire P., et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Journal of Biological Chemistry 1996, 271(51):32529-32537.
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.51
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
-
189
-
-
80052988662
-
Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the warburg effect
-
Seo M., Kim J.D., Neau D., Sehgal I., Lee Y.H. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the warburg effect. PLoS One 2011, 6(9):e24179.
-
(2011)
PLoS One
, vol.6
, Issue.9
-
-
Seo, M.1
Kim, J.D.2
Neau, D.3
Sehgal, I.4
Lee, Y.H.5
-
190
-
-
70350787200
-
Efficacy of antitumour colon cancer cell vaccine modified by Escherichia coli cytosine deaminase gene
-
Shen L.Z., Wang J.H., Wang H.Q., Hua Y.B., Wu W.X. Efficacy of antitumour colon cancer cell vaccine modified by Escherichia coli cytosine deaminase gene. Zhonghua Wei Chang Wai Ke Za Zhi 2006, 9(5):425-428.
-
(2006)
Zhonghua Wei Chang Wai Ke Za Zhi
, vol.9
, Issue.5
, pp. 425-428
-
-
Shen, L.Z.1
Wang, J.H.2
Wang, H.Q.3
Hua, Y.B.4
Wu, W.X.5
-
191
-
-
0033595121
-
Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus. [Comment research support, Non-U.S. Gov't Research support, U.S. Gov't, P.H.S. Review]
-
Shepherd P.R., Kahn B.B. Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus. [Comment research support, Non-U.S. Gov't Research support, U.S. Gov't, P.H.S. Review]. New England Journal of Medicine 1999, 341(4):248-257.
-
(1999)
New England Journal of Medicine
, vol.341
, Issue.4
, pp. 248-257
-
-
Shepherd, P.R.1
Kahn, B.B.2
-
192
-
-
65549170684
-
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion
-
Silva A.S., Yunes J.A., Gillies R.J., Gatenby R.A. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Research 2009, 69(6):2677-2684.
-
(2009)
Cancer Research
, vol.69
, Issue.6
, pp. 2677-2684
-
-
Silva, A.S.1
Yunes, J.A.2
Gillies, R.J.3
Gatenby, R.A.4
-
193
-
-
34248142302
-
2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells
-
Simons A.L., Ahmad I.M., Mattson D.M., Dornfeld K.J., Spitz D.R. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Research 2007, 67(7):3364-3370.
-
(2007)
Cancer Research
, vol.67
, Issue.7
, pp. 3364-3370
-
-
Simons, A.L.1
Ahmad, I.M.2
Mattson, D.M.3
Dornfeld, K.J.4
Spitz, D.R.5
-
194
-
-
23044507635
-
Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme
-
Singh D., Banerji A.K., Dwarakanath B.S., Tripathi R.P., Gupta J.P., Mathew T.L., et al. Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol 2005, 181(8):507-514.
-
(2005)
Strahlenther Onkol
, vol.181
, Issue.8
, pp. 507-514
-
-
Singh, D.1
Banerji, A.K.2
Dwarakanath, B.S.3
Tripathi, R.P.4
Gupta, J.P.5
Mathew, T.L.6
-
195
-
-
33749430399
-
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
-
Skeen J.E., Bhaskar P.T., Chen C.C., Chen W.S., Peng X.D., Nogueira V., et al. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 2006, 10(4):269-280.
-
(2006)
Cancer Cell
, vol.10
, Issue.4
, pp. 269-280
-
-
Skeen, J.E.1
Bhaskar, P.T.2
Chen, C.C.3
Chen, W.S.4
Peng, X.D.5
Nogueira, V.6
-
196
-
-
0031040944
-
DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides. [Comparative study]
-
Smith P.J., Blunt N.J., Desnoyers R., Giles Y., Patterson L.H. DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides. [Comparative study]. Cancer Chemotherapy and Pharmacology 1997, 39(5):455-461.
-
(1997)
Cancer Chemotherapy and Pharmacology
, vol.39
, Issue.5
, pp. 455-461
-
-
Smith, P.J.1
Blunt, N.J.2
Desnoyers, R.3
Giles, Y.4
Patterson, L.H.5
-
197
-
-
0017168930
-
Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells
-
Song C.W., Clement J.J., Levitt S.H. Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells. Journal of National Cancer Institute 1976, 57(3):603-605.
-
(1976)
Journal of National Cancer Institute
, vol.57
, Issue.3
, pp. 603-605
-
-
Song, C.W.1
Clement, J.J.2
Levitt, S.H.3
-
198
-
-
40249089741
-
Provascular strategy: targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment. [Research Support, Non-U.S. Gov't Review]
-
Sonveaux P. Provascular strategy: targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment. [Research Support, Non-U.S. Gov't Review]. Radiotherapy & Oncology 2008, 86(3):300-313.
-
(2008)
Radiotherapy & Oncology
, vol.86
, Issue.3
, pp. 300-313
-
-
Sonveaux, P.1
-
199
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]
-
Sonveaux P., Vegran F., Schroeder T., Wergin M.C., Verrax J., Rabbani Z.N., et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Journal of Clinical Investigation 2008, 118(12):3930-3942.
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.12
, pp. 3930-3942
-
-
Sonveaux, P.1
Vegran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
-
200
-
-
0024452528
-
The pharmacology of dichloroacetate
-
Stacpoole P.W. The pharmacology of dichloroacetate. Metabolism 1989, 38(11):1124-1144.
-
(1989)
Metabolism
, vol.38
, Issue.11
, pp. 1124-1144
-
-
Stacpoole, P.W.1
-
201
-
-
0023881210
-
Dichloroacetate in the treatment of lactic acidosis
-
Stacpoole P.W., Lorenz A.C., Thomas R.G., Harman E.M. Dichloroacetate in the treatment of lactic acidosis. Annals of Internal Medicine 1988, 108(1):58-63.
-
(1988)
Annals of Internal Medicine
, vol.108
, Issue.1
, pp. 58-63
-
-
Stacpoole, P.W.1
Lorenz, A.C.2
Thomas, R.G.3
Harman, E.M.4
-
202
-
-
0034811999
-
The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src
-
Stetak A., Lankenau A., Vantus T., Csermely P., Ullrich A., Keri G. The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src. Biochemical and Biophysical Research Communications 2001, 285(2):483-488.
-
(2001)
Biochemical and Biophysical Research Communications
, vol.285
, Issue.2
, pp. 483-488
-
-
Stetak, A.1
Lankenau, A.2
Vantus, T.3
Csermely, P.4
Ullrich, A.5
Keri, G.6
-
203
-
-
33847699250
-
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
-
Stetak A., Veress R., Ovadi J., Csermely P., Keri G., Ullrich A. Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Research 2007, 67(4):1602-1608.
-
(2007)
Cancer Research
, vol.67
, Issue.4
, pp. 1602-1608
-
-
Stetak, A.1
Veress, R.2
Ovadi, J.3
Csermely, P.4
Keri, G.5
Ullrich, A.6
-
204
-
-
34447312859
-
The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study. [Clinical trial, Phase I research support, Non-U.S. Gov't]
-
Steward W.P., Middleton M., Benghiat A., Loadman P.M., Hayward C., Waller S., et al. The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study. [Clinical trial, Phase I research support, Non-U.S. Gov't]. Annals of Oncology 2007, 18(6):1098-1103.
-
(2007)
Annals of Oncology
, vol.18
, Issue.6
, pp. 1098-1103
-
-
Steward, W.P.1
Middleton, M.2
Benghiat, A.3
Loadman, P.M.4
Hayward, C.5
Waller, S.6
-
205
-
-
0029133235
-
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
-
Stumvoll M., Nurjhan N., Perriello G., Dailey G., Gerich J.E. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. New England Journal of Medicine 1995, 333(9):550-554.
-
(1995)
New England Journal of Medicine
, vol.333
, Issue.9
, pp. 550-554
-
-
Stumvoll, M.1
Nurjhan, N.2
Perriello, G.3
Dailey, G.4
Gerich, J.E.5
-
206
-
-
84863012236
-
Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer
-
Sun J.D., Liu Q., Wang J., Ahluwalia D., Ferraro D., Wang Y., et al. Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clinical Cancer Research 2012, 18(3):758-770.
-
(2012)
Clinical Cancer Research
, vol.18
, Issue.3
, pp. 758-770
-
-
Sun, J.D.1
Liu, Q.2
Wang, J.3
Ahluwalia, D.4
Ferraro, D.5
Wang, Y.6
-
207
-
-
38849143765
-
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. [Research support, Non-U.S. Gov't review]
-
Supuran C.T. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. [Research support, Non-U.S. Gov't review]. Nature Reviews Drug Discovery 2008, 7(2):168-181.
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.2
, pp. 168-181
-
-
Supuran, C.T.1
-
208
-
-
0015900214
-
Reversible association of cytochalasin B with the human erythrocyte membrane. Inhibition of glucose transport and the stoichiometry of cytochalasin binding
-
Taverna R.D., Langdon R.G. Reversible association of cytochalasin B with the human erythrocyte membrane. Inhibition of glucose transport and the stoichiometry of cytochalasin binding. Biochimica et Biophysica Acta 1973, 323(2):207-219.
-
(1973)
Biochimica et Biophysica Acta
, vol.323
, Issue.2
, pp. 207-219
-
-
Taverna, R.D.1
Langdon, R.G.2
-
209
-
-
70350101307
-
Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. [Research support, N.I.H., extramural]
-
Thangaraju M., Karunakaran S.K., Itagaki S., Gopal E., Elangovan S., Prasad P.D., et al. Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. [Research support, N.I.H., extramural]. Cancer 2009, 115(20):4655-4666.
-
(2009)
Cancer
, vol.115
, Issue.20
, pp. 4655-4666
-
-
Thangaraju, M.1
Karunakaran, S.K.2
Itagaki, S.3
Gopal, E.4
Elangovan, S.5
Prasad, P.D.6
-
210
-
-
33748045490
-
Combined uptake of [18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients
-
Thorwarth D., Eschmann S.M., Holzner F., Paulsen F., Alber M. Combined uptake of [18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients. Radiotherapy Oncology 2006, 80(2):151-156.
-
(2006)
Radiotherapy Oncology
, vol.80
, Issue.2
, pp. 151-156
-
-
Thorwarth, D.1
Eschmann, S.M.2
Holzner, F.3
Paulsen, F.4
Alber, M.5
-
211
-
-
79952930841
-
Results from a phase I, dose-escalation study of PX-478, an orally available inhibitor of HIF-1α. [Abstract]
-
Tibes R.F.G.S., Von Hoff D.D., Weiss G.J., Iyengar T., Kurzrock R., Pestano L., et al. Results from a phase I, dose-escalation study of PX-478, an orally available inhibitor of HIF-1α. [Abstract]. Journal of Clinical Oncology 2010, 28.
-
(2010)
Journal of Clinical Oncology
, vol.28
-
-
Tibes, R.F.G.S.1
Von Hoff, D.D.2
Weiss, G.J.3
Iyengar, T.4
Kurzrock, R.5
Pestano, L.6
-
212
-
-
67650330459
-
First-line treatment in advanced non-small-cell lung cancer: the emerging role of the histologic subtype
-
Tiseo M., Bartolotti M., Gelsomino F., Ardizzoni A. First-line treatment in advanced non-small-cell lung cancer: the emerging role of the histologic subtype. Expert Review of Anticancer Therapy 2009, 9(4):425-435.
-
(2009)
Expert Review of Anticancer Therapy
, vol.9
, Issue.4
, pp. 425-435
-
-
Tiseo, M.1
Bartolotti, M.2
Gelsomino, F.3
Ardizzoni, A.4
-
213
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong R.T., Boucher Y., Kozin S.V., Winkler F., Hicklin D.J., Jain R.K. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Research 2004, 64(11):3731-3736.
-
(2004)
Cancer Research
, vol.64
, Issue.11
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
214
-
-
0034724520
-
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]
-
Travers K.J., Patil C.K., Wodicka L., Lockhart D.J., Weissman J.S., Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]. Cell 2000, 101(3):249-258.
-
(2000)
Cell
, vol.101
, Issue.3
, pp. 249-258
-
-
Travers, K.J.1
Patil, C.K.2
Wodicka, L.3
Lockhart, D.J.4
Weissman, J.S.5
Walter, P.6
-
215
-
-
0041062296
-
Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]
-
Tureci O., Sahin U., Vollmar E., Siemer S., Gottert E., Seitz G., et al. Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. [Research support, Non-U.S. Gov't research support, U.S. Gov't, P.H.S.]. Proceedings of the National Academy of Sciences U S A 1998, 95(13):7608-7613.
-
(1998)
Proceedings of the National Academy of Sciences U S A
, vol.95
, Issue.13
, pp. 7608-7613
-
-
Tureci, O.1
Sahin, U.2
Vollmar, E.3
Siemer, S.4
Gottert, E.5
Seitz, G.6
-
216
-
-
0026475672
-
Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole
-
Valk P.E., Mathis C.A., Prados M.D., Gilbert J.C., Budinger T.F. Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole. Journal of Nuclear Medicine 1992, 33(12):2133-2137.
-
(1992)
Journal of Nuclear Medicine
, vol.33
, Issue.12
, pp. 2133-2137
-
-
Valk, P.E.1
Mathis, C.A.2
Prados, M.D.3
Gilbert, J.C.4
Budinger, T.F.5
-
217
-
-
0034876111
-
The somatostatin analogue TT-232 induces apoptosis in A431 cells: sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases
-
Vantus T., Keri G., Krivickiene Z., Valius M., Stetak A., Keppens S., et al. The somatostatin analogue TT-232 induces apoptosis in A431 cells: sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases. Cell Signal 2001, 13(10):717-725.
-
(2001)
Cell Signal
, vol.13
, Issue.10
, pp. 717-725
-
-
Vantus, T.1
Keri, G.2
Krivickiene, Z.3
Valius, M.4
Stetak, A.5
Keppens, S.6
-
218
-
-
10644234769
-
The role of hypoxia-induced factors in tumor progression. [Review]
-
Vaupel P. The role of hypoxia-induced factors in tumor progression. [Review]. Oncologist 2004, 9(Suppl. 5):10-17.
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 5
, pp. 10-17
-
-
Vaupel, P.1
-
219
-
-
0035936563
-
Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors
-
Vera J.C., Reyes A.M., Velasquez F.V., Rivas C.I., Zhang R.H., Strobel P., et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry 2001, 40(3):777-790.
-
(2001)
Biochemistry
, vol.40
, Issue.3
, pp. 777-790
-
-
Vera, J.C.1
Reyes, A.M.2
Velasquez, F.V.3
Rivas, C.I.4
Zhang, R.H.5
Strobel, P.6
-
220
-
-
6344277190
-
LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. [Research support, Non-U.S. Gov't review]
-
Vester B., Wengel J. LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. [Research support, Non-U.S. Gov't review]. Biochemistry 2004, 43(42):13233-13241.
-
(2004)
Biochemistry
, vol.43
, Issue.42
, pp. 13233-13241
-
-
Vester, B.1
Wengel, J.2
-
221
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina C., Kudelski A., Sehgal S.N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. Journal of Antibiotics (Tokyo) 1975, 28(10):721-726.
-
(1975)
Journal of Antibiotics (Tokyo)
, vol.28
, Issue.10
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
222
-
-
79953319782
-
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. [Research support, Non-U.S. Gov't]
-
Volkmann K., Lucas J.L., Vuga D., Wang X., Brumm D., Stiles C., et al. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. [Research support, Non-U.S. Gov't]. Journal of Biological Chemistry 2011, 286(14):12743-12755.
-
(2011)
Journal of Biological Chemistry
, vol.286
, Issue.14
, pp. 12743-12755
-
-
Volkmann, K.1
Lucas, J.L.2
Vuga, D.3
Wang, X.4
Brumm, D.5
Stiles, C.6
-
223
-
-
0034104328
-
Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors
-
von Pawel J., von Roemeling R., Gatzemeier U., Boyer M., Elisson L.O., Clark P., et al. Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors. Journal of Clinical Oncology 2000, 18(6):1351-1359.
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.6
, pp. 1351-1359
-
-
von Pawel, J.1
von Roemeling, R.2
Gatzemeier, U.3
Boyer, M.4
Elisson, L.O.5
Clark, P.6
-
224
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956, 123(3191):309-314.
-
(1956)
Science
, vol.123
, Issue.3191
, pp. 309-314
-
-
Warburg, O.1
-
227
-
-
79955490434
-
Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies
-
Weiss G.J., Infante J.R., Chiorean E.G., Borad M.J., Bendell J.C., Molina J.R., et al. Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies. Clinical Cancer Research 2011, 17(9):2997-3004.
-
(2011)
Clinical Cancer Research
, vol.17
, Issue.9
, pp. 2997-3004
-
-
Weiss, G.J.1
Infante, J.R.2
Chiorean, E.G.3
Borad, M.J.4
Bendell, J.C.5
Molina, J.R.6
-
228
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
Welsh S., Williams R., Kirkpatrick L., Paine-Murrieta G., Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Molecular Cancer Therapeutics 2004, 3(3):233-244.
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
230
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett C.G., Boucher Y., di Tomaso E., Duda D.G., Munn L.L., Tong R.T., et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature Medicine 2004, 10(2):145-147.
-
(2004)
Nature Medicine
, vol.10
, Issue.2
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
di Tomaso, E.3
Duda, D.G.4
Munn, L.L.5
Tong, R.T.6
-
231
-
-
77955042029
-
A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer
-
Willett C.G., Duda D.G., Ancukiewicz M., Shah M., Czito B.G., Bentley R., et al. A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. Oncologist 2010, 15(8):845-851.
-
(2010)
Oncologist
, vol.15
, Issue.8
, pp. 845-851
-
-
Willett, C.G.1
Duda, D.G.2
Ancukiewicz, M.3
Shah, M.4
Czito, B.G.5
Bentley, R.6
-
232
-
-
67649921334
-
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study
-
Willett C.G., Duda D.G., di Tomaso E., Boucher Y., Ancukiewicz M., Sahani D.V., et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. Journal of Clinical Oncology 2009, 27(18):3020-3026.
-
(2009)
Journal of Clinical Oncology
, vol.27
, Issue.18
, pp. 3020-3026
-
-
Willett, C.G.1
Duda, D.G.2
di Tomaso, E.3
Boucher, Y.4
Ancukiewicz, M.5
Sahani, D.V.6
-
233
-
-
73149107238
-
In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. [Research support, Non-U.S. Gov't]
-
Williams K.J., Albertella M.R., Fitzpatrick B., Loadman P.M., Shnyder S.D., Chinje E.C., et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. [Research support, Non-U.S. Gov't]. Molecular Cancer Therapeutics 2009, 8(12):3266-3275.
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, Issue.12
, pp. 3266-3275
-
-
Williams, K.J.1
Albertella, M.R.2
Fitzpatrick, B.3
Loadman, P.M.4
Shnyder, S.D.5
Chinje, E.C.6
-
234
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F., Kozin S.V., Tong R.T., Chae S.S., Booth M.F., Garkavtsev I., et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004, 6(6):553-563.
-
(2004)
Cancer Cell
, vol.6
, Issue.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
Garkavtsev, I.6
-
235
-
-
82955173044
-
Drug resistance and cellular adaptation to tumor acidic pH microenvironment
-
Wojtkowiak J.W., Verduzco D., Schramm K.J., Gillies R.J. Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Molecular Pharmacology 2011, 8(6):2032-2038.
-
(2011)
Molecular Pharmacology
, vol.8
, Issue.6
, pp. 2032-2038
-
-
Wojtkowiak, J.W.1
Verduzco, D.2
Schramm, K.J.3
Gillies, R.J.4
-
236
-
-
44549083746
-
Dichloroacetate induces apoptosis in endometrial cancer cells
-
Wong J.Y., Huggins G.S., Debidda M., Munshi N.C., De Vivo I. Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecologic Oncology 2008, 109(3):394-402.
-
(2008)
Gynecologic Oncology
, vol.109
, Issue.3
, pp. 394-402
-
-
Wong, J.Y.1
Huggins, G.S.2
Debidda, M.3
Munshi, N.C.4
De Vivo, I.5
-
237
-
-
56249134557
-
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
-
Wood T.E., Dalili S., Simpson C.D., Hurren R., Mao X., Saiz F.S., et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Molecular Cancer Therapeutics 2008, 7(11):3546-3555.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.11
, pp. 3546-3555
-
-
Wood, T.E.1
Dalili, S.2
Simpson, C.D.3
Hurren, R.4
Mao, X.5
Saiz, F.S.6
-
238
-
-
66449103009
-
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
-
Xie H., Valera V.A., Merino M.J., Amato A.M., Signoretti S., Linehan W.M., et al. LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Molecular Cancer Therapeutics 2009, 8(3):626-635.
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, Issue.3
, pp. 626-635
-
-
Xie, H.1
Valera, V.A.2
Merino, M.J.3
Amato, A.M.4
Signoretti, S.5
Linehan, W.M.6
-
239
-
-
78651235027
-
Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells
-
Xie J., Wang B.S., Yu D.H., Lu Q., Ma J., Qi H., et al. Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells. International Journal of Oncology 2011, 38(2):409-417.
-
(2011)
International Journal of Oncology
, vol.38
, Issue.2
, pp. 409-417
-
-
Xie, J.1
Wang, B.S.2
Yu, D.H.3
Lu, Q.4
Ma, J.5
Qi, H.6
-
240
-
-
0035400746
-
Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4
-
Yu Y., Deck J.A., Hunsaker L.A., Deck L.M., Royer R.E., Goldberg E., et al. Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4. Biochemical Pharmacology 2001, 62(1):81-89.
-
(2001)
Biochemical Pharmacology
, vol.62
, Issue.1
, pp. 81-89
-
-
Yu, Y.1
Deck, J.A.2
Hunsaker, L.A.3
Deck, L.M.4
Royer, R.E.5
Goldberg, E.6
-
241
-
-
0042348003
-
A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates
-
Zagorevskii D., Song M., Breneman C., Yuan Y., Fuchs T., Gates K.S., et al. A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates. Journal of the American Society for Mass Spectrometry 2003, 14(8):881-892.
-
(2003)
Journal of the American Society for Mass Spectrometry
, vol.14
, Issue.8
, pp. 881-892
-
-
Zagorevskii, D.1
Song, M.2
Breneman, C.3
Yuan, Y.4
Fuchs, T.5
Gates, K.S.6
-
242
-
-
33751284806
-
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
-
Zakikhani M., Dowling R., Fantus I.G., Sonenberg N., Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Research 2006, 66(21):10269-10273.
-
(2006)
Cancer Research
, vol.66
, Issue.21
, pp. 10269-10273
-
-
Zakikhani, M.1
Dowling, R.2
Fantus, I.G.3
Sonenberg, N.4
Pollak, M.5
-
243
-
-
0022493495
-
SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman E.M., Brown J.M., Lemmon M.J., Hirst V.K., Lee W.W. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. International Journal of Radiation Oncology, Biology, Physics 1986, 12(7):1239-1242.
-
(1986)
International Journal of Radiation Oncology, Biology, Physics
, vol.12
, Issue.7
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
244
-
-
77951246917
-
Chemosensitizing and cytotoxic effects of 2-deoxy-D-glucose on breast cancer cells
-
Zhang F., Aft R.L. Chemosensitizing and cytotoxic effects of 2-deoxy-D-glucose on breast cancer cells. Jounal of Cancer Research and Therapeutics 2009, 5(Suppl 1):S41-43.
-
(2009)
Jounal of Cancer Research and Therapeutics
, vol.5
, Issue.SUPPL 1
-
-
Zhang, F.1
Aft, R.L.2
-
245
-
-
30444441659
-
Metabolism and transport of oxazaphosphorines and the clinical implications
-
Zhang J., Tian Q., Yung Chan S., Chuen Li S., Zhou S., Duan W., et al. Metabolism and transport of oxazaphosphorines and the clinical implications. Drug Metabolism Reviews 2005, 37(4):611-703.
-
(2005)
Drug Metabolism Reviews
, vol.37
, Issue.4
, pp. 611-703
-
-
Zhang, J.1
Tian, Q.2
Yung Chan, S.3
Chuen Li, S.4
Zhou, S.5
Duan, W.6
-
246
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., et al. Role of AMP-activated protein kinase in mechanism of metformin action. Journal of Clinical Investigation 2001, 108(8):1167-1174.
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.8
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
-
247
-
-
84855363557
-
Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't research support, U.S. Gov't, Non-P.H.S.]
-
Zhou Y., Tozzi F., Chen J., Fan F., Xia L., Wang J., et al. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. [Research support, N.I.H., Extramural research support, Non-U.S. Gov't research support, U.S. Gov't, Non-P.H.S.]. Cancer Research 2012, 72(1):304-314.
-
(2012)
Cancer Research
, vol.72
, Issue.1
, pp. 304-314
-
-
Zhou, Y.1
Tozzi, F.2
Chen, J.3
Fan, F.4
Xia, L.5
Wang, J.6
|